Page last updated: 2024-11-01

nifedipine and Myocardial Ischemia

nifedipine has been researched along with Myocardial Ischemia in 104 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

Research Excerpts

ExcerptRelevanceReference
"We sought to determine the effect of nifedipine gastrointestinal therapeutic system (GITS) or atenolol on ischemic left ventricular dysfunction induced by mental stress."9.08Effects of therapy with nifedipine GITS or atenolol on mental stress-induced ischemic left ventricular dysfunction. ( Andrews, TC; Carlson, W; Cummings, N; Friedman, R; Jacobs, S; MacCallum, G; Mannting, F; Muller, JE; Parker, JD; Stone, PH; Tofler, GH, 1998)
"In a randomized, cross-over, double-blind study, the effects of nifedipine were compared with those of diltiazem in 20 patients with severe stable angina pectoris and multivessel coronary artery disease treated with nitrates and beta-blockers."9.07Effects of nifedipine and diltiazem on myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers. ( Meluzín, J; Simek, P; Stĕtka, F; Zeman, K, 1992)
"META-ANALYSIS: A meta-analysis of published randomized control trials of nifedipine in hypertension and stable angina pectoris was performed."8.79Searching for signals: mortality and cardiovascular events in published randomized control trials of nifedipine in ischemic heart disease and hypertension. ( Caubet, JF; Chalmers, TC; Cory, D; Kupelnick, B; Ross, SD; Schmid, CH; Stason, W; Whiting, G, 1996)
"In patients with coronary disease, the use of short-acting nifedipine in moderate to high doses causes an increase in total mortality."8.79Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. ( Furberg, CD; Meyer, JV; Psaty, BM, 1995)
" The effects of the calcium channel blockers, verapamil and nifedipine on myocardial ischaemia and oedema evoked by endothelin-1 (ET-1) or IRL 1620, an ETB receptor-selective agonist were studied in anaesthetized and conscious rats."7.69Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat. ( Filep, JG; Földes-Filep, E; Fournier, A; Skrobik, Y, 1996)
"Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem."7.69Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis. ( Araki, H; Higuchi, S; Kishi-Tanikawa, S; Takahashi, K; Takahashi, T; Tsuchida, K, 1996)
"Gingival hyperplasia caused by the use of nifedipine has been extensively reported."7.69Clinical assessment of gingival hyperplasia in patients treated with nifedipine. ( Bullon, P; Lacalle, JR; Machuca, G; Martinez-Sahuquillo, A; Rios, JV; Rojas, J, 1994)
"We investigated the effect of abrupt cessation of nifedipine after regular administration (20 mg, four times daily) for 5 weeks in seven patients with stable angina pectoris."7.68Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris. ( Koutishenko, N; Martsevich, SY; Metelitsa, VI, 1993)
"To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0."6.67[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993)
"Nifedipine was administered to 20 patients (8 in group 1, and 12 in group 2)."6.67Transient myocardial ischemia during nifedipine therapy in stable angina pectoris, and its relation to coronary collateral flow and comparison with metoprolol. ( Andersen, PE; Egstrup, K, 1993)
"A randomized study was performed on 70 patients undergoing elective coronary bypass grafting to examine whether the combined infusion of the calcium channel blocker nifedipine (10 micrograms/kg per hour) and the beta 1-blocker metopropol (12 micrograms/kg per hour, n = 34) reduces the prevalence of perioperative myocardial ischemia and arrhythmias."5.08Comparison of perioperative myocardial protection with nifedipine versus nifedipine and metoprolol in patients undergoing elective coronary artery bypass grafting. ( Binder, TM; Podesser, BK; Schwarzacher, S; Seitelberger, R; Wolner, E; Zwoelfer, W, 1995)
"We compared the effects of bisoprolol on transient myocardial ischemia with those of nifedipine in patients with chronic stable angina."5.08Medical treatment to reduce total ischemic burden: total ischemic burden bisoprolol study (TIBBS), a multicenter trial comparing bisoprolol and nifedipine. The TIBBS Investigators. ( von Arnim, T, 1995)
"The effects of bisoprolol on transient myocardial ischemia have been compared with those of nifedipine in patients with coronary artery disease in end-stage renal failure maintained on haemodialysis."5.08[Effectiveness and tolerability of bisoprolol vs. nifedipine in uremic patients with ischemic cardiopathy in dialysis treatment]. ( Cice, G; Di Benedetto, A; Ferrara, L; Iacono, A; Sorice, P; Tagliamonte, E, 1997)
"We sought to determine the effect of nifedipine gastrointestinal therapeutic system (GITS) or atenolol on ischemic left ventricular dysfunction induced by mental stress."5.08Effects of therapy with nifedipine GITS or atenolol on mental stress-induced ischemic left ventricular dysfunction. ( Andrews, TC; Carlson, W; Cummings, N; Friedman, R; Jacobs, S; MacCallum, G; Mannting, F; Muller, JE; Parker, JD; Stone, PH; Tofler, GH, 1998)
" Patients of stable angina pectoris treated with Radix Codonopsitis Pilosulae (50 cases) or Nifedipine (20 cases) were observed as well."5.08[Clinical study on relationship among Heart-Qi Deficiency, left ventricular function and myocardial ischemia in patients with coronary heart disease]. ( Lu, X; Wang, S; Zhao, M, 1998)
"A randomised study was performed on 70 patients undergoing elective coronary by-pass procedure to examine whether the combined, perioperative, 24-hour infusion of nifedipine and metoprolol reduces the incidence of perioperative myocardial ischemia and arrhythmias."5.07Perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary by-pass surgery. ( Binder, T; Huber, S; Peschl, F; Podesser, B; Schwarzacher, S; Seitelberger, R; Spatt, J; Wolner, E; Zwölfer, W, 1994)
"A randomized study was performed on 70 patients undergoing elective coronary bypass surgery to examine whether the combined, perioperative, 24-hour infusion of the calcium-channel blocker nifedipine (10 micrograms/kg/h) and the beta 1-blocker metoprolol (12 micrograms/kg/h) reduces the incidence of perioperative myocardial ischemia and arrhythmias (group NM, n = 34)."5.07Combined perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary bypass surgery. ( Binder, TM; Huber, S; Peschl, F; Podesser, B; Schwarzacher, S; Seitelberger, R; Spatt, J; Zwölfer, W, 1993)
"The effects of verapamil, nifedipine, propranolol, and combinations of nifedipine+propranolol and nifedipine+verapamil were studied in 60 patients with stable angina pectoris."5.07[Effect of various antianginal agents on the frequency and duration of myocardial ischemic episodes in patients with stable angina pectoris]. ( Lysenko, AF; Voronkov, LG, 1992)
"In a randomized, cross-over, double-blind study, the effects of nifedipine were compared with those of diltiazem in 20 patients with severe stable angina pectoris and multivessel coronary artery disease treated with nitrates and beta-blockers."5.07Effects of nifedipine and diltiazem on myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers. ( Meluzín, J; Simek, P; Stĕtka, F; Zeman, K, 1992)
"META-ANALYSIS: A meta-analysis of published randomized control trials of nifedipine in hypertension and stable angina pectoris was performed."4.79Searching for signals: mortality and cardiovascular events in published randomized control trials of nifedipine in ischemic heart disease and hypertension. ( Caubet, JF; Chalmers, TC; Cory, D; Kupelnick, B; Ross, SD; Schmid, CH; Stason, W; Whiting, G, 1996)
"In patients with coronary disease, the use of short-acting nifedipine in moderate to high doses causes an increase in total mortality."4.79Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. ( Furberg, CD; Meyer, JV; Psaty, BM, 1995)
"Electron paramagnetic resonance (EPR) spectroscopy was used to investigate the gamma-radiation damage in the crystalline powder form of nine calcium channel blockers from the 1,4-dihydropyridine derivatives, which are in clinical use for treatment of arteria hypertension and ischemic heart disease."3.74The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state. ( Mielcarek, J; Naskrent, M, 2007)
" The effects of diltiazem, verapamil, and nifedipine on extracellular potassium concentration ([K+]e), acidosis, and level of metabolic markers were examined during 30-min global ischemia and postischemic left ventricular (LV) function in isolated guinea pig hearts."3.70Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts. ( Nagao, T; Sato, R; Yamazaki, J, 1999)
