nifedipine has been researched along with Sensitivity and Specificity in 51 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " After oral lidocaine, cirrhotic patients has a longer time to peak concentration (Tmax) and elimination half-life (t1/2), and a higher area under the curve (AUC)." | 6.68 | Pharmacokinetics of oral lidocaine and nifedipine in patients with liver cirrhosis. ( Klangwarnwong, D; Manorot, M; Praisontarangkul, OA; Tonsuwannont, W, 1996) |
| "In order to study the effects of calcium-blocking therapy on cardiovascular homeostasis in elderly subjects with isolated systolic hypertension, we performed a randomised double-blind placebo-controlled crossover study of 6 weeks therapy with modified-release nifedipine or placebo." | 5.09 | Baroreflex sensitivity changes with calcium antagonist therapy in elderly subjects with isolated systolic hypertension. ( James, MA; Panerai, RB; Potter, JF; Rakicka, H, 1999) |
| "002; multivariate analysis of variance), with 7 significant univariate treatment effects, all favoring COER-verapamil, being noted-pedal edema, polyuria, rapid heart beat or palpitations, hives, muscle cramps, abdominal cramps, and headaches." | 5.09 | Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life. ( Anderson, RB; Hollenberg, NK; Williams, GH, 1999) |
| "The influence of methimazole-induced hypothyroidism on spontaneous rhythmic contractions and Ca2+ channel function of rat uterus was examined." | 3.71 | Influence of hypothyroid state on 45Ca(2+) influx and sensitivity of rat uterus to nifedipine and diltiazem. ( Mishra, SK; Parija, SC; Raviprakash, V; Telang, AG; Varshney, VP, 2001) |
| " The method was fully validated and successfully applied to a clinical pharmacokinetic study of nifedipine sustained-release tablet in healthy male volunteers." | 2.76 | Determination of nifedipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. ( Jiang, K; Li, F; Lu, X; Qin, F; Wang, D; Yang, S, 2011) |
| " With the use of the highly accurate and specific technique of IDMS it can now be unequivocally established that the different progestins in the tested oral contraceptives have no influence on the bioavailability of EE2 (area under EE2 serum concentration curves, as usually defined in pharmacokinetics)." | 2.69 | Gestodene and desogestrel do not have a different influence on concentration profiles of ethinylestradiol in women taking oral contraceptives--results of isotope dilution mass spectrometry measurements. ( Albring, M; Bidlingmaier, F; Brill, K; Siekmann, A; Siekmann, L, 1998) |
| "Nifedipine was also found to be photostable for at least 120 min in plasma, 30 min in blood and for 60 min in aqueous solutions after exposure to light." | 2.69 | Liquid chromatographic assay of nifedipine in human plasma and its application to pharmacokinetic studies. ( Abou-Auda, HS; Al-Fawzan, NF; Al-Hadiya, BM; Al-Khamis, KI; Ghilzai, NM; Najjar, TA, 2000) |
| " After oral lidocaine, cirrhotic patients has a longer time to peak concentration (Tmax) and elimination half-life (t1/2), and a higher area under the curve (AUC)." | 2.68 | Pharmacokinetics of oral lidocaine and nifedipine in patients with liver cirrhosis. ( Klangwarnwong, D; Manorot, M; Praisontarangkul, OA; Tonsuwannont, W, 1996) |
