nimesulide has been researched along with Inflammation in 59 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever." | 9.07 | A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993) |
| "The efficacy and tolerability of nimesulide and naproxen were compared in a randomised double-blind study of patients with pain and inflammation after haemorrhoidectomy." | 9.07 | Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation. ( Bechi, P; Nava, ML; Panconesi, R; Scaricabarozzi, I; Zuckermann, M, 1993) |
| " Nimesulide have been studied in a double blind study compared with flurbiprofen, in 98 patients aged between 18 and 75 suffering from pain-inflammatory pathologies of ENT nature." | 9.07 | [Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat]. ( Lomeo, G; Monea, P; Rossi, M; Scaricabarozzi, I; Trezzani, R; Tringali, G, 1991) |
| "Nimesulide is a new non-steroidal anti-inflammatory analgesic agent given orally or rectally on a twice daily basis in a number of inflammatory and pain states." | 8.77 | Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states. ( Brogden, RN; Ward, A, 1988) |
| "Rat astrocytoma cells (C6) were stimulated with LPS (10 microg/ml) alone and in combinations with different concentrations of guggulipid or nimesulide for 24h of incubation." | 7.76 | Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). ( Kamat, PK; Nath, C; Niranjan, R; Shukla, R, 2010) |
| "The meeting aimed to provide a continuous and up-to-date evaluation of the clinical and safety profile of nimesulide, and of its role in the treatment of inflammatory pain, in light of existing therapeutic alternatives, through a revision and critical discussion on the information available on the drug among authoritative experts in different fields of medical science." | 7.73 | Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus. ( Rainsford, KD, 2006) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 7.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| "Both nimesulide and bromeline were well tolerated." | 6.67 | Controlled clinical studies of nimesulide in the treatment of urogenital inflammation. ( Corrado, F; Corrado, G; Garofalo, F; Imbimbo, C; Lotti, T; Mirone, V; Scaricabarozzi, I, 1993) |
| "Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties." | 6.67 | [The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]. ( Scaricabarozzi, I; Scolari, G; Vargiu, G, 1990) |
| "Nimesulide has been tested by the Authors on a group of 40 adults patients of both sexes that had undergone oral surgery." | 6.67 | [Nimesulide and algo-edematous pathology of the oral cavity]. ( De Francesco, G; Palattella, D, 1990) |
| "Nimesulide treatment brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache and produced a rapid lowering in body temperature." | 6.65 | Nimesulide for the treatment of painful inflammatory process in the ear, nose and throat areas: a double-blind controlled study with benzydamine. ( Milvio, C, 1984) |
| "Neuroinflammation is an integral part of neurodegenerative diseases." | 5.37 | Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-kB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6. ( Nath, C; Niranjan, R; Shukla, R, 2011) |
| "The efficacy and tolerability of nimesulide were assessed and compared with those of paracetamol in the treatment of 35 children with pain and inflammation following adenotonsillectomy." | 5.07 | An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy. ( D'Agostino, R; Pasquale, G; Scaricabarozzi, I; Taborelli, G; Vallarino, R, 1993) |
| "The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever." | 5.07 | A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993) |
| "The efficacy and tolerability of nimesulide and naproxen were compared in a randomised double-blind study of patients with pain and inflammation after haemorrhoidectomy." | 5.07 | Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation. ( Bechi, P; Nava, ML; Panconesi, R; Scaricabarozzi, I; Zuckermann, M, 1993) |