"The effects of the Ca2+ channel blockers diltiazem, nifedipine and amlodipine were investigated on both arterial hypertension and myocardial changes induced by chronic blockade of nitric oxide synthesis."3.70Effect of Ca2+ channel blockers on arterial hypertension and heart ischaemic lesions induced by chronic blockade of nitric oxide in the rat. ( Antunes, E; de Luca, IM; de Nucci, G; de Oliveira, CF; Metze, K; Moreno, H; Nathan, LP; Sucupira, M; Zappellini, A; Zatz, R, 1999)
"These results indicate that the calcium channel blocker nifedipine mediates coronary vasodilation and improves myocardial ischemia through both bradykinin/NO-dependent and -independent mechanisms."3.70Nifedipine-induced coronary vasodilation in ischemic hearts is attributable to bradykinin- and NO-dependent mechanisms in dogs. ( Asakura, M; Asanuma, H; Hori, M; Kitakaze, M; Kuzuya, T; Minamino, T; Sakata, Y; Sanada, S; Takashima, S; Ueda, Y, 2000)
"Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem."3.69Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis. ( Araki, H; Higuchi, S; Kishi-Tanikawa, S; Takahashi, K; Takahashi, T; Tsuchida, K, 1996)
"The effect of abrupt discontinuation of nifedipine (N) on exercise tolerance and myocardial ischemia was studied in 7 patients with stable angina pectoris of effort (AP)."3.69[The nifedipine withdrawal syndrome in patients with stable stenocardia of effort]. ( Kutishenko, NP; Martsevich, SIu; Metelitsa, VI, 1995)
" But in a pig model of myocardial ischemia, intracoronary nifedipine was found to reverse the inverted T wave induced by ischemia to upright promptly."3.69[Effect of nifedipine on T wave in ischemic myocardium]. ( He, X; Huang, N; Li, X; Shen, X; Wang, S, 1994)
" The effects of the calcium channel blockers, verapamil and nifedipine on myocardial ischaemia and oedema evoked by endothelin-1 (ET-1) or IRL 1620, an ETB receptor-selective agonist were studied in anaesthetized and conscious rats."3.69Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat. ( Filep, JG; Földes-Filep, E; Fournier, A; Skrobik, Y, 1996)
"To evaluate the effect of acute blood pressure (BP) changes on the myocardial perfusion in hypertensives, 10 patients with and 10 patients without left ventricular hypertrophy (LVH) were examined with 99TCm-Sestamibi scintigraphy at rest and after acute pharmacological BP reduction using nifedipine and captopril."3.69Blood pressure and myocardial perfusion in hypertensive patients with and without left ventricular hypertrophy. ( Berglund, G; Boström, PA; Diemer, H; Lilja, B; Mansour, P; Mattiasson, I; Nehoum, A, 1995)
"Gingival hyperplasia caused by the use of nifedipine has been extensively reported."3.69Clinical assessment of gingival hyperplasia in patients treated with nifedipine. ( Bullon, P; Lacalle, JR; Machuca, G; Martinez-Sahuquillo, A; Rios, JV; Rojas, J, 1994)
"We investigated the effect of abrupt cessation of nifedipine after regular administration (20 mg, four times daily) for 5 weeks in seven patients with stable angina pectoris."3.68Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris. ( Koutishenko, N; Martsevich, SY; Metelitsa, VI, 1993)
"Therapy with OSMO-Adalat of patients with AH combination with KPA provides a good hypotensive effect and relieves symptoms of encephalopathy, myocardial ischemia and orthostatic insufficiency in low risk of side effects."2.70[Efficacy of OSMO-Adalat in patients with arterial hypertension in combination with kinked precerebral arteries]. ( Khirmanov, VN; Sorokoumov, VA; Tiurina, TV; Zakharova, IV, 2001)
"Fourteen patients with ischemic heart disease (12 men and two women; mean age 64 years) were administered nifedipine retard at a daily dose of 20-40 mg."2.70Effects of nifedipine retard on heart rate and autonomic balance in patients with ischemic heart disease. ( Aizawa, T; Arai, H; Fukuda, E; Long-Tai, FL; Sato, H; Tsutsumi, Y; Yamamoto, M, 2001)
"Of them 36 had dilated cardiomyopathy (DC), 30 ischemic heart disease (IHD), 19 suffered from essential hypertension (EH)."2.67[Differential use of vasodilators in various types of cardiac insufficiency]. ( Cheltsov, VV; Moiseev, VS; Shatkovskiĭ, NP, 1993)
"To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0."2.67[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993)
" After a 4 week run-in period on atenolol, patients were randomly allocated to receive either atenolol alone or its combination with nifedipine and then crossed over to the alternative treatment for a further 4 weeks."2.67Comparison of the efficacy of atenolol and its combination with slow-release nifedipine in chronic stable angina. ( Adnams, C; Commerford, P; Meyer, TE, 1993)
" Nifedipine at a dosage of 200 micrograms or placebo was added to each 1000 ml of St."2.67Cardioprotection by nifedipine cardioplegia during coronary artery surgery. ( Haider, W; Laczkovics, A; Moritz, A; Trubel, W; Zwoelfer, W, 1994)
"Nifedipine was administered to 20 patients (8 in group 1, and 12 in group 2)."2.67Transient myocardial ischemia during nifedipine therapy in stable angina pectoris, and its relation to coronary collateral flow and comparison with metoprolol. ( Andersen, PE; Egstrup, K, 1993)
" During the chronic use of long-acting dihydropyridine (DHP) CCBs, most evidence suggests that there is little or no catecholamine activation, or in the case of amlodipine, even a decrease in plasma catecholamine levels."2.40Calcium channel blockers for hypertension: dissecting the evidence for adverse effects. ( Opie, LH, 1997)
" However, the direct cardiotoxicity in vitro and its mechanisms of toxic action remain unclear."1.38Direct cardiac toxicity of the tentacle-only extract from the jellyfish Cyanea capillata demonstrated in isolated rat heart. ( Beilei, W; Jia, L; Liang, X; Liming, Z; Lin, Z; Qian, H; Qianqian, W; Tao, W; Xiaojuan, W; Xuting, Y, 2012)
" Chronic administration (45 days) produced no toxic effects in vital organs and systems of Wistar rats and ISIAH rats."1.37Glycidipine, a promising hypotensive and cardioprotective agent. ( Belenichev, IF; Bryzgalov, AO; Khvostov, MV; Pavlov, SV; Tolstikova, TG, 2011)
"Diltiazem has cardioprotective properties following myocardial ischemic injury."1.31Protective effect of diltiazem against ischemia-induced decreases in regional myocardial flow in rat heart. ( Higuchi, H; Katsumata1, N; Ma, X, 2000)
"38 patients with ischemic heart disease (IHD) and sick sinus syndrome (SSS) received combined therapy with nifedipine (Corinfar-Retard) and talinolol (Cordanum)."1.30[The use of Cordanum in combination with Corinfar-Retard for the treatment of ectopic arrhythmias in the sick sinus syndrome in patients with ischemic heart disease]. ( Arsent'eva, NR; Chernova, EV; Doshchitsin, VL; Kuchinskaia, NG; Lindo, IN; Martynova, VN; Shatukhina, EIu, 1997)
"Nisoldipine did not produce any beneficial effect without the inhibition of the increase in end-diastolic pressure during ischemia nor did it do so without the increase of reperfusion flow."1.29Improvement of ischemic myocardial dysfunction by nisoldipine in relation to its coronary vasodilating action. ( Saida, K; Umeda, M, 1993)
"Nifedipine was applied in a concentration (EC50) known to reduce the contractile force by one-half of its basal value."1.29Cardioprotection by nifedipine in isolated working hearts: a comparative study on three different types of experimental ischemia. ( Mathy, MJ; Pfaffendorf, M; Pijl, AJ; van Zwieten, PA, 1993)
" First, dose-response curves were constructed; from these data the EC50 concentration for the three calcium antagonists was calculated."1.29Hemodynamic and antiischemic effects of nifedipine, lacidipine, and nisoldipine in rat isolated working heart. ( Pfaffendorf, M; Pijl, AJ; van Zwieten, PA, 1993)
"Nifedipine was the most effective with only 5 +/- 2% reduction in blood flow after five ischaemic episodes, whereas reduction of myocardial blood flow was 30 +/- 4% in the presence of gallopamil."1.29Preservation of myocardial blood flow by calcium antagonists does not prevent attenuation of regional myocardial function after repetitive brief periods of myocardial ischaemia in the rat heart. ( Amann, K; Kübler, W; Parekh, N; Rauch, B; Tiefenbacher, CP; Tillmanns, H; Zimmermann, R, 1995)

