Page last updated: 2024-11-01

nifedipine and Migraine Disorders

nifedipine has been researched along with Migraine Disorders in 23 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Research Excerpts

ExcerptRelevanceReference
"Ninety patients, 50 males and 40 females, and their ages ranged between 42 and 70 years, with severe hypertension were treated by either sublingual verapamil tablets 40 mg (30 patients) or 80 mg (30 patients) or sublingual nifedipine capsules 10 mg (30 patients)."7.70Efficacy of sublingual verapamil in patients with severe essential hypertension: comparison with sublingual nifedipine. ( Al-Waili, NS; Hasan, NA, 1999)
"A 39-year-old woman suffering from migraine took two suppositories of an ergotamine-containing proprietary drug (Cafergot, containing 2 mg ergotamine tartrate) for the first time again after an abstinence of two years."5.28[Extremity-threatening ischemia in ergotism. Successful treatment with the intra-arterial administration of nifedipine]. ( Brandt, J; Ernst, R; Mumme, A; Schäfer, K; Zumtobel, V, 1991)
"Flunarizine's effect in migraine probably involves monoamine mechanisms which bear no relation to calcium."3.77[Calcium channel blockers and prevention of migraine]. ( Montastruc, JL; Senard, JM, 1992)
"Ninety patients, 50 males and 40 females, and their ages ranged between 42 and 70 years, with severe hypertension were treated by either sublingual verapamil tablets 40 mg (30 patients) or 80 mg (30 patients) or sublingual nifedipine capsules 10 mg (30 patients)."3.70Efficacy of sublingual verapamil in patients with severe essential hypertension: comparison with sublingual nifedipine. ( Al-Waili, NS; Hasan, NA, 1999)
"Nifedipine is a useful agent for the management of migraine as it reduces frequency and severity of pain but the drug cannot be recommended for tension headache."2.68Nifedipine in migraine and tension headache: a randomised double blind crossover study. ( Ahuja, RC; Garg, RK; Nag, D; Shukla, R, 1995)
"Efficacy in migraine prophylaxis has been claimed for drugs belonging to all three classes of calcium channel blockers (nifedipine-like, verapamil-like, and flunarizine-like), but the extent and quality of the evidence varies, and a comparison of efficacy between different calcium channel blockers has not been reported."2.67Comparison of the efficacy between flunarizine and nifedipine in the prophylaxis of migraine. ( Lamsudin, R; Sadjimin, T, 1993)
"Patients with migraine with aura treated each of six acute attacks with either nifedipine or vehicle administered in double-blind, randomized form."2.67A double-blind controlled study of nifedipine as an abortive treatment in acute attacks of migraine with aura. ( Hoffert, MJ; Kanter, R; Scholz, MJ, 1992)
"Nifedipine was of no value in the prophylaxis of migraine."2.67Responders and non-responders to metoprolol, propranolol and nifedipine treatment in migraine prophylaxis: a dose-range study based on time-series analysis. ( Diener, HC; Gerber, WD; Niederberger, U; Scholz, E, 1991)
"Twenty-four patients with classic migraine attacks were treated with either nifedipine or placebo for up to 12 weeks."2.66Nifedipine in the prophylaxis of classic migraine: a crossover, double-masked, placebo-controlled study of headache frequency and side effects. ( Marek, K; McArthur, J; McArthur, JC; Peroutka, SJ; Pestronk, A, 1989)
"At baseline, migraine patients had significantly higher VEP amplitudes and longer latencies than did a group of 87 healthy control subjects."2.66Central effects of drugs used in migraine prophylaxis evaluated by visual evoked potentials. ( Bille, A; Dichgans, J; Diener, HC; Gerber, WD; Jäck, A; Niederberger, U; Scholz, E, 1989)
"Nifedipine was effective in only 30% of patients (6/20)."2.66Nifedipine versus propranolol for the initial prophylaxis of migraine. ( Albers, GW; Hamik, A; Peroutka, SJ; Simon, LT, 1989)
"In the therapy of acute cerebral ischemia the therapeutic efficacy of nimodipine administered orally is not therapeutically proved until now; the intravenous administration of nimodipine offers the risk of acute hypotensive reactions."2.38[Calcium channel blockers in therapy of neurologic diseases]. ( Wessely, P; Wöber-Bingöl, C, 1993)
"Migraine is one of the risk factor for ischemic stroke."1.37Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. ( Iizuka, R; Ishii, M; Kiuchi, Y; Mori, Y; Shimizu, S, 2011)
"A 39-year-old woman suffering from migraine took two suppositories of an ergotamine-containing proprietary drug (Cafergot, containing 2 mg ergotamine tartrate) for the first time again after an abstinence of two years."1.28[Extremity-threatening ischemia in ergotism. Successful treatment with the intra-arterial administration of nifedipine]. ( Brandt, J; Ernst, R; Mumme, A; Schäfer, K; Zumtobel, V, 1991)
"It is postulated that, in migraine, calcium entry blockers may prevent exaggerated responses to catecholaminergic stimulation."1.27Pupillary and vascular effects of calcium antagonists in migraine. ( Boccuni, M; Cangi, F; Fanciullacci, M; Fusco, BM; Gatto, G; Marabini, S; Pietrini, U, 1985)
"Fifteen women regularly suffering from migraine during the menstrual period reported increased headache after intake of the drug."1.26Trial of the calcium antagonist nifedipine in the treatment of primary dysmenorrhoea. ( Andersson, KE; Sandahl, B; Ulmsten, U, 1979)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199014 (60.87)18.7374
1990's8 (34.78)18.2507
2000's0 (0.00)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ishii, M1
Iizuka, R1
Kiuchi, Y1
Mori, Y1
Shimizu, S1
Kahan, A1
Weber, S1
Amor, B1
Guerin, F1
Degeorges, M1
Meyer, JS1
Hardenberg, J1
Peroutka, SJ3
Miller, FW1
Santoro, TJ1
Wessely, P1
Wöber-Bingöl, C1
Lamsudin, R1
Sadjimin, T1
Shukla, R1
Garg, RK1
Nag, D1
Ahuja, RC1
Al-Waili, NS1
Hasan, NA1
Sandahl, B1
Ulmsten, U1
Andersson, KE1
Montastruc, JL1
Senard, JM1
Hoffert, MJ1
Scholz, MJ1
Kanter, R1
Mumme, A1
Ernst, R1
Brandt, J1
Schäfer, K1
Zumtobel, V1
Gerber, WD2
Diener, HC2
Scholz, E2
Niederberger, U2
Greenberg, DA1
Mayerhofer, S1
McArthur, JC1
Marek, K1
Pestronk, A1
McArthur, J1
Dichgans, J1
Jäck, A1
Bille, A1
Albers, GW1
Simon, LT1
Hamik, A1
Goldner, JA1
Levitt, LP1
Solomon, GD1
Fournier, JA1
Fernández-Cortacero, JA1
Granado, C1
Gascón, D1
Fanciullacci, M1
Boccuni, M1
Pietrini, U1
Cangi, F1
Gatto, G1
Marabini, S1
Fusco, BM1