| "Nifedipine is a dihydropyridine calcium channel blocker used widely in the management of hypertension and other cardiovascular disorders." | 1.40 | Determination of nifedipine in dog plasma by high-performance liquid chromatography with tandem mass spectrometric detection. ( Fu, Q; Hu, X; Pan, X; Wu, J; Zhou, S, 2014) |
| "A more rapid, sensitive and specific high-performance liquid chromatography coupled to -tandem mass spectrometry (HPLC-MS/MS) was developed and validated for the quantification of nifedipine in human plasma, and applied to the pharmacokinetic study of nifedipine in Chinese healthy volunteers." | 1.39 | A more rapid, sensitive, and specific HPLC-MS/MS method for nifedipine analysis in human plasma and application to a pharmacokinetic study. ( Chen, R; Guo, R; Huang, J; Li, R; Liu, X; Lv, C; Wang, B; Wei, C; Yuan, G, 2013) |
| " The validated assay method was successfully applied to a pharmacokinetic study in humans." | 1.39 | Sensitive LC-MS/MS-ESI method for simultaneous determination of nifedipine and atenolol in human plasma and its application to a human pharmacokinetic study. ( Inamadugu, JK; Kallem, RR; Ramesh, M; Seshagirirao, JV, 2013) |
| " The method was successfully applied to a clinical pharmacokinetic study of lacidipine in healthy volunteers following oral administration." | 1.35 | Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study. ( Cheng, G; Peng, W; Tang, J; Zhao, R; Zhu, R, 2008) |
| "Felodipine was used as the internal standard." | 1.34 | Simultaneous determination of nitrendipine and one of its metabolites in plasma samples by gas chromatography with electron-capture detection. ( Kvetina, J; Macek, K; Mejstríková, L; Pastera, J; Zoulová, J, 2007) |
| "Addition of CGRP stimulated rhythmic contractility but only in the presence of calcium, with a dose-response to the level of calcium ions." | 1.34 | The role of sympathetic innervation in the developing rat gubernaculum. ( Clarke, MC; Hutson, JM; Sasaki, Y, 2007) |
| "Treatment with nifedipine (10, 20 mg/kg) significantly improved the renal dysfunction, tissue and urine total nitric oxide levels, and renal oxidative stress and prevented the alterations in renal morphology." | 1.33 | Nifedipine attenuates changes in nitric oxide levels, renal oxidative stress, and nephrotoxicity induced by cyclosporine. ( Chander, V; Chopra, K, 2005) |
| "Nifedipine is a calcium-channel antagonist drug used in the management of angina pectoris and hypertension through inhibition of calcium influx." | 1.32 | Cathodic adsorptive stripping square-wave voltammetric determination of nifedipine drug in bulk, pharmaceutical formulation and human serum. ( Ghoneim, MM; Khashaba, PY; Tawfik, A, 2003) |
| " The method was not interfered with by other plasma components and was applied for the determination of nifedipine in pharmacokinetic study after single oral administration of 10 mg nifedipine to 18 healthy male subjects." | 1.32 | Determination of nifedipine in human plasma by solid-phase extraction and high-performance liquid chromatography: validation and application to pharmacokinetic studies. ( Daftsios, AC; Niopas, I, 2003) |
| "A new simple, sensitive and reproducible spectrophotometric method for the determination of nifedipine in pure and dosage forms has been proposed." | 1.31 | Spectrophotometric method for the determination of nifedipine with 4-(methylamino)phenol and potassium dichromate. ( Hoda, MN; Rahman, N, 2002) |
