Page last updated: 2024-11-01

nimesulide and Lung Neoplasms

nimesulide has been researched along with Lung Neoplasms in 12 studies

nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"Nimesulide treatment decreased the secretion of MCP-1 and PGE2 from lung cancer cells."1.91Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin. ( Hanaoka, J; Kataoka, Y; Kawaguchi, Y; Ohshio, Y; Okamoto, K; Shiratori, T; Suzuki, T; Ueda, K; Watanabe, A, 2023)
"Lung cancer is the leading cause of cancer-related deaths in the United States."1.33Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo. ( Fang, F; Grimes, KR; St Clair, WH; Warren, GW; Xu, Y, 2006)
"Nimesulide was formulated into a metered dose inhaler (MDI) formulation and characterized for aerodynamic particle size and medication delivery."1.32Evaluation of an aerosolized selective COX-2 inhibitor as a potentiator of doxorubicin in a non-small-cell lung cancer cell line. ( Chatterjee, A; Haynes, A; Shaik, MS; Singh, M, 2003)
"Nimesulide treatment showed a dose-dependent growth-inhibitory effect of A549 tumors with a maximum of 77."1.32Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma. ( Chatterjee, A; Shaik, MS; Singh, M, 2004)
"To study the effects of cyclooxygenase 2 selective inhibitor Nimesulide (NIM) combined with Cisplatin (DDP) on human lung cancer and the possible mechanisms, the proliferation and apoptosis of human lung cancer cell line A549 were evaluated by MTT reduction assay and flow cytometry respectively."1.32The effects of nimesulide combined with cisplatin on lung cancer. ( Liu, J; Xing, L; Xu, Y; Zhang, H; Zhang, Z, 2004)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (75.00)29.6817
2010's2 (16.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Kawaguchi, Y3
Ohshio, Y3
Watanabe, A3
Shiratori, T3
Okamoto, K3
Ueda, K3
Kataoka, Y3
Suzuki, T3
Hanaoka, J3
Serresi, M1
Siteur, B1
Hulsman, D1
Company, C1
Schmitt, MJ1
Lieftink, C1
Morris, B1
Cesaroni, M1
Proost, N1
Beijersbergen, RL1
van Lohuizen, M1
Gargiulo, G1
Kim, BM1
Won, J1
Maeng, KA1
Han, YS1
Yun, YS1
Hong, SH1
Lang, Z1
Chen, G1
Wang, DC1
Haynes, A1
Shaik, MS2
Chatterjee, A2
Singh, M2
Xing, L1
Zhang, Z1
Xu, Y2
Zhang, H1
Liu, J1
Han, S2
Roman, J2
Grimes, KR1
Warren, GW1
Fang, F1
St Clair, WH1
Kozaki, K2
Miyaishi, O1
Tsukamoto, T1
Tatematsu, Y1
Hida, T2
Takahashi, T3
Muramatsu, H1
Masuda, A1
Shimizu, S1
Mitsudomi, T1
Sugiura, T1
Ogawa, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Radiosensitization With a COX-2 Inhibitor (Celecoxib), With Chemoradiation for Cancer of the Head and Neck[NCT00581971]Phase 1/Phase 230 participants (Actual)Interventional2002-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Response as Evaluated by Recurrence of Diseases

Evaluate the response to concurrent celecoxib, carboplatin, paclitaxel, and radiotherapy in the treatment of locally advanced SSC of the head and neck. Response is determined by local control only, local and distant metastasis, distant metastasis only, second primary, and surgical salvage. (NCT00581971)
Timeframe: 2 years from end of treatment (Radiation therapy)

InterventionParticipants (Number)
Local Control OnlyLocal Control and Distant MetastasisDistant Metastatsis OnlySecondary Primary - Site UnknownSurgical Salvage
Recurrence62123

Toxicity of Celecoxib With Concurrent Weekly Chemotherapy and Radiotherapy in the Treatment of Locally Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck.

Particpants experiencing Acute Toxicities > Grade 3 (NCT00581971)
Timeframe: 2 years from radiation therapy

Interventionparticipants (Number)
HematologicDermatitisMucositis/Dysphagia
Acute Toxicity12716

Other Studies

12 other studies available for nimesulide and Lung Neoplasms

ArticleYear
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin.
    Cancer science, 2023, Volume: 114, Issue:3

    Topics: Animals; Cell Line, Tumor; Cisplatin; Dinoprostone; Lung Neoplasms; Mice; Tumor Microenvironment; Tu

2023
Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
    The Journal of experimental medicine, 2018, 12-03, Volume: 215, Issue:12

    Topics: A549 Cells; Animals; Bortezomib; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Enhancer of Zes

2018
Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3.
    International journal of oncology, 2009, Volume: 34, Issue:5

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Caspase 3; Caspase 8; Cell Line, Tumor; Cyclooxygenase 2 In

2009
[Inhibitory effect of nimesulide and oxaliplatin on tumor growth and lymphatic metastasis of transplanted human lung cancer in nude mice].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2012, Volume: 34, Issue:10

    Topics: Animals; Antineoplastic Agents; beta Catenin; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inh

2012
Evaluation of an aerosolized selective COX-2 inhibitor as a potentiator of doxorubicin in a non-small-cell lung cancer cell line.
    Pharmaceutical research, 2003, Volume: 20, Issue:9

    Topics: Aerosols; Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung;

2003
Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-15, Volume: 10, Issue:4

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibito

2004
The effects of nimesulide combined with cisplatin on lung cancer.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2004, Volume: 24, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplat

2004
COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites.
    International journal of cancer, 2005, Sep-10, Volume: 116, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cyclooxygenase Inhibitors; Extracellular Signal-Regul

2005
COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals.
    Lung cancer (Amsterdam, Netherlands), 2006, Volume: 51, Issue:3

    Topics: Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase Inhibitors; Flavonoids;

2006
Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo.
    Oncology reports, 2006, Volume: 16, Issue:4

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Combined Modality

2006
Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation.
    Cancer research, 2000, May-01, Volume: 60, Issue:9

    Topics: Animals; Basement Membrane; Blotting, Northern; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibit

2000
Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Survival; Cyclooxygenase 2; C

2000