Reviews

4 reviews available for nifedipine and Migraine Disorders

ArticleYear
[Calcium channel blockers in therapy of neurologic diseases].
    Wiener medizinische Wochenschrift (1946), 1993, Volume: 143, Issue:19-20

    Topics: Brain Ischemia; Calcium Channel Blockers; Cluster Headache; Flunarizine; Humans; Migraine Disorders;

1993
[Calcium channel blockers and prevention of migraine].
    Pathologie-biologie, 1992, Volume: 40, Issue:4

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Diltiazem; Flunarizine; Humans; Migraine Diso

1992
Calcium channel antagonists and the treatment of migraine.
    Clinical neuropharmacology, 1986, Volume: 9, Issue:4

    Topics: Calcium; Calcium Channel Blockers; Cinnarizine; Diltiazem; Flunarizine; Humans; Ion Channels; Kineti

1986
Comparative efficacy of calcium antagonist drugs in the prophylaxis of migraine.
    Headache, 1985, Volume: 25, Issue:7

    Topics: Calcium Channel Blockers; Cinnarizine; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Flu

1985

Trials

12 trials available for nifedipine and Migraine Disorders

ArticleYear
Nifedipine in the treatment of migraine in patients with Raynaud's phenomenon.
    The New England journal of medicine, 1983, May-05, Volume: 308, Issue:18

    Topics: Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Migraine Disorders; Nifedipine; Prospec

1983
Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headaches.
    Headache, 1983, Volume: 23, Issue:6

    Topics: Adult; Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Cluster Head

1983
The pharmacology of calcium channel antagonists: a novel class of anti-migraine agents?
    Headache, 1983, Volume: 23, Issue:6

    Topics: Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Cyproheptadine; Dil

1983
Comparison of the efficacy between flunarizine and nifedipine in the prophylaxis of migraine.
    Headache, 1993, Volume: 33, Issue:6

    Topics: Adolescent; Adult; Double-Blind Method; Female; Flunarizine; Humans; Male; Middle Aged; Migraine Dis

