nimesulide has been researched along with Acute Disease in 29 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nimesulide, a selective inhibitor of COX-2, has been shown to relieve pain rapidly in arthritis." | 9.10 | Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis. ( Belton, O; Bresnihan, B; Duffy, T; FitzGerald, D; FitzGerald, O, 2003) |
| "The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)." | 9.09 | Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999) |
| "The results confirmed that the COX-2-selective inhibitor nimesulide is an effective and well-tolerated agent for use in general practices to treat acute low back pain." | 9.09 | Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen. ( Autio, L; Jekunen, A; Pohjolainen, T; Vuorela, H, 2000) |
| "In a double-blind study, the efficacy and tolerability of nimesulide (100mg twice daily) were compared with those of diclofenac (50mg twice daily) when administered orally to 50 patients with acute superficial thrombophlebitis of the lower limbs." | 9.07 | A comparison of nimesulide and diclofenac in the treatment of acute superficial thrombophlebitis. ( Ferrari, E; Pratesi, C; Scaricabarozzi, I, 1993) |
| "The efficacy and safety of nimesulide suspension were evaluated in comparison with mefenamic acid in a double-blind multicentre study that recruited 100 children with acute respiratory tract infections." | 9.07 | A double-blind comparison of nimesulide and mefenamic acid in the treatment of acute upper respiratory tract infections in children. ( Giambonini, S; Maurizio, M; Monti, T; Roulet, D; Salzberg, R; Zahn, J, 1993) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 7.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| " In conclusion, nimesulide appears to be a safe and effective treatment for paediatric patients with pharyngo-amygdalitis and it has shown superior efficacy and tolerability when compared with naproxen." | 6.67 | Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study. ( Arista Viveros, HA; Lopez, E; Lujan, ME; Maciel, RM; Salmòn Rodriguez, LE; Trujillo, CL, 1993) |
| "Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)." | 6.47 | Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011) |
| "The diagnosis of toxic hepatitis due to nimesulide was supported by the time-course of drug usage, sex, age, absence of other causes of liver disease, a compatible liver biopsy and the improvement after drug withdrawal." | 5.31 | [Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case]. ( Meneses, M; Reyes, H; Tejos, S; Torrejón, N, 2000) |
| "Evaluate aspirin challenge as a means to distinguish single from multiple NSAID intolerance in patients with a clinical history of acute urticaria induced by a single NSAID." | 5.11 | Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs. ( Asero, R, 2005) |
| " Nimesulide, a selective inhibitor of COX-2, has been shown to relieve pain rapidly in arthritis." | 5.10 | Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis. ( Belton, O; Bresnihan, B; Duffy, T; FitzGerald, D; FitzGerald, O, 2003) |
| "The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)." | 5.09 | Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999) |
| "The results confirmed that the COX-2-selective inhibitor nimesulide is an effective and well-tolerated agent for use in general practices to treat acute low back pain." | 5.09 | Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen. ( Autio, L; Jekunen, A; Pohjolainen, T; Vuorela, H, 2000) |
| "In a double-blind study, the efficacy and tolerability of nimesulide (100mg twice daily) were compared with those of diclofenac (50mg twice daily) when administered orally to 50 patients with acute superficial thrombophlebitis of the lower limbs." | 5.07 | A comparison of nimesulide and diclofenac in the treatment of acute superficial thrombophlebitis. ( Ferrari, E; Pratesi, C; Scaricabarozzi, I, 1993) |