Research

Studies (104)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's82 (78.85)18.2507
2000's19 (18.27)29.6817
2010's3 (2.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beilei, W1
Lin, Z1
Qian, H1
Qianqian, W1
Tao, W1
Jia, L1
Xiaojuan, W1
Xuting, Y1
Liang, X1
Liming, Z1
Tolstikova, TG1
Khvostov, MV1
Bryzgalov, AO1
Belenichev, IF1
Pavlov, SV1
Mamedov, MN1
Möllhoff, T1
Schmidt, C1
Van Aken, H1
Berendes, E1
Buerkle, H1
Marmann, P1
Reinbold, T1
Prenger-Berninghoff, R1
Tjan, TD1
Scheld, HH1
Deng, MC1
Altura, BM1
Kostellow, AB1
Zhang, A1
Li, W1
Morrill, GA1
Gupta, RK1
Altura, BT1
Huelsing, DJ1
Spitzer, KW1
Pollard, AE1
Camara, AK1
Chen, Q1
Rhodes, SS1
Riess, ML1
Stowe, DF1
Higashikuni, Y1
Sata, M1
Nagai, R1
Karpov, IuA1
Kosicka, T1
Kara-Perz, H1
Głuszek, J1
Perz, S1
Naskrent, M1
Mielcarek, J1
Noda, T1
Yaginuma, T1
O'Rourke, MF1
Hosoda, S1
Podesser, BK1
Schwarzacher, S3
Zwoelfer, W2
Binder, TM2
Wolner, E2
Seitelberger, R3
Pijl, AJ3
Pfaffendorf, M3
van Zwieten, PA3
Hendriks, MG1
Kam, KL1
Wout van den Toren, E1
de Vries, RJ1
Portegies, MC1
Blanksma, PK1
van Gilst, WH1
Hillege, HJ1
van Veldhuisen, DJ1
Lie, KI1
Mazur, NA1
Pavlova, TS1
Vasil'eva, NN1
Kul'ginskaia, IV1
Furberg, CD1
Psaty, BM1
Meyer, JV1
Martsevich, SIu2
Kutishenko, NP1
Metelitsa, VI2
Mathy, MJ1
Podesser, B2
Zwölfer, W2
Binder, T1
Spatt, J2
Peschl, F2
Huber, S2
von Arnim, T3
Molodan, AV1
Salgalov, AV1
Osaulenko, VV1
Materukhin, AN1
Wang, S2
Shen, X1
Li, X1
Huang, N1
He, X1
Palócz, E1
Kerkovits, G1
Pepine, CJ4
Geller, NL3
Knatterud, GL4
Bourassa, MG2
Chaitman, BR2
Davies, RF3
Day, P1
Deanfield, JE1
Goldberg, AD2
McMahon, RP2
Sopko, G3
Pratt, C2
Stone, PH5
Rogers, WJ1
Meyer, TE1
Adnams, C1
Commerford, P1
Bardenheuer, HJ1
Fabry, A1
Höfling, B1
Peter, K1
Martsevich, SY1
Koutishenko, N1
Trubel, W1
Moritz, A1
Laczkovics, A1
Haider, W1
Bullon, P3
Machuca, G3
Martinez-Sahuquillo, A2
Rios, JV2
Rojas, J2
Lacalle, JR2
Knyshov, GV1
Vykhovaniuk, IV1
Tkhor, NV1
Furkalo, SN1
Korchinskaia, OI1
Shalev, Y1
Ben-Hur, H1
Hagay, Z1
Blickstein, I1
Epstein, M1
Ayzenberg, O1
Gelven, A1
Caspi, A1
Lee, DD1
Rigonan, K1
Dequattro, V1
Moiseev, VS1
Shatkovskiĭ, NP1
Cheltsov, VV1
Ikram, H1
Low, CJ1
Shirlaw, TM1
Foy, SG1
Crozier, IG1
Richards, AM1
Khurmi, NS1
Horsburgh, RJ1
Andrews, TC3
Fenton, T2
Toyosaki, N1
Glasser, SP3
Young, PM2
MacCallum, G3
Gibson, RS1
Shook, TL2
Pupita, G1
Mazzara, D1
Centanni, M1
Rimatori, C1
Ferretti, GF1
Dessì-Fulgheri, P1
Russo, P1
Rappelli, A1
Lombardi, M1
Morales, MA1
Michelassi, C1
Moscarelli, E1
Distante, A1
L'Abbate, A1
Umeda, M1
Saida, K1
Molinero De Miguel, E1
Salcedo Arruti, A1
Sagastagoitia Gorostiza, JD1
Iriarte Ezkurdia, MM1
Fernandez Vidal, P1
Velasco Quintana, J1
Garrido García, J1
Egstrup, K1
Andersen, PE1
Iriarte, M1
Molinero, E1
Sagastagoitia, JD1
Arzubiaga, J1
Aguirre, J1
Salcedo, A1
Mauser, M1
Voelker, W1
Ickrath, O1
Karsch, KR1
Borzak, S1
Kato, M1
Nakashima, Y2
Levine, J1
Goldiner, PL1
Oka, Y1
Beevers, DG1
Sleight, P1
Tiefenbacher, CP1
Zimmermann, R1
Parekh, N1
Amann, K1
Tillmanns, H1
Rauch, B1
Kübler, W1
Pratt, CM1
Goldstein, S1
Dyrda, I1
Frishman, WH1
Hill, JA1
Morgan, NA1
Conti, CR3
Rayo Llerena, I1
Marín Huerta, E1
Cohen, JD1
Pomar Domingo, F1
Cosín Aguilar, J1
Hernándiz, A1
Portoles, M1
Pallarés, V1
Andrés, F1
Boström, PA1
Mansour, P1
Diemer, H1
Mattiasson, I1
Nehoum, A1
Lilja, B1
Berglund, G1
