niflumic acid has been researched along with Neuroblastoma in 2 studies
Niflumic Acid: An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human neuroblastoma cell lines (LAN5, SHEP and IMR32), mycophenolic acid (MPA) at concentrations (10(-7)-10(-6) M) readily attainable during immunosuppressive therapy with mycophenolate mofetil (Cellcept), induces guanine nucleotide depletion leading to cell cycle arrest and apoptosis through a p53 mediated pathway (up-regulation of p53, p21 and bax and down-regulation of bcl-2 and survivin)." | 3.72 | Potential role of mycophenolate mofetil in the management of neuroblastoma patients. ( Barile, L; Giacomello, A; Lupi, F; Messina, E, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Messina, E | 1 |
| Barile, L | 1 |
| Lupi, F | 1 |
| Giacomello, A | 1 |
| O'Reilly, N | 1 |
| Xia, Z | 1 |
| Fiander, H | 1 |
| Tauskela, J | 1 |
| Small, DL | 1 |
2 other studies available for niflumic acid and Neuroblastoma
| Article | Year |
|---|---|
Potential role of mycophenolate mofetil in the management of neuroblastoma patients.
Topics: Allopurinol; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Prolifer | 2004 |
Disparity between ionic mediators of volume regulation and apoptosis in N1E 115 mouse neuroblastoma cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 2002 |