nifedipine and Labor, Premature studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Research Excerpts

Excerpt	Relevance	Reference
"There is a lack of sufficient evidence regarding efficacy and safety of amlodipine on treating hypertension during pregnancy."	9.22	Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. ( Du, P; Mei, Z; Qin, S; Shi, S; Yin, J, 2022)
"To compare the effectiveness, safety, and possible adverse effects of terbutaline and nifedipine in prolonging pregnancy beyond 48 h."	9.13	Terbutaline versus nifedipine for prolongation of pregnancy in patients with preterm labor. ( Duminy, P; Mawaldi, L; Tamim, H, 2008)
"In this study, we presented 2 cases and evaluated the evidence for symptomatic hypocalcemia after treatment with magnesium sulfate alone or combined with use of nifedipine."	8.82	Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipine. ( Friedman, SA; Koontz, SL; Schwartz, ML, 2004)
"To evaluate the risk of developing pulmonary edema in women exposed to nifedipine, magnesium sulfate (MgSO4), or both in a preterm setting."	7.80	Effect of magnesium sulfate and nifedipine on the risk of developing pulmonary edema in preterm births. ( Abenhaim, HA; Gangal, M; Xiao, C, 2014)
"Nifedipine treatment did not reduce gene expression or protein secretion of pro-inflammatory cytokines in either cultured myometrial cells or ex vivo tissues."	5.91	Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth. ( Arman, BM; Beard, S; Binder, NK; de Alwis, N; Debruin, DA; Hannan, NJ; Hayes, A; Kaitu'u-Lino, TJ; Tong, S, 2023)
"This was a randomized, double-blind, placebo-controlled trial of nifedipine in women with a singleton pregnancy between 28 0/7 and 33 6/7 weeks of gestation who were admitted with uterine activity, intact membranes, and cervical dilatation from 2 to 4 cm."	5.41	Nifedipine for Acute Tocolysis of Preterm Labor: A Placebo-Controlled Randomized Trial. ( Casey, BM; Hawkins, JS; Leveno, KJ; McIntire, DD; Wells, CE, 2021)
" Moreover, as the combination did not cause severe maternal side effects, it may be considered as a safe and effective method to prolong gestation in patients with preterm labor."	5.40	The influence of ritodrine alone or in combination with nifedipine on maternal cardiovascular side effects and pregnancy outcomes. ( Bae, JY; Hwang, I; Kim, MJ; Seong, WJ, 2014)
"Risk factors for preterm labor commonly observed in the study group were urinary tract infection (60."	5.39	Pregnancy outcomes and successful rate of nifedipine therapeutic protocol implementation in a hospital of San Juan. ( Catalano, LN; Negron, I; Rivera Rosa, E; Vázquez Guzmán, M; Villar Diaz, M, 2013)
"Nifedipine was associated with a minimal but significant decrease in blood pressure."	5.37	Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug. ( Luewan, S; Mahathep, R; Tongsong, T, 2011)
"There is a lack of sufficient evidence regarding efficacy and safety of amlodipine on treating hypertension during pregnancy."	5.22	Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. ( Du, P; Mei, Z; Qin, S; Shi, S; Yin, J, 2022)
"Nifedipine may be better for delayed delivery and less likely to produce adverse pregnancy outcomes, followed by indomethacin."	5.22	Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis. ( Pei, S; Xiong, Z; Zhu, Z, 2022)
" The aim of this trial was to study the effect of prolonged tocolysis with nifedipine versus placebo in women with PPROM on perinatal outcome and prolongation of pregnancy."	5.22	Nifedipine versus placebo in the treatment of preterm prelabor rupture of membranes: a randomized controlled trial: Assessment of perinatal outcome by use of tocolysis in early labor-APOSTEL IV trial. ( Bax, CJ; Bloemenkamp, KW; de Lange, TS; Franx, A; Kok, M; Mol, BW; Naaktgeboren, CA; Nijman, TA; Oude Rengerink, K; Oudijk, MA; Scheepers, HC; van Eyck, J; van Vliet, EO; Woiski, M, 2016)
" The study was designed to establish a correlation between body weight and nifedipine plasma level."	5.20	Pharmacokinetics of nifedipine slow-release during sustained tocolysis. ( Kwee, A; Lotgering, FK; Mol, BW; Papatsonis, DN; Porath, MM; Roos, C; Spaanderman, ME; ter Laak, MA; Touw, DJ; van 't Veer, NE; van der Post, JA; van Hattum, PR; van Pampus, MG, 2015)
"The aim of our study was to compare the efficacy and safety of nifedipine and progesterone for maintenance tocolysis after arrested preterm labour, in prolonging pregnancy and preventing recurrence of preterm labour."	5.19	Comparison of nifedipine and progesterone for maintenance tocolysis after arrested preterm labour. ( Kamat, S; Rani, R; Veena, P, 2014)
"Women with a singleton pregnancy in threatened preterm labour (24(+0) to 33(+6) weeks) with a positive fetal fibronectin test were randomised to nifedipine or placebo."	5.19	The NIFTY study: a multicentre randomised double-blind placebo-controlled trial of nifedipine maintenance tocolysis in fetal fibronectin-positive women in threatened preterm labour. ( Hayward, L; McCowan, L; Mol, BW; Parry, E; Roos, C; Stone, P, 2014)
" This multicenter randomised clinical trial aims to compare nifedipine and atosiban in terms of neonatal outcome, duration of pregnancy and maternal side effects."	5.19	Nifedipine versus atosiban in the treatment of threatened preterm labour (Assessment of Perinatal Outcome after Specific Tocolysis in Early Labour: APOSTEL III-Trial). ( Bax, CJ; Bijvank, BN; Bloemenkamp, KW; Duvekot, HJ; Franssen, MT; Franx, A; Gyselaers, W; Heida, KY; Jaquemyn, Y; Kok, JH; Kok, M; Mol, BW; Opmeer, BC; Oudijk, MA; Porath, MM; Scheepers, HC; Schuit, E; van Beek, E; van Vliet, EO; Woiski, M, 2014)
"We examined pregnancy outcomes in women receiving nifedipine tocolysis having recurrent preterm labor (RPTL)."	5.14	An examination of the clinical benefits and cost-effectiveness of tocolytic replacement following recurrent preterm labor. ( de la Torre, L; Desch, C; Flick, AA; González-Quintero, VH; Istwan, N; Rhea, D; Roca, LE, 2010)
"To compare the effectiveness, safety, and possible adverse effects of terbutaline and nifedipine in prolonging pregnancy beyond 48 h."	5.13	Terbutaline versus nifedipine for prolongation of pregnancy in patients with preterm labor. ( Duminy, P; Mawaldi, L; Tamim, H, 2008)
"When compared with placebo, maintenance nifedipine tocolysis did not confer a large reduction in preterm birth or improvement in neonatal outcomes."	5.13	Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. ( Caughey, AB; Chitkara, U; Druzin, ML; El-Sayed, YY; Lyell, DJ; Mannan, J; Pullen, KM, 2008)
"To compare the efficacy of nifedipine and ritodrine in prolonging pregnancy beyond 48 h, 1 week and 36."	5.12	Nifedipine versus ritodrine for suppression of preterm labor. Comparison of their efficacy and secondary effects. ( Cararach, V; Cobo, T; Coll, O; Deulofeu, P; Martínez, S; Palacio, M; Sánchez, M, 2006)