| " Nimesulide have been studied in a double blind study compared with flurbiprofen, in 98 patients aged between 18 and 75 suffering from pain-inflammatory pathologies of ENT nature." | 5.07 | [Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat]. ( Lomeo, G; Monea, P; Rossi, M; Scaricabarozzi, I; Trezzani, R; Tringali, G, 1991) |
| "This review summarizes the principal therapeutic responses to the preferential COX-2 NSAID, nimesulide, in treating musculo-skeletal joint symptoms and various acute and chronic pain conditions and the mode of action in relation to therapy in these states." | 4.83 | Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide. ( Rainsford, KD, 2006) |
| "Nimesulide is a new non-steroidal anti-inflammatory analgesic agent given orally or rectally on a twice daily basis in a number of inflammatory and pain states." | 4.77 | Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states. ( Brogden, RN; Ward, A, 1988) |
| " The aim was to investigate and compare the effect of docosahexaenoic acid (DHA) ester of PZ (PZ-DHA) and its parent compounds (phloridzin and DHA), phloretin (the aglycone of PZ) and cyclooxygenase inhibitory drugs (diclofenac and nimesulide) on production of pro-inflammatory biomarkers in inflammation-induced macrophages by lipopolysaccharide (LPS)-stimulation." | 3.81 | Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. ( Rupasinghe, HP; Sekhon-Loodu, S, 2015) |
| "Rat astrocytoma cells (C6) were stimulated with LPS (10 microg/ml) alone and in combinations with different concentrations of guggulipid or nimesulide for 24h of incubation." | 3.76 | Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). ( Kamat, PK; Nath, C; Niranjan, R; Shukla, R, 2010) |
| " Nimesulide-treated mice showed augmented eosinophilic inflammation, LTC4/D4/E4 concentrations and mucous cell metaplasia." | 3.73 | Augmentation of allergic inflammation in the airways of cyclooxygenase-2-deficient mice. ( Kondo, M; Nagai, A; Nakata, J; Nohara, M; Takemiya, T; Tamaoki, J; Yamagata, K, 2005) |
| "Female CD-1 (ICR) mice were given a single intraperitoneal administration of AOM (10 mg/kg body weight) and followed by one-week oral exposure of 2% (w/v) DSS in drinking water, and then maintained on the basal diets mixed with or without nimesulide (0." | 3.73 | Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| " The oral administration of aspartame (2-16mg/kg, po) significantly increased the pain threshold against acetic acid-induced writhes in mice." | 3.73 | Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs. ( Jain, NK; Kulkarni, SK; Sharma, S, 2005) |
| "The meeting aimed to provide a continuous and up-to-date evaluation of the clinical and safety profile of nimesulide, and of its role in the treatment of inflammatory pain, in light of existing therapeutic alternatives, through a revision and critical discussion on the information available on the drug among authoritative experts in different fields of medical science." | 3.73 | Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus. ( Rainsford, KD, 2006) |
| "This study demonstrates that CSF biomarker profiles, as detected by SELDI technology, can consistently and reproducibly differentiate inflammatory from neuropathic pain, and reflect the analgesic action produced by the preferential COX-2 inhibitor, nimesulide." | 3.72 | High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide. ( Bianchi, M; Gineste, C; Ho, L; Pasinetti, GM; Pompl, P, 2003) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 3.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| "The effective nimesulide and SC-236-induced amelioration of the severity of the colitis in acetic acid and iodoacetamide-treated rats confirms the role of eicosanoids in their pathogenesis and suggests that COX-2 inhibitors may be of value in the treatment of inflammatory bowel disease." | 3.70 | Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. ( Cohen, P; Karmeli, F; Rachmilewitz, D, 2000) |
| "Nimesulide was more effective and more rapid than ketoprofen in ameliorating the painful inflammatory symptoms (pain at rest and upon mastication) and signs (swelling and hyperaemia) associated with the operation." | 2.67 | A double-blind comparison of nimesulide and ketoprofen in dental surgery. ( Pierleoni, P; Scaricabarozzi, I; Tonelli, P, 1993) |
