nilutamide and Chemical and Drug Induced Liver Injury studies

nilutamide and Chemical and Drug Induced Liver Injury

Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Research Excerpts

Excerpt	Relevance	Reference
"We report the case of a 69-year-old patient treated for stage C adenocarcinoma of the prostate with the combination of the luteinizing hormone-releasing hormone agonist [D-Trp6, des-Gly-NH2(10)] LHRH ethylamide and the antiandrogen nilutamide (Anandron) who developed simultaneous liver and lung toxicity."	3.68	Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report. ( Cusan, L; Dupont, A; Gomez, JL; Labrie, F; Tremblay, M, 1992)

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (33.33)	18.2507
2000's	2 (22.22)	29.6817
2010's	4 (44.44)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

3 (33.33)

18.2507

2000's

2 (22.22)

29.6817

2010's

4 (44.44)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Fourches, D	1
Barnes, JC	1
Day, NC	1
Bradley, P	1
Reed, JZ	1
Tropsha, A	1
Liu, Z	1
Shi, Q	1
Ding, D	1
Kelly, R	1
Fang, H	1
Tong, W	2
Sakatis, MZ	1
Reese, MJ	1
Harrell, AW	1
Taylor, MA	1
Baines, IA	1
Chen, L	1
Bloomer, JC	1
Yang, EY	1
Ellens, HM	1
Ambroso, JL	1
Lovatt, CA	1
Ayrton, AD	1
Clarke, SE	1
Chen, M	1
Suzuki, A	1
Thakkar, S	1
Yu, K	1
Hu, C	1
Edouard, A	1
Robinel, R	1
Rat, C	1
Lombard, F	1
Lorinet, C	1
Escarmant, P	1
Boelsterli, UA	1
Ho, HK	1
Zhou, S	1
Leow, KY	1
Pescatore, P	1
Hammel, P	2
Durand, F	1
Bertheau, P	1
Bernuau, J	1
Huc, D	1
Gerbal, JL	1
Degott, C	1
Benhamou, JP	1
Gomez, JL	1
Dupont, A	1
Cusan, L	1
Tremblay, M	2
Labrie, F	1
Ducreux, M	1
Bismuth, E	1
Ladouch-Badre, A	1
Benoit, G	1
Buffet, C	1
Etienne, JP	1

Studies

Fourches, D

Barnes, JC

Day, NC

Bradley, P

Reed, JZ

Tropsha, A

Liu, Z

Shi, Q

Ding, D

Kelly, R

Fang, H

Tong, W

Sakatis, MZ

Reese, MJ

Harrell, AW

Taylor, MA

Baines, IA

Chen, L

Bloomer, JC

Yang, EY

Ellens, HM

Ambroso, JL

Lovatt, CA

Ayrton, AD

Clarke, SE

Chen, M

Suzuki, A

Thakkar, S

Yu, K

Hu, C

Edouard, A

Robinel, R

Rat, C

Lombard, F

Lorinet, C

Escarmant, P

Boelsterli, UA

Ho, HK

Zhou, S

Leow, KY

Pescatore, P

Hammel, P

Durand, F

Bertheau, P

Bernuau, J

Huc, D

Gerbal, JL

Degott, C

Benhamou, JP

Gomez, JL

Dupont, A

Cusan, L

Tremblay, M

Labrie, F

Ducreux, M

Bismuth, E

Ladouch-Badre, A

Benoit, G

Buffet, C

Etienne, JP

Reviews

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr	2016
Bioactivation and hepatotoxicity of nitroaromatic drugs. Current drug metabolism, 2006, Volume: 7, Issue:7 Topics: Benzophenones; Biotransformation; Chemical and Drug Induced Liver Injury; Flutamide; Imidazolidines;	2006

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016

Bioactivation and hepatotoxicity of nitroaromatic drugs.

Current drug metabolism, 2006, Volume: 7, Issue:7

Topics: Benzophenones; Biotransformation; Chemical and Drug Induced Liver Injury; Flutamide; Imidazolidines;

2006

Other Studies

7 other studies available for nilutamide and Chemical and Drug Induced Liver Injury

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI	2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme	2012
[Fatal fulminating hepatitis induced by nilutamide]. Gastroenterologie clinique et biologique, 2003, Volume: 27, Issue:12 Topics: Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Fatal Outcome; Humans; Imidazol	2003
[Fatal fulminant hepatitis induced by nilutamide (Anandron)]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:6-7 Topics: Adenocarcinoma; Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Drug Interaction	1993
Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report. The American journal of medicine, 1992, Volume: 92, Issue:5 Topics: Adenocarcinoma; Aged; Androgen Antagonists; Antineoplastic Agents; Antineoplastic Combined Chemother	1992
[Nilutamide-induced acute hepatitis]. Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:6-7 Topics: Acute Disease; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Humans; Imidazol	1991

Article

Year

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chemical research in toxicology, 2010, Volume: 23, Issue:1

Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

PLoS computational biology, 2011, Volume: 7, Issue:12

Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012

[Fatal fulminating hepatitis induced by nilutamide].

Gastroenterologie clinique et biologique, 2003, Volume: 27, Issue:12

Topics: Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Fatal Outcome; Humans; Imidazol

2003

[Fatal fulminant hepatitis induced by nilutamide (Anandron)].

Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:6-7

Topics: Adenocarcinoma; Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Drug Interaction

1993

Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report.

The American journal of medicine, 1992, Volume: 92, Issue:5

Topics: Adenocarcinoma; Aged; Androgen Antagonists; Antineoplastic Agents; Antineoplastic Combined Chemother

1992

[Nilutamide-induced acute hepatitis].

Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:6-7

Topics: Acute Disease; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Humans; Imidazol

1991