"To study the effect of a calcium channel antagonist--Nifedipine(NIF) on the prevention and treatment of premature labor, the suppression of uterine contraction, the prolongation of pregnancy, and to observe the side effects of NIF."	5.10	[Clinical observations on the prevention and treatment of premature labor with nifedipine]. ( Liu, M; Zhang, X, 2002)
"Maintenance therapy with oral nifedipine does not significantly prolong pregnancy in patients initially treated with intravenous magnesium sulfate for preterm labor."	5.09	Maintenance oral nifedipine for preterm labor: a randomized clinical trial. ( Carr, DB; Clark, AL; Kernek, K; Spinnato, JA, 1999)
" There was no significant difference between atosiban and nifedipine for pregnancy prolongation of 48 hours or more regarding efficacy (RR 1."	5.01	Systematic review and meta-analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor. ( Abdel-Daim, MM; Ahmed, AMM; Ali, AA; Anwar, AT; El Sherif, L; Elgebaly, A; Loutfi, GO; Mohamed, HB; Sayed, AK; Taha, AS; Yahia, RM, 2019)
" No difference in the incidence of preterm birth was found when calcium channel blocker (nifedipine) maintenance therapy was compared with no treatment."	4.82	Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. ( Crowther, CA; Gaunekar, NN, 2004)
"In this study, we presented 2 cases and evaluated the evidence for symptomatic hypocalcemia after treatment with magnesium sulfate alone or combined with use of nifedipine."	4.82	Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipine. ( Friedman, SA; Koontz, SL; Schwartz, ML, 2004)
"Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD)."	3.91	Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development. ( Feldstein, O; Friedlander, E; Harel-Gadassi, A; Israel, S; Laiba, E; Mankuta, D; Yaari, M; Yirmiya, N, 2019)
"To evaluate the risk of developing pulmonary edema in women exposed to nifedipine, magnesium sulfate (MgSO4), or both in a preterm setting."	3.80	Effect of magnesium sulfate and nifedipine on the risk of developing pulmonary edema in preterm births. ( Abenhaim, HA; Gangal, M; Xiao, C, 2014)
"To characterize the pharmacokinetics and pharmacogenetics of nifedipine in pregnancy."	3.79	Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic. ( Caritis, SN; Clark, S; Clay, JM; Haas, DM; Hebert, MF; Quinney, SK; Renbarger, JL; Umans, JG, 2013)
"To analyse the expression of 15 genes encoding receptors and enzymes associated with the molecular mechanism of the tocolytic drugs atosiban (oxytocin receptor antagonist), nifedipine (calcium channel blocker) and celecoxib (selective cyclo-oxygenase-2 inhibitor) in preterm labor patients with premature rupture of fetal membranes in relation to symptoms of intrauterine infection and preterm labor risk factors."	3.78	Expression of selected genes in preterm premature rupture of fetal membranes. ( Chyczewski, L; Kowalczuk, O; Kuć, P; Laudański, P; Laudański, T, 2012)
" Pregnancy outcomes of women resuming nifedipine tocolysis ( N = 418) following hospitalization were compared with those having an alteration in treatment ( N = 238) to continuous subcutaneous terbutaline."	3.74	Management of recurrent preterm labor in twin gestations with nifedipine tocolysis. ( de la Torre, L; Desch, C; González-Quintero, VH; Istwan, NB; Rhea, DJ; Roca, L; Stanziano, GJ, 2008)
"The purpose of this study was to investigate the effects of K+ channel blockade on the uterorelaxant effects of nifedipine in human myometrium during pregnancy."	3.74	The relaxant effect of nifedipine in human uterine smooth muscle and the BK(Ca) channel. ( Morrison, JJ; Moynihan, AT; Smith, TJ, 2008)
" On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia."	3.69	Massive vulvar edema complicating tocolysis in a patient with twins. A case report. ( Bennert, H; Stubblefield, PG; Trice, L, 1996)
"To study the tocolytic action of nifedipine combined with sildenafil citrate (SC) and if the combination is superior to nifedipine alone in inhibiting threatened preterm labour (PTL)."	2.90	Nifedipine alone or combined with sildenafil citrate for management of threatened preterm labour: a randomised trial. ( El-Khadry, SW; Maher, MA; Sayyed, TM, 2019)
"Women with symptoms of preterm labor between 24 and 34 weeks, intact membranes, cervical length between 10 and 30 mm, and negative fibronectin test were randomly allocated to nifedipine (80 mg/day) or placebo."	2.80	Randomized comparison of nifedipine and placebo in fibronectin-negative women with symptoms of preterm labor and a short cervix (APOSTEL-I Trial). ( Bax, CJ; Bloemenkamp, KW; Bolte, AC; Bossuyt, PM; Cornette, J; Duvekot, JJ; Franssen, MT; Kwee, A; Mol, BW; Nij Bijvank, SW; Opmeer, BC; Oudijk, MA; Porath, MM; Scheepers, HC; Sollie, KM; Spaanderman, ME; van Baaren, GJ; van der Post, JA; van Eyck, J; van Lith, JM; Vandenbussche, FP; Vis, JY; Wilms, FF; Woiski, M, 2015)
" In women in preterm labour, we compared the impact of terbutaline versus nifedipine on inhibition of uterine contractions, preterm birth, neonatal sepsis, intracranial haemorrhage or necrotizing enterocolitis, death or admission to a neonatal intensive care unit and maternal adverse reactions."	2.80	Nifedipine versus terbutaline, tocolytic effectiveness and maternal and neonatal adverse effects: a randomized, controlled pilot trial. ( Guyatt, G; Lopes, LC; Padovani, TR, 2015)
"Management of preterm labor and prevention from preterm delivery in order to lower these risks have always been under serious concern."	2.79	Comparison between nitroglycerin dermal patch and nifedipine for treatment of preterm labor: a randomized clinical trial. ( Kashanian, M; Sheikhansari, N; Zamen, Z, 2014)
"In threatened preterm labor, maintenance tocolysis with nifedipine, after an initial course of tocolysis and corticosteroids for 48 hours, may improve perinatal outcome."	2.78	Effect of maintenance tocolysis with nifedipine in threatened preterm labor on perinatal outcomes: a randomized controlled trial. ( Bloemenkamp, KW; Bolte, AC; Cornette, J; de Groot, CJ; Duvekot, JJ; Franssen, MT; Kok, JH; Kwee, A; Lotgering, FK; Merién, A; Mol, BW; Nij Bijvank, B; Opmeer, BC; Oudijk, MA; Papatsonis, DN; Porath, MM; Roos, C; Scheepers, HC; Scherjon, SA; Schuit, E; Sollie, KM; Spaanderman, ME; van der Post, JA; van Eyck, J; van Pampus, MG; Vijgen, SM; Willekes, C, 2013)
"Nifedipine was appropriate for contraction inhibition when the cervical length was less than 30 mm with statistical significance."	2.77	Effect of cervical length to the efficacy of nifedipine and bed rest for inhibiting threatened preterm labor. ( Chawanpaiboon, S; Sutantawibul, A, 2012)
" Non-compartmental pharmacokinetic analysis was used to estimate nifedipine exposure at steady state."	2.77	A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic. ( Haas, DM; Jones, DR; McCormick, CL; Quinney, SK; Renbarger, JL, 2012)
"Atosiban has fewer failures within 48 hours."	2.77	Nifedipine compared with atosiban for treating preterm labor: a randomized controlled trial. ( Baram, S; Garmi, G; Nachum, Z; Salim, R; Shalev, E; Zafran, N, 2012)
