nimesulide has been researched along with Cognition Disorders in 4 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Abusive head trauma (AHT) is a major cause of traumatic brain injury in infancy." | 1.91 | Abusive head trauma in infants: An observational single centre study comparing developmental and functional outcome between 18 months and 5 years. ( Azanan, MS; Jayanath, S; Lai, CD; Marret, MJ, 2023) |
| " Chronic administration of NSAIDs at the ED(50) doses (nimesulide, rofecoxib and naproxen for 15 days) significantly reversed the age or scopolamine-induced retention deficits in both test paradigms." | 1.31 | Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide-induced cognitive dysfunction in mice. ( Jain, NK; Kulkarni, SK; Patil, CS; Singh, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, CD | 1 |
| Marret, MJ | 1 |
| Jayanath, S | 1 |
| Azanan, MS | 1 |
| Zolotovskaia, IA | 1 |
| Davydkin, IL | 1 |
| Jain, NK | 1 |
| Patil, CS | 1 |
| Kulkarni, SK | 1 |
| Singh, A | 1 |
| Cernak, I | 1 |
| O'Connor, C | 1 |
| Vink, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PET Imaging of Translocator Protein in Subjects With Traumatic Brain Injury[NCT01547780] | Phase 1/Phase 2 | 52 participants (Actual) | Interventional | 2012-01-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To determine total distribution volume of [C-11]PBR28 in the whole brain using PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan
| Intervention | mL/cm^3 (Mean) |
|---|---|
| Baseline Brain PET in Acute TBI Patient | 2.53 |
| Repeat Brain PET in Acute TBI Patient | 2.21 |
| Single Brain PET in Chronic TBI Patient | 3.21 |
| Single Brain PET in Healthy Subjects | 3.22 |
Total distribution volume divided by plasma free fraction (fp) of [C-11]PBR28. Measured with PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan
| Intervention | mL/cm^3 (Mean) |
|---|---|
| Baseline Brain PET in Acute TBI Patient | 93.72 |
| Repeat Brain PET in Acute TBI Patient | 80.32 |
| Single Brain PET in Chronic TBI Patient | 118.73 |
| Single Brain PET in Healthy Subjects | 103.99 |
4 other studies available for nimesulide and Cognition Disorders
| Article | Year |
|---|---|
Abusive head trauma in infants: An observational single centre study comparing developmental and functional outcome between 18 months and 5 years.
Topics: Brain Injuries, Traumatic; Child; Child, Preschool; Cognition Disorders; Craniocerebral Trauma; Cros | 2023 |
[Cognitive-cytokine effect of nonsteroidal antiinflammatory drugs in the therapy of elderly patients with osteoarthritis].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cognition; Cognition Disorders; Cytokines; | 2017 |
Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide-induced cognitive dysfunction in mice.
Topics: Aging; Animals; Anxiety; Avoidance Learning; Cognition Disorders; Cyclooxygenase 1; Cyclooxygenase 2 | 2002 |
Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloox | 2001 |