nimesulide and Disease Models, Animal studies

nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
"Nimesulide was compared with vehicle in groups of 4-10 rats that were randomly tested with different models of pain."	9.10	Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003)
"Cyclooxygenase (COX)-derived prostanoids contribute to angiotensin II (ANG II) hypertension (HTN)."	7.79	Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat. ( Asirvatham-Jeyaraj, N; Fink, GD; King, AJ; Madan, S; Northcott, CA, 2013)
"The purpose of this study was to compare the topical anti-inflammatory effects of the nonselective cyclooxygenase (COX) inhibitor, ketorolac, with the selective COX-2 inhibitor, nimesulide, in an animal model of dry eye in albino rabbits."	7.74	Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits. ( El-Gohary, AA; El-Hossary, GG; El-Shazly, AH; El-Shazly, LH, 2008)
"The effects of the cyclooxygenase (COX)-2 inhibitor nimesulide on bombesin-enhanced peritoneal metastasis of azoxymethane (AOM)-induced intestinal adenocarcinomas were investigated in male Wistar rats."	7.72	Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. ( Akedo, H; Baba, M; Higashino, K; Iishi, H; Mukai, M; Tatsuta, M; Yano, H, 2003)
" We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat."	7.71	Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001)
"Chronic colitis was induced in mice by four cycles of administration of dextran sulfate sodium (DSS) (i."	5.35	Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. ( Hirata, I; Inoue, T; Murano, M, 2008)
"In the control group, esophagitis, Barrett's esophagus (BE) and adenocarcinoma (EAC) were observed, and the frequency of these conditions increased with time."	5.34	[Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide]. ( Fujimura, T; Fushida, S; Kinami, S; Miyashita, T; Ninomiya, I; Ohta, T; Oyama, K, 2007)
"Women with endometriosis have elevated levels of cyclooxygenase-2 (COX-2) in peritoneal macrophages and endometriotic tissue."	5.33	Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis. ( Butt, RP; Charnock-Jones, DS; Hull, ML; Phillips, SC; Prentice, A; Smith, SK; Wang, DY, 2005)
"Acute colitis was induced by exposing female ICR mice to 5% DSS in drinking water for 1 week."	5.32	Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. ( Hayashi, R; Kwon, KH; Murakami, A; Ohigashi, H; Safitri, R; Takana, T; Tanaka, T, 2003)
"Treatment with nimesulide did not improve NSS (NSS at 24 h = 11+/-6 [median +/- range] in group 3 and 12+/-4 in group 4) or edema formation (brain water content at 24 h = 84."	5.31	Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. ( Artru, AA; Kaplanski, J; Koyfman, L; Rubin, M; Shapira, Y; Talmor, D, 2000)
"Nimesulide was compared with vehicle in groups of 4-10 rats that were randomly tested with different models of pain."	5.10	Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003)
"The present study was designed to determine the effects of cyclooxygenase-2 (COX-2) inhibitor-nimesulide on platelet activating factor (PAF) and arachidonic acid (AA)-induced platelet aggregation during myocardial infarction (Ml) and ischaemia in rabbits."	3.81	Anti-platelet effects of nimesulide in isoproterenol-induced myocardial ischaemia and infarction in rabbits. ( Ahmed, S; Dima, L; Gul, S; Moga, M; Ze Jaafar, H; Zia-Ul-Haq, M, 2015)
" In the present study an experimental rabbit model of hypercholesterolemia was developed and the effects of COX-2 inhibitors, nimesulide and celecoxib were observed on the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS)."	3.80	Cyclooxygenase-2 inhibition improves antioxidative defense during experimental hypercholesterolemia. ( Ahmed, S; Ercisli, S; Gul, H; Gul, S; Zia-Ul-Haq, M, 2014)
"Cyclooxygenase (COX)-derived prostanoids contribute to angiotensin II (ANG II) hypertension (HTN)."	3.79	Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat. ( Asirvatham-Jeyaraj, N; Fink, GD; King, AJ; Madan, S; Northcott, CA, 2013)
"The purpose of this study was to compare the topical anti-inflammatory effects of the nonselective cyclooxygenase (COX) inhibitor, ketorolac, with the selective COX-2 inhibitor, nimesulide, in an animal model of dry eye in albino rabbits."	3.74	Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits. ( El-Gohary, AA; El-Hossary, GG; El-Shazly, AH; El-Shazly, LH, 2008)
