nifedipine has been researched along with Liver Dysfunction in 15 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to determine if pretreatment with misoprostol (a prostaglandin analogue) or nifedipine (a calcium antagonist), know protectants of the whole liver, would ameliorate the ischemia-reperfusion injury (IRI) of resected liver associated with vascular occlusion." | 7.69 | Hepatic ischemia-reperfusion injury modification during liver surgery in rats: pretreatment with nifedipine or misoprostol. ( Hardy, KJ; Shulkes, A; Tancheroen, S, 1995) |
| "The aim of the study was to determine if pretreatment with misoprostol (a prostaglandin analogue) or nifedipine (a calcium antagonist), know protectants of the whole liver, would ameliorate the ischemia-reperfusion injury (IRI) of resected liver associated with vascular occlusion." | 3.69 | Hepatic ischemia-reperfusion injury modification during liver surgery in rats: pretreatment with nifedipine or misoprostol. ( Hardy, KJ; Shulkes, A; Tancheroen, S, 1995) |
| "To investigate the pharmacokinetic (PK) profiles and safety of nifedipine and candesartan after a single oral dose of nifedipine gastrointestinal therapeutic system (GITS) 30 mg/candesartan cilexetil 8 mg (N30/C8 mg) fixed-dose combination (FDC) in adults with mild to moderate hepatic impairment." | 2.84 | Pharmacokinetics and safety of nifedipine GITS/candesartan fixed-dose combination in subjects with hepatic impairment . ( Blode, H; Boettcher, MF; Brendel, E; Halabi, A; Liu, Y; Schmidt, A; Unger, S, 2017) |
| "To determine whether verapamil, diltiazem, or nifedipine affect digitoxin kinetics, glycoside plasma concentrations and renal excretion were measured before and during steady-state dosing in 30 patients with cardiac insufficiency." | 2.66 | Effects of verapamil, diltiazem, and nifedipine on plasma levels and renal excretion of digitoxin. ( Kuhlmann, J, 1985) |
| " These products are well absorbed from the gastrointestinal tract but undergo variable degrees of transformation during the first passage through the liver." | 2.37 | [Clinical pharmacology of calcium inhibitors]. ( Martre, H; Singlas, E; Taburet, AM, 1985) |
| " The time to Cmax was not significantly different in the two groups." | 1.27 | Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency. ( Burkholder, DE; Krol, GJ; Lasseter, KC; Murdoch, AA; Shamblen, EC; Taylor, RJ; Vanov, SK, 1984) |
| " There was a fourfold increase in the elimination half-life (434 +/- 74 minutes in the cirrhotics compared with 102 +/- 11 minutes in the healthy subjects)." | 1.27 | Pharmacokinetics of nifedipine after oral administration in chronic liver disease. ( Ene, MD; Roberts, CJ, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 1 |
| Boettcher, MF | 1 |
| Schmidt, A | 1 |
| Unger, S | 1 |
| Halabi, A | 1 |
| Brendel, E | 1 |
| Blode, H | 1 |
| Lasseter, KC | 1 |
| Shamblen, EC | 1 |
| Murdoch, AA | 1 |
| Burkholder, DE | 1 |
| Krol, GJ | 1 |
| Taylor, RJ | 1 |
| Vanov, SK | 1 |
| Hardy, KJ | 1 |
| Tancheroen, S | 1 |
| Shulkes, A | 1 |
| Neĭko, IeM | 1 |
| Mytnyk, ZM | 1 |
| Holovach, IIu | 1 |
| Deakin, CD | 1 |
| Gove, CD | 1 |
| Fagan, EA | 1 |
| Tredger, JM | 1 |
| Williams, R | 1 |
| Pinquier, JL | 1 |
| Urien, S | 1 |
| Chaumet-Riffaud, P | 1 |
| Tillement, JP | 1 |
| Babany, G | 1 |
| Uzzan, F | 1 |
| Larrey, D | 1 |
| Degott, C | 1 |
| Bourgeois, P | 1 |
| René, E | 1 |
| Vissuzaine, C | 1 |
| Erlinger, S | 1 |
| Benhamou, JP | 1 |
| Lejeune, P | 1 |
| Desager, JP | 1 |
| Meunier, H | 1 |
| Harvengt, C | 1 |
| Bhadoria, DP | 1 |
| Srivastava, AK | 1 |
| Sharma, M | 1 |
| Deswal, A | 1 |
| Bhadoria, P | 1 |
| Malhotra, KK | 1 |
| Ene, MD | 1 |
| Roberts, CJ | 1 |
| Lauterburg, BH | 1 |
| Padrini, R | 1 |
| Piovan, D | 1 |
| Bova, S | 1 |
| Moretto, R | 1 |
| Cargnelli, G | 1 |
| Ferrari, M | 1 |
| Kuhlmann, J | 1 |
| Singlas, E | 1 |
| Martre, H | 1 |
| Taburet, AM | 1 |
| Bruzzese, V | 1 |
| Coccia, G | 1 |
| Di Bartolomeo, R | 1 |
| Fiorini, G | 1 |
| Rossi, A | 1 |
| Ruggieri, P | 1 |
1 review available for nifedipine and Liver Dysfunction
| Article | Year |
|---|---|
[Clinical pharmacology of calcium inhibitors].