Filep, JG1
Skrobik, Y1
Fournier, A1
Földes-Filep, E1
Takahashi, T1
Takahashi, K1
Kishi-Tanikawa, S1
Tsuchida, K1
Araki, H1
Higuchi, S1
Cheng, DC1
Jiang, MT1
Asokumar, B1
Boylen, P1
Sandler, A1
Velasco, E1
Leor, J1
Battler, A1
Stason, W1
Schmid, CH1
Caubet, JF1
Kupelnick, B1
Cory, D1
Whiting, G1
Chalmers, TC1
Ross, SD1
Kobusiewicz, W1
Ogonowska-Kobusiewicz, M1
Michalak, J1
Ledwozyw, A1
Killip, T1
Forman, S1
Geller, N1
Deanfield, J1
Opie, LH1
Yokoyama, T1
Ichihara, K1
Abiko, Y1
Cice, G1
Di Benedetto, A1
Tagliamonte, E1
Ferrara, L1
Sorice, P1
Iacono, A1
Shibasaki, K1
Arai, Y1
Uchida, W1
Okazaki, T1
Asano, M1
Takenaka, T1
Doshchitsin, VL1
Martynova, VN1
Lindo, IN1
Kuchinskaia, NG1
Chernova, EV1
Shatukhina, EIu1
Arsent'eva, NR1
Smart, SC1
Sagar, KB1
Warltier, DC1
Tomiyama, H1
Watanabe, G1
Siojima, K1
Nishikawa, E1
Nakayama, T1
Yamamoto, A1
Ishikawa, Y1
Yoshida, H1
Doba, N1
Kobayashi, E1
Kitoh, Y1
Fujimura, A1
Garganeeva, AA1
Tepliakov, AT1
Chernov, VI1
Braslavskaia, TG1
Parker, JD1
Jacobs, S1
Friedman, R1
Cummings, N1
Mannting, F1
Tofler, GH1
Carlson, W1
Muller, JE1
Weber, F1
Schneider, H1
Urbaszek, W1
Wenzel, UO1
Pfalzer, B1
Meinertz, T1
Stahl, RA1
Sato, R1
Yamazaki, J1
Nagao, T2
Wang, Y1
Ashraf, M1
Zervos, G1
Zusman, RM1
Swindle, LA1
Alpert, NM1
Fischman, AJ1
Gewirtz, H1
de Oliveira, CF1
Nathan, LP1
Metze, K1
Moreno, H1
de Luca, IM1
Sucupira, M1
Zatz, R1
Zappellini, A1
Antunes, E1
de Nucci, G1
Becker, BF1
Möbert, J1
Kitakaze, M1
Asanuma, H1
Takashima, S1
Minamino, T1
Ueda, Y1
Sakata, Y1
Asakura, M1
Sanada, S1
Kuzuya, T1
Hori, M1
Mahmoudian, M1
Shafiei, M1
Mirkhani, H1
Omrani, GR1
Yamamoto, Y1
Ikegaki, I1
Sasaki, Y1
Uchida, T1
Katsumata1, N1
Ma, X1
Higuchi, H1
Frishman, W1
White, WB1
Stone, P1
Johnson, MF1
Sakamoto, K1
Ishikawa, M1
Koga, K1
Urushidani, T1
Matsumoto, N1
Ideishi, M1
Sasaguri, M1
Nii, T1
Arakawa, K1
Zhao, M1
Lu, X1
Khirmanov, VN1
Tiurina, TV1
Sorokoumov, VA1
Zakharova, IV1
Armas, JR1
Rojas, JL1
Jiménez, G1
Sato, H1
Arai, H1
Fukuda, E1
Tsutsumi, Y1
Yamamoto, M1
Aizawa, T1
Long-Tai, FL1
Saeki, K1
Obi, I1
Ogiku, N1
Shigekawa, M1
Imagawa, T1
Matsumoto, T1
Burger, W1
Fuchs, S1
Burger, KJ1
Kober, G1
Meluzín, J1
Zeman, K1
Stĕtka, F1
Simek, P1
Vorob'ev, LP1
Maev, IV1
V'iuchnova, ES1
Lutaĭ, MI1
Lomakovskiĭ, AN1
Stroganova, NP1
Voronkov, LG1
Lysenko, AF1
Glezer, GA1
Moskalenko, NP1
Gaponenko, VA1
Stoliarov, AS1
Saitova, RA1
Simbirina, TE1
Neĭman, DIu1
Chilikina, ON1
Akhmetova, MG1
Babaev, AB1
Rettig, GF1
Jakob, M1
Koch, HP1
Dupuis, JY1
Nathan, HJ1
Laganière, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000478]Phase 30 participants Interventional1990-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for nifedipine and Myocardial Ischemia

ArticleYear
[Ischemic heart disease combined with hypertension: peculiarities of course and selection of therapy].
    Kardiologiia, 2005, Volume: 45, Issue:12

    Topics: Adrenergic beta-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive

2005
[Indications for calcium channel antagonist therapy according to the latest large clinical trials].
    Polskie Archiwum Medycyny Wewnetrznej, 2005, Volume: 114, Issue:6

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Antihypertensive Agents; Calcium Channel Blockers; Cli

2005
Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.
    Circulation, 1995, Sep-01, Volume: 92, Issue:5

    Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Confidence Intervals; Coronary Dise

1995
Short acting dihydropyridine (vasodilating) calcium channel blockers for hypertension: is there a risk?
    BMJ (Clinical research ed.), 1996, May-04, Volume: 312, Issue:7039

    Topics: Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Humans;

1996
[Silent myocardial ischemia. Arguments against treatment].
    Revista espanola de cardiologia, 1996, Volume: 49, Issue:1

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Atenolol; Bisoprolol; Calcium Channe

1996
1995: the year of the calcium antagonist controversy.
    Current opinion in nephrology and hypertension, 1996, Volume: 5, Issue:3

    Topics: Calcium Channel Blockers; Humans; Hypertension; Myocardial Infarction; Myocardial Ischemia; Nifedipi

1996
Searching for signals: mortality and cardiovascular events in published randomized control trials of nifedipine in ischemic heart disease and hypertension.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1996, Volume: 14, Issue:2

    Topics: Humans; Hypertension; Myocardial Ischemia; Nifedipine; Randomized Controlled Trials as Topic; Vasodi

1996
[Nifedipine in ischemic heart disease: a ban on its use or a differential approach to therapy?].
    Terapevticheskii arkhiv, 1996, Volume: 68, Issue:9

    Topics: Calcium Channel Blockers; Drug Tolerance; Humans; Myocardial Ischemia; Nifedipine; Safety

1996
Calcium channel blockers for hypertension: dissecting the evidence for adverse effects.
    American journal of hypertension, 1997, Volume: 10, Issue:5 Pt 1

    Topics: Calcium Channel Blockers; Catecholamines; Cerebrovascular Disorders; Drug Evaluation; Gastrointestin

1997
Circadian heart rate response to chronotherapy versus conventional therapy in patients with hypertension and myocardial ischemia.
    Clinical cardiology, 2000, Volume: 23, Issue:7

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Amlodipine; Atenolol; Blood Pressure; C

2000

Trials

39 trials available for nifedipine and Myocardial Ischemia

ArticleYear
Myocardial ischaemia in patients with impaired left ventricular function undergoing coronary artery bypass grafting--milrinone versus nifedipin.
    European journal of anaesthesiology, 2002, Volume: 19, Issue:11

    Topics: Aged; Anesthesia, General; Calcium Channel Blockers; Coronary Artery Bypass; Coronary Disease; Creat

2002
Comparison of perioperative myocardial protection with nifedipine versus nifedipine and metoprolol in patients undergoing elective coronary artery bypass grafting.
    The Journal of thoracic and cardiovascular surgery, 1995, Volume: 110, Issue:5

    Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Artery Bypass;

1995
Effect of isradipine and nifedipine on diastolic function in patients with left ventricular dysfunction due to coronary artery disease: a randomized, double-blind, nuclear, stethoscope study.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:6

    Topics: Adult; Aged; Angina Pectoris; Atrial Function, Right; Cardiac Pacing, Artificial; Diastole; Double-B

1994
[The comparative efficacy of verapamil, nifedipine and propranolol in patients with IHD and an enhanced risk of a fatal outcome].
    Terapevticheskii arkhiv, 1994, Volume: 66, Issue:8

    Topics: Adult; Cardiac Complexes, Premature; Electrocardiography, Ambulatory; Exercise Tolerance; Humans; Ma

1994
Perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary by-pass surgery.
    The Journal of cardiovascular surgery, 1994, Volume: 35, Issue:6 Suppl 1

    Topics: Arrhythmias, Cardiac; Coronary Artery Bypass; Creatine Kinase; Electrocardiography, Ambulatory; Enda

1994
Medical treatment to reduce total ischemic burden: total ischemic burden bisoprolol study (TIBBS), a multicenter trial comparing bisoprolol and nifedipine. The TIBBS Investigators.
    Journal of the American College of Cardiology, 1995, Volume: 25, Issue:1

    Topics: Adult; Aged; Angina Pectoris; Bisoprolol; Double-Blind Method; Electrocardiography, Ambulatory; Euro

1995
The Asymptomatic Cardiac Ischemia Pilot (ACIP) study: design of a randomized clinical trial, baseline data and implications for a long-term outcome trial.
    Journal of the American College of Cardiology, 1994, Volume: 24, Issue:1

    Topics: Aged; Angina Pectoris; Atenolol; Diltiazem; Drug Therapy, Combination; Female; Humans; Isosorbide Di

1994
Effects of treatment strategies to suppress ischemia in patients with coronary artery disease: 12-week results of the Asymptomatic Cardiac Ischemia Pilot (ACIP) study.
    Journal of the American College of Cardiology, 1994, Volume: 24, Issue:1

    Topics: Aged; Atenolol; Coronary Disease; Diltiazem; Drug Therapy, Combination; Female; Humans; Isosorbide D

1994
Comparison of the efficacy of atenolol and its combination with slow-release nifedipine in chronic stable angina.
    Cardiovascular drugs and therapy, 1993, Volume: 7, Issue:6

    Topics: Angina Pectoris; Atenolol; Blood Pressure; Chronic Disease; Delayed-Action Preparations; Double-Blin

1993
Cardioprotection by nifedipine cardioplegia during coronary artery surgery.
    European journal of anaesthesiology, 1994, Volume: 11, Issue:2

    Topics: Arrhythmias, Cardiac; Bicarbonates; Calcium Chloride; Cardiac Output; Cardiac Output, Low; Cardiople

1994
Increased blood pressure and neural tone in the silent ischemia of hypertension: disparate effects of immediate release nifedipine.
    Journal of the American College of Cardiology, 1993, Nov-01, Volume: 22, Issue:5

    Topics: Activities of Daily Living; Adult; Aged; Angina Pectoris; Blood Pressure; Circadian Rhythm; Echocard

1993
[Differential use of vasodilators in various types of cardiac insufficiency].
    Klinicheskaia meditsina, 1993, Volume: 71, Issue:4

    Topics: Adult; Aged; Blood Pressure; Captopril; Cardiomyopathy, Dilated; Female; Humans; Hypertension; Male;

1993
Angiotensin converting enzyme inhibition in chronic stable angina: effects on myocardial ischaemia and comparison with nifedipine.
    British heart journal, 1994, Volume: 71, Issue:1

    Topics: Adult; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Chronic Diseas

1994
Subsets of ambulatory myocardial ischemia based on heart rate activity. Circadian distribution and response to anti-ischemic medication. The Angina and Silent Ischemia Study Group (ASIS)
    Circulation, 1993, Volume: 88, Issue:1

    Topics: Circadian Rhythm; Diltiazem; Double-Blind Method; Electrocardiography, Ambulatory; Female; Heart Rat

1993
Ischemia in collateral-dependent myocardium: effects of nifedipine and diltiazem in man.
    American heart journal, 1993, Volume: 126, Issue:1

    Topics: Aged; Blood Pressure; Collateral Circulation; Coronary Disease; Diltiazem; Electrocardiography; Exer

