nifedipine and Puerperal Disorders studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.

Research Excerpts

Excerpt	Relevance	Reference
"To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension."	9.24	Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial. ( Greene, N; Kilpatrick, SJ; Sharma, KJ, 2017)
"A 34-year-old mother developed acute myocardial infarction (MI) 10 days postpartum while taking bromocriptine for ablactation."	7.69	Acute myocardial infarction in a healthy mother using bromocriptine for milk suppression. ( Hopp, L; Iffy, L; Weisse, AB, 1996)
"The calcium antagonist, nifedipine, was given orally to 21 women with acute episodes of severe hypertension during pregnancy or in the puerperium."	7.67	Treatment of severe pregnancy-associated hypertension with the calcium antagonist nifedipine. ( Redman, CW; Walters, BN, 1984)
"To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension."	5.24	Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial. ( Greene, N; Kilpatrick, SJ; Sharma, KJ, 2017)
"A 34-year-old mother developed acute myocardial infarction (MI) 10 days postpartum while taking bromocriptine for ablactation."	3.69	Acute myocardial infarction in a healthy mother using bromocriptine for milk suppression. ( Hopp, L; Iffy, L; Weisse, AB, 1996)
"The calcium antagonist, nifedipine, was given orally to 21 women with acute episodes of severe hypertension during pregnancy or in the puerperium."	3.67	Treatment of severe pregnancy-associated hypertension with the calcium antagonist nifedipine. ( Redman, CW; Walters, BN, 1984)

Research

Studies (12)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Time (Hours) to Attain Sustained Blood Pressure Goal After Treatment Initiated With Antihypertensive Medication

Total Length of Hospital Stay in Days

Mean Arterial Blood Pressure (MAP)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (16.67)	18.7374
1990's	4 (33.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Sharma, KJ	2
Kilpatrick, SJ	2
Jansen, S	1
Sampene, K	1
Greene, N	1
Veena, P	1
Perivela, L	1
Raghavan, SS	1
Bornstein, A	1
Dalal, P	1
Tischler, J	1
Novack, S	1
Michaelson, S	1
Walters, BN	1
Redman, CW	1
Korzets, Z	1
Ben-Chitrit, S	1
Bernheim, J	1
Hopp, L	1
Weisse, AB	1
Iffy, L	1
Hironaka, K	1
Makino, H	1
Kumagai, I	1
Haramoto, T	1
Yamasaki, Y	1
Shikata, K	1
Takahashi, M	1
Nishii, M	1
Ota, Z	1
Walss Rodríguez, RJ	1
Villarreal Ordaz, F	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized Control Trial of Furosemide or Placebo With Usual Antihypertensives in the Antepartum Management of Severe Hypertension With Wide Pulse Pressure[NCT04615624]	Phase 3	65 participants (Actual)	Interventional	2021-01-04	Completed
Comparison of Oral Nifedipine to Oral Labetolol for the Management of Severe Postpartum Hypertension[NCT02168309]		50 participants (Actual)	Interventional	2014-06-30	Completed
Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension: A Randomized Controlled Noninferiority Trial[NCT04790279]	Phase 4	132 participants (Actual)	Interventional	2021-04-09	Completed
Lasix for the Prevention of De Novo Postpartum Hypertension: A Randomized Controlled Trial (LAPP Trial)[NCT04752475]	Phase 3	82 participants (Actual)	Interventional	2021-10-20	Completed
Postpartum Management of Gestational Hypertensive Disorders Using Furosemide: A Randomized Controlled Trial[NCT04343235]	Phase 4	13 participants (Actual)	Interventional	2020-05-01	Terminated (stopped due to Challenges with enrollment; primary investigator left the institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	hours (Mean)
Labetalol	37.6
Nifedipine	38.2

Intervention	days (Mean)
Labetalol	4.0
Nifedipine	4.3

Difference in MAP averaged over the 24 hours prior to discharge or the 24 hours prior to antihypertensive therapy initiation (whichever occurs first) (NCT04752475)
Timeframe: 24 hours prior to discharge through discharge, up to 7 days

Breastfeeding Status

Intervention	mmHg (Mean)
Lasix (Furosemide)	88.9
Placebo	86.8

breastfeeding continuation after discharge (NCT04343235)
Timeframe: at 1 week postpartum visit

Change of Dose for Antihypertensive Therapy

Intervention	Participants (Count of Participants)
Labetalol + Furosemide	1
Labetalol Only	3

number of patients who require a change in the dose of labetalol to control BP (NCT04343235)
Timeframe: Change in dose of hypertensive therapy from randomization until hospital discharge (up to 7 days)

