Page last updated: 2024-11-01

nifedipine and Subarachnoid Hemorrhage

nifedipine has been researched along with Subarachnoid Hemorrhage in 17 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.

Research Excerpts

ExcerptRelevanceReference
" The sublingual adminstration of nifedipine reversed both the acute and the delayed cerebral arterial spasm."7.66Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine. ( Allen, GS; Bahr, AL, 1979)
"We examined the efficacy of slow-release, and prolonged diffusion silicone pellets mixed with papaverine hydrochloride in the treatment of cerebral vasospasms following subarachnoid hemorrhage."3.67[Sustained-release pellet of vasodilators--basic experiment]. ( Arimitsu, T; Mori, K; Oda, Y; Okumura, T, 1984)
" The sublingual adminstration of nifedipine reversed both the acute and the delayed cerebral arterial spasm."3.66Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine. ( Allen, GS; Bahr, AL, 1979)
"Nimodipine was found to be more potent, both in the chamber and in the live dog experiments."2.66Role of calcium antagonists in cerebral arterial spasm. ( Allen, GS, 1985)
"Cerebral aneurysm rupture and subarachnoid hemorrhage (SAH) inflict disability and death on thousands of individuals each year."1.33Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage. ( Honda, A; Ishiguro, M; Russell, SR; Tranmer, BI; Wellman, GC; Wellman, TL, 2005)
"In experiments where a minor subarachnoid hemorrhage was made by the injection micropipette injuring capillaries just before the perivascular microapplication of nifedipine, a dilatatory response invariably ensued in spite of the perivascular blood which in itself constricted the arterioles under examination."1.26Effects of nifedipine of pial arteriolar calibre: an in vivo study. ( Andersson, KE; Bengtsson, B; Brandt, L; Edvinsson, L; Ljunggren, B; MacKenzie, ET, 1979)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199012 (70.59)18.7374
1990's1 (5.88)18.2507
2000's1 (5.88)29.6817
2010's3 (17.65)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bain, J1
Segal, D1
Amin, R1
Monoky, D1
Thompson, SJ1
Shi, X1
Fu, Y1
Liao, D1
Chen, Y1
Liu, J1
Egea-Guerrero, JJ1
Murillo-Cabezas, F1
Muñoz-Sánchez, MÁ1
Vilches-Arenas, A1
Porras-González, C1
Castellano, A1
Ureña, J1
González-Montelongo, Mdel C1
Ishiguro, M1
Wellman, TL1
Honda, A1
Russell, SR1
Tranmer, BI1
Wellman, GC1
Weir, B1
Payen, DM1
Pinaud, ML1
Lampron, N1
De Kersaint Gilly, A1
Nicolas, FM1
Okumura, T1
Oda, Y1
Arimitsu, T1
Mori, K1
Handa, J1
Matsuda, M1
Nakasu, Y1
Nakasu, S1
Kidooka, M1
Watanabe, K1
Abe, S1
Brandt, L3
Ljunggren, B2
Anderson, KE1
Hindfelt, B1
Teasdale, G1
Hongo, K1
Kobayashi, S1
Edvinsson, L2
Andersson, KE2
Bengtsson, B2
Allen, GS2
Bahr, AL1
MacKenzie, ET1
Gill, JS1
Zezulka, AV1
Horrocks, PM1
Zabramski, J1
Spetzler, RF1
Bonstelle, C1

Reviews

2 reviews available for nifedipine and Subarachnoid Hemorrhage

ArticleYear
Calcium antagonists, cerebral ischemia and vasospasm.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1984, Volume: 11, Issue:2

    Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebral Arteries; Cerebrovascular Circulat

1984
Calcium antagonists for the treatment of vasospasm following subarachnoid haemorrhage.
    Neurological research, 1993, Volume: 15, Issue:4

    Topics: Animals; Calcium Channel Blockers; Cerebrovascular Circulation; Diltiazem; Humans; Ischemic Attack,

1993

Trials

2 trials available for nifedipine and Subarachnoid Hemorrhage

ArticleYear
Calcium antagonists, cerebral ischemia and vasospasm.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1984, Volume: 11, Issue:2

    Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebral Arteries; Cerebrovascular Circulat

1984
Role of calcium antagonists in cerebral arterial spasm.
    The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3

    Topics: Animals; Calcium Channel Blockers; Cerebral Arteries; Clinical Trials as Topic; Dogs; Double-Blind M

1985

Other Studies

14 other studies available for nifedipine and Subarachnoid Hemorrhage

ArticleYear
Call-Fleming syndrome: headache in a 16-year-old girl.
    Pediatric neurology, 2013, Volume: 49, Issue:2

    Topics: Adolescent; Angiography; Anxiety; Attention Deficit Disorder with Hyperactivity; Female; Headache; H

2013
Alterations of voltage-dependent calcium channel currents in basilar artery smooth muscle cells at early stage of subarachnoid hemorrhage in a rabbit model.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Basilar Artery; Blood Pressure; Body Weight; Brain; Calcium Channels; Calcium Channels, L-T

2014
Role of L-type Ca(2+) channels, sarcoplasmic reticulum and Rho kinase in rat basilar artery contractile properties in a new model of subarachnoid hemorrhage.
    Vascular pharmacology, 2015, Volume: 72

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium; Calcium Channel Blo

2015
Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage.
    Circulation research, 2005, Mar-04, Volume: 96, Issue:4

    Topics: Animals; Blood; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, R-Typ

2005
Common carotid haemodynamic and metabolic effects of acutely administered nifedipine in human subarachnoid haemorrhage.
    Cardiovascular research, 1984, Volume: 18, Issue:10

    Topics: Adult; Blood Flow Velocity; Carotid Arteries; Female; Hemodynamics; Humans; Male; Middle Aged; Nifed

1984
[Sustained-release pellet of vasodilators--basic experiment].
    No shinkei geka. Neurological surgery, 1984, Volume: 12, Issue:11

    Topics: Delayed-Action Preparations; Diltiazem; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; N

1984
Early operation of aneurysmal subarachnoid hemorrhage--use of nicardipine, a calcium channel blocker.
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1984, Sep-01, Volume: 53, Issue:5

    Topics: Adult; Aged; Calcium Channel Blockers; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Nic

1984
[Clinical and experimental studies on the role of Ca++ in etiology of cerebral vasospasm].
    No shinkei geka. Neurological surgery, 1983, Volume: 11, Issue:11

    Topics: Adult; Aged; Animals; Calcium; Dinoprost; Dogs; Female; Humans; Ischemic Attack, Transient; Male; Mi

1983
Vasoconstrictive effects of human post-hemorrhagic cerebrospinal fluid on cat pial arterioles in situ.
    Journal of neurosurgery, 1981, Volume: 54, Issue:3

    Topics: Adult; Animals; Arterioles; Cats; Cerebrospinal Fluid; Female; Humans; Intracranial Aneurysm; Male;

1981
Effect of a calcium antagonist on experimental constriction of human brain vessels.
    Surgical neurology, 1979, Volume: 11, Issue:5

    Topics: Calcium; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine

1979
Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine.
    Neurosurgery, 1979, Volume: 4, Issue:1

    Topics: Acute Disease; Administration, Oral; Animals; Cerebral Arterial Diseases; Chronic Disease; Dogs; Dru

1979
Effects of nifedipine of pial arteriolar calibre: an in vivo study.
    Surgical neurology, 1979, Volume: 12, Issue:5

    Topics: Animals; Cats; Cerebral Arteries; Female; Male; Nifedipine; Pyridines; Subarachnoid Hemorrhage; Vaso

1979
Rupture of a cerebral aneurysm associated with nifedipine treatment.
    Postgraduate medical journal, 1986, Volume: 62, Issue:733

    Topics: Adult; Female; Humans; Hypertension; Intracranial Aneurysm; Nifedipine; Rupture, Spontaneous; Subara

1986
Chronic cerebral vasospasm: effect of calcium antagonists.
    Neurosurgery, 1986, Volume: 18, Issue:2

    Topics: Animals; Cerebral Angiography; Chronic Disease; Disease Models, Animal; Dogs; Injections; Ischemic A

1986