1993
Efficacy of isosorbide-5-mononitrate versus nifedipine in preventing spontaneous and ergonovine-induced myocardial ischaemia. A double-blind, placebo-controlled study.
    European heart journal, 1993, Volume: 14, Issue:6

    Topics: Administration, Oral; Adult; Angina Pectoris, Variant; Double-Blind Method; Echocardiography; Electr

1993
Comparative study of gallopamil versus nifedipine in patients with ischemic heart disease.
    International journal of cardiology, 1993, Jul-01, Volume: 40, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Double-Blind Method; Electrocardiography; Exercis

1993
Combined perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary bypass surgery.
    The Thoracic and cardiovascular surgeon, 1993, Volume: 41, Issue:3

    Topics: Aged; Arrhythmias, Cardiac; Coronary Artery Bypass; Drug Therapy, Combination; Electrocardiography,

1993
Transient myocardial ischemia during nifedipine therapy in stable angina pectoris, and its relation to coronary collateral flow and comparison with metoprolol.
    The American journal of cardiology, 1993, Jan-15, Volume: 71, Issue:2

    Topics: Angina Pectoris; Collateral Circulation; Coronary Angiography; Coronary Circulation; Double-Blind Me

1993
Usefulness of exercise testing performed with vasodilators for predicting the severity of myocardial ischaemia during daily activities and treatment.
    European heart journal, 1993, Volume: 14, Issue:3

    Topics: Activities of Daily Living; Adult; Angina Pectoris; Coronary Circulation; Coronary Disease; Drug The

1993
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
    Zeitschrift fur Kardiologie, 1993, Volume: 82, Issue:1

    Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodip

1993
Discordance between effects of anti-ischemic therapy on ambulatory ischemia, exercise performance and anginal symptoms in patients with stable angina pectoris. The Angina and Silent Ischemia Study Group (ASIS).
    Journal of the American College of Cardiology, 1993, Volume: 21, Issue:7

    Topics: Aged; Angina Pectoris; Diltiazem; Double-Blind Method; Electrocardiography, Ambulatory; Exercise Tes

1993
Comparison of subgroups assigned to medical regimens used to suppress cardiac ischemia (the Asymptomatic Cardiac Ischemia Pilot [ACIP] Study).
    The American journal of cardiology, 1996, Jun-15, Volume: 77, Issue:15

    Topics: Angina Pectoris; Atenolol; Case-Control Studies; Delayed-Action Preparations; Diltiazem; Drug Therap

1996
Prognostic significance of transient ischemic episodes: response to treatment shows improved prognosis. Results of the Total Ischemic Burden Bisoprolol Study (TIBBs) follow-up.
    Journal of the American College of Cardiology, 1996, Volume: 28, Issue:1

    Topics: Adrenergic beta-Antagonists; Bisoprolol; Calcium Channel Blockers; Delayed-Action Preparations; Dise

1996
Asymptomatic Cardiac Ischemia Pilot (ACIP) study two-year follow-up: outcomes of patients randomized to initial strategies of medical therapy versus revascularization.
    Circulation, 1997, Apr-15, Volume: 95, Issue:8

    Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Atenolol; Calcium Channel Blocker

1997
[Effectiveness and tolerability of bisoprolol vs. nifedipine in uremic patients with ischemic cardiopathy in dialysis treatment].
    Cardiologia (Rome, Italy), 1997, Volume: 42, Issue:4

    Topics: Adrenergic beta-Antagonists; Bisoprolol; Calcium Channel Blockers; Female; Humans; Male; Middle Aged

1997
Relationship between calcium channel antagonists and nocturnal hypotension and autonomic imbalance in patients with a previous myocardial infarction.
    Japanese circulation journal, 1998, Volume: 62, Issue:1

    Topics: Adult; Aged; Angina Pectoris; Autonomic Nervous System; Blood Pressure; Blood Pressure Monitoring, A

1998
Effects of therapy with nifedipine GITS or atenolol on mental stress-induced ischemic left ventricular dysfunction.
    Journal of the American College of Cardiology, 1998, Nov-15, Volume: 32, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Cross-Over Studies; Diastole; Double-Blind Metho

1998
Heart rate variability and ischaemia in patients with coronary heart disease and stable angina pectoris; influence of drug therapy and prognostic value. TIBBS Investigators Group. Total Ischemic Burden Bisoprolol Study.
    European heart journal, 1999, Volume: 20, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Bisoprolol; Calcium Channel Blockers; Cir

1999
Effects of a slow-release nifedipine on 24-hour ambulatory blood pressure and ischemic changes on 24-hour ambulatory electrocardiogram in patients with severe coronary artery disease.
    Cardiology, 2000, Volume: 94, Issue:1

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Blood Pressure Monitoring, Ambulatory; Calcium Channe

2000
[Clinical study on relationship among Heart-Qi Deficiency, left ventricular function and myocardial ischemia in patients with coronary heart disease].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1998, Volume: 18, Issue:8

    Topics: Aged; Angina Pectoris; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Myocardial Contract

1998
[Efficacy of OSMO-Adalat in patients with arterial hypertension in combination with kinked precerebral arteries].
    Terapevticheskii arkhiv, 2001, Volume: 73, Issue:9

    Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Carotid Artery Diseases; De

2001
Effects of nifedipine retard on heart rate and autonomic balance in patients with ischemic heart disease.
    International journal of clinical pharmacology research, 2001, Volume: 21, Issue:2

    Topics: Aged; Autonomic Nervous System; Calcium Channel Blockers; Circadian Rhythm; Delayed-Action Preparati

2001
Comparison of negative inotropic and vasodilator effects of isradipine and nifedipine after complete autonomic blockade in ischemic heart disease.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:4

    Topics: Autonomic Nerve Block; Depression, Chemical; Double-Blind Method; Heart Rate; Hemodynamics; Humans;

1992
Effects of nifedipine and diltiazem on myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Diltiazem; Double-Blind Method; Electroca

1992
[Effect of various antianginal agents on the frequency and duration of myocardial ischemic episodes in patients with stable angina pectoris].
    Kardiologiia, 1992, Volume: 32, Issue:11-12

    Topics: Angina Pectoris; Drug Therapy, Combination; Humans; Myocardial Ischemia; Nifedipine; Periodicity; Pr

1992
[The anti-ischemic effect of gallopamil-retard in comparison with nifedipine-retard in stable angina pectoris].
    Zeitschrift fur Kardiologie, 1992, Volume: 81, Issue:10

    Topics: Aged; Angina Pectoris; Blood Pressure; Coronary Disease; Delayed-Action Preparations; Dose-Response

1992
Intravenous nifedipine for prevention of myocardial ischaemia after coronary revascularization.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:10

    Topics: Blood Pressure; Coronary Artery Bypass; Creatine Kinase; Electrocardiography; Electrocardiography, A

1992
Clinical investigation of asymptomatic cardiac ischemia.
    Clinical cardiology, 1991, Volume: 14, Issue:12

    Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Atenolol; Coronary Artery Bypass; Coronary Disease;

