nimesulide has been researched along with Brain Injuries in 3 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nimesulide treatment group after injury was treated with nimesulide [6 mg/(kg x d)] in peritoneum." | 1.37 | [The effect of nimesulide on learning and memory function after serve traumatic brain injury in rats]. ( Zhang, T; Zhang, YX, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, T | 1 |
| Zhang, YX | 1 |
| Cernak, I | 2 |
| O'Connor, C | 2 |
| Vink, R | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PET Imaging of Translocator Protein in Subjects With Traumatic Brain Injury[NCT01547780] | Phase 1/Phase 2 | 52 participants (Actual) | Interventional | 2012-01-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To determine total distribution volume of [C-11]PBR28 in the whole brain using PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan
| Intervention | mL/cm^3 (Mean) |
|---|---|
| Baseline Brain PET in Acute TBI Patient | 2.53 |
| Repeat Brain PET in Acute TBI Patient | 2.21 |
| Single Brain PET in Chronic TBI Patient | 3.21 |
| Single Brain PET in Healthy Subjects | 3.22 |
Total distribution volume divided by plasma free fraction (fp) of [C-11]PBR28. Measured with PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan
| Intervention | mL/cm^3 (Mean) |
|---|---|
| Baseline Brain PET in Acute TBI Patient | 93.72 |
| Repeat Brain PET in Acute TBI Patient | 80.32 |
| Single Brain PET in Chronic TBI Patient | 118.73 |
| Single Brain PET in Healthy Subjects | 103.99 |
3 other studies available for nimesulide and Brain Injuries
| Article | Year |
|---|---|
[The effect of nimesulide on learning and memory function after serve traumatic brain injury in rats].
Topics: Animals; Brain Injuries; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Learning; Male; Memory Disorde | 2011 |
Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats.
Topics: Animals; Blotting, Western; Brain Injuries; Cognition; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors | 2002 |
Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloox | 2001 |