nimesulide has been researched along with Pain, Postoperative in 40 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and tolerability of nimesulide and naproxen were compared in a randomised double-blind study of patients with pain and inflammation after haemorrhoidectomy." | 9.07 | Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation. ( Bechi, P; Nava, ML; Panconesi, R; Scaricabarozzi, I; Zuckermann, M, 1993) |
| "Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties." | 6.67 | [The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]. ( Scaricabarozzi, I; Scolari, G; Vargiu, G, 1990) |
| "Nimesulide has been tested by the Authors on a group of 40 adults patients of both sexes that had undergone oral surgery." | 6.67 | [Nimesulide and algo-edematous pathology of the oral cavity]. ( De Francesco, G; Palattella, D, 1990) |
| "Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)." | 6.47 | Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011) |
| "Pain peaks occurred after 6 h (nimesulide-placebo [N-P] group) and 8 h (nimesulide group)." | 5.51 | Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial. ( Cesário, FRAS; Cetira Filho, EL; Choquenaira-Quispe, C; Costa, FWG; da Cruz Fonseca, SG; de Aguiar, ASW; de Sousa Nogueira, G; de Sousa, AVC; Silva, PGB; Wong, DVT, 2022) |
| "The efficacy and tolerability of nimesulide and naproxen were compared in a randomised double-blind study of patients with pain and inflammation after haemorrhoidectomy." | 5.07 | Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation. ( Bechi, P; Nava, ML; Panconesi, R; Scaricabarozzi, I; Zuckermann, M, 1993) |
| "The efficacy and tolerability of nimesulide were assessed and compared with those of paracetamol in the treatment of 35 children with pain and inflammation following adenotonsillectomy." | 5.07 | An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy. ( D'Agostino, R; Pasquale, G; Scaricabarozzi, I; Taborelli, G; Vallarino, R, 1993) |
| "Test drugs provided a reduction in postoperative pain scores and lower use of rescue medication when compared to placebo." | 3.30 | Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single-implant surgery: A randomized clinical trial. ( Alvarenga-Brant, R; Costa, FO; Cota, LOM; Esteves-Lima, RP; Mattos-Pereira, GH, 2023) |
| "This study aimed to evaluate acute postoperative pain management and trismus in 35 patients undergoing extractions of the two mandibular third molars, in mesioangular positions, at two different visits who consumed nimesulide + thiocolchicoside or only nimesulide." | 3.11 | Randomized split-mouth study for evaluating the efficacy of nimesulide and nimesulide + Thiocolchicoside combination following impacted mandibular third molar surgery. ( Cebi, AT; Kasapoglu, MB, 2022) |
| "Oedema and trismus were similar in the two treatment groups and decreased over time postoperatively." | 2.84 | Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. ( Almeida, RA; Barbalho, JC; de Araújo, SQ; de Morais, HH; Lucena, EE; Rêbelo, HL; Santos, LA; Vasconcellos, RJ, 2017) |
| "There was less trismus in the meloxicam group (P > 0." | 2.77 | Effect of partially selective cyclooxygenase-2 inhibitor in the removal of third molars. ( Antunes, AA; Avelar, RL; de Oliveira e Silva, ED; Magalhães, MT; Primo, BT; Rocha, A; Vogt, BF, 2012) |
| "To evaluate postoperative pain using a multimodal analgesic protocol in women with uterine fibroids managed with minimally invasive myomectomy." | 2.76 | Improved recovery using multimodal perioperative analgesia in minimally invasive myomectomy: a randomised study. ( Kalogiannidis, I; Papadopoulos, E; Prapas, N; Prapas, Y; Xiromeritis, P, 2011) |
| "Nimesulide was significantly more effective than placebo for the treatment of postoperative pain, as measured by the primary efficacy variable of summed pain intensity difference within 6 hours after first treatment (10." | 2.73 | Nimesulide in the treatment of postoperative pain: a double-blind, comparative study in patients undergoing arthroscopic knee surgery. ( Binning, A, 2007) |
