nigakinone and Edema
nigakinone has been researched along with Edema* in 1 studies
Other Studies
1 other study(ies) available for nigakinone and Edema
| Article | Year |
|---|---|
In vitro and in vivo anti-inflammatory effects of 4-methoxy-5- hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides.
In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis. Topics: Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Cell Line; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edema; Indoles; Lipopolysaccharides; Macrophages; Mice; Naphthyridines; Nitric Oxide; Phytotherapy; Picrasma; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Xylenes | 2013 |