Topics: Age Factors; Animals; Bepridil; Biological Availability; Biotransformation; Calcium Channel Blockers | 1985 |
2 trials available for nifedipine and Liver Dysfunction
| Article | Year |
|---|---|
Pharmacokinetics and safety of nifedipine GITS/candesartan fixed-dose combination in subjects with hepatic impairment
.
Topics: Administration, Oral; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; | 2017 |
Effects of verapamil, diltiazem, and nifedipine on plasma levels and renal excretion of digitoxin.
Topics: Aged; Benzazepines; Clinical Trials as Topic; Digitoxin; Diltiazem; Drug Interactions; Drug Therapy, | 1985 |
12 other studies available for nifedipine and Liver Dysfunction
| Article | Year |
|---|---|
Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chronic Disea | 1984 |
Hepatic ischemia-reperfusion injury modification during liver surgery in rats: pretreatment with nifedipine or misoprostol.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Hepatectomy; Liver; Liver Diseases; Liver | 1995 |
[Different therapeutic approaches for chronic diffuse liver lesions using ornicetil, lactulose, etimizol and corinfar].
Topics: Etimizol; Hepatic Encephalopathy; Hepatitis, Chronic; Humans; Lactulose; Liver Cirrhosis; Liver Dise | 2002 |
Delayed calcium channel blockade with diltiazem reduces paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diltiaz | 1991 |
Differences in the serum binding determinants of isradipine and darodipine--consequences for serum protein binding in various diseases.
Topics: Adult; Blood Proteins; Calcium Channel Blockers; Fatty Acids, Nonesterified; Female; Humans; Hydroge | 1989 |
Alcoholic-like liver lesions induced by nifedipine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis, Alcoholic; | 1989 |
Kinetics of a single dose combination of nifedipine/acebutolol in patients with chronic liver disease.
Topics: Acebutolol; Adult; Aged; Chronic Disease; Drug Combinations; Female; Humans; Liver Diseases; Male; M | 1988 |
Safe use of clonidine, nifedipine and vitamin K in hepatic porphyria.
Topics: Adult; Clonidine; Humans; Hypertension; Liver Diseases; Male; Nifedipine; Porphyrias; Vitamin K | 1988 |
Pharmacokinetics of nifedipine after oral administration in chronic liver disease.
Topics: Administration, Oral; Adult; Aged; Chronic Disease; Half-Life; Humans; Liver Diseases; Male; Middle | 1987 |
[Clinical pharmacology of calcium antagonists].
Topics: Aging; Arrhythmias, Cardiac; Biological Availability; Calcium Channel Blockers; Diltiazem; Drug Inte | 1987 |
Physiological, pharmacological and pathological factors affecting the pharmacokinetics of calcium entry blockers.
Topics: Aging; Animals; Calcium Channel Blockers; Diltiazem; Drug Administration Schedule; Guinea Pigs; Huma | 1987 |
[Acute unusual hemodynamic effects of the calcium-antagonists].
Topics: Aged; Asthenia; Bradycardia; Humans; Liver; Liver Diseases; Male; Middle Aged; Nifedipine; Verapamil | 1985 |