| "Nimesulide was administered orally the evening before surgery and at 12-h intervals for 5 days postoperatively." | 2.73 | Nimesulide 90 mg orally twice daily does not influence postoperative morphine requirements after major chest surgery. ( Cagney, G; Dooley, M; Dowd, NP; Fitzgerald, DJ; Harhen, B; Harney, DF; McCrory, C; McGuiness, N, 2008) |
| "Which isoform of COX is responsible for postsurgical pain and, consequently, should be targeted, is unclear." | 2.71 | Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2. ( Fitzgerald, D; McCrory, C, 2004) |
| "Nimesulide was more effective and more rapid than ketoprofen in ameliorating the painful inflammatory symptoms (pain at rest and upon mastication) and signs (swelling and hyperaemia) associated with the operation." | 2.67 | A double-blind comparison of nimesulide and ketoprofen in dental surgery. ( Pierleoni, P; Scaricabarozzi, I; Tonelli, P, 1993) |
| "Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties." | 2.67 | [The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]. ( Scaricabarozzi, I; Scolari, G; Vargiu, G, 1990) |
| "Nimesulide has been tested by the Authors on a group of 40 adults patients of both sexes that had undergone oral surgery." | 2.67 | [Nimesulide and algo-edematous pathology of the oral cavity]. ( De Francesco, G; Palattella, D, 1990) |
| "Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)." | 2.47 | Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011) |
| "Nimesulide was the most prescribed NSAID (68%), followed by diclofenac, ketoprofen and ibuprofen." | 1.35 | Prescriptions of NSAIDs to patients undergoing third molar surgery : an observational, prospective, multicentre survey. ( Bandettini, M; Bertelli, E; Caputi, S; Carraro, M; Garau, V; Levrini, L; Lörincz, A; Pelliccioni, GA; Rizzo, S; Salgarello, S; Szûcs, A, 2008) |
| "Nimesulide was effective in reducing post-surgery oedema and spontaneous and caused pain." | 1.28 | [Use of nimesulide in orthognathic surgery of the jaws]. ( Bianchi, A; Campobassi, A; Marchetti, C; Mazzani, E, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.50) | 18.7374 |
| 1990's | 11 (27.50) | 18.2507 |
| 2000's | 10 (25.00) | 29.6817 |
| 2010's | 9 (22.50) | 24.3611 |
| 2020's | 5 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kasapoglu, MB | 1 |
| Cebi, AT | 1 |
| Cetira Filho, EL | 1 |
| Silva, PGB | 1 |
| Wong, DVT | 1 |
| Choquenaira-Quispe, C | 1 |
| Cesário, FRAS | 1 |
| de Sousa Nogueira, G | 1 |
| de Sousa, AVC | 1 |
| de Aguiar, ASW | 1 |
| da Cruz Fonseca, SG | 1 |
| Costa, FWG | 1 |
| Liu, X | 1 |
| Liao, X | 1 |
| Yang, Z | 1 |
| Chen, J | 1 |
| Zheng, F | 1 |
| He, M | 1 |
| Mattos-Pereira, GH | 1 |
| Esteves-Lima, RP | 1 |
| Cota, LOM | 2 |
| Alvarenga-Brant, R | 1 |
| Costa, FO | 2 |
| Santos, BFE | 1 |
| Vasconcelos, AMA | 1 |
| Cyrino, RM | 1 |
| Kılıç, E | 1 |
| Mızrak, A | 1 |
| Göksu, S | 1 |
| Cesur, M | 1 |
| Pouchain, EC | 1 |
| Costa, FW | 1 |
| Bezerra, TP | 1 |
| Soares, EC | 1 |
| Barbalho, JC | 1 |
| Vasconcellos, RJ | 2 |
| de Morais, HH | 2 |
| Santos, LA | 1 |
| Almeida, RA | 1 |
| Rêbelo, HL | 1 |
| Lucena, EE | 1 |
| de Araújo, SQ | 1 |
| Levrini, L | 1 |
| Carraro, M | 1 |
| Rizzo, S | 1 |
| Salgarello, S | 1 |
| Bertelli, E | 1 |
| Pelliccioni, GA | 1 |
| Garau, V | 1 |
| Bandettini, M | 1 |
| Caputi, S | 1 |
| Lörincz, A | 1 |
| Szûcs, A | 1 |
| De Menezes, SA | 1 |
| Cury, PR | 1 |
| Loh, JS | 1 |
| Ong, CW | 1 |
| Moll, R | 1 |
| Derry, S | 1 |
| Moore, RA | 1 |
| McQuay, HJ | 1 |
| Xiromeritis, P | 1 |
| Kalogiannidis, I | 1 |
| Papadopoulos, E | 1 |
| Prapas, N | 1 |
| Prapas, Y | 1 |
| da Costa Araújo, FA | 1 |
| de Santana Santos, T | 1 |
| Laureano Filho, JR | 1 |
| de Oliveira E Silva, ED | 2 |
| Avelar, RL | 1 |
| Primo, BT | 1 |