| "The treatment with nimesulide produced good results in all pathologies, significantly reducing the intensity of symptomatology." | 2.67 | [Multicenter study in the Campania region on the clinical effectiveness and tolerance of nimesulide in gynecologic inflammatory diseases]. ( Bedoschi, D; Chiantera, A; Scaricabarozzi, I, 1990) |
| "Nimesulide has been tested by the Authors on a group of 40 adults patients of both sexes that had undergone oral surgery." | 2.67 | [Nimesulide and algo-edematous pathology of the oral cavity]. ( De Francesco, G; Palattella, D, 1990) |
| "Both nimesulide and bromeline were well tolerated." | 2.67 | Controlled clinical studies of nimesulide in the treatment of urogenital inflammation. ( Corrado, F; Corrado, G; Garofalo, F; Imbimbo, C; Lotti, T; Mirone, V; Scaricabarozzi, I, 1993) |
| "Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties." | 2.67 | [The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]. ( Scaricabarozzi, I; Scolari, G; Vargiu, G, 1990) |
| "Nimesulide treatment brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache and produced a rapid lowering in body temperature." | 2.65 | Nimesulide for the treatment of painful inflammatory process in the ear, nose and throat areas: a double-blind controlled study with benzydamine. ( Milvio, C, 1984) |
| " At the recommended dosage of 100 mg b." | 2.40 | In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. ( Famaey, JP, 1997) |
| "Nimesulide is an inhibitor of COX-2 with antioxidant and anti-inflammatory effects." | 1.56 | Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide. ( Luo, W; Luo, Y; Yang, J, 2020) |
| "Inflammation is one condition for demonstrated variable drug response, attributed in part, to changes in function of drug transporters." | 1.39 | Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry. ( Muller, CD; Peluso, J; Saab, L; Ubeaud-Sequier, G, 2013) |
| "One component of airway remodeling involves fibroblast accumulation and activation, resulting in deposition of collagen I around small bronchi." | 1.37 | Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. ( Jancar, S; Peters-Golden, M; Stumm, CL; Wettlaufer, SH, 2011) |
| "Neuroinflammation is an integral part of neurodegenerative diseases." | 1.37 | Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-kB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6. ( Nath, C; Niranjan, R; Shukla, R, 2011) |
| "The effect of the COX inhibitors on thrombus formation was evaluated in a model of carotid artery thrombosis secondary to electrolytic-induced vessel wall injury." | 1.35 | Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis. ( Barrett, TD; Hong, TT; Huang, J; Lucchesi, BR, 2008) |
| "Piperine is an inhibitor of various hepatic and other enzymes involved in the biotransformation of drugs." | 1.31 | Comparative anti-nociceptive, anti-inflammatory and toxicity profile of nimesulide vs nimesulide and piperine combination. ( Bansal, P; Bhardwaj, RK; Gupta, SK; Velpandian, T, 2000) |
| " dapsone, nimesulide and sulphapyridine, have the potential to reduce the bioavailability of neutrophil-derived HOCl and, in turn, to favour the alpha 1-antitrypsin-dependent control of neutrophil elastolytic activity." | 1.29 | Sulphonamides as anti-inflammatory agents: old drugs for new therapeutic strategies in neutrophilic inflammation? ( Balbi, A; Bevilacqua, M; Dallegri, F; Dapino, P; Ottonello, L; Scirocco, MC, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (10.17) | 18.7374 |
| 1990's | 23 (38.98) | 18.2507 |
| 2000's | 19 (32.20) | 29.6817 |
| 2010's | 10 (16.95) | 24.3611 |
| 2020's | 1 (1.69) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Luo, W | 1 |
| Luo, Y | 1 |
| Yang, J | 1 |
| Serresi, M | 1 |
| Siteur, B | 1 |
| Hulsman, D | 1 |
| Company, C | 1 |
| Schmitt, MJ | 1 |
| Lieftink, C | 1 |
| Morris, B | 1 |
| Cesaroni, M | 1 |
| Proost, N | 1 |
| Beijersbergen, RL | 1 |
| van Lohuizen, M | 1 |
| Gargiulo, G | 1 |