| "Nifedipine, a calcium-channel blocking drug was analysed in dog plasma after oral dosing with two different formulations." | 1.29 | Sensitive high-performance liquid chromatographic determination of nifedipine in dog plasma using an automated sample preparation system with laboratory robot. ( Balogh-Nemes, K; Gödörházy, L; Horvai, G; Horváth, V; Hrabéczy-Páll, A; Klebovich, I; Kocsi, E; Niegreisz, Z; Tolokán, A, 1996) |
| "The results confirm that effective treatment of hypertension significantly reduced basal [Ca2+]i in platelets but raise doubts whether elevated basal [Ca2+]i is necessarily the sole mechanism by which the sensitivity of platelets to aggregatory agents is increased in hypertension." | 1.28 | Treatment of hypertension induces a fall in platelet basal cytoplasmic calcium concentration without influencing platelet aggregation. ( Baig, MW; Davies, JA; Lees, AD; Orchard, MA; Perrins, EJ; Prentice, CR; Wilson, J, 1992) |
| "We studied the action of nifedipine on the bioavailability of cefixime, a molecule absorbed via the gut wall dipeptide carrier system in the rat, and on the bioavailability of D-xylose, which is absorbed via a pH (and Na(+)-)-dependent transporter." | 1.28 | Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system. ( Bouten, A; Carbon, C; Deslandes, A; Duverne, C; Farinotti, R; Trouvin, JH; Westphal, JF, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (45.10) | 18.2507 |
| 2000's | 22 (43.14) | 29.6817 |
| 2010's | 6 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 2 |
| Sun, Y | 1 |
| He, Z | 1 |
| Chen, R | 1 |
| Huang, J | 1 |
| Lv, C | 1 |
| Wei, C | 1 |
| Li, R | 1 |
| Yuan, G | 1 |
| Wang, B | 1 |
| Guo, R | 1 |
| Pan, X | 1 |
| Zhou, S | 1 |
| Fu, Q | 1 |
| Hu, X | 1 |
| Wu, J | 1 |
| Tang, J | 1 |
| Zhu, R | 1 |
| Zhao, R | 1 |
| Cheng, G | 1 |
| Peng, W | 1 |
| Cheng, H | 1 |
| Smith, GL | 1 |
| Orchard, CH | 1 |
| Hancox, JC | 1 |
| Zhang, J | 1 |
| Song, HJ | 1 |
| Bu, FL | 1 |
| Wei, CM | 1 |
| Yuan, GY | 1 |
| Liu, XY | 1 |
| Wang, BJ | 1 |
| Guo, RC | 1 |
| Wang, D | 1 |
| Jiang, K | 1 |
| Yang, S | 1 |
| Qin, F | 1 |
| Lu, X | 1 |
| Li, F | 1 |
| Patel, DP | 1 |
| Sharma, P | 1 |
| Sanyal, M | 1 |
| Singhal, P | 1 |
| Shrivastav, PS | 1 |
| Kallem, RR | 1 |
| Inamadugu, JK | 1 |
| Ramesh, M | 2 |
| Seshagirirao, JV | 1 |
| Rosenbaum, T | 1 |
| Castañares, DT | 1 |
| López-Valdés, HE | 1 |
| Hiriart, M | 1 |
| Yue, H | 1 |
| Lee, JD | 1 |
| Shimizu, H | 1 |
| Uzui, H | 1 |
| Mitsuke, Y | 1 |
| Ueda, T | 1 |
| Ghoneim, MM | 1 |
| Tawfik, A | 1 |
| Khashaba, PY | 1 |
| Niopas, I | 1 |
| Daftsios, AC | 1 |
| Chander, V | 1 |
| Chopra, K | 1 |
| Rahman, N | 2 |
| Azmi, SN | 1 |
| Hung, GH | 1 |
| Jones, RL | 1 |
| Lam, FF | 1 |
| Chan, KM | 1 |
| Hidaka, H | 1 |
| Suzuki, M | 1 |
| Sasaki, Y | 2 |
| Pastera, J | 1 |
| Mejstríková, L | 1 |
| Zoulová, J | 1 |
| Macek, K | 1 |
| Kvetina, J | 1 |
| Hutson, JM | 1 |
| Clarke, MC | 1 |
| Wang, XD | 1 |
| Li, JL | 1 |
| Lu, Y | 1 |
| Chen, X | 1 |
| Huang, M | 1 |
| Chowbay, B | 1 |
| Zhou, SF | 1 |
| Vo, D | 1 |
| Matowe, WC | 1 |
| Iqbal, N | 1 |
| Wolowyk, MW | 1 |
| Howlett, SE | 1 |
| Knaus, EE | 1 |
| Takeuchi, A | 1 |
| Kimura, T | 1 |
| Satoh, S | 1 |
| Grundy, JS | 1 |
| Kherani, R | 1 |
| Foster, RT | 1 |
| Bainton, CR | 1 |
| Strichartz, GR | 1 |
| Powell, J | 1 |
| Pickering, A | 1 |
| Wyke, M | 1 |
| Goggin, T | 1 |
| Smart, D | 1 |
