nimesulide has been researched along with Acute Brain Injuries in 3 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nimesulide treatment group after injury was treated with nimesulide [6 mg/(kg x d)] in peritoneum." | 1.37 | [The effect of nimesulide on learning and memory function after serve traumatic brain injury in rats]. ( Zhang, T; Zhang, YX, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, T | 1 |
| Zhang, YX | 1 |
| Cernak, I | 2 |
| O'Connor, C | 2 |
| Vink, R | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PET Imaging of Translocator Protein in Subjects With Traumatic Brain Injury[NCT01547780] | Phase 1/Phase 2 | 52 participants (Actual) | Interventional | 2012-01-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To determine total distribution volume of [C-11]PBR28 in the whole brain using PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan
| Intervention | mL/cm^3 (Mean) |
|---|---|
| Baseline Brain PET in Acute TBI Patient | 2.53 |
| Repeat Brain PET in Acute TBI Patient | 2.21 |
| Single Brain PET in Chronic TBI Patient | 3.21 |
| Single Brain PET in Healthy Subjects | 3.22 |
Total distribution volume divided by plasma free fraction (fp) of [C-11]PBR28. Measured with PET and arterial input function (concentration of radioligand in arterial plasma over time). (NCT01547780)
Timeframe: 120 minutes from the start of the PET scan
| Intervention | mL/cm^3 (Mean) |
|---|---|
| Baseline Brain PET in Acute TBI Patient | 93.72 |
| Repeat Brain PET in Acute TBI Patient | 80.32 |
| Single Brain PET in Chronic TBI Patient | 118.73 |
| Single Brain PET in Healthy Subjects | 103.99 |
3 other studies available for nimesulide and Acute Brain Injuries
| Article | Year |
|---|---|
[The effect of nimesulide on learning and memory function after serve traumatic brain injury in rats].
Topics: Animals; Brain Injuries; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Learning; Male; Memory Disorde | 2011 |
Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats.
Topics: Animals; Blotting, Western; Brain Injuries; Cognition; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors | 2002 |
Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloox | 2001 |