"Women in acute preterm labor with cervical dilatation 1-6 cm were randomized to receive one of three first-line tocolytic drugs."	2.77	Effect of antenatal tocolysis on neonatal outcomes. ( Briery, CM; Keiser, SD; Klauser, CK; Kosek, MA; Martin, RW; Morrison, JC, 2012)
"Women diagnosed with threatened preterm labor between 22 and 35 weeks' gestation scheduled to receive nifedipine tocolysis and prophylactic antenatal corticosteroid were randomized to a single intramuscular injection of 250 mg of 17-OHPC or placebo saline in a double-blind fashion."	2.77	Single dose 17 alpha-hydroxyprogesterone caproate in preterm labor: a randomized trial. ( King, AS; Omar, SZ; Tan, PC; Vallikkannu, N, 2012)
"Indomethacin was less effective than nifedipine for the fast treatment of preterm labor."	2.76	Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor. ( Bahasadri, S; Kashanian, M; Zolali, B, 2011)
"At present, women with threatened preterm labor before 32 weeks of gestation are, after transfer to a perinatal center, treated with tocolytics and corticosteroids."	2.74	Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial). ( Bloemenkamp, KW; Bolte, AC; Cornette, J; Derks, JB; Duvekot, JJ; Kwee, A; Lotgering, FK; Mol, BW; Opmeer, BC; Oudijk, MA; Porath, MM; Scheepers, HC; Scherjon, SA; Sollie, KM; Spaanderman, ME; van der Post, JA; van Eyck, J; van Pampus, MG; Vis, JY; Willekes, C; Wilms, FF, 2009)
"Nifedipine was associated with fewer maternal adverse effects."	2.73	Magnesium sulfate compared with nifedipine for acute tocolysis of preterm labor: a randomized controlled trial. ( Burrs, D; Campbell, L; Caughey, AB; Ching, S; Chitkara, U; Druzin, ML; El-Sayed, YY; Lyell, DJ; Pullen, K, 2007)
"Terbutaline was initially infused with the rate 10 g/min with an increment 5 microg/min every 10 minutes if required, until 25 microg/min was reached."	2.73	Safety and efficacy of oral nifedipine versus terbutaline injection in preterm labor. ( Laohapojanart, N; Ratanajamit, C; Soorapan, S; Wacharaprechanont, T, 2007)
"GITS tablets 90 mg/d are an alternative dosage regimen to previous used slow-release tablets 60 mg/d for tocolysis with similar pharmacokinetic profile and a good tolerance."	2.73	Nifedipine gastrointestinal therapeutic system (GITS) as an alternative to slow-release for tocolysis--tolerance and pharmacokinetic profile. ( Burkhardt, T; Juon, AM; Krähenmann, F; Kühn-Velten, WN; von Mandach, U; Zimmermann, R, 2008)
"The study included 73 patients with preterm labor with intact membranes."	2.71	Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor. ( Balkanli-Kaplan, P; Sayin, M; Sayin, NC; Varol, FG, 2004)
"Atosiban is an effective and safe drug for the acute treatment of preterm labor with minimal side effects, and it can be an option in the treatment of preterm labor, especially in patients with heart disease and multi-fetal pregnancies."	2.71	Atosiban and nifedipin for the treatment of preterm labor. ( Akbarian, AR; Kashanian, M; Soltanzadeh, M, 2005)
"Use of nifedipine for preterm labor is associated with a lower incidence of adverse hemodynamic and metabolic changes compared with ritodrine after 24 and 48 h of tocolysis."	2.71	Hemodynamic and metabolic effects after nifedipine and ritodrine tocolysis. ( Adèr, HJ; Bleker, OP; Dekker, GA; Papatsonis, DN; van Geijn, HP, 2003)
"Nifedipine is a valid and well-tolerated alternative among the tocolytic drugs, and apparently does not significantly alter fetal vascular blood flow."	2.69	A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor. ( García-Velasco, JA; González González, A, 1998)
"Nifedipine for treatment of preterm labor was associated with a lower incidence of neonatal morbidity than ritodrine."	2.69	Neonatal effects of nifedipine and ritodrine for preterm labor. ( Adèr, HJ; Bleker, OP; Dekker, GA; Kok, JH; Papatsonis, DN; van Geijn, HP, 2000)
"Nifedipine was as effective as terbutaline in preventing recurrent labor, 26% versus 24%, and in achieving a gestation > 34 weeks, 62% versus 68%."	2.67	Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study. ( Glock, JL; Morales, WJ, 1993)
"Treatment of preterm labor with beta-sympathomimetics has been questioned because of the many maternal and fetal complications associated with its use."	2.67	Comparison of nifedipine and ritodrine for the treatment of preterm labor. ( Bracero, LA; Kirshenbaum, N; Leikin, E; Tejani, N, 1991)
"Fifty-eight women in preterm labor were selected randomly to receive either oral nifedipine or intravenous ritodrine hydrochloride."	2.67	Nifedipine versus ritodrine for suppressing preterm labor. ( Graves, WL; Meyer, WR; Randall, HW, 1990)
"Nifedipine was found to be significantly more effective than ritodrine or withholding therapy, and was almost devoid of side-effects."	2.66	The use of a calcium antagonist (nifedipine) to suppress preterm labour. ( Read, MD; Wellby, DE, 1986)
"Following a systematic review of the literature, we have provided an overview of the use of tocolytics for the prevention of preterm birth and have examined the fetal and maternal adverse effects of the various tocolytic agents currently in use."	2.53	The safety of tocolytics used for the inhibition of preterm labour. ( Jørgensen, JS; Lamont, CD; Lamont, RF, 2016)
" Another important focus for future trials is identifying optimal dosage regimens of different types of CCBs (high versus low, particularly addressing speed of onset of uterine quiescence) and formulation (capsules versus tablets)."	2.50	Calcium channel blockers for inhibiting preterm labour and birth. ( Carbonne, B; Flenady, V; Jardine, LA; Murray, L; Papatsonis, DN; Stock, OM; Wojcieszek, AM, 2014)
"When preterm labor is actually threatening, current pharmacological therapies focus on inhibition of preterm contractions."	2.50	Preterm labor: current pharmacotherapy options for tocolysis. ( Boormans, EM; de Lange, TS; Mol, BW; Oudijk, MA; van Vliet, EO, 2014)
"The pathophysiology leading to preterm labor is not well understood and often multifactorial; initiating factors include intrauterine infection, inflammation, ischemia, overdistension, and hemorrhage."	2.48	Tocolytic therapy for acute preterm labor. ( Abramovici, A; Cantu, J; Jenkins, SM, 2012)
"Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gestation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, neonatal jaundice, and admission to the neonatal intensive care unit when compared with β₂-adrenergic-receptor agonists."	2.47	Nifedipine in the management of preterm labor: a systematic review and metaanalysis. ( Conde-Agudelo, A; Kusanovic, JP; Romero, R, 2011)
"Preterm birth is the major cause of perinatal mortality and morbidity in the developed world."	2.44	Developments in the pharmacotherapeutic management of spontaneous preterm labor. ( Kam, KY; Lamont, RF, 2008)
"Atosiban is a new advance in the management of spontaneous preterm labor."	2.44	The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban. ( Lamont, RF; Lyndrup, J, 2007)