| Vogt, BF | 1 |
| Antunes, AA | 1 |
| Magalhães, MT | 1 |
| Rocha, A | 1 |
| Mathai, S | 1 |
| Singh, D | 1 |
| Raghuraman, TS | 1 |
| Bracco, P | 1 |
| Debernardi, C | 1 |
| Coscia, D | 1 |
| Pasqualini, D | 1 |
| Pasqualicchio, F | 1 |
| Calabrese, N | 1 |
| Alotti, N | 1 |
| Bodó, E | 1 |
| Gombocz, K | 1 |
| Gábor, V | 1 |
| Rashed, A | 1 |
| McCrory, C | 2 |
| Fitzgerald, D | 1 |
| Villa, G | 1 |
| Binning, A | 1 |
| Harney, DF | 1 |
| Dooley, M | 1 |
| Harhen, B | 1 |
| McGuiness, N | 1 |
| Cagney, G | 1 |
| Fitzgerald, DJ | 1 |
| Dowd, NP | 1 |
| Ramella, G | 1 |
| Costagli, V | 1 |
| Vetere, M | 1 |
| Capra, C | 1 |
| Casella, G | 1 |
| Sogni, A | 1 |
| Scaricabarozzi, I | 7 |
| Ragot, JP | 1 |
| Monti, T | 1 |
| Macciocchi, A | 1 |
| Pierleoni, P | 1 |
| Tonelli, P | 2 |
| Coscarelli, S | 1 |
| Nava, ML | 2 |
| Alajmo, E | 1 |
| Zuckermann, M | 1 |
| Panconesi, R | 1 |
| Bechi, P | 1 |
| Pasquale, G | 1 |
| D'Agostino, R | 1 |
| Taborelli, G | 1 |
| Vallarino, R | 1 |
| Calderon, A | 1 |
| Harish, J | 1 |
| Chowdhary, SK | 1 |
| Narasimhan, KL | 1 |
| Mahajan, JK | 1 |
| Rao, KL | 1 |
| Amodeo, C | 1 |
| De Marco, M | 1 |
| Gambarini, G | 1 |
| Stefanoni, G | 1 |
| Saccomanno, F | 1 |
| Volontieri, G | 1 |
| Persiani, L | 1 |
| Boselli, A | 1 |
| Beretta, P | 1 |
| Giroda, M | 1 |
| Scolari, G | 1 |
| Vargiu, G | 1 |
| De Francesco, G | 1 |
| Palattella, D | 1 |
| Bianchi, A | 1 |
| Campobassi, A | 1 |
| Marchetti, C | 1 |
| Mazzani, E | 1 |
| Moniaci, D | 1 |
| Mozzati, M | 1 |
| Anglesio Farina, G | 1 |
| Giacometti, E | 1 |
| Bergamini, M | 1 |
| Aliventi, F | 1 |
| Lupidi, A | 1 |
| Rufini, R | 1 |
| Schmoekel, W | 1 |
| Bisaz, E | 1 |
| Schoenle, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Improved Recovery Using Multimodal Peri-operative Analgesia in Minimally Invasive Myomectomy.A Randomized Study.[NCT00978601] | 95 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nimesulide and Pain, Postoperative
| Article | Year |
|---|---|
Single dose oral mefenamic acid for acute postoperative pain in adults.
Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans | 2011 |
28 trials available for nimesulide and Pain, Postoperative
| Article | Year |
|---|---|
Randomized split-mouth study for evaluating the efficacy of nimesulide and nimesulide + Thiocolchicoside combination following impacted mandibular third molar surgery.
Topics: Colchicine; Edema; Humans; Molar, Third; Mouth; Pain, Postoperative; Sulfonamides; Tooth Extraction; | 2022 |
Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial.
Topics: Double-Blind Method; Edema; Humans; Low-Level Light Therapy; Molar, Third; Mouth; Oxidative Stress; | 2022 |
Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single-implant surgery: A randomized clinical trial.
Topics: Acetaminophen; Dental Implants; Double-Blind Method; Etoricoxib; Female; Humans; Ibuprofen; Male; Mi | 2023 |
Preemptive effects of ibuprofen and nimesulide on postoperative pain control after open flap periodontal surgeries: A randomized placebo-controlled split-mouth clinical trial.
Topics: Double-Blind Method; Humans; Ibuprofen; Mouth; Pain, Postoperative; Sulfonamides; Tooth Extraction | 2022 |
[Preemptive analgesic efficacy of gabapentin and nimesulide in the functional endoscopic sinus surgery].
Topics: Adolescent; Adult; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Administration Schedu | 2014 |
Comparative efficacy of nimesulide and ketoprofen on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Double-Blind M | 2015 |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Brazil; Dexamethasone; Drug Therapy, Com | 2017 |
Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar.
Topics: Cross-Over Studies; Cyclooxygenase Inhibitors; Edema; Female; Humans; Male; Meloxicam; Molar, Third; | 2010 |
Improved recovery using multimodal perioperative analgesia in minimally invasive myomectomy: a randomised study.