"The present study was designed to investigate whether the neuroprotective effect of nimesulide was mediated by inhibiting expression of matrix metalloproteinase-9 (MMP-9) and/or matrix metalloproteinase-2 (MMP-2) in a rat model of thrombolytic reperfusion after the embolic focal cerebral ischemia (FCI)."	3.74	A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases. ( Deng, XL; Wang, Y; Xiao, XH; Yuan, BX, 2007)
" With this background, the present study was designed to explore the possible effect of nimesulide (a preferential COX-2 inhibitor) against pentylenetetrazol (PTZ)-induced kindling epilepsy in mice."	3.74	Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2007)
" The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebral ischemia in rats."	3.72	Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. ( Candelario-Jalil, E; Fiebich, BL; García-Cabrera, M; González-Falcón, A; León, OS, 2004)
"This study demonstrates that CSF biomarker profiles, as detected by SELDI technology, can consistently and reproducibly differentiate inflammatory from neuropathic pain, and reflect the analgesic action produced by the preferential COX-2 inhibitor, nimesulide."	3.72	High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide. ( Bianchi, M; Gineste, C; Ho, L; Pasinetti, GM; Pompl, P, 2003)
"The effects of the cyclooxygenase (COX)-2 inhibitor nimesulide on bombesin-enhanced peritoneal metastasis of azoxymethane (AOM)-induced intestinal adenocarcinomas were investigated in male Wistar rats."	3.72	Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. ( Akedo, H; Baba, M; Higashino, K; Iishi, H; Mukai, M; Tatsuta, M; Yano, H, 2003)
" We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat."	3.71	Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001)
"In this model of chronic inflammation, aspirin, more selective for the inhibition of COX-1 is more effective than the selective COX-2 inhibitors nimesulide and NS-398 at inhibiting granuloma dry weight, vascularity and COX activity."	3.70	Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation. ( Gilroy, DW; Tomlinson, A; Willoughby, DA, 1998)
" The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay."	3.70	Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. ( Barreiro, EJ; Fraga, CA; Lages, AS; Miranda, AL; Silva, KC, 1998)
"Nimesulide significantly decreased the extent of colitis induced by acetic acid."	3.70	Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. ( Cohen, P; Karmeli, F; Rachmilewitz, D, 2000)
" In both acute (18 h) and chronic (14 d) phases of adjuvant arthritis, nimesulide gel was more effective than diclofenac or piroxicam gels."	3.69	Anti-inflammatory activity of topical nimesulide gel in various experimental models. ( Awor, L; Gupta, SK; Joshi, S; Prakash, J; Sengupta, S; Velpandian, T, 1996)
" pylori, especially after MNU administration to promote carcinogenesis and the effects of the long-term administration of rebamipide or nimesulide were evaluated."	2.42	Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? ( Cho, SW; Hahm, KB; Han, SU; Kim, DY; Kim, JH; Kim, MW; Kim, YB; Lee, JS; Nahm, KT; Oh, TY; Song, YJ; Surh, YJ; Yoo, BM, 2003)
"Nimesulide is a sulfonanilide compound with anti-inflammatory properties."	2.40	In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. ( Famaey, JP, 1997)
"Nimesulide is an inhibitor of COX-2 with antioxidant and anti-inflammatory effects."	1.56	Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide. ( Luo, W; Luo, Y; Yang, J, 2020)
"Although migraine is a common neurological condition, the pathomechanism is not yet fully understood."	1.42	Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine. ( Chen, J; Dong, X; Hu, Y; Jing, L, 2015)
"Nimesulide (NIM) is an insoluble nonsteroidal anti-inflammatory drug (NSAID)."	1.40	Nimesulide/methyl β-cyclodextrin inclusion complexes: physicochemical characterization, solubility, dissolution, and biological studies. ( Auda, SH, 2014)
" Their combination as stroke treatment has the potential benefits of decreasing individual drug dosage and fewer adverse effects."	1.38	Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. ( Huang, CY; Tsai, KJ; Wang, HK; Wang, LC; Wu, MH, 2012)
