nimesulide has been researched along with Alcoholism in 2 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimesulide treatment (10 mg/kg) prevented the ethanol withdrawal-induced alterations in the levels of TNF-α, IL-1β, and IL-6 in the hippocampus, prefrontal cortex, and striatum." | 1.72 | Attenuation of the levels of pro-inflammatory cytokines prevents depressive-like behavior during ethanol withdrawal in mice. ( Buss, ZS; Doneda, DL; Fernandes, IL; Fraga-Junior, EB; Lima, E; Rios-Santos, F; Rohden, CAH; Vandresen-Filho, S; Ynoue, HN, 2022) |
| " Mice were made physically dependent on alcohol by the chronic administration of ethanol (2 g/kg of 10% v/v), intragastrically, twice on day 1 and then once-daily on successive days for a total of 7 days." | 1.33 | Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fraga-Junior, EB | 1 |
| Fernandes, IL | 1 |
| Rohden, CAH | 1 |
| Doneda, DL | 1 |
| Ynoue, HN | 1 |
| Rios-Santos, F | 1 |
| Lima, E | 1 |
| Buss, ZS | 1 |
| Vandresen-Filho, S | 1 |
| Dhir, A | 1 |
| Naidu, PS | 1 |
| Kulkarni, SK | 1 |
2 other studies available for nimesulide and Alcoholism
| Article | Year |
|---|---|
Attenuation of the levels of pro-inflammatory cytokines prevents depressive-like behavior during ethanol withdrawal in mice.
Topics: Alcoholism; Animals; Behavior, Animal; Cytokines; Depression; Ethanol; Hippocampus; Interleukin-6; L | 2022 |
Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Behavior, Animal; Brain; Cyclooxygenase 2 Inhibito | 2005 |