nimesulide has been researched along with Colonic Neoplasms in 14 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Female CD-1 (ICR) mice were given a single intraperitoneal administration of AOM (10 mg/kg body weight) and followed by one-week oral exposure of 2% (w/v) DSS in drinking water, and then maintained on the basal diets mixed with or without nimesulide (0." | 3.73 | Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| "Colon cancer was induced by administering azoxymethane to wild-type and PPARbeta/delta-null mice." | 1.35 | Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. ( Billin, AN; Borland, MG; Gonzalez, FJ; Hollingshead, HE; Peters, JM; Willson, TM, 2008) |
| "To investigate the effects of 5-aminosalicylic acid (5-ASA) in combination with nimesulide on the proliferation of HT-29 colon carcinoma cells and its potential mechanisms." | 1.34 | 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro. ( Fang, HM; Ma, WJ; Mei, Q; Xu, JM, 2007) |
| "Nimesulide was formulated into a metered dose inhaler (MDI) formulation and characterized for aerodynamic particle size and medication delivery." | 1.32 | Evaluation of an aerosolized selective COX-2 inhibitor as a potentiator of doxorubicin in a non-small-cell lung cancer cell line. ( Chatterjee, A; Haynes, A; Shaik, MS; Singh, M, 2003) |
| "Transduction of murine colon cancer cells with control vector, carrying the neomycin-resistance gene alone, failed to increase tumor growth rate and COX-2 protein expression or PGE(2) production." | 1.32 | Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells. ( Agbaria, R; Ben-Kasus, T; Danon, A; Konson, A; Mahajna, JA; Rimon, G, 2004) |
| "nimesulide-treated groups were 0." | 1.30 | Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice. ( Fukuda, K; Fukutake, M; Isoi, T; Mamiya, S; Nakatsugi, S; Ohta, T; Sato, H; Sugimura, T; Takahashi, M; Taniguchi, Y; Wakabayashi, K, 1998) |
| "Nimesulide is a selective inhibitor of cyclooxygenase 2 and has been shown to have a more potent anti-inflammatory action than piroxicam, but be less ulcerogenic and, therefore, a potentially more useful chemopreventive agent." | 1.29 | Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2. ( Fukutake, M; Ishida, K; Sugimura, T; Takahashi, M; Wakabayashi, K; Yokota, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 11 (78.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ottanà , R | 1 |
| Carotti, S | 1 |
| Maccari, R | 1 |
| Landini, I | 1 |
| Chiricosta, G | 1 |
| Caciagli, B | 1 |
| Vigorita, MG | 1 |
| Mini, E | 1 |
| Foreman, JE | 1 |
| Sorg, JM | 1 |
| McGinnis, KS | 1 |
| Rigas, B | 1 |
| Williams, JL | 1 |
| Clapper, ML | 1 |
| Gonzalez, FJ | 2 |
| Peters, JM | 2 |
| Godlewski, MM | 1 |
| Gajkowska, B | 1 |
| Lamparska-Przybysz, M | 1 |
| Motyl, T | 1 |
| Haynes, A | 1 |
| Shaik, MS | 1 |
| Chatterjee, A | 1 |
| Singh, M | 1 |
| Konson, A | 1 |
| Ben-Kasus, T | 1 |
| Mahajna, JA | 1 |
| Danon, A | 1 |
| Rimon, G | 1 |
| Agbaria, R | 1 |
| Kohno, H | 1 |
| Suzuki, R | 1 |
| Sugie, S | 1 |
| Tanaka, T | 1 |
| Fang, HM | 1 |
| Mei, Q | 1 |
| Xu, JM | 1 |
| Ma, WJ | 1 |
| Hollingshead, HE | 1 |
| Borland, MG | 1 |
| Billin, AN | 1 |
| Willson, TM | 1 |
| Takahashi, M | 2 |
| Fukutake, M | 2 |
| Yokota, S | 1 |
| Ishida, K | 1 |
| Wakabayashi, K | 4 |
| Sugimura, T | 2 |
| Seed, MP | 1 |
| Freemantle, CN | 1 |
| Alam, CA | 1 |
| Colville-Nash, PR | 1 |
| Brown, JR | 1 |
| Papworth, JL | 1 |
| Somerville, KW | 1 |
| Willoughby, DA | 1 |
| Nakatsugi, S | 2 |
| Isoi, T | 1 |
| Ohta, T | 1 |
| Mamiya, S | 1 |
| Taniguchi, Y | 1 |
| Sato, H | 1 |
| Fukuda, K | 1 |
| Zhang, Z | 1 |
| DuBois, RN | 1 |
| Watanabe, K | 1 |
| Kawamori, T | 2 |
1 review available for nimesulide and Colonic Neoplasms
| Article | Year |
|---|---|
COX-2 and iNOS, good targets for chemoprevention of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; E | 2000 |
13 other studies available for nimesulide and Colonic Neoplasms
| Article | Year |
|---|---|
In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 1; Cy | 2005 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Coloni | 2009 |
Colocalization of BAX with BID and VDAC-1 in nimesulide-induced apoptosis of human colon adenocarcinoma COLO 205 cells.
Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Weste | 2002 |
Evaluation of an aerosolized selective COX-2 inhibitor as a potentiator of doxorubicin in a non-small-cell lung cancer cell line.
Topics: Aerosols; Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; | 2003 |
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Proliferation; Chromatography, High Pressure | 2004 |
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bezafibrate; Body Weight; Chromans; Col | 2005 |
5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Proliferation; Colonic Neop | 2007 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.
Topics: Animals; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Ligands; Mic | 2008 |
Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 1996 |
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm | 1997 |
Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; | 1998 |
Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Norther | 2000 |
COX-2 and prostanoid receptors: good targets for chemoprevention.
Topics: Animals; Breast Neoplasms; Celecoxib; Cell Transformation, Neoplastic; Chemoprevention; Colonic Neop | 2002 |