nimesulide has been researched along with Acute Liver Injury, Drug-Induced in 64 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the meeting was to provide the state of the art on the pathophysiology and treatment of acute pain with special emphasis on nimesulide, a non-steroidal anti-inflammatory drug (NSAID) indicated for the treatment of acute pain and primary dysmenorrhea." | 8.93 | Acute pain: a multifaceted challenge - the role of nimesulide. ( Baltov, A; Basiński, A; Berghea, F; Castellsague, J; Codreanu, C; Copaciu, E; Giamberardino, MA; Hakl, M; Hrazdira, L; Kokavec, M; Kress, HG; Lejčko, J; Nachtnebl, L; Stančík, R; Švec, A; Tóth, T; Vlaskovska, MV; Woroń, J, 2016) |
| "Nimesulide (NIM) is a classic nonsteroidal anti-inflammatory drug." | 5.46 | Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis. ( Chen, X; Jiang, J; Pang, X; Zhong, D; Zhou, L, 2017) |
| "The diagnosis of toxic hepatitis due to nimesulide was supported by the time-course of drug usage, sex, age, absence of other causes of liver disease, a compatible liver biopsy and the improvement after drug withdrawal." | 5.31 | [Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case]. ( Meneses, M; Reyes, H; Tejos, S; Torrejón, N, 2000) |
| "The aim of the meeting was to provide the state of the art on the pathophysiology and treatment of acute pain with special emphasis on nimesulide, a non-steroidal anti-inflammatory drug (NSAID) indicated for the treatment of acute pain and primary dysmenorrhea." | 4.93 | Acute pain: a multifaceted challenge - the role of nimesulide. ( Baltov, A; Basiński, A; Berghea, F; Castellsague, J; Codreanu, C; Copaciu, E; Giamberardino, MA; Hakl, M; Hrazdira, L; Kokavec, M; Kress, HG; Lejčko, J; Nachtnebl, L; Stančík, R; Švec, A; Tóth, T; Vlaskovska, MV; Woroń, J, 2016) |
| " An example is nimesulide, a selective cyclo-oxygenase-2 inhibitor widely used for the treatment of inflammatory and pain conditions, which has been recently associated with rare but serious and unpredictable adverse reactions in the liver (increases in serum aminotransferase activities, hepatocellular necrosis, and/or intrahepatic cholestasis)." | 4.81 | Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide. ( Boelsterli, UA, 2002) |
| " Presentation was jaundice in 22 patients and hepatic failure in 3 (all attributed to nimesulide)." | 3.76 | Clinical course and outcomes of drug-induced liver injury: nimesulide as the first implicated medication. ( Almasio, PL; Calvaruso, V; Cappello, M; Craxì, A; Licata, A, 2010) |
| " We report a case of acute liver failure associated with Nimesulide in a 67-year-old man, with a medical history of chronic alcohol abuse." | 3.74 | Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. ( Di Campli, C; Gasbarrini, A; Gasbarrini, G; Leone, G; Pola, P; Rapaccini, GL; Rutella, S; Tittoto, P; Zocco, MA, 2007) |
| "A 15-year-old girl was admitted with cholestasis probably related to treatment with clarithromycin and nimesulide for an upper respiratory tract infection." | 3.73 | Steroid therapy for a case of severe drug-induced cholestasis. ( D'Ambrosi, M; Giannattasio, A; Iorio, R; Volpicelli, M, 2006) |
| "A 54-year-old Arabic woman treated with nimesulide for chronic low back pain was admitted to the hospital with acute hepatitis confirmed by biopsy." | 3.71 | Nimesulide-induced acute hepatitis. ( Cohen, HI; Farah, R; Krivoy, N; Reshef, R; Sbeit, W; Shiller, M; Struminger, L, 2001) |
