nimesulide has been researched along with Cerebral Ischemia in 8 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The main objective of the study was to determine the neuroprotective effect of allopurinol and nimesulide against the cerebral ischemic reperfusion injury in diabetic and nondiabetic rats." | 7.79 | Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats. ( Ansari, MA; Goli, D; Hussain, SK; Mudagal, MP, 2013) |
| "This investigation was performed to evaluate the effects of nimesulide (NIM), a selective cyclo-oxygenase-2 (COX-2) inhibitor, on forebrain ischemia-induced in vivo oxidative stress damage in the rat hippocampus." | 7.72 | Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. ( Al-Gonaiah, MA; Al-Majed, AA; Al-Yahya, AA; Asiri, Y; Mostafa, AM, 2004) |
| "Nimesulide is a preferential inhibitor of cyclooxygenase-2 (COX-2) and it is one of the most prescribed non-steroidal anti-inflammatory drugs (NSAID) worldwide." | 6.44 | Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences. ( Candelario-Jalil, E, 2008) |
| "The main objective of the study was to determine the neuroprotective effect of allopurinol and nimesulide against the cerebral ischemic reperfusion injury in diabetic and nondiabetic rats." | 3.79 | Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats. ( Ansari, MA; Goli, D; Hussain, SK; Mudagal, MP, 2013) |
| "The present study was designed to investigate whether the neuroprotective effect of nimesulide was mediated by inhibiting expression of matrix metalloproteinase-9 (MMP-9) and/or matrix metalloproteinase-2 (MMP-2) in a rat model of thrombolytic reperfusion after the embolic focal cerebral ischemia (FCI)." | 3.74 | A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases. ( Deng, XL; Wang, Y; Xiao, XH; Yuan, BX, 2007) |
| " In the present study, we examined the possibility that the neuroprotective effects of the cyclooxygenase-2 inhibitor nimesulide would depend upon reduction of oxidative stress following cerebral ischemia." | 3.72 | Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. ( Alvarez, D; Candelario-Jalil, E; León, OS; Merino, N, 2003) |
| "This investigation was performed to evaluate the effects of nimesulide (NIM), a selective cyclo-oxygenase-2 (COX-2) inhibitor, on forebrain ischemia-induced in vivo oxidative stress damage in the rat hippocampus." | 3.72 | Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. ( Al-Gonaiah, MA; Al-Majed, AA; Al-Yahya, AA; Asiri, Y; Mostafa, AM, 2004) |
| "Nimesulide is a preferential inhibitor of cyclooxygenase-2 (COX-2) and it is one of the most prescribed non-steroidal anti-inflammatory drugs (NSAID) worldwide." | 2.44 | Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences. ( Candelario-Jalil, E, 2008) |
| " Their combination as stroke treatment has the potential benefits of decreasing individual drug dosage and fewer adverse effects." | 1.38 | Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. ( Huang, CY; Tsai, KJ; Wang, HK; Wang, LC; Wu, MH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wood, CE | 1 |
| Powers Fraites, M | 1 |
| Keller-Wood, M | 1 |
| Wang, LC | 1 |
| Huang, CY | 1 |
| Wang, HK | 1 |
| Wu, MH | 1 |
| Tsai, KJ | 1 |
| Ansari, MA | 1 |
| Hussain, SK | 1 |
| Mudagal, MP | 1 |
| Goli, D | 1 |
| Candelario-Jalil, E | 2 |
| Alvarez, D | 1 |
| Merino, N | 1 |
| León, OS | 1 |
| Al-Majed, AA | 1 |
| Al-Yahya, AA | 1 |
| Asiri, Y | 1 |
| Al-Gonaiah, MA | 1 |
| Mostafa, AM | 1 |
| Wang, Y | 1 |
| Deng, XL | 1 |
| Xiao, XH | 1 |
| Yuan, BX | 1 |
| Wakita, H | 1 |
| Tomimoto, H | 1 |
| Akiguchi, I | 1 |
| Lin, JX | 1 |
| Miyamoto, K | 1 |
| Oka, N | 1 |
1 review available for nimesulide and Cerebral Ischemia
| Article | Year |
|---|---|
Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cyclooxygenase Inhibitors; Humans; | 2008 |
7 other studies available for nimesulide and Cerebral Ischemia
| Article | Year |
|---|---|
Blockade of PGHS-2 inhibits the hypothalamus-pituitary-adrenal axis response to cerebral hypoperfusion in the sheep fetus.
Topics: Adrenocorticotropic Hormone; Animals; Baroreflex; Blood Pressure; Brachiocephalic Trunk; Brain; Brai | 2009 |
Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Cyclooxygenase Inhibitors; Disease Models, Animal; | 2012 |
Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats.
Topics: Allopurinol; Animals; Brain Ischemia; Catalase; Diabetes Mellitus, Experimental; Female; Male; Neuro | 2013 |
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils.
Topics: Animals; Brain Ischemia; Cyclooxygenase 2; Dose-Response Relationship, Drug; Gerbillinae; Isoenzymes | 2003 |
Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus.
Topics: Animals; Brain Ischemia; Catalase; Cyclooxygenase 2 Inhibitors; Glutathione; Hippocampus; Male; Malo | 2004 |
A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cereb | 2007 |
A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia.
Topics: Analysis of Variance; Animals; Brain Ischemia; Chronic Disease; Cyclooxygenase 2; Cyclooxygenase 2 I | 1999 |