| "The efficacy and safety of nimesulide suspension were evaluated in comparison with mefenamic acid in a double-blind multicentre study that recruited 100 children with acute respiratory tract infections." | 5.07 | A double-blind comparison of nimesulide and mefenamic acid in the treatment of acute upper respiratory tract infections in children. ( Giambonini, S; Maurizio, M; Monti, T; Roulet, D; Salzberg, R; Zahn, J, 1993) |
| "A double-blind, multi-centre study was carried out in 42 hospitalized children, aged 6 months to 8 years, suffering from acute respiratory tract infections with fever, to investigate the antipyretic activity of nimesulide." | 5.07 | Antipyretic effects of nimesulide in paediatric practice: a double-blind study. ( Lecomte, J; Monti, T; Pochobradsky, MG, 1991) |
| "5%) dropped out in the nimesulide group (two early recovery, one lack of effect, one adverse event), compared with 13 (21." | 3.79 | Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide. ( Wober, W, 1999) |
| "In a term pregnancy, nimesulide administration can rapidly cause premature ductal constriction." | 3.74 | Acute premature constriction of the ductus arteriosus after maternal self-medication with nimesulide. ( De Biasio, P; Marasini, M; Prefumo, F; Venturini, PL, 2008) |
| "A 54-year-old Arabic woman treated with nimesulide for chronic low back pain was admitted to the hospital with acute hepatitis confirmed by biopsy." | 3.71 | Nimesulide-induced acute hepatitis. ( Cohen, HI; Farah, R; Krivoy, N; Reshef, R; Sbeit, W; Shiller, M; Struminger, L, 2001) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 3.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| "Nimesulide-induced liver injury can present with hepatocellular necrosis or with pure cholestasis." | 3.70 | Nimesulide-induced acute hepatitis: evidence from six cases. ( Büscher, H; De Bondt, J; Desmet, V; Laporta, T; Peeters, P; Roskams, T; Staessen, D; Van Steenbergen, W, 1998) |
| "Nimesulide therapy was also very well tolerated and no patient reported an adverse event." | 2.67 | Nimesulide granules for the treatment of acute inflammation of the ear, nose or throat. ( Monti, T; Nouri, E, 1993) |
| "Nimesulide was metabolised to its principal hydroxy metabolite, which was detectable in samples obtained 0." | 2.67 | Clinical and pharmacokinetic study of nimesulide in children. ( Berardi, M; Guarnaccia, S; Renzetti, I; Ugazio, AG, 1993) |
| "Nimesulide treatment was associated with a more rapid and greater antipyretic effect than lysine-acetylsalicylate: 94% of nimesulide recipients and 77% of lysine-acetylsalicylate recipients were considered by physicians to have a good or very good response to therapy (p < 0." | 2.67 | Efficacy and tolerability of nimesulide and lysine-acetylsalicylate in the treatment of paediatric acute upper respiratory tract inflammation. ( Cappella, L; Cavazzuti, GB; Guerra, A; Laudizi, L, 1993) |
| " In conclusion, nimesulide appears to be a safe and effective treatment for paediatric patients with pharyngo-amygdalitis and it has shown superior efficacy and tolerability when compared with naproxen." | 2.67 | Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study. ( Arista Viveros, HA; Lopez, E; Lujan, ME; Maciel, RM; Salmòn Rodriguez, LE; Trujillo, CL, 1993) |
| "Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID)." | 2.47 | Single dose oral mefenamic acid for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moll, R; Moore, RA, 2011) |
