nifuroxazide and Acute-Disease

In a double-blind, controlled randomized trial, 88 adult patients with acute diarrhea (more than three watery stools per day) received either 400 mg of nifuroxazide twice daily or placebo for 5 days. The mean duration of diarrhea in the nifuroxazide group was 2.09 days versus 3.26 days in the placebo group (p less than 0.004). The number of bowel movements per day diminished and mucus disappeared more quickly in patients treated by nifuroxazide than in patients of the placebo group. Nifuroxazide was well tolerated and no side effects were observed. Nifuroxazide is an effective therapy for acute diarrhea and can be prescribed from the onset of diarrhea without waiting for stool culture results which can be late or negative.

Topics: Acute Disease; Adult; Anti-Infective Agents; Diarrhea; Double-Blind Method; Female; France; Humans; Hydroxybenzoates; Male; Multicenter Studies as Topic; Nitrofurans

Topics: Acute Disease; Aged; Anti-Infective Agents; Erythema; Exanthema; Fever; Humans; Hydroxybenzoates; Male; Nitrofurans; Skin Diseases, Papulosquamous

The clinical effects of Nifuroxasid (N), Trimetoprim sulphametoxasol (TS) and Bactisubtil (B) on bacillar dysentery and alimentary toxicoinfections in the patients treated at the Clinic from January 1984 to the end of December 1989 have been analysed. According to the clinical signs, patients have been divided in ten categories of light, mild and heavy forms. In total, 329 cases of bacillar dysentery and 89 cases of alimentary toxicoinfections have been analysed. The following was established: A. Bacilar dysentery: the fastest normalization of the stool was achieved with N in every clinical form (averages 2.2, 3.5 and 4.05 days). With TS the effects were slower (3.0, 3.9 and 4.4 days), but the slowest normalization was recorded with B (3.4, 4.6 and 5.4 days). However, with TS, some Shigella strains showed resistance (in 23 out of 94 antibiograms), which diminished the effects. B. Alimentary toxicoinfections were treated only with N and B, since these forms of diarrhea caused by toxigenic factors were milder. Better results were achieved with N in this case as well.

Topics: Acute Disease; Adjuvants, Immunologic; Anti-Infective Agents; Bacillus subtilis; Biological Factors; Diarrhea; Dysentery, Bacillary; Foodborne Diseases; Humans; Hydroxybenzoates; Nitrofurans; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Acute Disease; Anti-Infective Agents; Gastroenteritis; Humans; Hydroxybenzoates; Infant; Nitrofurans