nimesulide has been researched along with Edema in 32 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimesulide has been tested by the Authors on a group of 40 adults patients of both sexes that had undergone oral surgery." | 6.67 | [Nimesulide and algo-edematous pathology of the oral cavity]. ( De Francesco, G; Palattella, D, 1990) |
| "Pain peaks occurred after 6 h (nimesulide-placebo [N-P] group) and 8 h (nimesulide group)." | 5.51 | Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial. ( Cesário, FRAS; Cetira Filho, EL; Choquenaira-Quispe, C; Costa, FWG; da Cruz Fonseca, SG; de Aguiar, ASW; de Sousa Nogueira, G; de Sousa, AVC; Silva, PGB; Wong, DVT, 2022) |
| "Nimesulide is a COX 2 selective anti-inflammatory that is poorly soluble in water." | 5.38 | Natural lipid nanoparticles containing nimesulide: synthesis, characterization and in vivo antiedematogenic and antinociceptive activities. ( Alves, MP; Antonow, MB; Fagan, SB; Lima, A; Lorenzoni, R; Raffin, RP; Turra, C, 2012) |
| " Moreover, nanoencapsulation significantly increased the anti-inflammatory activity of nimesulide in two chronic inflammation models (chronic arthritis and granuloma)." | 3.78 | Semi-solid topical formulations containing nimesulide-loaded nanocapsules showed in-vivo anti-inflammatory activity in chronic arthritis and fibrovascular tissue models. ( Alves, MP; Guterres, SS; Lenz, QF; Pohlmann, A, 2012) |
| "7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain." | 3.77 | Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. ( Barbosa Filho, JM; Couto, RD; de Lima, FO; Nonato, FR; Nunes, XP; Ribeiro dos Santos, R; Soares, MB; Villarreal, CF, 2011) |
| " The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats." | 3.76 | In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives. ( Achar, KC; Hosamani, KM; Seetharamareddy, HR, 2010) |
| " The oral administration of aspartame (2-16mg/kg, po) significantly increased the pain threshold against acetic acid-induced writhes in mice." | 3.73 | Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs. ( Jain, NK; Kulkarni, SK; Sharma, S, 2005) |
| " Azorellanol exhibited the highest topical anti-inflammatory potency on AA (arachidonic acid) and TPA (12-deoxyphorbol 13-tetradecanoate) induced oedema, and it effect was similar to the reference drugs (nimesulide and indomethacin)." | 3.72 | Pharmaco-toxicological study of diterpenoids. ( Backhouse, N; Bórquez, J; Delporte, C; Loyola, A; Salinas, P; San-Martín, A, 2003) |
| " The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay." | 3.70 | Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. ( Barreiro, EJ; Fraga, CA; Lages, AS; Miranda, AL; Silva, KC, 1998) |
| " When rats were given a prophylactic dose (20 mg/kg), roxithromycin suppressed the oedema produced by injecting carrageenin into the paw with effects almost equal to that seen with the non-steroidal anti-inflammatory drug nimesulide." | 3.70 | Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin. ( Rossoni, G; Scaglione, F, 1998) |
| " Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively." | 3.70 | Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors. ( Jain, NK; Kulkarni, SK; Kumar, A, 2000) |