| Sekhon-Loodu, S | 1 |
| Rupasinghe, HP | 1 |
| Niranjan, R | 2 |
| Kamat, PK | 1 |
| Nath, C | 2 |
| Shukla, R | 2 |
| Hsieh, PS | 1 |
| Lu, KC | 1 |
| Chiang, CF | 1 |
| Chen, CH | 1 |
| Zhu, B | 1 |
| Bai, R | 1 |
| Kennett, MJ | 1 |
| Kang, BH | 1 |
| Gonzalez, FJ | 1 |
| Peters, JM | 1 |
| Stumm, CL | 1 |
| Wettlaufer, SH | 1 |
| Jancar, S | 1 |
| Peters-Golden, M | 1 |
| Rapposelli, S | 1 |
| Digiacomo, M | 1 |
| Franchi, S | 2 |
| Moretti, S | 1 |
| Pinza, M | 1 |
| Sacerdote, P | 2 |
| Balsamo, A | 1 |
| Saab, L | 1 |
| Peluso, J | 1 |
| Muller, CD | 1 |
| Ubeaud-Sequier, G | 1 |
| Frezzolini, A | 1 |
| De Pità, O | 1 |
| Cassano, N | 1 |
| D'Argento, V | 1 |
| Ferranti, G | 1 |
| Filotico, R | 1 |
| Vena, GA | 1 |
| Lin, DT | 1 |
| Subbaramaiah, K | 1 |
| Shah, JP | 1 |
| Dannenberg, AJ | 1 |
| Boyle, JO | 1 |
| Arcimowicz, M | 1 |
| Samoliński, B | 1 |
| Gotlib, T | 1 |
| Nyckowska, J | 1 |
| Gineste, C | 1 |
| Ho, L | 1 |
| Pompl, P | 1 |
| Bianchi, M | 2 |
| Pasinetti, GM | 1 |
| Ribeiro, M | 1 |
| Cella, M | 1 |
| Farina, M | 1 |
| Franchi, A | 1 |
| Nakata, J | 1 |
| Kondo, M | 1 |
| Tamaoki, J | 1 |
| Takemiya, T | 1 |
| Nohara, M | 1 |
| Yamagata, K | 1 |
| Nagai, A | 1 |
| Freitas, MN | 1 |
| Marchetti, JM | 1 |
| Kohno, H | 1 |
| Suzuki, R | 1 |
| Sugie, S | 1 |
| Tanaka, T | 1 |
| Sharma, S | 1 |
| Jain, NK | 2 |
| Kulkarni, SK | 2 |
| Rainsford, KD | 2 |
| Martucci, C | 1 |
| Ferrario, P | 1 |
| Hong, TT | 1 |
| Huang, J | 1 |
| Barrett, TD | 1 |
| Lucchesi, BR | 1 |
| Milvio, C | 1 |
| Lotti, T | 1 |
| Mirone, V | 1 |
| Imbimbo, C | 1 |
| Corrado, F | 1 |
| Corrado, G | 1 |
| Garofalo, F | 1 |
| Scaricabarozzi, I | 14 |
| Canale, D | 1 |
| Turchi, P | 1 |
| Giorgi, PM | 1 |
| Menchini-Fabris, GF | 1 |
| Ramella, G | 1 |
| Costagli, V | 1 |
| Vetere, M | 1 |
| Capra, C | 1 |
| Casella, G | 1 |
| Sogni, A | 1 |
| Pierleoni, P | 1 |
| Tonelli, P | 2 |
| Ferrari Parabita, G | 1 |
| Zanetti, U | 1 |
| Scalvini, F | 1 |
| Rossi, D | 1 |
| Coscarelli, S | 1 |
| Nava, ML | 2 |
| Alajmo, E | 1 |
| Marconcini, C | 1 |
| Sbrana, E | 1 |
| Zuckermann, M | 1 |
| Panconesi, R | 1 |
| Bechi, P | 1 |
| Polidori, G | 1 |
| Titti, G | 1 |
| Pieragostini, P | 1 |
| Comito, A | 1 |
| Pasquale, G | 1 |
| D'Agostino, R | 1 |
| Taborelli, G | 1 |
| Vallarino, R | 1 |
| Tognella, S | 1 |
| Ottonello, L | 4 |
| Dapino, P | 2 |
| Pastorino, G | 1 |
| Montagnani, G | 1 |
| Gatti, F | 1 |
| Guidi, G | 1 |
| Dallegri, F | 4 |
| Scirocco, MC | 1 |
| Balbi, A | 1 |
| Bevilacqua, M | 2 |
| Botrel, MA | 1 |
| Haak, T | 1 |
| Legrand, C | 1 |
| Concordet, D | 1 |
| Chevalier, R | 1 |
| Toutain, PL | 1 |
| Harada, Y | 1 |
| Hatanaka, K | 1 |
| Kawamura, M | 1 |
| Saito, M | 1 |
| Ogino, M | 1 |
| Majima, M | 1 |
| Ohno, T | 1 |
| Ogino, K | 1 |
| Yamamoto, K | 1 |
| Taketani, Y | 1 |
| Yamamoto, S | 1 |
| Katori, M | 1 |
| Famaey, JP | 1 |
| Karmeli, F | 1 |
| Cohen, P | 1 |
| Rachmilewitz, D | 1 |
| Gupta, SK | 1 |
| Bansal, P | 1 |
| Bhardwaj, RK | 1 |
| Velpandian, T | 1 |
| Guo, X | 1 |
| Liu, ES | 1 |
| Ko, JK | 1 |
| Wong, BC | 1 |
| Ye, Y | 1 |
| Lam, S | 1 |
| Cho, C | 1 |
| Singh, A | 1 |
| Mejza, F | 1 |
| Nizankowska, E | 1 |
| Kankuri, E | 1 |
| Vaali, K | 1 |
| Korpela, R | 1 |
| Paakkari, I | 1 |
| Vapaatalo, H | 1 |
| Moilanen, E | 1 |
| Rossi, M | 1 |
| Monea, P | 1 |
| Lomeo, G | 1 |
| Tringali, G | 1 |
| Trezzani, R | 1 |
| Stefanoni, G | 1 |
| Saccomanno, F | 1 |
| Volontieri, G | 1 |
| Persiani, L | 1 |
| Boselli, A | 1 |
| Beretta, P | 1 |
| Giroda, M | 1 |
| Scolari, G | 1 |
| Vargiu, G | 1 |
| Patrone, F | 1 |
| Ballestrero, A | 1 |
| Ferrando, F | 1 |
| Sacchetti, C | 1 |
| Chiantera, A | 1 |
| Bedoschi, D | 1 |
| De Francesco, G | 1 |
| Palattella, D | 1 |
| Solimei, GE | 1 |
| Malan, R | 1 |
| Viti, M | 1 |
| Moniaci, D | 1 |
| Re, G | 1 |
| Mattei, R | 1 |
| Sortino, G | 1 |
| Ferleto, S | 1 |
| Cordioli, GP | 1 |
| Capsoni, F | 1 |
| Venegoni, E | 1 |
| Minonzio, F | 1 |
| Ongari, AM | 1 |
| Maresca, V | 1 |
| Zanussi, C | 1 |
| Di Leo, S | 1 |
| Meli, MT | 1 |
| Dal Prà, ML | 1 |
| Ward, A | 1 |
| Brogden, RN | 1 |
| Bergamini, M | 1 |