"One component of airway remodeling involves fibroblast accumulation and activation, resulting in deposition of collagen I around small bronchi."	1.37	Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. ( Jancar, S; Peters-Golden, M; Stumm, CL; Wettlaufer, SH, 2011)
"Inflammatory hyperalgesia was measured following intraplantar injection of carrageenan."	1.35	Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain. ( Alexander, SP; Barrett, DA; Bennett, AJ; Chapman, V; Garle, MJ; Jhaveri, MD; Kendall, DA; Patel, A; Richardson, D; Robinson, I; Sagar, DR; Sun, Y, 2008)
"The effect of the COX inhibitors on thrombus formation was evaluated in a model of carotid artery thrombosis secondary to electrolytic-induced vessel wall injury."	1.35	Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis. ( Barrett, TD; Hong, TT; Huang, J; Lucchesi, BR, 2008)
"Chronic colitis was induced in mice by four cycles of administration of dextran sulfate sodium (DSS) (i."	1.35	Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. ( Hirata, I; Inoue, T; Murano, M, 2008)
"Body weight was increased significantly and similarly in HFa, HFa-Cel, and HFa-Mes."	1.35	COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. ( Chan, PC; Chen, CH; Chiang, CF; Hsieh, PS; Jin, JS; Shih, KC, 2009)
"In the control group, esophagitis, Barrett's esophagus (BE) and adenocarcinoma (EAC) were observed, and the frequency of these conditions increased with time."	1.34	[Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide]. ( Fujimura, T; Fushida, S; Kinami, S; Miyashita, T; Ninomiya, I; Ohta, T; Oyama, K, 2007)
"Patients with ulcerative colitis (UC) exhibit an increased risk for the development of cancer of the colon and rectum."	1.34	Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis. ( Abe, Y; Hirata, I; Inoue, T; Katsu, K; Maemura, K; Morita, E; Murano, M; Murano, N; Nishikawa, T; Toshina, K; Yasumoto, S, 2007)
"Women with endometriosis have elevated levels of cyclooxygenase-2 (COX-2) in peritoneal macrophages and endometriotic tissue."	1.33	Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis. ( Butt, RP; Charnock-Jones, DS; Hull, ML; Phillips, SC; Prentice, A; Smith, SK; Wang, DY, 2005)
" Mice were made physically dependent on alcohol by the chronic administration of ethanol (2 g/kg of 10% v/v), intragastrically, twice on day 1 and then once-daily on successive days for a total of 7 days."	1.33	Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2005)
"Five and 6 samples of superficial bladder cancer cases with and without recurrence after complete TUR were examined by immunohistochemical analysis."	1.32	Expression of cyclooxygenase-2 in primary superficial bladder cancer tissue may predict risk of its recurrence after complete transurethral resection. ( Fujimoto, K; Hirao, Y; Ohnishi, S; Ohta, M; Okajima, E; Ozono, S; Tanaka, M; Tani, M; Uemura, H, 2003)
"Acute colitis was induced by exposing female ICR mice to 5% DSS in drinking water for 1 week."	1.32	Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. ( Hayashi, R; Kwon, KH; Murakami, A; Ohigashi, H; Safitri, R; Takana, T; Tanaka, T, 2003)
"Treatment with nimesulide did not improve NSS (NSS at 24 h = 11+/-6 [median +/- range] in group 3 and 12+/-4 in group 4) or edema formation (brain water content at 24 h = 84."	1.31	Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. ( Artru, AA; Kaplanski, J; Koyfman, L; Rubin, M; Shapira, Y; Talmor, D, 2000)
"Quisqualic acid was injected into the right nucleus basalis of rats."	1.31	Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. ( Casamenti, F; Pepeu, G; Prosperi, C; Scali, C; Vannucchi, MG, 2000)
"nimesulide (0."	1.31	Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor. ( Cetin, A; Guvenal, T; Kaya, T; Ozdemir, H; Yanar, O, 2001)
"Indomethacin was associated with electron microscopy changes suggestive of uncoupling in 60%-70% of enterocytes examined, whereas nimesulide affected 10%-30% of enterocytes, depending on the dose."	1.30	Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. ( Bjarnason, I; Foster, R; Jacob, M; Mahmud, T; Rafi, S; Roseth, A; Sigthorsson, G; Simpson, R; Somasundaram, S; Tavares, I; Wrigglesworth, J, 1998)
" Animals were dosed daily, p."	1.30	The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat. ( Gilroy, DW; Greenslade, K; Seed, MP; Tomlinson, A; Willoughby, DA, 1998)