| " In adjuvant arthritis, 50 mg of nimesulide, diclofenac or piroxicam were applied daily to injected paws for 14 days." | 3.69 | Anti-inflammatory activity of topical nimesulide gel in various experimental models. ( Awor, L; Gupta, SK; Joshi, S; Prakash, J; Sengupta, S; Velpandian, T, 1996) |
| "This study aimed to evaluate acute postoperative pain management and trismus in 35 patients undergoing extractions of the two mandibular third molars, in mesioangular positions, at two different visits who consumed nimesulide + thiocolchicoside or only nimesulide." | 3.11 | Randomized split-mouth study for evaluating the efficacy of nimesulide and nimesulide + Thiocolchicoside combination following impacted mandibular third molar surgery. ( Cebi, AT; Kasapoglu, MB, 2022) |
| "Oedema and trismus were similar in the two treatment groups and decreased over time postoperatively." | 2.84 | Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. ( Almeida, RA; Barbalho, JC; de Araújo, SQ; de Morais, HH; Lucena, EE; Rêbelo, HL; Santos, LA; Vasconcellos, RJ, 2017) |
| "Nimesulide has been tested by the Authors on a group of 40 adults patients of both sexes that had undergone oral surgery." | 2.67 | [Nimesulide and algo-edematous pathology of the oral cavity]. ( De Francesco, G; Palattella, D, 1990) |
| "Because atherosclerosis is an inflammatory process involving a series of pathological events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby report the synthesis and evaluation of novel compounds in which antioxidant, anti-inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activities are combined in simple molecules through design." | 1.40 | Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity. ( Kourounakis, AP; Matralis, AN, 2014) |
| "Nimesulide (NIM) is an insoluble nonsteroidal anti-inflammatory drug (NSAID)." | 1.40 | Nimesulide/methyl β-cyclodextrin inclusion complexes: physicochemical characterization, solubility, dissolution, and biological studies. ( Auda, SH, 2014) |
| "Nimesulide is a COX 2 selective anti-inflammatory that is poorly soluble in water." | 1.38 | Natural lipid nanoparticles containing nimesulide: synthesis, characterization and in vivo antiedematogenic and antinociceptive activities. ( Alves, MP; Antonow, MB; Fagan, SB; Lima, A; Lorenzoni, R; Raffin, RP; Turra, C, 2012) |
| "Pretreatment with indomethacin (10 mg kg[-1], s." | 1.30 | Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs. ( Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1997) |
| "Nimesulide was administered intramuscularly at increasing doses of 1." | 1.30 | Anti-inflammatory activity and pharmacokinetic profile of a new parenteral formulation of nimesulide. ( Bhardwaj, RK; Gupta, SK; Sengupta, S; Tyagi, P; Velpandian, T, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 8 (25.00) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 14 (43.75) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Lages, AS | 1 |
| Silva, KC | 1 |
| Miranda, AL | 3 |
| Fraga, CA | 3 |
| Barreiro, EJ | 3 |
| Julémont, F | 1 |
| de Leval, X | 1 |
| Michaux, C | 1 |
| Damas, J | 1 |
| Charlier, C | 1 |
| Durant, F | 1 |
| Pirotte, B | 1 |
| Dogné, JM | 1 |
| Duarte, CD | 2 |
| Tributino, JL | 2 |
| Lacerda, DI | 1 |
