nimesulide has been researched along with Alzheimer Disease in 5 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among the most widely prescribed drugs worldwide, non-steroidal anti-inflammatory drugs (NSAIDs) are effective for relieving pain, but they are also associated with a high incidence of gastrointestinal (GI) adverse events." | 2.41 | Do selective cyclo-oxygenase inhibitors eliminate the adverse events associated with nonsteroidal anti-inflammatory drug therapy? ( Devière, J, 2002) |
| " These findings indicate that chronic administration of indomethacin by blocking the activation of the NF-kappa B significantly reduces the amyloid pathology in Tg2576 mice, and provide insights into the mechanisms by which this drug could slow progression of AD." | 1.32 | Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. ( Lee, EB; Lee, VM; Praticò, D; Shineman, D; Sung, S; Trojanowski, JQ; Uryu, K; Yang, H; Zhao, L, 2004) |
| "Quisqualic acid was injected into the right nucleus basalis of rats." | 1.31 | Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. ( Casamenti, F; Pepeu, G; Prosperi, C; Scali, C; Vannucchi, MG, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Devière, J | 1 |
| Sung, S | 1 |
| Yang, H | 1 |
| Uryu, K | 1 |
| Lee, EB | 1 |
| Zhao, L | 1 |
| Shineman, D | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Praticò, D | 1 |
| Scali, C | 1 |
| Prosperi, C | 1 |
| Vannucchi, MG | 1 |
| Pepeu, G | 1 |
| Casamenti, F | 1 |
| Spielman, L | 1 |
| Winger, D | 1 |
| Ho, L | 1 |
| Aisen, PS | 2 |
| Shohami, E | 1 |
| Pasinetti, GM | 2 |
| Schmeidler, J | 1 |
1 review available for nimesulide and Alzheimer Disease
| Article | Year |
|---|---|
Do selective cyclo-oxygenase inhibitors eliminate the adverse events associated with nonsteroidal anti-inflammatory drug therapy?
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Hu | 2002 |
1 trial available for nimesulide and Alzheimer Disease
| Article | Year |
|---|---|
Randomized pilot study of nimesulide treatment in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Human | 2002 |
3 other studies available for nimesulide and Alzheimer Disease
| Article | Year |
|---|---|
Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory | 2004 |
Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline O-Acetyl | 2000 |
Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2.
Topics: Alzheimer Disease; Animals; Brain; Complement C1q; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cy | 2002 |