1991

Other Studies

55 other studies available for nifedipine and Myocardial Ischemia

ArticleYear
Direct cardiac toxicity of the tentacle-only extract from the jellyfish Cyanea capillata demonstrated in isolated rat heart.
    Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:4

    Topics: Animals; Calcium Channels, L-Type; Cnidarian Venoms; Coronary Vasospasm; Dose-Response Relationship,

2012
Glycidipine, a promising hypotensive and cardioprotective agent.
    Bulletin of experimental biology and medicine, 2011, Volume: 151, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cardiotonic Agents; Drug Combinations; Dru

2011
[Broadened indications for the use of selective β-adrenoblockers].
    Kardiologiia, 2012, Volume: 52, Issue:5

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Bisoprolol; Calcium Channel Blockers; Female;

2012
Expression of the nuclear factor-kappaB and proto-oncogenes c-fos and c-jun are induced by low extracellular Mg2+ in aortic and cerebral vascular smooth muscle cells: possible links to hypertension, atherogenesis, and stroke.
    American journal of hypertension, 2003, Volume: 16, Issue:9 Pt 1

    Topics: Animals; Aorta, Thoracic; Biomarkers; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Di

2003
Spontaneous activity induced in rabbit Purkinje myocytes during coupling to a depolarized model cell.
    Cardiovascular research, 2003, Sep-01, Volume: 59, Issue:3

    Topics: Action Potentials; Animals; Cadmium; Coculture Techniques; Gap Junctions; Heart Ventricles; Lithium;

2003
Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:2

    Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cytosol; Diacetyl; Dihy

2004
Reversible left ventricular hypertrophy after tako-tsubo-like cardiomyopathy.
    Acta cardiologica, 2005, Volume: 60, Issue:1

    Topics: Aged; Aspirin; Benzimidazoles; Biphenyl Compounds; Cardiomyopathy, Dilated; Chest Pain; Drug Therapy

2005
The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2007, Volume: 67, Issue:1

    Topics: Calcium Channel Blockers; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Gamma

2007
Effects of nifedipine on systemic and pulmonary vascular impedance in subjects undergoing cardiac catheterization.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2006, Volume: 29, Issue:7

    Topics: Administration, Sublingual; Adult; Algorithms; Calcium Channel Blockers; Cardiac Catheterization; Ca

2006
Hemodynamic and antiischemic effects of nifedipine, lacidipine, and nisoldipine in rat isolated working heart.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:3

    Topics: Animals; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Dihydropyridines; Dose-Resp

1993
Antiischemic effects of nifedipine in isolated working heart preparations of healthy, diabetic, and hypertensive rats.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:3

    Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Cardiac Output; Coronary Circulation; Diabetes

1994
[The nifedipine withdrawal syndrome in patients with stable stenocardia of effort].
    Terapevticheskii arkhiv, 1995, Volume: 67, Issue:6

    Topics: Angina Pectoris; Electrocardiography; Exercise Test; Exercise Tolerance; Humans; Myocardial Ischemia

1995
Cardioprotection by nifedipine in isolated working hearts: a comparative study on three different types of experimental ischemia.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:1

    Topics: Animals; Cardiac Output; Coronary Circulation; Dimethyl Sulfoxide; Electric Stimulation; Heart; Male

1993
[The preoperative drug correction of disorders in myocardial functional reserve in patients with ischemic heart disease].
    Klinicheskaia khirurgiia, 1994, Issue:5

    Topics: Adult; Amiodarone; Combined Modality Therapy; Coronary Artery Bypass; Drug Therapy, Combination; Hea

1994
[Effect of nifedipine on T wave in ischemic myocardium].
    Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1994, Volume: 25, Issue:3

    Topics: Adenosine; Animals; Electrocardiography; Female; Male; Myocardial Ischemia; Nifedipine; Swine

1994
Comparative examination of Adalat and Cordaflex in anti-ischaemic therapy.
    Therapia Hungarica (English edition), 1993, Volume: 41, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Electrocardiog

1993
Adenosine: a sensitive marker of myocardial ischaemia in man.
    Cardiovascular research, 1994, Volume: 28, Issue:5

    Topics: Adenosine; Aged; Angioplasty, Balloon, Coronary; Biomarkers; Coronary Circulation; Coronary Disease;

1994
Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris.
    International journal of cardiology, 1993, Dec-31, Volume: 42, Issue:3

    Topics: Angina Pectoris; Exercise Test; Exercise Tolerance; Humans; Male; Middle Aged; Myocardial Ischemia;

1993
Clinical assessment of gingival hyperplasia in patients treated with nifedipine.
    Journal of clinical periodontology, 1994, Volume: 21, Issue:4

    Topics: Dental Plaque Index; Dose-Response Relationship, Drug; Female; Gingival Hemorrhage; Gingival Hyperpl

1994
[Hemodynamic basis of antianginal effect of calcium antagonists in patients with ischemic heart disease after aortocoronary shunting: myocardial reserve potentials and their mechanisms].
    Kardiologiia, 1993, Volume: 33, Issue:12

    Topics: Adult; Angina Pectoris; Coronary Artery Bypass; Dose-Response Relationship, Drug; Exercise Test; Hem

1993
Successful delivery following myocardial ischemia during the second trimester of pregnancy.
    Clinical cardiology, 1993, Volume: 16, Issue:10

    Topics: Acute Disease; Adult; Atenolol; Cardiac Catheterization; Coronary Angiography; Female; Heparin; Huma

1993
Improvement of ischemic myocardial dysfunction by nisoldipine in relation to its coronary vasodilating action.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:1

    Topics: Animals; Blood Pressure; Coronary Circulation; Diltiazem; Heart Rate; In Vitro Techniques; Male; Myo

1993
Does transesophageal echocardiography improve postoperative outcome in patients undergoing coronary artery bypass surgery?
    Journal of cardiothoracic and vascular anesthesia, 1993, Volume: 7, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Cardiac Output; Coronary Artery Bypass; Creatine Kin

1993
Preservation of myocardial blood flow by calcium antagonists does not prevent attenuation of regional myocardial function after repetitive brief periods of myocardial ischaemia in the rat heart.
    European heart journal, 1995, Volume: 16, Issue:8

    Topics: Animals; Blood Flow Velocity; Calcium Channel Blockers; Female; Gallopamil; Infusions, Intravenous;

1995
[Effects of nitroglycerin and nifedipine on stunned myocardium due to brief repeated ischemias].
    Revista espanola de cardiologia, 1996, Volume: 49, Issue:5

    Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Data Interpretation, Statistical; Dogs; Ele

1996
Blood pressure and myocardial perfusion in hypertensive patients with and without left ventricular hypertrophy.
    Journal of human hypertension, 1995, Volume: 9, Issue:12

    Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Captopril; Coron

1995
Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat.
    British journal of pharmacology, 1996, Volume: 118, Issue:4

    Topics: Albumins; Animals; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Edema

1996
Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3

    Topics: Angina Pectoris; Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiaze

1996
Comparison of nifedipine and metoprolol on collateral coronary blood flow in a swine model of chronic coronary obstruction and acute ischaemia during isoflurane anaesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthetics, Inhalation; Animals; Calcium Channel Blockers; Chronic Dis

1996
Evaluation of gingival and periodontal conditions following causal periodontal treatment in patients treated with nifedipine and diltiazem.
    Journal of clinical periodontology, 1996, Volume: 23, Issue:7

    Topics: Analysis of Variance; Calcium Channel Blockers; Chi-Square Distribution; Dental Care for Chronically

1996
Calcium channel blocker debate: true lies?
    Cardiovascular drugs and therapy, 1996, Volume: 10, Issue:4

    Topics: Angina Pectoris; Calcium Channel Blockers; Humans; Hypertension; Myocardial Contraction; Myocardial

1996
The influence of nifedipine and verapamil on the ischaemia-induced changes in canine sarcolemmal membranes.
    Archivum veterinarium Polonicum, 1995, Volume: 35, Issue:1-2

    Topics: Animals; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Membrane; Dog Diseases; Dogs;

1995
Silent myocardial ischemia: some good news.
    Circulation, 1997, Apr-15, Volume: 95, Issue:8

    Topics: Adrenergic beta-Antagonists; Atenolol; Calcium Channel Blockers; Combined Modality Therapy; Coronary

1997
Effect of efonidipine, a novel dihydropyridine derivative, on myocardial metabolic changes induced by coronary artery ligation in dogs: comparison with nifedipine.
    Fundamental & clinical pharmacology, 1997, Volume: 11, Issue:3

    Topics: Animals; Calcium Channel Blockers; Carbohydrate Metabolism; Dihydropyridines; Dogs; Energy Metabolis

1997
Antianginal effects of YM430, a novel calcium entry-blocking and beta-adrenoceptor-blocking agent in several experimental angina models.
    General pharmacology, 1997, Volume: 29, Issue:4

    Topics: 4-Aminopyridine; Adrenergic beta-Antagonists; Amifampridine; Angina Pectoris; Animals; Calcium Chann

1997
[The use of Cordanum in combination with Corinfar-Retard for the treatment of ectopic arrhythmias in the sick sinus syndrome in patients with ischemic heart disease].
    Terapevticheskii arkhiv, 1997, Volume: 69, Issue:9

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Delayed-Action Preparations; Drug Evaluat

1997
Differential roles of myocardial Ca2+ channels and Na+/Ca2+ exchange in myocardial reperfusion injury in open chest dogs: relative roles during ischemia and reperfusion.
    Cardiovascular research, 1997, Volume: 36, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1997
A potential risk of sublingual nifedipine treatment in surgically treated patients in Japan.
    Critical care medicine, 1998, Volume: 26, Issue:7

    Topics: Administration, Sublingual; Calcium Channel Blockers; Clinical Competence; Humans; Japan; Myocardial

1998
[Adalat effects on clinical course of coronary heart disease, peripheral circulation and myocardial perfusion in patients with stenosing coronary atherosclerosis].
    Terapevticheskii arkhiv, 1998, Volume: 70, Issue:9

    Topics: Adult; Blood Flow Velocity; Calcium Channel Blockers; Coronary Artery Disease; Coronary Circulation;

1998
[A 73-year-old patient with hypertensive crisis. Was the use of calcium antagonist nifedipine justified?].
    Der Internist, 1999, Volume: 40, Issue:2

    Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Drug Therapy, Combination; Electrocardiogra

1999
Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Acidosis; Adenosine Triphosphate; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem

1999
Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium.
    Circulation research, 1999, May-28, Volume: 84, Issue:10

    Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium; Calcium Channel Blockers;

1999
Effects of nifedipine on myocardial blood flow and systolic function in humans with ischemic heart disease.
    Coronary artery disease, 1999, Volume: 10, Issue:3

    Topics: Aged; Blood Flow Velocity; Coronary Circulation; Female; Humans; Male; Middle Aged; Myocardial Ische

1999
Effect of Ca2+ channel blockers on arterial hypertension and heart ischaemic lesions induced by chronic blockade of nitric oxide in the rat.
    European journal of pharmacology, 1999, Jun-04, Volume: 373, Issue:2-3

    Topics: Animals; Blood Pressure; Blood Pressure Determination; Body Weight; Calcium Channel Blockers; Diltia

1999
Low-dose calcium antagonists reduce energy demand and cellular damage of isolated hearts during both ischemia and reperfusion.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:3

    Topics: Amlodipine; Animals; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dose-Response Relati

1999
Nifedipine-induced coronary vasodilation in ischemic hearts is attributable to bradykinin- and NO-dependent mechanisms in dogs.
    Circulation, 2000, Jan-25, Volume: 101, Issue:3

    Topics: Animals; Bradykinin; Calcium Channel Blockers; Coronary Vessels; Cyclic GMP; Dogs; Heart Rate; Myoca

2000
Effects of different vasodilators on human internal mammary artery in vitro.
    Advances in experimental medicine and biology, 1999, Volume: 471

    Topics: Ethanolamines; Female; Humans; In Vitro Techniques; Isoproterenol; Isosorbide Dinitrate; Male; Mamma

1999
The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Movement; Diltiazem; Electrocardiograph

2000
Protective effect of diltiazem against ischemia-induced decreases in regional myocardial flow in rat heart.
    European journal of pharmacology, 2000, Jun-09, Volume: 398, Issue:1

    Topics: Animals; Calcium Channel Blockers; Cardiovascular Agents; Coronary Circulation; Diltiazem; Heart; He

2000
Energy preserving effect of l-cis diltiazem in isolated ischemic and reperfused guinea pig hearts: a 31P-NMR study.
    Japanese journal of pharmacology, 2000, Volume: 83, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Heart; Hydrogen-I

2000
The gingival inflammatory infiltrate in cardiac patients treated with calcium antagonists.
    Journal of clinical periodontology, 2001, Volume: 28, Issue:10

    Topics: Analysis of Variance; Calcium Channel Blockers; Case-Control Studies; Chi-Square Distribution; Dilti

2001
Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart.
    Japanese journal of pharmacology, 2002, Volume: 89, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Binding, Competitive; Calcium; CHO Cells; Cri

2002
[The effect of nitrosorbide, korinfar, obzidan and spesikor on cardiovascular function in a right bundle of His block].
    Terapevticheskii arkhiv, 1992, Volume: 64, Issue:12

    Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiovascular System; Drug Evaluation; Electroc

1992
[Correlation of antianginal effect of corinfar and diastolic function in patients with ischemic heart disease].
    Kardiologiia, 1992, Volume: 32, Issue:11-12

    Topics: Diastole; Humans; Male; Middle Aged; Myocardial Ischemia; Nifedipine; Ventricular Function, Left

1992
[ Combined therapy with isosorbide dinitrate, propranolol and nifedipine in patients with chronic ischemic heart disease].
    Kardiologiia, 1992, Volume: 32, Issue:11-12

    Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Drug Therapy, Combination; Heart Rate; Hemodynamics;

1992