nifedipine has been researched along with Morphine Dependence in 11 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with nifedipine partially restores the analgesic action of morphine in morphine-tolerant rats." | 5.29 | Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1993) |
| " Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated." | 3.74 | L-type calcium channel blockade attenuates morphine withdrawal: in vivo interaction between L-type calcium channels and corticosterone. ( Ahmadiani, A; Esmaeili-Mahani, S; Fathi, Y; Hosseinpanah, F; Motamedi, F, 2008) |
| " In vivo studies have indicated the involvement of dihydropyridine-sensitive (L-type) voltage-gated channels in morphine abuse." | 3.72 | Effects of nifedipine on behavioral and biochemical parameters in rats after multiple morphine administration. ( Mitcheva, M; Vitcheva, V, 2004) |
| "Pretreatment with nifedipine partially restores the analgesic action of morphine in morphine-tolerant rats." | 1.29 | Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1993) |
| "Nifedipine treatment abolished the signs of abstinence and normalized the hot-plate latencies in morphine-dependent, naloxone-treated rats." | 1.28 | Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beregovoy, NA | 1 |
| Sorokina, NS | 1 |
| Starostina, MV | 1 |
| Joukar, S | 1 |
| Sheibani, M | 1 |
| Joukar, F | 1 |
| Vitcheva, V | 1 |
| Mitcheva, M | 1 |
| Leventhal, L | 1 |
| Cosmi, S | 1 |
| Deecher, D | 1 |
| Esmaeili-Mahani, S | 1 |
| Fathi, Y | 1 |
| Motamedi, F | 2 |
| Hosseinpanah, F | 1 |
| Ahmadiani, A | 1 |
| Antkiewicz-Michaluk, L | 2 |
| Michaluk, J | 2 |
| Romańska, I | 2 |
| Vetulani, J | 2 |
| Pourmotabbed, A | 1 |
| Fathollahi, Y | 1 |
| Mansouri, FA | 1 |
| Semnanian, S | 1 |
| Silverstone, PH | 2 |
| Done, C | 1 |
| Sharp, T | 1 |
| Schnur, P | 1 |
| Espinoza, M | 1 |
| Flores, R | 1 |
| Ortiz, S | 1 |
| Vallejos, S | 1 |
| Wainwright, M | 1 |
| Attenburrow, MJ | 1 |
| Robson, P | 1 |
1 trial available for nifedipine and Morphine Dependence
| Article | Year |
|---|---|
The calcium channel antagonist nifedipine causes confusion when used to treat opiate withdrawal in morphine-dependent patients.
Topics: Adult; Clonidine; Confusion; Double-Blind Method; Humans; Male; Methadone; Morphine Dependence; Nife | 1992 |
10 other studies available for nifedipine and Morphine Dependence
| Article | Year |
|---|---|
Participation of L-type voltage-gated calcium channels in facilitation of long-term potentiation during the formation of morphine dependence in rats.
Topics: Analysis of Variance; Animals; CA3 Region, Hippocampal; Calcium Channels, L-Type; Long-Term Potentia | 2010 |
Cardiovascular effect of nifedipine in morphine dependent rats: hemodynamic, histopathological, and biochemical evidence.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Calcium Channel Blockers; Dimethyl Sulfoxide; Heart Inj | 2012 |
Effects of nifedipine on behavioral and biochemical parameters in rats after multiple morphine administration.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Calcium Channel Blockers; Cytochrome P-450 Enz | 2004 |
Effect of calcium channel modulators on temperature regulation in ovariectomized rats.
Topics: Amines; Animals; Body Temperature Regulation; Calcium Channel Blockers; Calcium Channels; Cyclohexan | 2005 |
L-type calcium channel blockade attenuates morphine withdrawal: in vivo interaction between L-type calcium channels and corticosterone.
Topics: Adrenalectomy; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Corticosterone; Drug Int | 2008 |
Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine.
Topics: Analgesics; Animals; Cerebral Cortex; Drug Interactions; Drug Tolerance; Male; Morphine; Morphine De | 1993 |
Involvement of NMDA receptors and voltage-dependent calcium channels on augmentation of long-term potentiation in hippocampal CA1 area of morphine dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channel Blockers; Calcium Channels; Electrophysiology; | 1998 |
Clonidine but not nifedipine prevents the release of noradrenaline during naloxone-precipitated opiate withdrawal: an in vivo microdialysis study in the rat.
Topics: Animals; Behavior, Animal; Clonidine; Male; Microdialysis; Morphine Dependence; Naloxone; Nifedipine | 1992 |
Blocking naloxone-precipitated withdrawal in rats and hamsters.
Topics: Animals; Behavior, Animal; Clonidine; Cricetinae; Drug Implants; Mesocricetus; Morphine Dependence; | 1992 |
Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Cerebral Cor | 1990 |