Page last updated: 2024-11-01

nimesulide and Colitis

nimesulide has been researched along with Colitis in 11 studies

nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
" We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat."7.71Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001)
"Chronic colitis was induced in mice by four cycles of administration of dextran sulfate sodium (DSS) (i."5.35Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. ( Hirata, I; Inoue, T; Murano, M, 2008)
"Acute colitis was induced by exposing female ICR mice to 5% DSS in drinking water for 1 week."5.32Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. ( Hayashi, R; Kwon, KH; Murakami, A; Ohigashi, H; Safitri, R; Takana, T; Tanaka, T, 2003)
"Female CD-1 (ICR) mice were given a single intraperitoneal administration of AOM (10 mg/kg body weight) and followed by one-week oral exposure of 2% (w/v) DSS in drinking water, and then maintained on the basal diets mixed with or without nimesulide (0."3.73Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005)
" Celecoxib (10, 20 and 40 mg/kg(-l)) was significantly more potent at aggravating ischemia-reperfusion injury as compared to nimesulide."3.73Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors. ( Malhotra, S; Nada, R; Pandhi, P; Shafiq, N, 2005)
" We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat."3.71Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001)
"Nimesulide significantly decreased the extent of colitis induced by acetic acid."3.70Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. ( Cohen, P; Karmeli, F; Rachmilewitz, D, 2000)
"Anandamide was protective in the explant colitis model; however COX-2 inhibition did not alter its effects, associated with a lack of COX-2 induction in explant mucosal tissue."1.39Prostaglandin ethanolamides attenuate damage in a human explant colitis model. ( Harvey, BS; Nicotra, LL; Smid, SD; Vu, M, 2013)
"Chronic colitis was induced in mice by four cycles of administration of dextran sulfate sodium (DSS) (i."1.35Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. ( Hirata, I; Inoue, T; Murano, M, 2008)
"Acute colitis was induced by exposing female ICR mice to 5% DSS in drinking water for 1 week."1.32Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. ( Hayashi, R; Kwon, KH; Murakami, A; Ohigashi, H; Safitri, R; Takana, T; Tanaka, T, 2003)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (90.91)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nicotra, LL1
Vu, M1
Harvey, BS1
Smid, SD1
Murakami, A1
Hayashi, R1
Tanaka, T2
Kwon, KH1
Ohigashi, H1
Safitri, R1
Takana, T1
d'Halluin, PN1
Turlin, B1
Polard, E1
Dinasquet, M1
Pagenault, M1
Rioux, N1
Gosselin, M1
Bretagne, JF1
Heresbach, D1
Kohno, H1
Suzuki, R1
Sugie, S1
Shafiq, N1
Malhotra, S1
Pandhi, P1
Nada, R1
Inoue, T1
Hirata, I1
Murano, M1
Karmeli, F1
Cohen, P1
Rachmilewitz, D1
Tardieu, D1
Jaeg, JP1
Deloly, A1
Corpet, DE1
Cadet, J1
Petit, CR1
Oktar, BK1
Ercan, F1
Yeğen, BC1
Alican, I1
Guo, X1
Liu, ES1
Ko, JK1
Wong, BC1
Ye, Y1
Lam, S1
Cho, C1
Kankuri, E1
Vaali, K1
Korpela, R1
Paakkari, I1
Vapaatalo, H1
Moilanen, E1

Reviews

1 review available for nimesulide and Colitis

ArticleYear
[Selective COX-2 inhibitor-associated colitis: two case reports].
    Gastroenterologie clinique et biologique, 2003, Volume: 27, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase Inhibitors; Female; Humans; Meloxic

2003

Other Studies

10 other studies available for nimesulide and Colitis

ArticleYear
Prostaglandin ethanolamides attenuate damage in a human explant colitis model.
    Prostaglandins & other lipid mediators, 2013, Volume: 100-101

    Topics: Adult; Amides; Arachidonic Acids; Bimatoprost; Cloprostenol; Colitis; Colon, Sigmoid; Cyclooxygenase

2013
Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.
    Biochemical pharmacology, 2003, Oct-01, Volume: 66, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dextran Sulfate; Disease Models, Animal;

2003
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands.
    BMC cancer, 2005, May-16, Volume: 5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bezafibrate; Body Weight; Chromans; Col

2005
Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
    Indian journal of experimental biology, 2005, Volume: 43, Issue:7

    Topics: Animals; Celecoxib; Colitis; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastrointestinal Tract; Indo

2005
Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors.
    Inflammopharmacology, 2008, Volume: 16, Issue:1

    Topics: Administration, Oral; Analysis of Variance; Animals; Chi-Square Distribution; Chronic Disease; Colit

2008
Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats.
    European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase Inhibitors; Disease Models

2000
The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats.
    Carcinogenesis, 2000, Volume: 21, Issue:5

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Colitis; C

2000
The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat.
    Peptides, 2000, Volume: 21, Issue:8

    Topics: alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Colitis; Cyclo

2000
Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats.
    European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2

    Topics: Animals; Blotting, Western; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inh

2001
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
    Inflammation, 2001, Volume: 25, Issue:5

    Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen

2001