" Several relatively small randomised trials have compared calcium channel blockers with beta-agonists and the meta-analyses of these studies have demonstrated superior or comparable efficacy and a superior adverse events profile."	2.43	Calcium channel blockers for tocolysis: a review of their role and safety following reports of serious adverse events. ( Oei, SG, 2006)
"Nifedipine tocolysis was associated with a significant reduction in respiratory distress syndrome compared with atosiban (OR 0."	2.42	Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials. ( Coomarasamy, A; Gee, H; Khan, KS; Knox, EM; Song, F, 2003)
"Exploration of possible genetic predisposition is just beginning."	2.41	Preterm labour. ( Bennett, PR; Terzidou, V, 2002)
"Nifedipine is an effective and safe drug to use when tocolytic therapy is indicated for preterm labor."	2.41	Calcium channel blockers in the management of preterm labor and hypertension in pregnancy. ( Bos, JM; Dekker, GA; Geijn, HP; Lok, CA; Papatsonis, DN, 2001)
"Treatment with nifedipine was interrupted significantly less often because of side effects (OR 0."	2.41	Tocolysis with nifedipine or beta-adrenergic agonists: a meta-analysis. ( Carbonne, B; Dekker, G; Goffinet, F; Papatsonis, D; Tsatsaris, V, 2001)
"Nifedipine also has the benefit of oral administration, in contrast with beta 2-sympathicomimetics which are administered intravenously."	2.41	[Nifedipine first choice in management of threatening preterm labor]. ( Oei, SG; Papatsonis, DN; Timmerman, CC; van Geijn, HP, 2002)
"Nifedipine has both vasodilator and relaxant actions in arterial smooth muscle and other tissues, like uterus."	2.38	[Nifedipine in gynecology and obstetrics]. ( Palma-Aguirre, JA; Rodríguez-Palomares, C, 1992)
"Nifedipine treatment did not reduce gene expression or protein secretion of pro-inflammatory cytokines in either cultured myometrial cells or ex vivo tissues."	1.91	Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth. ( Arman, BM; Beard, S; Binder, NK; de Alwis, N; Debruin, DA; Hannan, NJ; Hayes, A; Kaitu'u-Lino, TJ; Tong, S, 2023)
"Nifedipine treatment seems not to affect systolic or diastolic functions."	1.72	Fetal echocardiographic evaluation before and after nifedipine treatment in preterm labor. ( Goncu Ayhan, S; Menekse Beser, D; Oluklu, D; Sahin, D; Tugrul Ersak, D; Uyan Hendem, D; Yildirim, M, 2022)
" Moreover, as the combination did not cause severe maternal side effects, it may be considered as a safe and effective method to prolong gestation in patients with preterm labor."	1.40	The influence of ritodrine alone or in combination with nifedipine on maternal cardiovascular side effects and pregnancy outcomes. ( Bae, JY; Hwang, I; Kim, MJ; Seong, WJ, 2014)
"Nifedipine is an effective oral tocolytic with few maternal side effects."	1.40	[Tocolysis with nifedipin; its use in current practice]. ( Dimitrov, G; Ivanov, S; Jordanova, D; Karamisheva, V; Marinov, B; Nachev, A, 2014)
"Risk factors for preterm labor commonly observed in the study group were urinary tract infection (60."	1.39	Pregnancy outcomes and successful rate of nifedipine therapeutic protocol implementation in a hospital of San Juan. ( Catalano, LN; Negron, I; Rivera Rosa, E; Vázquez Guzmán, M; Villar Diaz, M, 2013)
"Nifedipine was associated with a minimal but significant decrease in blood pressure."	1.37	Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug. ( Luewan, S; Mahathep, R; Tongsong, T, 2011)
"Pregnancy was extended for more than 48 hours after the first dose of nifedipine in 86."	1.36	[Management of pre-term labor: use of nifedipine in Conakry, Guinea]. ( Camara, MK; Cissoko, M; Diallo, A; Diallo, FB; Diallo, MS; Diallo, Y; Lontsi, GR; Sy, T, 2010)
"GITS dosage titrated to clinical response (30-150 mg/day)."	1.35	Nifedipine concentration in maternal and umbilical cord blood after nifedipine gastrointestinal therapeutic system for tocolysis. ( Juon, AM; Kühn-Velten, WN; Silberschmidt, AL; von Mandach, U; Zimmermann, R, 2008)
"Nifedipine is believed to be a superior tocolytic agent on the basis of efficacy and side-effect profile, but was never prospectively evaluated in a placebo-controlled randomized clinical trial (RCT)."	1.34	Feasibility of a randomized controlled trial testing nifedipine vs. placebo for the treatment of preterm labor. ( Abenhaim, HA; Audibert, F; Tremblay, L; Tremblay, V, 2007)
"Nifedipine serum levels were measured with liquid chromatography."	1.34	Nifedipine serum levels in pregnant women undergoing tocolysis with nifedipine. ( Burkhardt, T; Kraehenmann, F; Marin, TZ; Meier, R; Zimmermann, R, 2007)
"Nifedipine is an effective oral tocolytic and a rational alternative to other tocolytic agents in the management of preterm labour."	1.34	[Treatment of preterm delivery with calcium channel blockers--Nifedipine]. ( Diavolov, V; Dimitrov, A; Ivanov, S; Markov, D; Nikolov, A, 2007)
"Nifedipine maintenance was associated with a significant decline in maternal systolic and diastolic blood pressure after 24 h, while maternal heart rate and FHR were unaffected."	1.33	Nifedipine therapy for preterm labor: effects on placental, fetal cerebral and atrioventricular Doppler parameters in the first 48 hours. ( Baschat, AA; Demir, N; Gol, M; Guclu, S; Saygili, U; Sezer, O, 2006)
"Preterm labor is a major clinical hazard causing both maternal and neonatal morbidity and mortality."	1.32	Choosing calcium channel blockers for pregnant women with paroxysmal supraventriclar tachycardia and preterm labor: a case report. ( Lai, WT; Ou, KY; Su, JW; Tsai, EM; Yang, CH, 2004)
"Nifedipine was a well-tolerated and safe tocolytic in this population and warrants further investigation."	1.28	Nifedipine for treatment of preterm labor: a historic prospective study. ( Berga, S; Haverkamp, AD; Murray, C; Orleans, M; Pecht, D, 1992)
"Oral nifedipine retard treatment to suppress preterm labour was administered to 8 patients using a new scheme."	1.28	Long term treatment with nifedipine retard to suppress preterm labour. ( Ghirardini, G, 1991)
" The peak concentration of nifedipine during sublingual therapy ranged from 23."	1.28	Nifedipine pharmacokinetics during preterm labor tocolysis. ( Blaschke, T; Ferguson, JE; Pershe, R; Schutz, T; Stevenson, DK, 1989)
"We describe a successful, prolonged, inhibition of preterm labor using nifedipine combined with terbutaline in a patient undergoing complicated obstetrical problems."	1.27	The management of preterm labor with the calcium channel-blocking agent nifedipine combined with the beta-mimetic terbutaline. ( Friedman, PA; Frigoletto, FD; Kaul, AF; Osathanondh, R; Safon, LE, 1985)
"Similarly, when premature labor was induced by ovariectomy (OVX) on day 16, OVX control rats (n = 6) receiving 5 microgram/day of estradiol delivered 82% of the fetuses within 48 hours of OVX, whereas the rats treated with nicardipine (n = 7) delivered only 4% of the fetuses."	1.26	Deactivation of the uterus during normal and premature labor by the calcium antagonist nicardipine. ( Csapo, AI; Henzl, MR; Puri, CP; Tarro, S, 1982)

