nimesulide has been researched along with Brain Ischemia in 8 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The main objective of the study was to determine the neuroprotective effect of allopurinol and nimesulide against the cerebral ischemic reperfusion injury in diabetic and nondiabetic rats." | 7.79 | Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats. ( Ansari, MA; Goli, D; Hussain, SK; Mudagal, MP, 2013) |
| "This investigation was performed to evaluate the effects of nimesulide (NIM), a selective cyclo-oxygenase-2 (COX-2) inhibitor, on forebrain ischemia-induced in vivo oxidative stress damage in the rat hippocampus." | 7.72 | Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. ( Al-Gonaiah, MA; Al-Majed, AA; Al-Yahya, AA; Asiri, Y; Mostafa, AM, 2004) |
| "Nimesulide is a preferential inhibitor of cyclooxygenase-2 (COX-2) and it is one of the most prescribed non-steroidal anti-inflammatory drugs (NSAID) worldwide." | 6.44 | Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences. ( Candelario-Jalil, E, 2008) |
| "The main objective of the study was to determine the neuroprotective effect of allopurinol and nimesulide against the cerebral ischemic reperfusion injury in diabetic and nondiabetic rats." | 3.79 | Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats. ( Ansari, MA; Goli, D; Hussain, SK; Mudagal, MP, 2013) |
| "The present study was designed to investigate whether the neuroprotective effect of nimesulide was mediated by inhibiting expression of matrix metalloproteinase-9 (MMP-9) and/or matrix metalloproteinase-2 (MMP-2) in a rat model of thrombolytic reperfusion after the embolic focal cerebral ischemia (FCI)." | 3.74 | A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases. ( Deng, XL; Wang, Y; Xiao, XH; Yuan, BX, 2007) |
| " In the present study, we examined the possibility that the neuroprotective effects of the cyclooxygenase-2 inhibitor nimesulide would depend upon reduction of oxidative stress following cerebral ischemia." | 3.72 | Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. ( Alvarez, D; Candelario-Jalil, E; León, OS; Merino, N, 2003) |
| "This investigation was performed to evaluate the effects of nimesulide (NIM), a selective cyclo-oxygenase-2 (COX-2) inhibitor, on forebrain ischemia-induced in vivo oxidative stress damage in the rat hippocampus." | 3.72 | Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. ( Al-Gonaiah, MA; Al-Majed, AA; Al-Yahya, AA; Asiri, Y; Mostafa, AM, 2004) |
| "Nimesulide is a preferential inhibitor of cyclooxygenase-2 (COX-2) and it is one of the most prescribed non-steroidal anti-inflammatory drugs (NSAID) worldwide." | 2.44 | Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences. ( Candelario-Jalil, E, 2008) |
| " Their combination as stroke treatment has the potential benefits of decreasing individual drug dosage and fewer adverse effects." | 1.38 | Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. ( Huang, CY; Tsai, KJ; Wang, HK; Wang, LC; Wu, MH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wood, CE | 1 |
| Powers Fraites, M | 1 |
| Keller-Wood, M | 1 |
| Wang, LC | 1 |
| Huang, CY | 1 |
| Wang, HK | 1 |
| Wu, MH | 1 |
| Tsai, KJ | 1 |
| Ansari, MA | 1 |
| Hussain, SK | 1 |
| Mudagal, MP | 1 |
| Goli, D | 1 |
| Candelario-Jalil, E | 2 |
| Alvarez, D | 1 |
| Merino, N | 1 |
| León, OS | 1 |
| Al-Majed, AA | 1 |
| Al-Yahya, AA | 1 |
| Asiri, Y | 1 |
| Al-Gonaiah, MA | 1 |
| Mostafa, AM | 1 |
| Wang, Y | 1 |
| Deng, XL | 1 |
| Xiao, XH | 1 |
| Yuan, BX | 1 |
| Wakita, H | 1 |
| Tomimoto, H | 1 |
| Akiguchi, I | 1 |
| Lin, JX | 1 |
| Miyamoto, K | 1 |
| Oka, N | 1 |
1 review available for nimesulide and Brain Ischemia
| Article | Year |
|---|---|
Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cyclooxygenase Inhibitors; Humans; | 2008 |
7 other studies available for nimesulide and Brain Ischemia
| Article | Year |
|---|---|
Blockade of PGHS-2 inhibits the hypothalamus-pituitary-adrenal axis response to cerebral hypoperfusion in the sheep fetus.
Topics: Adrenocorticotropic Hormone; Animals; Baroreflex; Blood Pressure; Brachiocephalic Trunk; Brain; Brai | 2009 |
Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Cyclooxygenase Inhibitors; Disease Models, Animal; | 2012 |
Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats.
Topics: Allopurinol; Animals; Brain Ischemia; Catalase; Diabetes Mellitus, Experimental; Female; Male; Neuro | 2013 |
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils.
Topics: Animals; Brain Ischemia; Cyclooxygenase 2; Dose-Response Relationship, Drug; Gerbillinae; Isoenzymes | 2003 |
Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus.
Topics: Animals; Brain Ischemia; Catalase; Cyclooxygenase 2 Inhibitors; Glutathione; Hippocampus; Male; Malo | 2004 |
A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cereb | 2007 |
A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia.
Topics: Analysis of Variance; Animals; Brain Ischemia; Chronic Disease; Cyclooxygenase 2; Cyclooxygenase 2 I | 1999 |