nimesulide has been researched along with Osteoarthritis, Knee in 9 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis." | 9.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "The present data confirm our previous observations in patients with rheumatoid arthritis, further suggesting that nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect." | 9.10 | A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee. ( Bianchi, M; Broggini, M, 2003) |
| "Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis." | 5.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "The present data confirm our previous observations in patients with rheumatoid arthritis, further suggesting that nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect." | 5.10 | A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee. ( Bianchi, M; Broggini, M, 2003) |
| "The intensity of joint pain was assessed with a 100-mm visual analogue scale (VAS)." | 2.73 | Effects of nimesulide on pain and on synovial fluid concentrations of substance P, interleukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecoxib. ( Balzarini, P; Bianchi, M; Broggini, M; Franchi, S; Sacerdote, P, 2007) |
| "Osteoarthritis (OA) affects mainly older people who are more sensitive to adverse effects of classic nonsteroidal anti-inflammatory drugs." | 2.73 | Efficacy and safety of topical nimesulide in the treatment of knee osteoarthritis. ( Bodur, H; Ergün, H; Külcü, D; Kutlay, S; Tulunay, FC, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, SK | 1 |
| Ramakrishnan, S | 1 |
| Mishra, K | 1 |
| Srivastava, R | 1 |
| Agarwal, GG | 1 |
| Singh, R | 1 |
| Sircar, AR | 1 |
| Kullich, WC | 1 |
| Niksic, F | 1 |
| Klein, G | 1 |
| Bianchi, M | 2 |
| Broggini, M | 2 |
| Manicourt, DH | 1 |
| Bevilacqua, M | 1 |
| Righini, V | 1 |
| Famaey, JP | 1 |
| Devogelaer, JP | 1 |
| Maĭko, OIu | 1 |
| Bagirova, GG | 1 |
| Balzarini, P | 1 |
| Franchi, S | 1 |
| Sacerdote, P | 1 |
| Ergün, H | 1 |
| Külcü, D | 1 |
| Kutlay, S | 1 |
| Bodur, H | 1 |
| Tulunay, FC | 1 |
| Roy, V | 1 |
| Gupta, U | 1 |
| Sharma, S | 1 |
| Dhaon, BK | 1 |
| Singh, NP | 1 |
| Gulati, P | 1 |
| Zgradie, I | 1 |
7 trials available for nimesulide and Osteoarthritis, Knee
| Article | Year |
|---|---|
A randomized controlled trial to evaluate the slow-acting symptom-modifying effects of colchicine in osteoarthritis of the knee: a preliminary report.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Drug Therapy, Combination; Female; Gout Suppres | 2002 |
A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee.
Topics: Adult; Aged; Analysis of Variance; Celecoxib; Double-Blind Method; Female; Humans; Knee; Lactones; M | 2003 |
Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Collagen; Collagen Typ | 2005 |
Effects of nimesulide on pain and on synovial fluid concentrations of substance P, interleukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecoxib.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Celecoxib; Double-Blind Method; Female; H | 2007 |
Efficacy and safety of topical nimesulide in the treatment of knee osteoarthritis.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female | 2007 |
Comparative efficacy and tolerability of nimesulide and piroxicam in osteoarthritis with specific reference to chondroprotection: a double blind randomised study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cyclo | 1999 |
Comparison of therapeutic efficacy of nimesulide and diclofenac in patients with degenerative joint diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dou | 1999 |
2 other studies available for nimesulide and Osteoarthritis, Knee
| Article | Year |
|---|---|
Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study.
Topics: Acute Disease; Adult; Aged; Analysis of Variance; Cartilage Oligomeric Matrix Protein; Cyclooxygenas | 2002 |
[Functional indices in assessment of gonarthrosis treatment efficacy with structum and chondrolon].
Topics: Adult; Chondroitin Sulfates; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female; Humans; M | 2006 |