Page last updated: 2024-11-05

nikethamide and Seizures

nikethamide has been researched along with Seizures in 18 studies

Nikethamide: A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" Mice pretreated with procaine, lidocaine, and tetracaine had a lower incidence of seizures when convulsive doses of either nikethamide or doxapram hydrochloride were given intraperitoneally."3.65Interaction between local anesthetics and analeptic drugs. ( Aldrete, JA; Thompson, RG, 1975)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199017 (94.44)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wu, XY1
Zhao, JL1
Zhang, M1
Li, F1
Zhao, T1
Yang, LQ1
PLOTNIKOFF, N1
KEITH, J1
HEIMANN, M1
KEITH, W1
PERRY, C1
FROMMEL, E2
SEYDOUX, J2
NAKAJIMA, S1
SETNIKAR, I1
MAGISTRETTI, MJ1
DRIESEN, W1
HAHN, F2
RUMMEL, W1
GARAT, BR1
ROSSI RICHERI, OF1
TRACCHIA, RO1
Sinitskiĭ, VN1
Longo, VG1
Massotti, M1
Sagratella, S1
Thompson, RG1
Aldrete, JA1
Taylor, WJ1
Lüdtke, AH1
Scharrer, P1
Schmidt, L1
Frank, GB2
Jhamandas, K2
Kita, T1
Hata, T1
Murakami, T1
Udall, ND1
May, HU1

Other Studies

18 other studies available for nikethamide and Seizures

ArticleYear
Sedative, hypnotic and anticonvulsant activities of the ethanol fraction from Rhizoma Pinelliae Praeparatum.
    Journal of ethnopharmacology, 2011, May-17, Volume: 135, Issue:2

    Topics: Animals; Anticonvulsants; Ethanol; Hypnotics and Sedatives; Locomotion; Mice; Mice, Inbred ICR; Nike

2011
STIMULANT EFFECTS OF TETRAHYDROCYCLOHEPTAQUINOLINE DERIVATIVES.
    Archives internationales de pharmacodynamie et de therapie, 1963, Dec-01, Volume: 146

    Topics: Acridines; Amphetamine; Amphetamines; Barbiturates; Behavior, Animal; Blood Pressure; Blood Pressure

1963
[ON THE EFFECT OF ETHANOL ON THE BRAIN. RESULTS OF SO-CALLED NEUROPHARMACOLOGIC TESTS IN ANIMALS].
    Helvetica physiologica et pharmacologica acta, 1964, Volume: 22

    Topics: Alcoholic Intoxication; Amphetamine; Amphetamines; Body Temperature Regulation; Brain; Electroconvul

1964
EFFECTS OF CHEMICAL INJECTION INTO THE RETICULAR FORMATION OF RATS.
    Journal of comparative and physiological psychology, 1964, Volume: 58

    Topics: Chlorides; Citrates; Coma; Fear; Injections; Nikethamide; Pentobarbital; Potassium; Procaine; Rats;

1964
CARDIAC EFFECTS OF DIMEFLINE COMPARED WITH THOSE OF OTHER CENTRAL NERVOUS SYSTEM STIMULANTS.
    Archives internationales de pharmacodynamie et de therapie, 1964, Sep-01, Volume: 151

    Topics: Aminobutyrates; Bemegride; Benzene; Calcium; Central Nervous System Stimulants; Chlorides; Coronary

1964
STUDY OF THE EFFECTS OF MORPHINE AND NALORPHINE.
    Archives internationales de pharmacodynamie et de therapie, 1964, Nov-01, Volume: 152

    Topics: Animals; Body Temperature Regulation; Chlordiazepoxide; Chlorpromazine; Electroshock; Ether; Guinea

1964
[Effect of cardiazol, coramine and pyramidon on the electroencephalogram and electromyelogram in cats and rabbits].
    Deutsche Zeitschrift fur Nervenheilkunde, 1950, Volume: 164, Issue:4

    Topics: Aminopyrine; Animals; Cats; Electroencephalography; Lagomorpha; Nikethamide; Pentylenetetrazole; Rab

1950
[Treatment of asthmatic seizures with nebulized 10% coramin suspension].
    La Semana medica, 1951, Jan-04, Volume: 58, Issue:1

    Topics: Asthma; Humans; Nikethamide; Seizures

1951
[On the mechanism of a disposition to convulsions].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1966, Volume: 66, Issue:12

    Topics: Animals; Camphor; Injections, Intravenous; Nikethamide; Rabbits; Reflex; Seizures

1966
Convulsant drugs and changes in the electrical activity of the brain: an investigation of the effects of opioids on chemoconvulsions.
    Progress in clinical and biological research, 1983, Volume: 124

    Topics: Animals; Brain; Convulsants; Electroencephalography; Electrophysiology; GABA Antagonists; Morphine;

1983
Interaction between local anesthetics and analeptic drugs.
    Southern medical journal, 1975, Volume: 68, Issue:2

    Topics: Anesthetics, Local; Animals; Central Nervous System Stimulants; Doxapram; Drug Interactions; Lidocai

1975
Inhibition of nikethamide by nicotinamide.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1969, Volume: 2, Issue:1

    Topics: Animals; Mice; Niacinamide; Nikethamide; Seizures; Tachyphylaxis

1969
[The effects of Bemegride, Pentetrazole and Nikethamide on blood pressure, heart rate and respiration in alcohol-intoxicated rats].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:10

    Topics: Alcoholic Intoxication; Animals; Bemegride; Blood Pressure; Central Nervous System Stimulants; Heart

1970
Effects of drugs acting alone and in combination on the motor activity of intact mice.
    British journal of pharmacology, 1970, Volume: 39, Issue:4

    Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central

1970
Effects of general stimulant drugs on the electrical responses of isolated slabs of cat's cerebral cortex.
    British journal of pharmacology, 1970, Volume: 39, Issue:4

    Topics: Action Potentials; Animals; Bemegride; Caffeine; Cats; Central Nervous System Stimulants; Cerebral C

1970
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Jul-20, Volume: 66, Issue:4

    Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous Sy

1970
The toxicity of the molluscicides metaldehyde and methiocarb to dogs.
    The Veterinary record, 1973, Oct-13, Volume: 93, Issue:15

    Topics: Acetaldehyde; Animals; Atropine; Carbamates; Dog Diseases; Dogs; Gluconates; Glucose; Hyperemia; Kid

1973
Concerning the depressant activity of analeptics (pentylenetetrazol, bemegride, nikethamide, picrotoxin).
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:2

    Topics: Anesthesia; Animals; Barbiturates; Bemegride; Depression, Chemical; Guinea Pigs; Nikethamide; Nitrou

1970