Research

Studies (62)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Receptor Binding (Vt)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (11.29)	18.2507
2000's	40 (64.52)	29.6817
2010's	13 (20.97)	24.3611
2020's	2 (3.23)	2.80

Authors	Studies
Lages, AS	1
Silva, KC	1
Miranda, AL	2
Fraga, CA	2
Barreiro, EJ	2
Tributino, JL	1
Duarte, CD	1
Corrêa, RS	1
Doriguetto, AC	1
Ellena, J	1
Romeiro, NC	1
Castro, NG	1
Solinski, HJ	1
Dranchak, P	1
Oliphant, E	1
Gu, X	1
Earnest, TW	1
Braisted, J	1
Inglese, J	1
Hoon, MA	1
Abrams, RPM	1
Yasgar, A	1
Teramoto, T	1
Lee, MH	1
Dorjsuren, D	1
Eastman, RT	1
Malik, N	1
Zakharov, AV	1
Li, W	1
Bachani, M	1
Brimacombe, K	1
Steiner, JP	1
Hall, MD	1
Balasubramanian, A	1
Jadhav, A	1
Padmanabhan, R	1
Simeonov, A	1
Nath, A	1
Luo, W	1
Luo, Y	1
Yang, J	1
Asirvatham-Jeyaraj, N	1
King, AJ	1
Northcott, CA	1
Madan, S	1
Fink, GD	1
Auda, SH	1
Ahmed, S	2
Gul, S	2
Gul, H	1
Zia-Ul-Haq, M	2
Ercisli, S	1
Dong, X	1
Hu, Y	1
Jing, L	1
Chen, J	1
Ze Jaafar, H	1
Moga, M	1
Dima, L	1
El-Shazly, AH	1
El-Gohary, AA	1
El-Shazly, LH	1
El-Hossary, GG	1
Jhaveri, MD	1
Richardson, D	1
Robinson, I	1
Garle, MJ	1
Patel, A	1
Sun, Y	1
Sagar, DR	1
Bennett, AJ	1
Alexander, SP	1
Kendall, DA	1
Barrett, DA	1
Chapman, V	1
Hsieh, PS	2
Jin, JS	1
Chiang, CF	2
Chan, PC	1
Chen, CH	2
Shih, KC	1
Wood, CE	1
Powers Fraites, M	1
Keller-Wood, M	1
Varvanina, GG	1
Tkachenko, EV	1
Drozdov, VN	1
Trubitsyna, IE	1
Foreman, JE	1
Sorg, JM	1
McGinnis, KS	1
Rigas, B	1
Williams, JL	1
Clapper, ML	1
Gonzalez, FJ	2
Peters, JM	2
Bility, MT	1
Zhu, B	1
Kang, BH	1
Lu, KC	1
Suckow, MA	1
Hodde, JP	1
Wolter, WR	1
Wood, KV	1
Hiles, MC	1
Janis, AD	1
Kumar, A	1
Kumari, B	1
Kumar, P	1
Stumm, CL	1
Wettlaufer, SH	1
Jancar, S	1
Peters-Golden, M	1
Wang, LC	1
Huang, CY	1
Wang, HK	1
Wu, MH	1
Tsai, KJ	1
Apostolidis, D	1
Ntinas, A	1
Kardassis, D	1
Koulouris, N	1
Thomareis, O	1
Karayannopoulou, G	1
Vrochides, D	1
Kitamura, T	1
Kawamori, T	1
Uchiya, N	1
Itoh, M	1
Noda, T	1
Matsuura, M	1
Sugimura, T	1
Wakabayashi, K	1
Hahm, KB	1
Song, YJ	1
Oh, TY	1
Lee, JS	1
Surh, YJ	1
Kim, YB	1
Yoo, BM	1
Kim, JH	1
Han, SU	1
Nahm, KT	1
Kim, MW	1
Kim, DY	1
Cho, SW	1
Pompl, PN	1
Ho, L	2
Bianchi, M	3
McManus, T	1
Qin, W	1
Pasinetti, GM	2
Tu, B	1
Bazan, NG	1
Murakami, A	1
Hayashi, R	1
Tanaka, T	1
Kwon, KH	1
Ohigashi, H	1
Safitri, R	1
Takana, T	1
Gineste, C	1
Pompl, P	1
Tassorelli, C	1
Greco, R	1
Sandrini, G	1
Nappi, G	1
Okajima, E	2
Uemura, H	1
Ohnishi, S	1
Tanaka, M	1
Ohta, M	1
Tani, M	1
Fujimoto, K	1
Ozono, S	1
Hirao, Y	1
Iishi, H	1
Tatsuta, M	1
Baba, M	1
Yano, H	1
Higashino, K	1
Mukai, M	1
Akedo, H	1
Candelario-Jalil, E	1
González-Falcón, A	1
García-Cabrera, M	1
León, OS	1
Fiebich, BL	1
Gendron, TF	1
Brunette, E	1
Mealing, GA	1
Nguyen, A	1
Tauskela, JS	1
Morley, P	1
Hull, ML	1
Prentice, A	1
Wang, DY	1
Butt, RP	1
Phillips, SC	1
Smith, SK	1
Charnock-Jones, DS	1
Dhir, A	2
Naidu, PS	2
Kulkarni, SK	2
Hiraga, T	1
Myoui, A	1
Choi, ME	1
Yoshikawa, H	1
Yoneda, T	1
Escalante, RD	1
de Oliveira, EC	1
Cunha, FQ	1
Vespúcio, MV	1
Ribeiro-Silva, A	1
Aprilli, F	1
Garcia, SB	1
Favrais, G	1
Schwendimann, L	1
Gressens, P	1
Lelièvre, V	1
Gan, HT	1
Pasricha, PJ	1
Chen, JD	1
Martucci, C	1
Ferrario, P	1
Franchi, S	1
Sacerdote, P	1
Funahashi, H	1
Satake, M	1
Dawson, D	1
Huynh, NA	1
Reber, HA	1
Hines, OJ	1
Eibl, G	1
Oyama, K	1
Fujimura, T	1
Ninomiya, I	1
Miyashita, T	1
Kinami, S	1
Fushida, S	1
Ohta, T	1
Wang, Y	1
Deng, XL	1
Xiao, XH	1
Yuan, BX	1
Inoue, T	2
Murano, M	2
Abe, Y	1
Morita, E	1
Murano, N	1
Yasumoto, S	1
Toshina, K	1
Nishikawa, T	1
Maemura, K	1
Hirata, I	2
Katsu, K	1
Hong, TT	1
Huang, J	1
Barrett, TD	1
Lucchesi, BR	1
Gu, B	1
Desjardins, P	1
Butterworth, RF	1
Botrel, MA	1
Haak, T	1
Legrand, C	1
Concordet, D	1
Chevalier, R	1
Toutain, PL	1
Gupta, SK	1
Prakash, J	1
Awor, L	1
Joshi, S	1
Velpandian, T	1
Sengupta, S	1
Famaey, JP	1
Gilroy, DW	2
Tomlinson, A	2
Willoughby, DA	2
Sigthorsson, G	1
Jacob, M	1
Wrigglesworth, J	1
Somasundaram, S	1
Tavares, I	1
Foster, R	1
Roseth, A	1
Rafi, S	1
Mahmud, T	1
Simpson, R	1
Bjarnason, I	1
Greenslade, K	1
Seed, MP	1
Koyfman, L	1
Kaplanski, J	1
Artru, AA	1
Talmor, D	1
Rubin, M	1
Shapira, Y	1
Karmeli, F	1
Cohen, P	1
Rachmilewitz, D	1
Scali, C	1
Prosperi, C	1
Vannucchi, MG	1
Pepeu, G	1
Casamenti, F	1
Guvenal, T	1
Cetin, A	1
Ozdemir, H	1
Yanar, O	1
Kaya, T	1
Cernak, I	1