| "Nimesulide pretreatment was found to protect the tissue from enhanced levels of lipid peroxidation, and also stimulated the levels of glutathione-S-transferase (GST) in liver and glutathione reductase in kidneys." | 1.32 | Nimesulide affects antioxidant status during acute lung inflammation in rats. ( Khanduja, KL; Sohi, KK, 2003) |
| "The diagnosis of toxic hepatitis due to nimesulide was supported by the time-course of drug usage, sex, age, absence of other causes of liver disease, a compatible liver biopsy and the improvement after drug withdrawal." | 1.31 | [Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case]. ( Meneses, M; Reyes, H; Tejos, S; Torrejón, N, 2000) |
| "The clinical diagnosis of Hallopeau's acrodermatitis (HA) restricted to nail and digital pulp may be difficult, and even dermatologists often fail to recognize this condition." | 1.29 | Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients. ( Fanti, PA; Morelli, R; Piraccini, BM; Tosti, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (51.72) | 18.2507 |
| 2000's | 13 (44.83) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koller, T | 1 |
| Banárová, A | 1 |
| Ondrias, F | 1 |
| Kollerová, J | 1 |
| Payer, J | 1 |
| Moll, R | 1 |
| Derry, S | 1 |
| Moore, RA | 1 |
| McQuay, HJ | 1 |
| Sohi, KK | 1 |
| Khanduja, KL | 1 |
| Kullich, WC | 1 |
| Niksic, F | 1 |
| Klein, G | 1 |
| Duffy, T | 1 |
| Belton, O | 1 |
| Bresnihan, B | 1 |
| FitzGerald, O | 1 |
| FitzGerald, D | 1 |
| Quadranti, P | 1 |
| Asero, R | 1 |
| Prefumo, F | 1 |
| Marasini, M | 1 |
| De Biasio, P | 1 |
| Venturini, PL | 1 |
| Nouri, E | 1 |
| Monti, T | 3 |
| Ferrari, E | 1 |
| Pratesi, C | 1 |
| Scaricabarozzi, I | 3 |
| Salzberg, R | 1 |
| Giambonini, S | 1 |
| Maurizio, M | 1 |
| Roulet, D | 1 |
| Zahn, J | 1 |
| Gianiorio, P | 1 |
| Zappa, R | 1 |
| Sacco, O | 1 |
| Fregonese, B | 1 |
| Rossi, GA | 1 |
| Ugazio, AG | 1 |
| Guarnaccia, S | 1 |
| Berardi, M | 1 |
| Renzetti, I | 1 |
| Barberi, I | 1 |
| Macchia, A | 1 |
| Spata, N | 1 |
| Nava, ML | 1 |
| Cappella, L | 1 |
| Guerra, A | 1 |
| Laudizi, L | 1 |
| Cavazzuti, GB | 1 |
| Salmòn Rodriguez, LE | 1 |
| Arista Viveros, HA | 1 |
| Lujan, ME | 1 |
| Maciel, RM | 1 |
| Trujillo, CL | 1 |
| Lopez, E | 1 |
| Piraccini, BM | 1 |
| Fanti, PA | 1 |
| Morelli, R | 1 |
| Tosti, A | 1 |
| Van Steenbergen, W | 1 |
| Peeters, P | 1 |
| De Bondt, J | 1 |
| Staessen, D | 1 |
| Büscher, H | 1 |
| Laporta, T | 1 |
| Roskams, T | 1 |
| Desmet, V | 1 |
| Romero-Gómez, M | 1 |
| Nevado Santos, M | 2 |
| Otero Fernández, MA | 1 |
| Fovelo, MJ | 1 |
| Suárez-García, E | 1 |
| Castro Fernández, M | 2 |
| Wober, W | 1 |
| Romero Gómez, M | 1 |
| Fobelo, MJ | 1 |
| Ulukol, B | 1 |
| Köksal, Y | 1 |
| Cin, S | 1 |
| Pohjolainen, T | 1 |
| Jekunen, A | 1 |
| Autio, L | 1 |
| Vuorela, H | 1 |
| Rodrigues de Oliveira, J | 1 |
| Correia, J | 1 |
| Silvestre, F | 1 |
| Meirelles, A | 1 |
| Bernardo, A | 1 |
| Tejos, S | 1 |
| Torrejón, N | 1 |
| Reyes, H | 1 |
| Meneses, M | 1 |
| Montesinos, S | 1 |
| Hallal, H | 1 |
| Rausell, V | 1 |
| Conesa, F | 1 |
| López, A | 1 |
| Sbeit, W | 1 |
| Krivoy, N | 1 |
| Shiller, M | 1 |
| Farah, R | 1 |
| Cohen, HI | 1 |
| Struminger, L | 1 |
| Reshef, R | 1 |
| Kankuri, E | 1 |
| Vaali, K | 1 |
| Korpela, R | 1 |
| Paakkari, I | 1 |
| Vapaatalo, H | 1 |
| Moilanen, E | 1 |
| Lecomte, J | 1 |
| Pochobradsky, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Randomized Double-Blind Comparison of Analgesic Efficacy Between Intravenous Forms of Ibuprofen 400 and Ibuprofen 800 mg in Acute Mechanical Low Back Pain in the Emergency Department[NCT06064175] | Phase 4 | 144 participants (Actual) | Interventional | 2022-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nimesulide and Acute Disease
| Article | Year |
|---|---|
Single dose oral mefenamic acid for acute postoperative pain in adults.
Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans | 2011 |
Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bursitis; Cyclooxygenase 2; Cyclooxyg | 1999 |
14 trials available for nimesulide and Acute Disease
| Article | Year |
|---|---|
Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis.
Topics: Acute Disease; Administration, Oral; Arthralgia; Arthritis; Cyclooxygenase 1; Cyclooxygenase 2; Dicl | 2003 |
Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anal | 2005 |
Nimesulide granules for the treatment of acute inflammation of the ear, nose or throat.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; | 1993 |
A comparison of nimesulide and diclofenac in the treatment of acute superficial thrombophlebitis.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Fema | 1993 |
A double-blind comparison of nimesulide and mefenamic acid in the treatment of acute upper respiratory tract infections in children.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Hu | 1993 |
Antipyretic and anti-inflammatory efficacy of nimesulide vs paracetamol in the symptomatic treatment of acute respiratory infections in children.
Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chi | 1993 |
Clinical and pharmacokinetic study of nimesulide in children.
Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Fema | 1993 |
Double-blind evaluation of nimesulide vs lysine-aspirin in the treatment of paediatric acute respiratory tract infections.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Double-Bli | 1993 |
Efficacy and tolerability of nimesulide and lysine-acetylsalicylate in the treatment of paediatric acute upper respiratory tract inflammation.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Female; Hu | 1993 |
Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Humans; Inf | 1993 |
Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bursitis; Cyclooxygenase 2; Cyclooxyg | 1999 |
Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Infla | 1999 |
Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, double-blind comparative trial versus ibuprofen.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In | 2000 |
Antipyretic effects of nimesulide in paediatric practice: a double-blind study.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Double-Blind Method | 1991 |
14 other studies available for nimesulide and Acute Disease
| Article | Year |
|---|---|
[Acute cholestasis following treatment with nimesulide and oral contraception: case report and review].
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cholestasis; Contraceptives, Oral, Sy | 2008 |
Nimesulide affects antioxidant status during acute lung inflammation in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Lipid Peroxidation; M | 2003 |
Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study.
Topics: Acute Disease; Adult; Aged; Analysis of Variance; Cartilage Oligomeric Matrix Protein; Cyclooxygenas | 2002 |
[Acute hepatitis after use of nimesulide: drug-induced or is there something more? Mononucleosis].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diag | 2004 |
Acute premature constriction of the ductus arteriosus after maternal self-medication with nimesulide.
Topics: Acute Disease; Adult; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Ductus Arteriosus; Fema | 2008 |
Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients.
Topics: Acrodermatitis; Acute Disease; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease | 1994 |
Nimesulide-induced acute hepatitis: evidence from six cases.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver | 1998 |
Acute cholestatic hepatitis induced by nimesulide.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Female; Humans; Mi | 1999 |
[Nimesulide acute hepatitis: description of 3 cases].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Female; Huma | 1999 |
[Severe acute hepatitis probably induced by nimesulide].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Huma | 2000 |
[Bleeding gastric ulcers and acute hepatitis: 2 simultaneous adverse reactions due to nimesulide in a case].
Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury | 2000 |
[Nimesulide-induced acute hepatitis].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Huma | 2001 |
Nimesulide-induced acute hepatitis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Fema | 2001 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 2001 |