| Lambert, DG | 1 |
| Beevers, DG | 1 |
| Sleight, P | 1 |
| Tonsuwannont, W | 1 |
| Praisontarangkul, OA | 1 |
| Manorot, M | 1 |
| Klangwarnwong, D | 1 |
| Borderies, JR | 1 |
| Jiménez, M | 1 |
| Angel, F | 1 |
| Horváth, V | 1 |
| Hrabéczy-Páll, A | 1 |
| Niegreisz, Z | 1 |
| Kocsi, E | 1 |
| Horvai, G | 1 |
| Gödörházy, L | 1 |
| Tolokán, A | 1 |
| Klebovich, I | 1 |
| Balogh-Nemes, K | 1 |
| Sentürk, Z | 1 |
| Ozkan, SA | 1 |
| Ozkan, Y | 1 |
| Siekmann, L | 1 |
| Siekmann, A | 1 |
| Bidlingmaier, F | 1 |
| Brill, K | 1 |
| Albring, M | 1 |
| Pawula, M | 1 |
| Watson, D | 1 |
| Teramura, T | 1 |
| Watanabe, T | 1 |
| Higuchi, S | 1 |
| Cheng, KN | 1 |
| Streel, B | 1 |
| Zimmer, C | 1 |
| Sibenaler, R | 1 |
| Ceccato, A | 1 |
| James, MA | 1 |
| Rakicka, H | 1 |
| Panerai, RB | 1 |
| Potter, JF | 1 |
| Anderson, RB | 1 |
| Hollenberg, NK | 1 |
| Williams, GH | 1 |
| Nakamura, I | 1 |
| Takahashi, M | 1 |
| Izumi, H | 1 |
| Maniewski, R | 1 |
| Leger, P | 1 |
| Lewandowski, P | 1 |
| Liebert, A | 1 |
| Bendayan, P | 1 |
| Boccalon, H | 1 |
| Bajorski, L | 1 |
| Möller, KO | 1 |
| Abou-Auda, HS | 1 |
| Najjar, TA | 1 |
| Al-Khamis, KI | 1 |
| Al-Hadiya, BM | 1 |
| Ghilzai, NM | 1 |
| Al-Fawzan, NF | 1 |
| Yriti, M | 1 |
| Parra, P | 1 |
| Iglesias, E | 1 |
| Barbanoj, JM | 1 |
| Konychev, AV | 1 |
| Koreshkina, TA | 1 |
| Kokorin, KV | 1 |
| Kaiukov, AV | 1 |
| Parija, SC | 1 |
| Raviprakash, V | 1 |
| Telang, AG | 1 |
| Varshney, VP | 1 |
| Mishra, SK | 1 |
| Belal, F | 1 |
| Abdine, H | 1 |
| Zoman, N | 1 |
| Kuroda, Y | 1 |
| Cao, B | 1 |
| Shibukawa, A | 1 |
| Nakagawa, T | 1 |
| Joseph, JA | 1 |
| Fisher, DR | 1 |
| Strain, J | 1 |
| Hoda, MN | 1 |
| Wilson, J | 1 |
| Orchard, MA | 1 |
| Prentice, CR | 1 |
| Lees, AD | 1 |
| Baig, MW | 1 |
| Perrins, EJ | 1 |
| Davies, JA | 1 |
| Roccatello, D | 1 |
| Picciotto, G | 1 |
| Rabbia, C | 1 |
| Pozzato, M | 1 |
| De Filippi, PG | 1 |
| Piccoli, G | 1 |
| Brunette, MG | 1 |
| Leclerc, M | 1 |
| Duverne, C | 1 |
| Bouten, A | 1 |
| Deslandes, A | 1 |
| Westphal, JF | 1 |
| Trouvin, JH | 1 |
| Farinotti, R | 1 |
| Carbon, C | 1 |
| France, LA | 1 |
| Lewis, JA | 1 |
| Kay, R | 1 |
2 reviews available for nifedipine and Sensitivity and Specificity
| Article | Year |
|---|---|
Short acting dihydropyridine (vasodilating) calcium channel blockers for hypertension: is there a risk?
Topics: Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Humans; | 1996 |
[Raynaud's phenomenon: clinical aspects of the disease].
Topics: Calcium Channel Blockers; Cold Temperature; Diagnosis, Differential; Female; Humans; Iloprost; Male; | 2001 |
8 trials available for nifedipine and Sensitivity and Specificity
| Article | Year |
|---|---|
Bioequivalence of nifedipine softgel and capsule in healthy Chinese volunteers by liquid chromatography-mass spectrometry.
Topics: Adult; Asian People; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cross-Over Stud | 2010 |
Determination of nifedipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
Topics: Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Stability; Humans; Least-Squ | 2011 |
The effects of anti-hypertensive medication on learning and memory.
Topics: Adult; Aged; Analysis of Variance; Atenolol; Blood Pressure; Cilazapril; Double-Blind Method; Female | 1993 |
Pharmacokinetics of oral lidocaine and nifedipine in patients with liver cirrhosis.