O'Connor, C	1
Vink, R	1
Kankuri, E	1
Vaali, K	1
Korpela, R	1
Paakkari, I	1
Vapaatalo, H	1
Moilanen, E	1
Tamarat, R	1
Silvestre, JS	1
Durie, M	1
Levy, BI	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
PET Imaging of Translocator Protein in Subjects With Traumatic Brain Injury[NCT01547780]	Phase 1/Phase 2	52 participants (Actual)	Interventional	2012-01-20	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To determine total distribution volume of [C-11]PBR28 in the whole brain using PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan

Receptor Binding Corrected for Plasma (Vt/fp)

Intervention	mL/cm^3 (Mean)
Baseline Brain PET in Acute TBI Patient	2.53
Repeat Brain PET in Acute TBI Patient	2.21
Single Brain PET in Chronic TBI Patient	3.21
Single Brain PET in Healthy Subjects	3.22

Total distribution volume divided by plasma free fraction (fp) of [C-11]PBR28. Measured with PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan

Article	Year
Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? Journal of biochemistry and molecular biology, 2003, Jan-31, Volume: 36, Issue:1 Topics: Alanine; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cyto	2003
In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase	1997

Article	Year
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. Bioorganic & medicinal chemistry letters, 1998, Jan-20, Volume: 8, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal;	1998
Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates. Bioorganic & medicinal chemistry, 2009, Feb-01, Volume: 17, Issue:3 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Carrageenan;	2009
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S	2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr	2020
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide. Scientific reports, 2020, 07-06, Volume: 10, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Cyclooxygenase 2 Inhibitors	2020
Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat. American journal of physiology. Heart and circulatory physiology, 2013, Nov-15, Volume: 305, Issue:10 Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2	2013
Nimesulide/methyl β-cyclodextrin inclusion complexes: physicochemical characterization, solubility, dissolution, and biological studies. Drug development research, 2014, Volume: 75, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Disease Models, Animal; Drug C	2014
Cyclooxygenase-2 inhibition improves antioxidative defense during experimental hypercholesterolemia. Bosnian journal of basic medical sciences, 2014, Volume: 14, Issue:2 Topics: Animals; Antioxidants; Celecoxib; Cholesterol, LDL; Cyclooxygenase 2 Inhibitors; Disease Models, Ani	2014
Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine. Molecular medicine reports, 2015, Volume: 12, Issue:2 Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Mod	2015
Anti-platelet effects of nimesulide in isoproterenol-induced myocardial ischaemia and infarction in rabbits. Acta cardiologica, 2015, Volume: 70, Issue:4 Topics: Animals; Disease Models, Animal; Isoproterenol; Myocardial Infarction; Platelet Activating Factor; P	2015
Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits. Acta pharmaceutica (Zagreb, Croatia), 2008, Volume: 58, Issue:2 Topics: Administration, Topical; Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxyg	2008
Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain. Neuropharmacology, 2008, Volume: 55, Issue:1 Topics: Amides; Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Carrageen	2008
COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity (Silver Spring, Md.), 2009, Volume: 17, Issue:6 Topics: Adipocytes; Adipogenesis; Adipose Tissue; Animals; Blood Glucose; Body Weight; Celecoxib; Cell Size;	2009
Blockade of PGHS-2 inhibits the hypothalamus-pituitary-adrenal axis response to cerebral hypoperfusion in the sheep fetus. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:6 Topics: Adrenocorticotropic Hormone; Animals; Baroreflex; Blood Pressure; Brachiocephalic Trunk; Brain; Brai	2009
[Experimental NSAID-associated gastric mucosa injuries]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2008, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models	2008