| Martins, MV | 1 |
| Alexandre-Moreira, MS | 1 |
| Dutra, F | 1 |
| Bechara, EJ | 1 |
| De-Paula, FS | 1 |
| Goulart, MO | 1 |
| Ferreira, J | 1 |
| Calixto, JB | 1 |
| Nunes, MP | 1 |
| Bertho, AL | 1 |
| Corrêa, RS | 1 |
| Doriguetto, AC | 1 |
| Ellena, J | 1 |
| Romeiro, NC | 1 |
| Castro, NG | 1 |
| Achar, KC | 1 |
| Hosamani, KM | 1 |
| Seetharamareddy, HR | 1 |
| Sharma, PK | 1 |
| Kumar, S | 1 |
| Kumar, P | 1 |
| Kaushik, P | 1 |
| Kaushik, D | 1 |
| Dhingra, Y | 1 |
| Aneja, KR | 1 |
| de Lima, FO | 1 |
| Nonato, FR | 1 |
| Couto, RD | 1 |
| Barbosa Filho, JM | 1 |
| Nunes, XP | 1 |
| Ribeiro dos Santos, R | 1 |
| Soares, MB | 1 |
| Villarreal, CF | 1 |
| Matralis, AN | 1 |
| Kourounakis, AP | 1 |
| Kasapoglu, MB | 1 |
| Cebi, AT | 1 |
| Cetira Filho, EL | 1 |
| Silva, PGB | 1 |
| Wong, DVT | 1 |
| Choquenaira-Quispe, C | 1 |
| Cesário, FRAS | 1 |
| de Sousa Nogueira, G | 1 |
| de Sousa, AVC | 1 |
| de Aguiar, ASW | 1 |
| da Cruz Fonseca, SG | 1 |
| Costa, FWG | 1 |
| Lino, RC | 1 |
| da Silva, DPB | 1 |
| Florentino, IF | 1 |
| da Silva, DM | 1 |
| Martins, JLR | 1 |
| Batista, DDC | 1 |
| Leite, KCS | 1 |
| Villavicencio, B | 1 |
| Vasconcelos, GA | 1 |
| Silva, ALP | 1 |
| de Ávila, RI | 1 |
| Verli, H | 1 |
| Valadares, MC | 1 |
| Gil, ES | 1 |
| Vaz, BG | 1 |
| Lião, LM | 1 |
| Menegatti, R | 1 |
| Costa, EA | 1 |
| Rubegni, P | 1 |
| Tognetti, L | 1 |
| Tosi, GM | 1 |
| Flori, ML | 1 |
| Fimiani, M | 1 |
| Vandana, KR | 1 |
| Yalavarthi, PR | 1 |
| Sundaresan, CR | 1 |
| Sriramaneni, RN | 1 |
| Vadlamudi, HC | 1 |
| Auda, SH | 1 |
| Caiazzo, E | 1 |
| Maione, F | 1 |
| Morello, S | 1 |
| Lapucci, A | 1 |
| Paccosi, S | 1 |
| Steckel, B | 1 |
| Lavecchia, A | 1 |
| Parenti, A | 1 |
| Iuvone, T | 1 |
| Schrader, J | 1 |
| Ialenti, A | 1 |
| Cicala, C | 1 |
| Barbalho, JC | 1 |
| Vasconcellos, RJ | 1 |
| de Morais, HH | 1 |
| Santos, LA | 1 |
| Almeida, RA | 1 |
| Rêbelo, HL | 1 |
| Lucena, EE | 1 |
| de Araújo, SQ | 1 |
| De Menezes, SA | 1 |
| Cury, PR | 1 |
| Loh, JS | 1 |
| Ong, CW | 1 |
| Lenz, QF | 1 |
| Guterres, SS | 1 |
| Pohlmann, A | 1 |
| Alves, MP | 2 |
| Raffin, RP | 1 |
| Lima, A | 1 |
| Lorenzoni, R | 1 |
| Antonow, MB | 1 |
| Turra, C | 1 |
| Fagan, SB | 1 |
| Delporte, C | 1 |
| Backhouse, N | 1 |
| Salinas, P | 1 |
| San-Martín, A | 1 |
| Bórquez, J | 1 |
| Loyola, A | 1 |
| Sharma, S | 1 |
| Jain, NK | 2 |
| Kulkarni, SK | 2 |
| Gupta, SK | 2 |
| Prakash, J | 1 |
| Awor, L | 1 |
| Joshi, S | 1 |
| Velpandian, T | 2 |
| Sengupta, S | 2 |
| Hirata, T | 1 |
| Ukawa, H | 1 |
| Yamakuni, H | 1 |
| Kato, S | 1 |
| Takeuchi, K | 1 |
| Scaglione, F | 1 |
| Rossoni, G | 1 |
| Bhardwaj, RK | 1 |
| Tyagi, P | 1 |
| Anandakesavan, TM | 1 |
| Kumar, A | 1 |
| Azab, AN | 1 |
| Kaplanski, J | 1 |
| Swingle, KF | 1 |
| Moore, GG | 1 |
| Grant, TJ | 1 |
| Tanaka, K | 1 |
| Shimotori, T | 1 |
| Makino, S | 1 |
| Aikawa, Y | 1 |
| Inaba, T | 1 |
| Yoshida, C | 1 |
| Takano, S | 1 |
| De Francesco, G | 1 |
| Palattella, D | 1 |
5 trials available for nimesulide and Edema
| Article | Year |
|---|---|
Randomized split-mouth study for evaluating the efficacy of nimesulide and nimesulide + Thiocolchicoside combination following impacted mandibular third molar surgery.