Research

Studies (205)

Authors

Clinical Trials (12)

Trial Overview

Trial Outcomes

Number of Participants With Preterm Birth

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (8.78)	18.7374
1990's	32 (15.61)	18.2507
2000's	82 (40.00)	29.6817
2010's	62 (30.24)	24.3611
2020's	11 (5.37)	2.80

Authors	Studies
Lorthe, E	2
Kayem, G	2
Xiong, Z	1
Pei, S	1
Zhu, Z	1
Yin, J	1
Mei, Z	1
Shi, S	1
Du, P	1
Qin, S	1
Menekse Beser, D	1
Oluklu, D	1
Uyan Hendem, D	1
Yildirim, M	1
Tugrul Ersak, D	1
Goncu Ayhan, S	1
Sahin, D	1
Arman, BM	1
Binder, NK	1
de Alwis, N	1
Beard, S	1
Debruin, DA	1
Hayes, A	1
Tong, S	1
Kaitu'u-Lino, TJ	1
Hannan, NJ	1
Siricilla, S	1
Hansen, CJ	1
Rogers, JH	1
De, D	1
Simpson, CL	1
Waterson, AG	1
Sulikowski, GA	1
Crockett, SL	1
Boatwright, N	1
Reese, J	1
Paria, BC	1
Newton, J	1
Herington, JL	1
Leal-Júnior, CC	1
Amorim, MMR	1
Souza, GFA	1
Lima, AKS	1
Souza, ASR	1
Yilmaz, O	1
Göncü, AŞ	1
Grin, L	1
Laish-Farkash, A	1
Bruoha, S	1
Rabinovich, M	1
Harlev, A	1
Anteby, E	1
Yosefy, C	1
Shenhav, S	1
Hawkins, JS	1
Wells, CE	1
Casey, BM	1
McIntire, DD	1
Leveno, KJ	1
Aggarwal, A	1
Bagga, R	1
Girish, B	1
Kalra, J	1
Kumar, P	1
Dehaene, I	1
Bergman, L	1
Turtiainen, P	1
Ridout, A	1
Mol, BW	14
Maher, MA	1
Sayyed, TM	1
El-Khadry, SW	1
Kashanian, M	4
Shirvani, S	1
Sheikhansari, N	2
Javanmanesh, F	1
Levin, G	1
Rottenstreich, A	1
Ali, AA	1
Sayed, AK	1
El Sherif, L	1
Loutfi, GO	1
Ahmed, AMM	1
Mohamed, HB	1
Anwar, AT	1
Taha, AS	1
Yahia, RM	1
Elgebaly, A	1
Abdel-Daim, MM	1
Friedlander, E	1
Yirmiya, N	1
Laiba, E	1
Harel-Gadassi, A	1
Yaari, M	1
Feldstein, O	1
Mankuta, D	2
Israel, S	1
Kutuk, MS	1
Ozgun, MT	1
Uludag, S	1
Dolanbay, M	1
Yildirim, A	1
Conde-Agudelo, A	2
Romero, R	2
Klauser, CK	3
Briery, CM	3
Martin, RW	3
Langston, L	1
Magann, EF	2
Morrison, JC	3
Naik Gaunekar, N	1
Raman, P	1
Bain, E	1
Crowther, CA	2
Catalano, LN	1
Villar Diaz, M	1
Vázquez Guzmán, M	1
Negron, I	1
Rivera Rosa, E	1
Jørgensen, JS	2
Weile, LK	1
Lamont, RF	8
Grzesiak, M	1
Ahmed, RB	1
Wilczynski, J	1
Kamat, S	1
Veena, P	1
Rani, R	1
Parry, E	1
Roos, C	7
Stone, P	1
Hayward, L	1
McCowan, L	1
van Vliet, EO	3
Boormans, EM	1
de Lange, TS	2
Oudijk, MA	9
Xiao, C	1
Gangal, M	1
Abenhaim, HA	2
Schuit, E	3
Heida, KY	1
Opmeer, BC	6
Kok, M	3
Gyselaers, W	1
Porath, MM	10
Woiski, M	3
Bax, CJ	3
Bloemenkamp, KW	8
Scheepers, HC	6
Jaquemyn, Y	1
van Beek, E	1
Duvekot, HJ	3
Franssen, MT	5
Bijvank, BN	1
Kok, JH	6
Franx, A	3
Zamen, Z	1
Wilms, FF	3
Vis, JY	4
de Wit-Zuurendonk, L	1
Flenady, V	2
Wojcieszek, AM	1
Papatsonis, DN	16
Stock, OM	1
Murray, L	1
Jardine, LA	1
Carbonne, B	9
Padovani, TR	1
Guyatt, G	1
Lopes, LC	1
ter Laak, MA	1
Touw, DJ	1
van Hattum, PR	1
Kwee, A	5
Lotgering, FK	6
van Pampus, MG	5
Spaanderman, ME	6
van der Post, JA	7
van 't Veer, NE	1
van Baaren, GJ	1
van Lith, JM	1
Bolte, AC	5
Cornette, J	4
Duvekot, JJ	5
Nij Bijvank, SW	1
van Eyck, J	8
Sollie, KM	3
Vandenbussche, FP	1
Bossuyt, PM	1
Karamisheva, V	1
Ivanov, S	2
Jordanova, D	1
Marinov, B	1
Dimitrov, G	1
Nachev, A	1
Lange, TS	1
Maisonneuve, E	1
Bejan-Angoulvant, T	1
Crochet, J	1
Jonville-Bera, AP	1
Parant, O	1
Deudon, R	1
Bennevent, J	1
Viard, C	1
Damase-Michel, C	1
Guyard-Boileau, B	1
Tucker, AR	1
Chauhan, SP	2
Kim, MJ	1
Hwang, I	1
Bae, JY	1
Seong, WJ	1
de Groot, C	1
Sollie, K	2
van Vliet, E	1
Seinen, L	1
Scheepers, H	1
Bloemenkamp, K	1
van Baar, A	1
van Wassenaer-Leemhuis, AG	1
van der Post, J	1
Mol, B	1
Rezk, M	1
Sayyed, T	1
Masood, A	1
Dawood, R	1
Lamont, CD	1
Ding, MX	1
Luo, X	1
Zhang, XM	1
Bai, B	1
Sun, JX	1
Qi, HB	1
Nijman, TA	1
Naaktgeboren, CA	1
Oude Rengerink, K	1
Nikolov, A	1
Markov, D	1
Dimitrov, A	1
Diavolov, V	1
Chan, LW	1
Sahota, DS	1
Yeung, SY	1
Leung, TY	1
Fung, TY	1
Lau, TK	1
Leung, TN	1
de la Torre, L	2
Istwan, NB	1
Desch, C	2
Rhea, DJ	1
Roca, L	1
Stanziano, GJ	1
González-Quintero, VH	2
Lyell, DJ	3
Pullen, KM	1
Mannan, J	1
Chitkara, U	2
Druzin, ML	2
Caughey, AB	2
El-Sayed, YY	2
Carlin, A	1
Norman, J	1
Cole, S	1
Smith, R	1
Nassar, AH	4
Abu-Musa, AA	1
Awwad, J	1
Khalil, A	1
Tabbara, J	1
Usta, IM	4
Siassakos, D	1
O'Brien, K	1
Draycott, T	1
Lima, MM	1
Souza, AS	1
Diniz, C	1
Porto, AM	1
Amorim, MM	1
Moron, AF	1
Derks, JB	2
Scherjon, SA	3
Willekes, C	3
Scheepers, LH	1
Bolte, A	1
Merién, A	2
Vijgen, SM	2
Flick, AA	1
Roca, LE	1
Istwan, N	2
Rhea, D	2
Blumenfeld, YJ	1
Kimber-Trojnar, Z	1
Leszczyńska-Gorzelak, B	1
Marciniak, B	1
Bartosiewicz, J	1
Oleszczuk, J	1
Sy, T	1
Diallo, FB	1
Diallo, Y	1
Camara, MK	1
Diallo, A	1
Cissoko, M	1
Lontsi, GR	1
Diallo, MS	1
Aoun, J	1
Luewan, S	1
Mahathep, R	1
Tongsong, T	1
Derbent, A	1
Simavli, S	1
Gümüş, II	1
Tatli, MM	1
Turhan, NO	1
Kusanovic, JP	1