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. Molecular carcinogenesis, 2009, Volume: 48, Issue:10 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Coloni	2009
Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 113, Issue:1 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell D	2010
Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats. European journal of clinical investigation, 2010, Volume: 40, Issue:2 Topics: Adiposity; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Glucose; Blood Pr	2010
Addition of nimesulide to small intestinal submucosa biomaterial inhibits postsurgical adhesiogenesis in rats. Journal of biomedical materials research. Part B, Applied biomaterials, 2010, Volume: 93, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Materials; Cecum; Cyclooxygenase Inh	2010
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neuroscience bulletin, 2010, Volume: 26, Issue:1 Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;	2010
Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:5 Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchi; Cell Proliferation; Chronic Disease; Collage	2011
Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. Journal of neurotrauma, 2012, May-01, Volume: 29, Issue:7 Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Cyclooxygenase Inhibitors; Disease Models, Animal;	2012
Nimesulide may be more efficient than allopurinol in protecting pancreas from acute ischemia/reperfusion injury in an animal model. Vascular and endovascular surgery, 2012, Volume: 46, Issue:8 Topics: Allopurinol; Animals; Biomarkers; Biopsy; Cytoprotection; Disease Models, Animal; Infusions, Intrave	2012
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. Carcinogenesis, 2002, Volume: 23, Issue:9 Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenas	2002
A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas	2003
Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex. Experimental neurology, 2003, Volume: 179, Issue:2 Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Disease	2003
Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochemical pharmacology, 2003, Oct-01, Volume: 66, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dextran Sulfate; Disease Models, Animal;	2003
High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide. Drugs, 2003, Volume: 63 Suppl 1 Topics: Analysis of Variance; Animals; Biomarkers; Cerebrospinal Fluid Proteins; Constriction; Cyclooxygenas	2003
Expression of cyclooxygenase-2 in primary superficial bladder cancer tissue may predict risk of its recurrence after complete transurethral resection. Aktuelle Urologie, 2003, Volume: 34, Issue:4 Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In	2003
Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. Clinical & experimental metastasis, 2003, Volume: 20, Issue:6 Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Bombesin; Carcinogen	2003
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. Brain research, 2004, May-08, Volume: 1007, Issue:1-2 Topics: Analysis of Variance; Animals; Behavior, Animal; Cerebral Infarction; Dinoprostone; Disease Models,	2004
Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity. European journal of pharmacology, 2004, Jun-16, Volume: 493, Issue:1-3 Topics: Animals; Calcium; Canada; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Cyclooxyge	2004
Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis. Human reproduction (Oxford, England), 2005, Volume: 20, Issue:2 Topics: Adult; Animals; Antibodies; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy	2005
Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes. Addiction biology, 2005, Volume: 10, Issue:4 Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Behavior, Animal; Brain; Cyclooxygenase 2 Inhibito	2005
Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer research, 2006, Feb-15, Volume: 66, Issue:4 Topics: Animals; Apoptosis; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cyclooxygena	2006
Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2006, Volume: 39, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Chagas Disease; Colorectal Neoplasms;	2006
Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice. Neurobiology of disease, 2007, Volume: 25, Issue:3 Topics: Animals; Animals, Newborn; Brain; Cerebral Palsy; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinop	2007