1993
Nifedipine in migraine and tension headache: a randomised double blind crossover study.
    The Journal of the Association of Physicians of India, 1995, Volume: 43, Issue:11

    Topics: Adult; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Drug Administration Schedu

1995
[Calcium channel blockers and prevention of migraine].
    Pathologie-biologie, 1992, Volume: 40, Issue:4

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Diltiazem; Flunarizine; Humans; Migraine Diso

1992
A double-blind controlled study of nifedipine as an abortive treatment in acute attacks of migraine with aura.
    Cephalalgia : an international journal of headache, 1992, Volume: 12, Issue:5

    Topics: Acute Disease; Adult; Double-Blind Method; Humans; Middle Aged; Migraine Disorders; Nifedipine; Sens

1992
Responders and non-responders to metoprolol, propranolol and nifedipine treatment in migraine prophylaxis: a dose-range study based on time-series analysis.
    Cephalalgia : an international journal of headache, 1991, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Dose-Response Relationship, Drug; Female; Follow-Up S

1991
Nifedipine in the prophylaxis of classic migraine: a crossover, double-masked, placebo-controlled study of headache frequency and side effects.
    Neurology, 1989, Volume: 39, Issue:2 Pt 1

    Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Migraine Disorders; Nifedipine; Placebos

1989
Central effects of drugs used in migraine prophylaxis evaluated by visual evoked potentials.
    Annals of neurology, 1989, Volume: 25, Issue:2

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Evoked Potentials, Visual; Female; Humans; Mal

1989
Nifedipine versus propranolol for the initial prophylaxis of migraine.
    Headache, 1989, Volume: 29, Issue:4

    Topics: Adult; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Migraine Disorders; Nifedipine;

1989
Comparative efficacy of calcium antagonist drugs in the prophylaxis of migraine.
    Headache, 1985, Volume: 25, Issue:7

    Topics: Calcium Channel Blockers; Cinnarizine; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Flu

1985

Other Studies

9 other studies available for nifedipine and Migraine Disorders

ArticleYear
Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.
    Molecular and cellular biochemistry, 2011, Volume: 358, Issue:1-2

    Topics: Animals; Benzamides; Calcium; Calcium Channel Blockers; Cell Death; Cells, Cultured; HEK293 Cells; H

2011
Nifedipine in the treatment of migraine headache and amaurosis fugax in patients with systemic lupus erythematosus.
    The New England journal of medicine, 1984, Oct-04, Volume: 311, Issue:14

    Topics: Adult; Blindness; Female; Humans; Lupus Erythematosus, Systemic; Male; Migraine Disorders; Nifedipin

1984
Efficacy of sublingual verapamil in patients with severe essential hypertension: comparison with sublingual nifedipine.
    European journal of medical research, 1999, May-26, Volume: 4, Issue:5

    Topics: Administration, Sublingual; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Female; Headache;

1999
Trial of the calcium antagonist nifedipine in the treatment of primary dysmenorrhoea.
    Archives of gynecology, 1979, Volume: 227, Issue:2

    Topics: Adolescent; Adult; Dysmenorrhea; Evaluation Studies as Topic; Female; Humans; Migraine Disorders; Ni

1979
[Extremity-threatening ischemia in ergotism. Successful treatment with the intra-arterial administration of nifedipine].
    Deutsche medizinische Wochenschrift (1946), 1991, Jan-25, Volume: 116, Issue:4

    Topics: Acute Disease; Adult; Arm; Caffeine; Drug Combinations; Ergotamine; Ergotism; Female; Humans; Infusi

1991
[Mechanism of action of calcium antagonists in the treatment of vascular diseases].
    Wiener medizinische Wochenschrift (1946), 1986, Nov-30, Volume: 136, Issue:21-22

    Topics: Arterial Occlusive Diseases; Calcium; Calcium Channel Blockers; Cerebrovascular Circulation; Flunari

1986
Treatment of complicated migraine with sublingual nifedipine.
    Headache, 1987, Volume: 27, Issue:9

    Topics: Administration, Sublingual; Adolescent; Electroencephalography; Female; Humans; Migraine Disorders;

1987
Familial migraine and coronary artery spasm in two siblings.
    Clinical cardiology, 1986, Volume: 9, Issue:3

    Topics: Angiography; Cardiac Catheterization; Coronary Vasospasm; Electrocardiography; Female; Hemodynamics;

1986
Pupillary and vascular effects of calcium antagonists in migraine.
    Cephalalgia : an international journal of headache, 1985, Volume: 5 Suppl 2

    Topics: Blood Pressure; Calcium Channel Blockers; Cinnarizine; Flunarizine; Humans; Migraine Disorders; Nife

1985