| "Nimesulide-induced liver injury can present with hepatocellular necrosis or with pure cholestasis." | 3.70 | Nimesulide-induced acute hepatitis: evidence from six cases. ( Büscher, H; De Bondt, J; Desmet, V; Laporta, T; Peeters, P; Roskams, T; Staessen, D; Van Steenbergen, W, 1998) |
| "Nimesulide is a potent non-steroidal anti-inflammatory drug." | 2.41 | [Toxic hepatitis caused by nimesulide, presentation of a new case and review of the literature]. ( Domínguez, AB; Espinel, J; Fernández, MJ; Ferreiro, C; Herrera, A; Jorquera, F; Muñoz, F; Olcoz, JL; Ortiz de Urbina, J; Vivas, S, 2000) |
| "Nimesulide is a non-steroidal anti-inflammatory drug still marketed in many countries." | 1.62 | Serious liver injury induced by Nimesulide: an international collaborative study. ( Alvarez-Alvarez, I; Anders, M; Andrade, RJ; Arrese, M; Bessone, F; Carrilho, F; Colombato, L; Fainboim, H; Fassio, E; Gualano, G; Hernandez, N; Lucena, MI; Medina-Caliz, I; Mendizabal, M; Niu, H; Ono, SK; Parana, R; Peralta, M; Reggiardo, MV; Ridruejo, E; Robles-Diaz, M; Stephens, C; Tanno, F; Tanno, H, 2021) |
| "Nimesulide (NIM) is a classic nonsteroidal anti-inflammatory drug." | 1.46 | Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis. ( Chen, X; Jiang, J; Pang, X; Zhong, D; Zhou, L, 2017) |
| "Inflammation is one condition for demonstrated variable drug response, attributed in part, to changes in function of drug transporters." | 1.39 | Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry. ( Muller, CD; Peluso, J; Saab, L; Ubeaud-Sequier, G, 2013) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Nimesulide is a widely prescribed nitroaromatic sulfoanilide-type nonsteroidal anti-inflammatory drug that, despite its favorable safety profile, has been associated with rare cases of idiosyncratic drug-induced liver injury (DILI)." | 1.36 | Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice. ( Boelsterli, UA; Hsiao, CJ; Kale, VM, 2010) |
| "Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) marketed in more than 50 countries." | 1.35 | In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation. ( Chordia, MD; Huang, T; Li, F; Macdonald, TL, 2009) |
| "The diagnosis of toxic hepatitis due to nimesulide was supported by the time-course of drug usage, sex, age, absence of other causes of liver disease, a compatible liver biopsy and the improvement after drug withdrawal." | 1.31 | [Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case]. ( Meneses, M; Reyes, H; Tejos, S; Torrejón, N, 2000) |
| "Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case." | 1.31 | Fatal hepatoxicity secondary to nimesulide. ( Cathomas, G; Fattinger, K; Fox, M; Kullak-Ublick, GA; Merlani, G; Oehen, HP; Renner, EL; Schneemann, M, 2001) |
| "Nimesulide may cause liver damage." | 1.30 | Nimesulide-induced hepatitis and acute liver failure. ( Bar-Meir, S; Brickman, CM; Bruck, R; Farfel, Z; Hassin, D; Mouallem, M; Tanay, A; Weiss, P, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (9.38) | 18.2507 |
| 2000's | 31 (48.44) | 29.6817 |
| 2010's | 23 (35.94) | 24.3611 |
| 2020's | 4 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Umar, M | 1 |
| Bin Naeem, MA | 1 |
| Zhou, L | 2 |
| Pang, XY | 1 |
| Hou, XY | 1 |
| Liu, L | 1 |
| Guo, ZT | 1 |
| Chen, XY | 1 |
| Bessone, F | 1 |
| Hernandez, N | 1 |
| Mendizabal, M | 1 |