Blockade of p38 mitogen-activated protein kinase pathway ameliorates delayed intestinal transit in burned rats. American journal of surgery, 2007, Volume: 193, Issue:4 Topics: Animals; Burns; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Gastrointest	2007
Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anima	2007
Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. Seizure, 2007, Volume: 16, Issue:8 Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Cyclooxygenase Inhibitors; Disease	2007
Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer research, 2007, Aug-01, Volume: 67, Issue:15 Topics: Animals; Carcinoma, Pancreatic Ductal; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, An	2007
[Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2007, Volume: 104, Issue:8 Topics: Adenocarcinoma; Animals; Barrett Esophagus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost	2007
A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases. Current neurovascular research, 2007, Volume: 4, Issue:3 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cereb	2007
Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis. Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:9 Topics: Animals; Colitis, Ulcerative; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Dinoprostone; Disease	2007
Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:1 Topics: Acetylcholine; Animals; Arachidonic Acid; Benzofurans; Carotid Arteries; Coronary Circulation; Coron	2008
Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. Inflammopharmacology, 2008, Volume: 16, Issue:1 Topics: Administration, Oral; Analysis of Variance; Animals; Chi-Square Distribution; Chronic Disease; Colit	2008
Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. Metabolic brain disease, 2008, Volume: 23, Issue:2 Topics: Animals; Brain; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Disease Models, Animal; Enzyme Activ	2008
Quantitative evaluation of an experimental inflammation induced with Freund's complete adjuvant in dogs. Journal of pharmacological and toxicological methods, 1994, Volume: 32, Issue:2 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bod	1994
Anti-inflammatory activity of topical nimesulide gel in various experimental models. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:12 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;	1996
Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47, Issue:2 Topics: Air; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Croton Oil; Cyclooxygenase	1998
Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scandinavian journal of gastroenterology, 1998, Volume: 33, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane Permeability; Cyclooxygenase Inhibit	1998
The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat. Inflammation, 1998, Volume: 22, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Bone and Bones; Cartilage,	1998
Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. Journal of neurosurgical anesthesiology, 2000, Volume: 12, Issue:1 Topics: Anesthetics, Inhalation; Animals; Body Water; Brain Chemistry; Brain Edema; Cerebral Cortex; Cycloox	2000
Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase Inhibitors; Disease Models	2000
Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. The European journal of neuroscience, 2000, Volume: 12, Issue:6 Topics: Acetylcholine; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline O-Acetyl	2000
Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor. Human reproduction (Oxford, England), 2001, Volume: 16, Issue:8 Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, A	2001
Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats. Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:11 Topics: Animals; Brain Injuries; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloox	2001
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. Inflammation, 2001, Volume: 25, Issue:5 Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen	2001
Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways. Laboratory investigation; a journal of technical methods and pathology, 2002, Volume: 82, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Benzimidazoles; B	2002

nimesulide and Disease Models, Animal