nimesulide has been researched along with Cerebral Infarction in 2 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was designed to investigate whether the neuroprotective effect of nimesulide was mediated by inhibiting expression of matrix metalloproteinase-9 (MMP-9) and/or matrix metalloproteinase-2 (MMP-2) in a rat model of thrombolytic reperfusion after the embolic focal cerebral ischemia (FCI)." | 3.74 | A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases. ( Deng, XL; Wang, Y; Xiao, XH; Yuan, BX, 2007) |
| " The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebral ischemia in rats." | 3.72 | Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. ( Candelario-Jalil, E; Fiebich, BL; García-Cabrera, M; González-Falcón, A; León, OS, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Candelario-Jalil, E | 1 |
| González-Falcón, A | 1 |
| García-Cabrera, M | 1 |
| León, OS | 1 |
| Fiebich, BL | 1 |
| Wang, Y | 1 |
| Deng, XL | 1 |
| Xiao, XH | 1 |
| Yuan, BX | 1 |
2 other studies available for nimesulide and Cerebral Infarction
| Article | Year |
|---|---|
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cerebral Infarction; Dinoprostone; Disease Models, | 2004 |
A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cereb | 2007 |