Topics: Acetaminophen; Adult; Analgesics; Clinical Protocols; Diclofenac; Drug Therapy, Combination; Female; | 2011 |
Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2012 |
Effect of partially selective cyclooxygenase-2 inhibitor in the removal of third molars.
Topics: Adolescent; Adult; Aged; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Male; Mel | 2012 |
Efficacy of rofecoxib and nimesulide in controlling postextraction pain in oral surgery: a randomised comparative study.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Lactones; Ma | 2004 |
[Management of postoperative inflammatory response and pain with nimesulide after cardiac surgery].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Cardiac Surgical Procedures; Cycl | 2003 |
Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2.
Topics: 6-Ketoprostaglandin F1 alpha; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibito | 2004 |
Nimesulide in the treatment of postoperative pain: a double-blind, comparative study in patients undergoing arthroscopic knee surgery.
Topics: Adult; Arthralgia; Arthroscopy; Calcium Channel Blockers; Double-Blind Method; Female; Humans; Knee | 2007 |
Nimesulide 90 mg orally twice daily does not influence postoperative morphine requirements after major chest surgery.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Aged; Analgesics, Opioid; Cyclooxygenase 2 Inhib | 2008 |
Comparison of nimesulide and diclofenac in the prevention and treatment of painful inflammatory postoperative complications of general surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inf | 1993 |
Controlled clinical investigation of acute analgesic activity of nimesulide in pain after oral surgery.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double | 1993 |
A double-blind comparison of nimesulide and ketoprofen in dental surgery.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Inflammat | 1993 |
A comparison of nimesulide and ketoprofen in the prevention and treatment of painful postoperative inflammatory complications of ear, nose and throat surgery.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Inflammat | 1993 |
Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Hemorrhoids; Huma | 1993 |
An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Humans; Inf | 1993 |
Efficacy of nimesulide in pain relief after day care surgery.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Anti-Inflammatory Agents, Non-Steroidal; Child; Child | 2002 |
[A clinical study of the efficacy and tolerance of nimesulide compared to flurbiprofen and sodium diclofenac in the prevention and treatment of postoperative pain and inflammatory symptoms in dentistry].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dou | 1992 |
[Clinical efficacy of nimesulide compared to diclofenac sodium in the prevention and treatment of postoperative pain-inflammation symptomatology].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inf | 1990 |
[The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Flurbiprofen; H | 1990 |
[Nimesulide and algo-edematous pathology of the oral cavity].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apicoectomy; Edema; Female; Humans; Inflammation; Ja | 1990 |
[Effect of nimesulid suppositories in surgical traumatologic practice].
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents; Clinical Trials as Topic; Drug Evaluation; | 1985 |
11 other studies available for nimesulide and Pain, Postoperative
| Article | Year |
|---|---|
Efficacy and safety of Lingnan surgery for the treatment of multi-quadrant acute incarcerated hemorrhoids: A retrospective study.
Topics: Activities of Daily Living; Hemorrhoids; Humans; Pain, Postoperative; Prisoners; Retrospective Studi | 2023 |
Prescriptions of NSAIDs to patients undergoing third molar surgery : an observational, prospective, multicentre survey.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Dental Health Surveys; Diclofenac; Drug Prescription | 2008 |
Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar [Int. J. Oral Maxillofac. Surg. 39 (2010) 580-584].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Edema; Humans; Meloxicam; Molar, | 2011 |
Efficacy of nimesulide in pain relief after day care surgery.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Humans; Pain Measureme | 2002 |
Efficacy of nimesulide in pain relief after day care surgery.
Topics: Ambulatory Surgical Procedures; Anti-Inflammatory Agents, Non-Steroidal; Humans; Pain, Postoperative | 2002 |
Comment on efficacy of rofecoxib and nimesulide in controlling post-extraction pain in oral surgery: a randomised comparative study.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Lactones; Pa | 2004 |
Prevention of apical periodontal ligament pain: a preliminary report of 100 vital pulp cases.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Dexamethasone; Drug Combina | 1993 |
[Use of nimesulide in orthognathic surgery of the jaws].
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Jaw Diseases; Male; Malo | 1989 |
[Evaluation of the efficacy and tolerability of nimesulide in various odonto-stomatologic pathologies].
Topics: Adolescent; Adult; Aged; Drug Evaluation; Female; Humans; Ketoprofen; Male; Middle Aged; Pain, Posto | 1988 |
[Nimesulide in oral surgery. Clinical experience in postoperative treatment].
Topics: Adult; Aged; Ambulatory Surgical Procedures; Drug Evaluation; Female; Humans; Inflammation; Male; Mi | 1988 |
[Nimesulide in clinical dental practice].
Topics: Adult; Ampicillin; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Male; Middle Aged; Mouth | 1987 |