| Ridruejo, E | 1 |
| Gualano, G | 1 |
| Fassio, E | 1 |
| Peralta, M | 1 |
| Fainboim, H | 1 |
| Anders, M | 1 |
| Tanno, H | 1 |
| Tanno, F | 1 |
| Parana, R | 1 |
| Medina-Caliz, I | 1 |
| Robles-Diaz, M | 1 |
| Alvarez-Alvarez, I | 1 |
| Niu, H | 1 |
| Stephens, C | 1 |
| Colombato, L | 1 |
| Arrese, M | 1 |
| Reggiardo, MV | 1 |
| Ono, SK | 1 |
| Carrilho, F | 1 |
| Lucena, MI | 2 |
| Andrade, RJ | 2 |
| Pereira, CMC | 1 |
| Júnior, GJD | 1 |
| Lima, JVDN | 1 |
| Alves Lemos, SI | 1 |
| da Rocha Rodrigues, L | 1 |
| Dos Santos Ferreira, J | 1 |
| Araújo, ASML | 1 |
| de Oliveira, JC | 1 |
| Monteiro, CE | 1 |
| Franco, ÁX | 1 |
| Pereira Alves, EH | 1 |
| Oliveira Silva, FG | 1 |
| de Carvalho Filgueiras, M | 1 |
| Soares, PMG | 1 |
| Pereira Vasconcelos, DF | 1 |
| de Oliveira, JS | 1 |
| de Brito, TV | 1 |
| Barbosa, ALR | 1 |
| Pinto, D | 1 |
| Silva, A | 1 |
| Heleno, B | 1 |
| Rodrigues, DS | 1 |
| Santos, I | 1 |
| Caetano, PA | 1 |
| Kwon, J | 1 |
| Kim, S | 1 |
| Yoo, H | 1 |
| Lee, E | 1 |
| Nguyen, V | 1 |
| Huang, J | 1 |
| Doan, V | 1 |
| Lin, X | 1 |
| Tang, X | 1 |
| Huang, Y | 1 |
| Tang, A | 1 |
| Yang, X | 1 |
| Huang, R | 1 |
| Kress, HG | 1 |
| Baltov, A | 1 |
| Basiński, A | 1 |
| Berghea, F | 1 |
| Castellsague, J | 2 |
| Codreanu, C | 1 |
| Copaciu, E | 1 |
| Giamberardino, MA | 1 |
| Hakl, M | 1 |
| Hrazdira, L | 1 |
| Kokavec, M | 1 |
| Lejčko, J | 1 |
| Nachtnebl, L | 1 |
| Stančík, R | 1 |
| Švec, A | 1 |
| Tóth, T | 1 |
| Vlaskovska, MV | 1 |
| Woroń, J | 1 |
| Donati, M | 1 |
| Conforti, A | 1 |
| Lenti, MC | 1 |
| Capuano, A | 1 |
| Bortolami, O | 1 |
| Motola, D | 1 |
| Moretti, U | 1 |
| Vannacci, A | 1 |
| Rafaniello, C | 1 |
| Vaccheri, A | 1 |
| Arzenton, E | 1 |
| Bonaiuti, R | 1 |
| Sportiello, L | 1 |
| Leone, R | 1 |
| Pang, X | 1 |
| Jiang, J | 1 |
| Zhong, D | 1 |
| Chen, X | 1 |
| Macchi, F | 1 |
| Li, F | 1 |
| Chordia, MD | 1 |
| Huang, T | 1 |
| Macdonald, TL | 1 |
| Altwegg, R | 1 |
| Licata, A | 1 |
| Calvaruso, V | 1 |
| Cappello, M | 1 |
| Craxì, A | 1 |
| Almasio, PL | 1 |
| Kale, VM | 1 |
| Hsiao, CJ | 1 |
| Boelsterli, UA | 3 |
| Venegoni, M | 2 |
| Da Cas, R | 2 |
| Menniti-Ippolito, F | 2 |
| Traversa, G | 2 |
| Stiefelhagen, P | 1 |
| Tripathi, M | 1 |
| Singh, BK | 1 |
| Raisuddin, S | 1 |
| Kakkar, P | 1 |
| Wang, Y | 1 |
| Zeng, Y | 1 |
| Xu, F | 1 |
| Abenavoli, L | 1 |
| Libri, E | 1 |
| Bosco, D | 1 |
| Gallo, D | 1 |
| Luzza, F | 1 |
| Saab, L | 1 |
| Peluso, J | 1 |
| Muller, CD | 1 |
| Ubeaud-Sequier, G | 1 |
| Lewin, S | 1 |
| Kumar, S | 1 |
| Saha, K | 1 |
| Bianchi, C | 1 |
| Abraha, I | 1 |
| Carvajal, A | 2 |
| Maciá, MA | 1 |
| del Pozo, JG | 2 |
| de Abajo, F | 1 |
| Quadranti, P | 1 |
| Giannattasio, A | 1 |
| D'Ambrosi, M | 1 |
| Volpicelli, M | 1 |
| Iorio, R | 1 |
| Lapeyre-Mestre, M | 1 |
| de Castro, AM | 1 |
| Bareille, MP | 1 |
| Requejo, AA | 1 |
| Arias, LM | 1 |
| Montastruc, JL | 1 |
| Gasbarrini, A | 1 |
| Rapaccini, GL | 1 |
| Rutella, S | 1 |
| Zocco, MA | 1 |
| Tittoto, P | 1 |
| Leone, G | 1 |
| Pola, P | 1 |
| Gasbarrini, G | 1 |
| Di Campli, C | 1 |
| Sanchez-Matienzo, D | 1 |
| Arana, A | 1 |
| Perez-Gutthann, S | 1 |
| Ho, HK | 1 |
| Zhou, S | 1 |
| Leow, KY | 1 |
| Dastis, SN | 1 |
| Rahier, J | 1 |
| Lerut, J | 1 |
| Geubel, AP | 1 |
| Bissoli, F | 1 |
| Van Steenbergen, W | 1 |
| Peeters, P | 1 |
| De Bondt, J | 1 |
| Staessen, D | 1 |
