nikkomycin and Lung-Neoplasms

nikkomycin has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for nikkomycin and Lung-Neoplasms

Article	Year
Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 A new series of nitrogen-containing heterocycles 4H-1,3,4-oxadiazin-5(6H)-ones derivatives with hydrophobic and long chains were designed and synthesized by direct cyclization reaction of N'-alkylation substituted aroylhydrazines with chloroacetyl chloride. The preliminary assays showed that some of the compounds displayed moderate to good inhibitory activities toward monoamine oxidase (MAO) at the concentration of 10(-5)-10(-3)M, and antitumor activities against human lung cancer A-549 and human prostate cancer PC-3 cell lines at muM level, which might provide new scaffold for anticancer agents. Furthermore, compounds 5i and 5m exhibited significant inhibitory activity on chitin biosynthesis, which might represent a novel class of highly potential inhibitors of chitin synthesis. Topics: Antineoplastic Agents; Cell Line, Tumor; Chitin; Drug Design; Humans; Hydrophobic and Hydrophilic Interactions; Lung Neoplasms; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Prostatic Neoplasms; Structure-Activity Relationship	2009

Article

Year

Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell.

European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

A new series of nitrogen-containing heterocycles 4H-1,3,4-oxadiazin-5(6H)-ones derivatives with hydrophobic and long chains were designed and synthesized by direct cyclization reaction of N'-alkylation substituted aroylhydrazines with chloroacetyl chloride. The preliminary assays showed that some of the compounds displayed moderate to good inhibitory activities toward monoamine oxidase (MAO) at the concentration of 10(-5)-10(-3)M, and antitumor activities against human lung cancer A-549 and human prostate cancer PC-3 cell lines at muM level, which might provide new scaffold for anticancer agents. Furthermore, compounds 5i and 5m exhibited significant inhibitory activity on chitin biosynthesis, which might represent a novel class of highly potential inhibitors of chitin synthesis.

Topics: Antineoplastic Agents; Cell Line, Tumor; Chitin; Drug Design; Humans; Hydrophobic and Hydrophilic Interactions; Lung Neoplasms; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Prostatic Neoplasms; Structure-Activity Relationship

2009