nimesulide has been researched along with Cholestasis in 7 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimesulide (NIM) is a classic nonsteroidal anti-inflammatory drug." | 5.46 | Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis. ( Chen, X; Jiang, J; Pang, X; Zhong, D; Zhou, L, 2017) |
| " An example is nimesulide, a selective cyclo-oxygenase-2 inhibitor widely used for the treatment of inflammatory and pain conditions, which has been recently associated with rare but serious and unpredictable adverse reactions in the liver (increases in serum aminotransferase activities, hepatocellular necrosis, and/or intrahepatic cholestasis)." | 4.81 | Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide. ( Boelsterli, UA, 2002) |
| "A 15-year-old girl was admitted with cholestasis probably related to treatment with clarithromycin and nimesulide for an upper respiratory tract infection." | 3.73 | Steroid therapy for a case of severe drug-induced cholestasis. ( D'Ambrosi, M; Giannattasio, A; Iorio, R; Volpicelli, M, 2006) |
| "Nimesulide-induced liver injury can present with hepatocellular necrosis or with pure cholestasis." | 3.70 | Nimesulide-induced acute hepatitis: evidence from six cases. ( Büscher, H; De Bondt, J; Desmet, V; Laporta, T; Peeters, P; Roskams, T; Staessen, D; Van Steenbergen, W, 1998) |
| "Nimesulide is a non-steroidal anti-inflammatory drug still marketed in many countries." | 1.62 | Serious liver injury induced by Nimesulide: an international collaborative study. ( Alvarez-Alvarez, I; Anders, M; Andrade, RJ; Arrese, M; Bessone, F; Carrilho, F; Colombato, L; Fainboim, H; Fassio, E; Gualano, G; Hernandez, N; Lucena, MI; Medina-Caliz, I; Mendizabal, M; Niu, H; Ono, SK; Parana, R; Peralta, M; Reggiardo, MV; Ridruejo, E; Robles-Diaz, M; Stephens, C; Tanno, F; Tanno, H, 2021) |
| "Nimesulide (NIM) is a classic nonsteroidal anti-inflammatory drug." | 1.46 | Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis. ( Chen, X; Jiang, J; Pang, X; Zhong, D; Zhou, L, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Bessone, F | 1 |
| Hernandez, N | 1 |
| Mendizabal, M | 1 |
| Ridruejo, E | 1 |
| Gualano, G | 1 |
| Fassio, E | 1 |
| Peralta, M | 1 |
| Fainboim, H | 1 |
| Anders, M | 1 |
| Tanno, H | 1 |
| Tanno, F | 1 |
| Parana, R | 1 |
| Medina-Caliz, I | 1 |
| Robles-Diaz, M | 1 |
| Alvarez-Alvarez, I | 1 |
| Niu, H | 1 |
| Stephens, C | 1 |
| Colombato, L | 1 |
| Arrese, M | 1 |
| Reggiardo, MV | 1 |
| Ono, SK | 1 |
| Carrilho, F | 1 |
| Lucena, MI | 1 |
| Andrade, RJ | 1 |
| Zhou, L | 1 |
| Pang, X | 1 |
| Jiang, J | 1 |
| Zhong, D | 1 |
| Chen, X | 1 |
| Koller, T | 1 |
| Banárová, A | 1 |
| Ondrias, F | 1 |
| Kollerová, J | 1 |
| Payer, J | 1 |
| Boelsterli, UA | 1 |
| Giannattasio, A | 1 |
| D'Ambrosi, M | 1 |
| Volpicelli, M | 1 |
| Iorio, R | 1 |
| Van Steenbergen, W | 1 |
| Peeters, P | 1 |
| De Bondt, J | 1 |
| Staessen, D | 1 |
| Büscher, H | 1 |
| Laporta, T | 1 |
| Roskams, T | 1 |
| Desmet, V | 1 |
| Liberopoulos, EN | 1 |
| Nonni, AB | 1 |
| Tsianos, EV | 1 |
| Elisaf, MS | 1 |
1 review available for nimesulide and Cholestasis
| Article | Year |
|---|---|
Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis; Cycloo | 2002 |
6 other studies available for nimesulide and Cholestasis
| Article | Year |
|---|---|
Serious liver injury induced by Nimesulide: an international collaborative study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Bilirubin; Chem | 2021 |
Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Carrie | 2017 |
[Acute cholestasis following treatment with nimesulide and oral contraception: case report and review].
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cholestasis; Contraceptives, Oral, Sy | 2008 |
Steroid therapy for a case of severe drug-induced cholestasis.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2006 |
Nimesulide-induced acute hepatitis: evidence from six cases.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 1998 |
Possible ranitidine-induced cholestatic jaundice.
Topics: Aged; Back Pain; Cholestasis; Cyclooxygenase Inhibitors; Female; Histamine H2 Antagonists; Humans; L | 2002 |