| Büscher, H | 1 |
| Laporta, T | 1 |
| Roskams, T | 1 |
| Desmet, V | 1 |
| Romero-Gómez, M | 1 |
| Nevado Santos, M | 2 |
| Otero Fernández, MA | 1 |
| Fovelo, MJ | 1 |
| Suárez-García, E | 1 |
| Castro Fernández, M | 2 |
| Bakhle, YS | 1 |
| Romero Gómez, M | 1 |
| Fobelo, MJ | 1 |
| Schattner, A | 1 |
| Sokolovskaya, N | 1 |
| Cohen, J | 1 |
| Fernández, MC | 1 |
| González, M | 1 |
| Weiss, P | 2 |
| Mouallem, M | 1 |
| Bruck, R | 1 |
| Hassin, D | 1 |
| Tanay, A | 1 |
| Brickman, CM | 1 |
| Farfel, Z | 1 |
| Bar-Meir, S | 1 |
| Rodrigues de Oliveira, J | 1 |
| Correia, J | 1 |
| Silvestre, F | 1 |
| Meirelles, A | 1 |
| Bernardo, A | 1 |
| Elmalem, E | 1 |
| Ferreiro, C | 1 |
| Vivas, S | 1 |
| Jorquera, F | 1 |
| Domínguez, AB | 1 |
| Espinel, J | 1 |
| Muñoz, F | 1 |
| Herrera, A | 1 |
| Fernández, MJ | 1 |
| Olcoz, JL | 1 |
| Ortiz de Urbina, J | 1 |
| Pérez-Moreno, J | 1 |
| Llerena Guerrero, RM | 1 |
| Puertas Montenegro, M | 1 |
| Jiménez Arjona, MJ | 1 |
| Tejos, S | 1 |
| Torrejón, N | 1 |
| Reyes, H | 1 |
| Meneses, M | 1 |
| Flint, SR | 1 |
| O'Sullivan, C | 1 |
| Arthur, N | 1 |
| Montesinos, S | 1 |
| Hallal, H | 1 |
| Rausell, V | 1 |
| Conesa, F | 1 |
| López, A | 1 |
| O'Beirne, JP | 1 |
| Cairns, SR | 1 |
| Merlani, G | 1 |
| Fox, M | 1 |
| Oehen, HP | 1 |
| Cathomas, G | 1 |
| Renner, EL | 1 |
| Fattinger, K | 1 |
| Schneemann, M | 1 |
| Kullak-Ublick, GA | 1 |
| Sbeit, W | 1 |
| Krivoy, N | 1 |
| Shiller, M | 1 |
| Farah, R | 1 |
| Cohen, HI | 1 |
| Struminger, L | 1 |
| Reshef, R | 1 |
| Dumortier, J | 1 |
| Borel, I | 1 |
| Delafosse, B | 1 |
| Vial, T | 1 |
| Scoazec, JY | 1 |
| Boillot, O | 1 |
| Gallego Rojo, FJ | 1 |
| Fernández Pérez, F | 1 |
| Fernández Pérez, R | 1 |
| Porcel, A | 1 |
| Blas, JM | 1 |
| Díez, F | 1 |
7 reviews available for nimesulide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Female; Humans; Liv | 2019 |
Acute pain: a multifaceted challenge - the role of nimesulide.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Comorbi | 2016 |
[Drug-induced liver injury].
Topics: Acetaminophen; Algorithms; Amoxicillin; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anti-Bact | 2012 |
Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis; Cycloo | 2002 |
Bioactivation and hepatotoxicity of nitroaromatic drugs.
Topics: Benzophenones; Biotransformation; Chemical and Drug Induced Liver Injury; Flutamide; Imidazolidines; | 2006 |
[Toxic hepatitis caused by nimesulide, presentation of a new case and review of the literature].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Humans; Male; | 2000 |
57 other studies available for nimesulide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Rampant Use Of Nimesulide In Pakistan, A Drug Associated With Hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Pak | 2023 |
Nimesulide increases the aldehyde oxidase activity of humans and rats.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Cells, Cultured; Chemical and Drug Induced Liver In | 2020 |
Serious liver injury induced by Nimesulide: an international collaborative study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Bilirubin; Chem | 2021 |
Phosphatidylinositol 3-kinase gamma participates in nimesulide-induced hepatic damage.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Free | 2021 |
Effect of European Medicines Agency's regulatory measures on nimesulide utilization in Portugal.
Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Drug Prescriptions; | 2018 |
Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dioxoles; Down-Regulation; Female; In | 2015 |
Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induce | 2016 |
Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Carrie | 2017 |
Comments on assessment of drug-induced liver injury in clinical practice by Lucena MI et al., Fundamental & Clinical Pharmacology 2008; 22: 141-158.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Drug Approval; Drug | 2008 |
In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation.
Topics: Anilides; Anti-Inflammatory Agents, Non-Steroidal; Benzene Derivatives; Chemical and Drug Induced Li | 2009 |
[Acute liver failure due to a treatment by nimesulide].
Topics: Amoxicillin-Potassium Clavulanate Combination; Anesthetics, Inhalation; Anti-Bacterial Agents; Anti- | 2009 |
Clinical course and outcomes of drug-induced liver injury: nimesulide as the first implicated medication.
Topics: Adult; Age Factors; Aged; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Chemical a | 2010 |
Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome | 2010 |
Effects of the European restrictive actions concerning nimesulide prescription: a simulation study on hepatopathies and gastrointestinal bleedings in Italy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Drug Prescriptions; | 2010 |
["Doing something good" for the body? Definitely not! Liver damage caused by food supplements].
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug | 2010 |
Abrogation of nimesulide induced oxidative stress and mitochondria mediated apoptosis by Fumaria parviflora Lam. extract.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Fumaria; Lipid Peroxidatio | 2011 |
Nimesulide: patients still exposed to a risk of severe hepatitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhi | 2011 |
Drug safety issues of nimesulide in China--nimesulide-induced liver injury.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug | 2011 |
Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
Post-marketing surveillance of nimesulide suspension.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Child; Humans; Indi | 2002 |
Drug linked to child deaths is still available in India.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Child; Drug Approva | 2003 |
Use of nimesulide in Indian children must be stopped.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Child; Drug Approva | 2003 |
Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induce | 2003 |
Small risk ratios may have strong public health impact.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Humans; Risk Factor | 2003 |
[Acute hepatitis after use of nimesulide: drug-induced or is there something more? Mononucleosis].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diag | 2004 |
Steroid therapy for a case of severe drug-induced cholestasis.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2006 |
Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug | 2006 |
Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Humans; Liver | 2007 |
Hepatic disorders in patients treated with COX-2 selective inhibitors or nonselective NSAIDs: a case/noncase analysis of spontaneous reports.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Celecoxib; Chemical and Drug | 2006 |
Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemical and Drug Induced Liver Injury; F | 2007 |
Nimesulide-induced hepatotoxicity and fatal hepatic failure.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Humans; Liver Failu | 2008 |
Nimesulide-induced acute hepatitis: evidence from six cases.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 1998 |
Acute cholestatic hepatitis induced by nimesulide.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Female; Humans; Mi | 1999 |
Nimesulide and COX-2 inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhi | 1999 |
[Nimesulide acute hepatitis: description of 3 cases].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Female; Huma | 1999 |
Fatal hepatitis and renal failure during treatment with nimesulide.
Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bacteremia; Chemical and Drug In | 2000 |
Fatal hepatitis associated with nimesulide.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chemical and Drug Ind | 2000 |
Nimesulide-induced hepatitis and acute liver failure.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Chemical and Drug Induc | 1999 |
Nimesulide-induced hepatitis and acute liver failure.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Bl | 1999 |
[Severe acute hepatitis probably induced by nimesulide].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Huma | 2000 |
Nimesulide, clavulanic acid and hepatitis.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Dr | 2000 |
[Nimesulide toxic hepatitis in pregnancy].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Female; Huma | 2000 |
[Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case].
Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury | 2000 |
An update of adverse drug reactions of relevance to general dental practice.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Amoxicillin-Potassium Clavulanate Combination; Anest | 2000 |
[Nimesulide-induced acute hepatitis].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Huma | 2001 |
Drug Points: Cholestatic hepatitis in association with celecoxib.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemical and Drug Induced Liver Injury; Cholesta | 2001 |
Fatal hepatoxicity secondary to nimesulide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Fatal Outcome; Fema | 2001 |
Nimesulide-induced acute hepatitis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Fema | 2001 |
[Subfulminant hepatitis associated with nimesulide treatment requiring liver transplantation].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Humans; Liver Trans | 2002 |
[Nimesulide-induced hepatotoxicity].
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver In | 2002 |