Hospital Length of Stay

Intervention	Participants (Count of Participants)
Labetalol + Furosemide	3
Labetalol Only	0

days in hospital after delivery (NCT04343235)
Timeframe: Number of days of hospital stay from randomization to discharge

Hospital Readmission

Intervention	days (Mean)
Labetalol + Furosemide	3.5
Labetalol Only	4.3

readmission for hypertension management (NCT04343235)
Timeframe: up to 14 days after discharge

Change of Gestational Hypertensive Disorder Symptoms (Diastolic BP)

Intervention	Participants (Count of Participants)
Labetalol + Furosemide	1
Labetalol Only	2

average diastolic blood pressure reading on Day 0, Day 1, and Day 2 (NCT04343235)
Timeframe: Average diastolic blood pressure on Day 0, Day 1, and Day 2

Change of Gestational Hypertensive Disorder Symptoms (Mean Arterial Pressure)

Intervention	mm of mercury (Mean)
	Day 0	Day 1	Day 2
Labetalol + Furosemide	84.1	81.8	78.8
Labetalol Only	80.1	80.7	75.5

average mean arterial pressure reading on Day 0, Day 1, and Day 2 (NCT04343235)
Timeframe: Average mean arterial pressure on Day 0, Day 1, and Day 2

Change of Gestational Hypertensive Disorder Symptoms (Systolic BP)

Intervention	mm of mercury (Mean)
	Day 0	Day 1	Day 2
Labetalol + Furosemide	102.4	99.5	98.0
Labetalol Only	100.0	100.1	96.0

average systolic blood pressure reading on Day 0, Day 1, and Day 2 (NCT04343235)
Timeframe: Average systolic blood pressure for Day 0, Day 1, and Day 2

Article	Year
Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Labetalol; Nifedipine;	2017
Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Labetalol; Nifedipine;	2017
Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Labetalol; Nifedipine;	2017
Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Labetalol; Nifedipine;	2017
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni	2017
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni	2017
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni	2017
Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Ni	2017
[Management of severe pre-eclampsia in the puerperium. Comparative study of sublingual nifedipine and hydralazine]. Ginecologia y obstetricia de Mexico, 1991, Volume: 59 Topics: Administration, Sublingual; Adolescent; Adult; Antihypertensive Agents; Female; Humans; Hydralazine;	1991

Article	Year
Committee Opinion No. 692 Summary: Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period. Obstetrics and gynecology, 2017, Volume: 129, Issue:4 Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Drug Administration Routes; E	2017
Committee Opinion No. 692: Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period. Obstetrics and gynecology, 2017, Volume: 129, Issue:4 Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Drug Administration Routes; E	2017
Raynaud Phenomenon of the Nipple: An Under-Recognized Condition. Obstetrics and gynecology, 2019, Volume: 133, Issue:5 Topics: Adult; Breast Diseases; Diagnosis, Differential; Female; Humans; Nifedipine; Nipples; Pain; Pregnanc	2019
Acute myocardial infarction in a thirty-six year old postpartum female. Angiology, 1984, Volume: 35, Issue:9 Topics: Adult; Aspirin; Digoxin; Electrocardiography; Ergonovine; Female; Heart Aneurysm; Humans; Isosorbide	1984
Treatment of severe pregnancy-associated hypertension with the calcium antagonist nifedipine. British journal of obstetrics and gynaecology, 1984, Volume: 91, Issue:4 Topics: Adolescent; Adult; Blood Pressure; Female; Humans; Hypertension; Nifedipine; Pilot Projects; Pregnan	1984
Bradycardia as a presenting feature of late postpartum eclampsia. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9, Issue:8 Topics: Adult; Bradycardia; Drug Therapy, Combination; Eclampsia; Female; Humans; Magnesium Sulfate; Nifedip	1994
Acute myocardial infarction in a healthy mother using bromocriptine for milk suppression. The Canadian journal of cardiology, 1996, Volume: 12, Issue:4 Topics: Adult; Bromocriptine; Coronary Vasospasm; Dose-Response Relationship, Drug; Female; Humans; Lactatio	1996
A case of nephrotic syndrome and renal dysfunction in a pregnant woman with diabetes mellitus. Diabetic medicine : a journal of the British Diabetic Association, 1992, Volume: 9, Issue:3 Topics: Adult; Basement Membrane; Biopsy; Calcium Channel Blockers; Capillaries; Diabetic Nephropathies; End	1992

nifedipine and Puerperal Disorders