Chawanpaiboon, S	2
Pimol, K	1
Sirisomboon, R	1
Bahasadri, S	1
Zolali, B	1
Haas, DM	2
Quinney, SK	2
McCormick, CL	1
Jones, DR	1
Renbarger, JL	2
Tan, PC	1
King, AS	1
Vallikkannu, N	1
Omar, SZ	1
Koster, MI	1
de Jong, MH	1
Derksen, MT	1
Van Gool, AR	1
Baumbach, J	1
Shi, SQ	1
Shi, L	1
Balducci, J	1
Coonrod, DV	1
Garfield, RE	1
Bina, I	1
Parveen, T	1
Khanom, A	1
Shamsunnahar, PA	1
Abramovici, A	1
Cantu, J	1
Jenkins, SM	1
Kuć, P	1
Laudański, P	1
Kowalczuk, O	1
Chyczewski, L	1
Laudański, T	1
Laas, E	1
Deis, S	1
Haddad, B	1
Valdés, E	1
Salinas, H	1
Toledo, V	1
Lattes, K	1
Cuellar, E	1
Perucca, E	1
Diaz, R	1
Montecinos, F	1
Reyes, A	1
Keiser, SD	1
Kosek, MA	1
Clay, JM	1
Hebert, MF	1
Clark, S	1
Umans, JG	1
Caritis, SN	1
Sutantawibul, A	1
Salim, R	1
Garmi, G	1
Nachum, Z	1
Zafran, N	1
Baram, S	1
Shalev, E	2
Cheung, CS	1
Li, TK	1
Lee, CP	1
Saleh, SS	1
Al-Ramahi, MQ	1
Al Kazaleh, FA	1
de Groot, CJ	1
Nij Bijvank, B	1
Timmerman, CC	1
Oei, SG	6
van Geijn, HP	12
Tsatsaris, V	4
Vayssière, C	1
Zhang, X	1
Liu, M	1
Bleker, OP	5
Adèr, HJ	4
Dekker, GA	10
Coomarasamy, A	1
Knox, EM	1
Gee, H	1
Song, F	1
Khan, KS	3
King, JF	3
Papatsonis, D	3
Dekker, G	2
Fleming, A	1
Bonebrake, R	1
Coleman, S	1
Stanziano, G	1
Hodges, R	1
Barkehall-Thomas, A	1
Tippett, C	1
Sayin, NC	1
Varol, FG	1
Balkanli-Kaplan, P	1
Sayin, M	1
Beattie, RB	1
Helmer, H	2
McNamara, H	1
Svare, J	2
Gaunekar, NN	1
Koontz, SL	1
Friedman, SA	1
Schwartz, ML	1
Flenady, VJ	2
Guclu, S	2
Saygili, U	2
Dogan, E	1
Demir, N	2
Baschat, AA	2
Ou, KY	1
Yang, CH	1
Tsai, EM	1
Lai, WT	1
Su, JW	1
van Veen, AJ	1
Pelinck, MJ	1
Erwich, JJ	1
Akbarian, AR	1
Soltanzadeh, M	1
Kurtoglu, S	1
Akcakus, M	1
Keskin, M	1
Ozcan, A	1
Hussain, K	1
Ables, AZ	1
Romero, AM	1
Beattie, B	1
Cabero Roura, L	1
Di Renzo, GC	1
Dudenhausen, JW	1
Kandysamy, V	1
Thomson, AJ	1
Johnson, KA	1
Mason, GC	1
Cararach, V	1
Palacio, M	1
Martínez, S	1
Deulofeu, P	1
Sánchez, M	1
Cobo, T	1
Coll, O	1
Boog, G	1
Marpeau, L	1
Closset, E	1
Vaast, P	1
Subtil, D	1
Houtzager, BA	1
Hogendoorn, SM	1
Samsom, JF	1
van Wassenaer, AG	1
Gol, M	1
Sezer, O	1
How, HY	1
Zafaranchi, L	1
Stella, CL	1
Recht, K	1
Maxwell, RA	1
Sibai, BM	1
Spinnato, JA	2
Parasuraman, R	1
Gandhi, MM	1
Liversedge, NH	1
Kim, A	1
Shim, JY	1
Lenglet, JE	1
van Schijndel, RJ	1
Vonk Noordegraaf, A	1
Burkett, G	1
Gilles, JM	1
Jacques, E	1
Perkins, RP	1
Maitra, N	1
Christian, V	1
Kavishvar, A	1
Ghazeeri, G	1
Dasari, P	1
Kodenchery, MM	1
Giles, W	1
Bisits, A	1
Marin, TZ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation: a Double-blinded Randomized Controlled Trial[NCT03976063]	Phase 3	850 participants (Anticipated)	Interventional	2019-10-07	Recruiting
Nifedipine for Acute Tocolysis of Preterm Labor[NCT02132533]	Phase 3	88 participants (Actual)	Interventional	2014-05-05	Completed
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686]	Phase 2/Phase 3	300 participants (Anticipated)	Interventional	2020-10-31	Not yet recruiting
The Tocolytic Efficacy of Nifedipine in the Management of Threatened and Advanced Preterm Labor: A Study on 444 Singleton Pregnant Women With Intact Membranes[NCT04644354]		444 participants (Anticipated)	Observational	2020-12-15	Not yet recruiting
Nifedipine for the Maintenance Tocolysis of Preterm Labor: Comparison to Placebo in a Prospective, Randomized Double Blind Trial[NCT00185952]		70 participants (Actual)	Interventional	2001-11-30	Completed
Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor[NCT01840228]		38 participants (Actual)	Interventional	2013-05-31	Terminated (stopped due to Low enrollment rate)
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361]	Early Phase 1	0 participants (Actual)	Interventional	2020-08-01	Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.)
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]		11,976 participants (Actual)	Interventional	2016-03-23	Completed
Nifedipine Compared to Atosiban for Treating Preterm Labor. A Randomized Controlled Trial.[NCT00599898]	Phase 4	145 participants (Actual)	Interventional	2008-01-31	Completed
Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial[NCT00185900]		192 participants (Actual)	Interventional	1999-04-30	Completed
The Endocannabinoid System in Human Gestational Tissues in Labor[NCT03752021]		20 participants (Actual)	Observational	2019-01-25	Completed
Randomized Double-Blinded Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor Between 24 to 32 6/7 Weeks' Gestation[NCT00306462]		33 participants (Actual)	Interventional	2006-03-31	Terminated (stopped due to No enrollment in past year, lack of interest)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