Topics: Colchicine; Edema; Humans; Molar, Third; Mouth; Pain, Postoperative; Sulfonamides; Tooth Extraction; | 2022 |
Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial.
Topics: Double-Blind Method; Edema; Humans; Low-Level Light Therapy; Molar, Third; Mouth; Oxidative Stress; | 2022 |
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Brazil; Dexamethasone; Drug Therapy, Com | 2017 |
Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar.
Topics: Cross-Over Studies; Cyclooxygenase Inhibitors; Edema; Female; Humans; Male; Meloxicam; Molar, Third; | 2010 |
[Nimesulide and algo-edematous pathology of the oral cavity].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apicoectomy; Edema; Female; Humans; Inflammation; Ja | 1990 |
27 other studies available for nimesulide and Edema
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; | 1998 |
Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.
Topics: Aminopyridines; Animals; Anions; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Crystallogr | 2002 |
Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Arachidonic Acids; Bi | 2007 |
Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Carrageenan; | 2009 |
In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Carrageen | 2010 |
Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory-antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Edema; Male; Pyrazoles; Rats; Ra | 2010 |
Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin.
Topics: Analgesics; Animals; Brazil; Dinoprostone; Edema; Freund's Adjuvant; Mice; Models, Animal; Molecular | 2011 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; | 2014 |
Pharmacological evaluation and molecular docking of new di-tert-butylphenol compound, LQFM-091, a new dual 5-LOX/COX inhibitor.
Topics: 3T3 Cells; Animals; Carrageenan; Cell Survival; Cyclooxygenase Inhibitors; Cytokines; Edema; Female; | 2017 |
Ocular involvement in generalized fixed drug eruption from nimesulide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Conjunctival Diseases; Drug Eruptions; Edema; Eyelid Diseas | 2013 |
In-vitro assessment and pharmacodynamics of nimesulide incorporated Aloe vera transemulgel.
Topics: Aloe; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Stability; Edema; Gels; Hy | 2014 |
Nimesulide/methyl β-cyclodextrin inclusion complexes: physicochemical characterization, solubility, dissolution, and biological studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Disease Models, Animal; Drug C | 2014 |
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
Topics: 5'-Nucleotidase; Adenosine; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2 Inhibitor | 2016 |
Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar [Int. J. Oral Maxillofac. Surg. 39 (2010) 580-584].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Edema; Humans; Meloxicam; Molar, | 2011 |
Semi-solid topical formulations containing nimesulide-loaded nanocapsules showed in-vivo anti-inflammatory activity in chronic arthritis and fibrovascular tissue models.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 2012 |
Natural lipid nanoparticles containing nimesulide: synthesis, characterization and in vivo antiedematogenic and antinociceptive activities.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Foot; Hyd | 2012 |
Pharmaco-toxicological study of diterpenoids.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2003 |
Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2005 |
Anti-inflammatory activity of topical nimesulide gel in various experimental models.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1996 |
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 1997 |
Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Azithromycin; Carrageenan; | 1998 |
Anti-inflammatory activity and pharmacokinetic profile of a new parenteral formulation of nimesulide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Response Relationshi | 1999 |
Nimesulide toxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Edema; Eye Diseases; Follow-Up Stu | 1999 |
Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageen | 2000 |
A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Exudates and Tra | 2001 |
4-nitro-2-phenoxymethanesulfonanilide (R-805): a chemically novel anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Edema; Erythema; Lethal Dose 50; Male; Rat | 1976 |
Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzopyrans; Dogs; Edema; | 1992 |