Topics: Administration, Oral; Adult; Anesthetics; Cross-Over Studies; Female; Hemodynamics; Humans; Lidocain | 1996 |
Gestodene and desogestrel do not have a different influence on concentration profiles of ethinylestradiol in women taking oral contraceptives--results of isotope dilution mass spectrometry measurements.
Topics: Administration, Oral; Area Under Curve; Biological Availability; Carbon Isotopes; Contraceptives, Or | 1998 |
Baroreflex sensitivity changes with calcium antagonist therapy in elderly subjects with isolated systolic hypertension.
Topics: Age Factors; Aged; Baroreflex; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cros | 1999 |
Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Constipation; Dou | 1999 |
Liquid chromatographic assay of nifedipine in human plasma and its application to pharmacokinetic studies.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; Nifedipine; Reference Values | 2000 |
41 other studies available for nifedipine and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
A more rapid, sensitive, and specific HPLC-MS/MS method for nifedipine analysis in human plasma and application to a pharmacokinetic study.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Humans; Male; Nifedipine; Sensitivity and | 2013 |
Determination of nifedipine in dog plasma by high-performance liquid chromatography with tandem mass spectrometric detection.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Linear Models; Male; Nifedipine; Reproducibilit | 2014 |
Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study.
Topics: Acetates; Administration, Oral; Buffers; Calcium Channel Blockers; Calibration; Chromatography, Liqu | 2008 |
Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node.
Topics: Acidosis; Animals; Atrioventricular Node; Calcium Channels, L-Type; Electrophysiology; Hydrogen-Ion | 2009 |
Highly sensitive and rapid ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of nifedipine in human plasma and its application to a bioequivalence study.
Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Drug Stability; High-Throughput Scree | 2012 |
Sensitive LC-MS/MS-ESI method for simultaneous determination of nifedipine and atenolol in human plasma and its application to a human pharmacokinetic study.
Topics: Atenolol; Chromatography, Liquid; Drug Stability; Humans; Linear Models; Liquid-Liquid Extraction; M | 2013 |
Nerve growth factor increases L-type calcium current in pancreatic beta cells in culture.
Topics: Animals; Bucladesine; Calcium Channels; Cells, Cultured; Islets of Langerhans; Male; Membrane Potent | 2002 |
Effects of magnesium on the production of extracellular matrix metalloproteinases in cultured rat vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Magn | 2003 |
Cathodic adsorptive stripping square-wave voltammetric determination of nifedipine drug in bulk, pharmaceutical formulation and human serum.
Topics: Calcium Channel Blockers; Electrochemistry; Electrodes; Humans; Nifedipine; Oxidation-Reduction; Pha | 2003 |
Determination of nifedipine in human plasma by solid-phase extraction and high-performance liquid chromatography: validation and application to pharmacokinetic studies.
Topics: Adult; Calcium Channel Blockers; Calibration; Chromatography, High Pressure Liquid; Humans; Male; Ni | 2003 |
Nifedipine attenuates changes in nitric oxide levels, renal oxidative stress, and nephrotoxicity induced by cyclosporine.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Cyclosporine; Disease Models, Animal; Immunohistochem | 2005 |
New spectrophotometric methods for the determination of nifedipine in pharmaceutical formulations.
Topics: Dimethyl Sulfoxide; Indicators and Reagents; Nifedipine; Pharmaceutical Preparations; Sensitivity an | 2005 |
Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Animals; Dinoprosto | 2006 |
Simultaneous determination of nitrendipine and one of its metabolites in plasma samples by gas chromatography with electron-capture detection.
Topics: Calibration; Chromatography, Gas; Drug Stability; Felodipine; Freezing; Humans; Molecular Structure; | 2007 |
The role of sympathetic innervation in the developing rat gubernaculum.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Calcium Chloride; Cryptorchidism; Dose-R | 2007 |
Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study.
Topics: Calcium Channel Blockers; Drug Interactions; Humans; Hypericum; Nifedipine; Reference Standards; Rep | 2007 |
Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate racemates and enantiomers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Effects of nifedipine and Bay-K-8644 on the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Sensitive high-performance liquid chromatographic assay for nifedipine in human plasma utilizing ultraviolet detection.