(NCT02132533)
Timeframe: At least 2 doses of betamethasone administered prior to delivery

Number of Participants With Preterm Birth

Composite Neonatal Outcome

Intervention	Participants (Count of Participants)
Nifedipine	36
Placebo	31

Intervention	Participants (Count of Participants)
Nifedipine	24
Placebo	20

Intervention	Participants (Count of Participants)
Nifedipine	8
Placebo	10

Intervention	Participants (Count of Participants)
Nifedipine	13
Placebo	14

A composite neonatal outcome comprising neonatal death, respiratory distress syndrome, bronchopulmonary dysplasia, severe (grade III/IV) interventricular hemorrhage, necrotizing enterocolitis, and sepsis. (NCT01840228)
Timeframe: Followed for duration of neonatal hospital stay, estimated maximum 16 weeks

Delivery Within 2 Weeks of Randomization

Infant Birth Weight

Neonatal Intensive Care Unit Admission

Intervention	Participants (Count of Participants)
Micronized Progesterone Suppository - SINGLETON	5
Placebo Suppository - SINGLETON	5
Micronized Progesterone Suppository - TWINS	3
Placebo Suppository - TWINS	7

Intervention	Participants (Count of Participants)
Micronized Progesterone Suppository	6
Placebo Suppository	4

Intervention	grams (Mean)
Micronized Progesterone Suppository - SINGLETON	2454.9
Placebo Suppository - SINGLETON	2523.1
Micronized Progesterone Suppository - TWINS	2164.4
Placebo Suppository - TWINS	1974.1

(NCT01840228)
Timeframe: Followed for duration of neonatal hospital stay, estimated maximum 16 weeks

Number of Participants Who Delivered Before 34 Weeks'

Intervention	Participants (Count of Participants)
Micronized Progesterone Suppository - SINGLETON	2
Placebo Suppository - SINGLETON	2
Micronized Progesterone Suppository - TWINS	0
Placebo Suppository - TWINS	1

