nigakinone and Edema

nigakinone has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for nigakinone and Edema

Article	Year
In vitro and in vivo anti-inflammatory effects of 4-methoxy-5- hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Feb-15, Volume: 20, Issue:3-4 In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis. Topics: Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Cell Line; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edema; Indoles; Lipopolysaccharides; Macrophages; Mice; Naphthyridines; Nitric Oxide; Phytotherapy; Picrasma; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Xylenes	2013

Article

Year

In vitro and in vivo anti-inflammatory effects of 4-methoxy-5- hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Feb-15, Volume: 20, Issue:3-4

In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis.

Topics: Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Cell Line; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edema; Indoles; Lipopolysaccharides; Macrophages; Mice; Naphthyridines; Nitric Oxide; Phytotherapy; Picrasma; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Xylenes

2013