Topics: Chromatography, High Pressure Liquid; Humans; Nifedipine; Regression Analysis; Sensitivity and Speci | 1994 |
Concentration dependence of lidocaine-induced irreversible conduction loss in frog nerve.
Topics: Action Potentials; Animals; Calcium Channels; Drug Interactions; In Vitro Techniques; Kinetics; Lido | 1994 |
Desensitization of the mu-opioid activation of phospholipase C in SH-SY5Y cells: the role of protein kinases C and A and Ca(2+)-activated K+ currents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Non-adrenergic, non-cholinergic inhibitory junction potential in rat colonic circular muscle is partly sensitive to omega-conotoxin GVIA and resistant to L-, P- or Q-type calcium channel blockers.
Topics: Adrenergic Fibers; Animals; Calcium; Calcium Channel Blockers; Cholinergic Fibers; Colon; Electric S | 1996 |
Sensitive high-performance liquid chromatographic determination of nifedipine in dog plasma using an automated sample preparation system with laboratory robot.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dogs; Electrochemistry; Nif | 1996 |
Electroanalytical study of nifedipine using activated glassy carbon electrode.
Topics: Calcium Channel Blockers; Carbon; Electrochemistry; Electrodes; Nifedipine; Oxidation-Reduction; Rep | 1998 |
Sensitive and specific liquid chromatographic-tandem mass spectrometric assay for barnidipine in human plasma.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Nifedipin | 1998 |
Simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Calcium Channel Blockers; Chromatography, Liquid; Humans; Mass Spectrometry; Nifedipine; Reproducibi | 1998 |
Sensitive high-performance liquid chromatographic determination of nifedipine in cat plasma following improved sample treatment.
Topics: Animals; Calcium Channel Blockers; Cats; Chromatography, High Pressure Liquid; Nifedipine; Reproduci | 1999 |
Spectral analysis of laser-Doppler perfusion signal measured during thermal test.
Topics: Adult; Algorithms; Case-Control Studies; Cold Temperature; Female; Humans; Laser-Doppler Flowmetry; | 1999 |
Quantitation of nifedipine in human plasma by on-line solid-phase extraction and high-performance liquid chromatography.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; Nifedipine; Reference Standa | 2000 |
Influence of hypothyroid state on 45Ca(2+) influx and sensitivity of rat uterus to nifedipine and diltiazem.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Diltiazem; Dose-Response Relation | 2001 |
Voltammetric determination of nilvadipine in dosage forms and spiked human urine.
Topics: Antihypertensive Agents; Dosage Forms; Humans; Hydrogen-Ion Concentration; Nifedipine; Polarography; | 2001 |
Effect of oxidation of low-density lipoprotein on drug binding affinity studied by high performance frontal analysis-capillary electrophoresis.
Topics: Calcium Channel Blockers; Electrophoresis, Capillary; Lipoproteins, LDL; Molecular Structure; Nifedi | 2001 |
Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells.
Topics: Aging; Animals; Antioxidants; Calcium; Calcium Channel Blockers; Cell Survival; Chlorocebus aethiops | 2002 |
Spectrophotometric method for the determination of nifedipine with 4-(methylamino)phenol and potassium dichromate.
Topics: Aminophenols; Ammonium Chloride; Drug Stability; Hot Temperature; Hydroxylamines; Linear Models; Nif | 2002 |
Treatment of hypertension induces a fall in platelet basal cytoplasmic calcium concentration without influencing platelet aggregation.
Topics: Adult; Aged; Basal Metabolism; Blood Platelets; Blood Pressure; Calcium; Cytoplasm; Drug Therapy, Co | 1992 |
Prospective study on captopril renography in hypertensive patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Captopril; Female; Humans; Hyperte | 1992 |
Ca2+ transport through the brush border membrane of human placenta syncytiotrophoblasts.
Topics: Adenosine Triphosphate; Biological Transport; Calcium; Calcium Radioisotopes; Calcium-Binding Protei | 1992 |
Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system.
Topics: Administration, Oral; Adult; Biological Availability; Biological Transport, Active; Cefixime; Cefota | 1992 |
The analysis of failure time data in crossover studies.
Topics: Analysis of Variance; Angina Pectoris; Atenolol; Bias; Clinical Trials as Topic; Confidence Interval | 1991 |