Evaluated in women enrolled prior to 32 weeks gestation (NCT01840228)
Timeframe: Duration of current pregnancy, anticipated maximum 18 weeks

Number of Participants Who Delivered Before 37 Weeks'

Intervention	Participants (Count of Participants)
Micronized Progesterone Suppository	3
Placebo Suppository	6

(NCT01840228)
Timeframe: Duration of current pregnancy, anticipated maximum 18 weeks

Number of Participants With Chorioamnionitis

Intervention	Participants (Count of Participants)
Micronized Progesterone Suppository	11
Placebo Suppository	10

(NCT01840228)
Timeframe: Duration of current pregnancy, anticipated maximum 18 weeks

Number of Weeks Pregnancy Prolongation

Intervention	Participants (Count of Participants)
Micronized Progesterone Suppository	0
Placebo Suppository	0

(NCT01840228)
Timeframe: Duration of current pregnancy, anticipated maximum 18 weeks

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

Fetal Outcome 4 - Incidence of Fetal Loss

Fetal Outcome 5 - Incidence of Spontaneous Abortion

Fetal Outcome 6 - Incidence of All Stillbirth

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

Intervention	weeks (Median)
Micronized Progesterone Suppository	5.3
Placebo Suppository	5.0

Intervention	Participants (Count of Participants)
Intervention Arm	189
Placebo Arm	230

Intervention	Participants (Count of Participants)
Intervention Arm	1078
Placebo Arm	1153

Intervention	Participants (Count of Participants)
Intervention Arm	78
Placebo Arm	101

Intervention	Participants (Count of Participants)
Intervention Arm	303
Placebo Arm	353

Intervention	Participants (Count of Participants)
Intervention Arm	134
Placebo Arm	152

Intervention	Participants (Count of Participants)
Intervention Arm	141
Placebo Arm	166

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

Incidence of Hypertensive Disorders of Pregnancy

Intervention	Participants (Count of Participants)
Intervention Arm	42
Placebo Arm	30

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

Incidence of Perinatal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	352
Placebo Arm	325

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Incidence of Preterm Birth

Intervention	Participants (Count of Participants)
Intervention Arm	264
Placebo Arm	309

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

Incidence of Small for Gestational Age (SGA)

Intervention	Participants (Count of Participants)
Intervention Arm	668
Placebo Arm	754

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 1 - Incidence of Vaginal Bleeding

Intervention	Participants (Count of Participants)
Intervention Arm	1506
Placebo Arm	1564

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	214
Placebo Arm	246

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	26
Placebo Arm	25

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 4 - Incidence of Maternal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	54
Placebo Arm	43

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 5 - Incidence of Late Abortion

Intervention	Participants (Count of Participants)
Intervention Arm	9
Placebo Arm	12

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 6 - Change in Maternal Hemoglobin

Intervention	Participants (Count of Participants)
Intervention Arm	23
Placebo Arm	30

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Intervention	Participants (Count of Participants)
Intervention Arm	290
Placebo Arm	333

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Composite Neonatal Morbidity

Intervention	Participants (Count of Participants)
Intervention Arm	8
Placebo Arm	21

Defined as any of the following: respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, sepsis or fetal/neonatal death. (NCT00185900)
Timeframe: From delivery until discharge from the hospital, up to 30 days of age

Gestational Age at Delivery

Intervention	Participants (Count of Participants)
Magnesium Sulfate	27
Nifedipine	22

Presented as weeks (NCT00185900)
Timeframe: Until delivery, up to 42 weeks of gestation

Neonatal Birth Weight

Intervention	weeks (Mean)
Magnesium Sulfate	35.8
Nifedipine	36.0

Presented as grams (NCT00185900)
Timeframe: Until delivery, up to 42 weeks of gestation

Number of Participants With Prevention of Preterm Delivery for 48 Hours With Attainment of Uterine Quiescence

Intervention	grams (Mean)
Magnesium Sulfate	2550
Nifedipine	2650

Uterine quiescence defined by 12 hours of six or fewer contractions per hour and no further cervical change within 48 hours of tocolytic initiation. (NCT00185900)
Timeframe: 48 hours after administration of study medication.

Serious Maternal Adverse Effect

Intervention	Participants (Count of Participants)
Magnesium Sulfate	80
Nifedipine	72

A composite of any of the following: chest pain, pulmonary edema, shortness of breath or hypotension. (NCT00185900)
Timeframe: From study enrollment until discharge from delivery hospital, up to 30 days after delivery.

Time to Uterine Quiescence

Intervention	Participants (Count of Participants)
Magnesium Sulfate	20
Nifedipine	10

Uterine quiescence was defined by 12 hours of six of fewer contractions per hour and no further cervical change. (NCT00185900)
Timeframe: Until delivery, up to 42 weeks of gestation

Article	Year
Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:7 Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Network Meta-Analysis; Nifedipine; Obstetric	2022
Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. Archives of gynecology and obstetrics, 2022, Volume: 306, Issue:6 Topics: Amlodipine; Female; Humans; Hypertension; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; P	2022
Maintaining and repeating tocolysis: A reflection on evidence. Seminars in perinatology, 2017, Volume: 41, Issue:8 Topics: Drug Administration Schedule; Evidence-Based Practice; Female; Humans; Nifedipine; Obstetric Labor,	2017
Systematic review and meta-analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019, Volume: 145, Issue:2 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Odds Ratio; Pregnancy; Randomized Con	2019
Transdermal nitroglycerin for the treatment of preterm labor: a systematic review and metaanalysis. American journal of obstetrics and gynecology, 2013, Volume: 209, Issue:6 Topics: Administration, Cutaneous; Adrenergic beta-2 Receptor Agonists; Female; Humans; Magnesium Sulfate; N	2013
Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. The Cochrane database of systematic reviews, 2013, Oct-31, Issue:10 Topics: Calcium Channel Blockers; Female; Humans; Incidence; Infant Mortality; Infant, Newborn; Labor, Obste	2013
Preterm labor: current pharmacotherapy options for tocolysis. Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:6 Topics: Female; Humans; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregnancy; Premature Birth;	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
Calcium channel blockers for inhibiting preterm labour and birth. The Cochrane database of systematic reviews, 2014, Jun-05, Issue:6 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2014
[Maintenance tocolysis with calcium channel blockers]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2015, Volume: 44, Issue:4 Topics: Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnan	2015
[Calcium channel blockers pharmacology and their use as tocolytics]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2015, Volume: 44, Issue:4 Topics: Adult; Calcium Channel Blockers; Female; Humans; Nicardipine; Nifedipine; