nileprost and Shock

nileprost has been researched along with Shock* in 1 studies

Other Studies

1 other study(ies) available for nileprost and Shock

Article	Year
Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice. Prostaglandins, leukotrienes, and essential fatty acids, 1990, Volume: 40, Issue:2 Prostaglandins and Prostaglandin-analogues were investigated for their ability to protect mice from platelet-activating factor (PAF) induced shock. 75% mortality in female NMRI mice was induced by i.v. injection of 75 micrograms/kg PAF. Nileprost and PGE1, the most potent substances, produced a dose dependent protection against PAF. Iloprost and PGI2 were less effective. PGE2, nalador, flunoprost and U 46619 were neither protective nor deleterious. The strong difference in the effectiveness between the two prostaglandins of the E-series and the poor effect of PGI2 and the PGI2 analogue is remarkable. Flunoprost and U 46619 that increased the TXB2 synthesis or release in two experimental models did not enhance the PAF mortality; TXA2 seems to be only a secondary mediator of the acute PAF-induced death. Topics: Animals; Cell Survival; Epoprostenol; Female; Iloprost; Mice; Platelet Activating Factor; Prostaglandins; Prostaglandins, Synthetic; Shock	1990

Article

Year

Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice.

Prostaglandins, leukotrienes, and essential fatty acids, 1990, Volume: 40, Issue:2

Prostaglandins and Prostaglandin-analogues were investigated for their ability to protect mice from platelet-activating factor (PAF) induced shock. 75% mortality in female NMRI mice was induced by i.v. injection of 75 micrograms/kg PAF. Nileprost and PGE1, the most potent substances, produced a dose dependent protection against PAF. Iloprost and PGI2 were less effective. PGE2, nalador, flunoprost and U 46619 were neither protective nor deleterious. The strong difference in the effectiveness between the two prostaglandins of the E-series and the poor effect of PGI2 and the PGI2 analogue is remarkable. Flunoprost and U 46619 that increased the TXB2 synthesis or release in two experimental models did not enhance the PAF mortality; TXA2 seems to be only a secondary mediator of the acute PAF-induced death.

Topics: Animals; Cell Survival; Epoprostenol; Female; Iloprost; Mice; Platelet Activating Factor; Prostaglandins; Prostaglandins, Synthetic; Shock

1990