8 reviews available for nimesulide and Inflammation
| Article | Year |
|---|---|
Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cyclooxygenase Inhibitors; Head and Neck Neoplasms; Humans; Imm | 2002 |
[Nimesulide (Aulin)--the selective COX-2 inhibitor in the treatment of ENT diseases].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2002 |
Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Humans; Inflammation; | 2006 |
Nimesulide as a downregulator of the activity of the neutrophil myeloperoxidase pathway. Focus on the histoprotective potential of the drug during inflammatory processes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Down-Regulation; Humans; Inflammation; Neutrophils; Oxidati | 1993 |
Possible modes of action of nimesulide in controlling neutrophilic inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Neutrophils; Sulfonamides | 1995 |
In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 1997 |
[Selective cyclooxygenase 2 inhibitors (COX-2)].
Topics: Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor | 2001 |
Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Pain; Sulfonamides | 1988 |
19 trials available for nimesulide and Inflammation
| Article | Year |
|---|---|
Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment.
Topics: Adolescent; Adult; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion Mole | 2002 |
Nimesulide for the treatment of painful inflammatory process in the ear, nose and throat areas: a double-blind controlled study with benzydamine.
Topics: Adult; Anti-Inflammatory Agents; Benzydamine; Double-Blind Method; Drug Evaluation; Female; Humans; | 1984 |
Controlled clinical studies of nimesulide in the treatment of urogenital inflammation.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bromelains; Double-Blind Method; Female; Femal | 1993 |
Treatment of abacterial prostato-vesiculitis with nimesulide.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Ketoprofen; Male; | 1993 |
Comparison of nimesulide and diclofenac in the prevention and treatment of painful inflammatory postoperative complications of general surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inf | 1993 |
A double-blind comparison of nimesulide and ketoprofen in dental surgery.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Inflammat | 1993 |
A controlled clinical study of the efficacy and tolerability of nimesulide vs naproxen in maxillo-facial surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Face; Female; Humans; Inflammat | 1993 |
A comparison of nimesulide and ketoprofen in the prevention and treatment of painful postoperative inflammatory complications of ear, nose and throat surgery.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Inflammat | 1993 |
Efficacy of nimesulide in the prevention of inflammatory complications after laser treatment of ocular diseases.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Eye Diseases; Female; Humans; Infl | 1993 |
Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Hemorrhoids; Huma | 1993 |
A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Fever; Huma | 1993 |
An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Humans; Inf | 1993 |
[Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Flurbiprofen; Hum | 1991 |
[Clinical efficacy of nimesulide compared to diclofenac sodium in the prevention and treatment of postoperative pain-inflammation symptomatology].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Female; Humans; Inf | 1990 |
[The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Flurbiprofen; H | 1990 |
[Multicenter study in the Campania region on the clinical effectiveness and tolerance of nimesulide in gynecologic inflammatory diseases].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Genital Diseases, Female; | 1990 |
[Nimesulide and algo-edematous pathology of the oral cavity].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apicoectomy; Edema; Female; Humans; Inflammation; Ja | 1990 |
[Nimesulide: multicenter clinical study for evaluation of its therapeutic effect in odontostomatology].
Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as | 1989 |
[Clinical experience with nimesulide in gynecologic inflammatory pathology].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-B | 1988 |
32 other studies available for nimesulide and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Cyclooxygenase 2 Inhibitors | 2020 |
Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
Topics: A549 Cells; Animals; Bortezomib; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Enhancer of Zes | 2018 |
Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Cyclooxygenase Inhibitors; | 2015 |
Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6).
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Astrocytoma; Cell Line, Tumor; Commiphora; Cyclooxy | 2010 |
Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats.
Topics: Adiposity; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Glucose; Blood Pr | 2010 |
Chemoprevention of chemically induced skin tumorigenesis by ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase 2.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Differentiation; Chemoprevention; Cyclooxygenase 2; Cycl | 2010 |
Guggulipid and nimesulide differentially regulated inflammatory genes mRNA expressions via inhibition of NF-kB and CHOP activation in LPS-stimulated rat astrocytoma cells, C6.
Topics: Animals; Astrocytoma; Calcium; Cell Line, Tumor; Commiphora; Cyclooxygenase 2; Cytokines; Gene Expre | 2011 |
Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchi; Cell Proliferation; Chronic Disease; Collage | 2011 |
Sodium N-(methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: a water-soluble nimesulide prodrug for parenteral use.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Inflammation; Injections, Intraperitoneal; Male; P | 2010 |
Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide.
Topics: Analysis of Variance; Animals; Biomarkers; Cerebrospinal Fluid Proteins; Constriction; Cyclooxygenas | 2003 |
Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinopr | 2004 |
Augmentation of allergic inflammation in the airways of cyclooxygenase-2-deficient mice.
Topics: Animals; Arachidonic Acid; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Broncho | 2005 |
Nimesulide PLA microspheres as a potential sustained release system for the treatment of inflammatory diseases.
Topics: Delayed-Action Preparations; Inflammation; Lactic Acid; Microspheres; Polyesters; Polymers; Solubili | 2005 |
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bezafibrate; Body Weight; Chromans; Col | 2005 |
Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2005 |
Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans | 2006 |
Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anima | 2007 |
Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.
Topics: Acetylcholine; Animals; Arachidonic Acid; Benzofurans; Carotid Arteries; Coronary Circulation; Coron | 2008 |
Nimesulide. New clinical opportunities.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Inflammation; Pain; Platelet Aggregation; Su | 1993 |
Sulphonamides as anti-inflammatory agents: old drugs for new therapeutic strategies in neutrophilic inflammation?
Topics: alpha 1-Antitrypsin; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultu | 1995 |
Quantitative evaluation of an experimental inflammation induced with Freund's complete adjuvant in dogs.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bod | 1994 |
Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Azo Compounds; Blotting, Western; C | 1996 |
Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase Inhibitors; Disease Models | 2000 |
Comparative anti-nociceptive, anti-inflammatory and toxicity profile of nimesulide vs nimesulide and piperine combination.
Topics: Administration, Oral; Alkaloids; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-St | 2000 |
Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inh | 2001 |
Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cell Migration Inhib | 2001 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 2001 |
Inactivation of neutrophil-derived hypochlorous acid by nimesulide: a potential mechanism for the tissue protection during inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Hydrogen Peroxide; Hypochlorous Acid; In Vitro Tech | 1990 |
Inhibition of neutrophil oxidative metabolism by nimesulide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytochrome c Group; Depression, Chemical; Fre | 1987 |
[Nimesulide in oral surgery. Clinical experience in postoperative treatment].
Topics: Adult; Aged; Ambulatory Surgical Procedures; Drug Evaluation; Female; Humans; Inflammation; Male; Mi | 1988 |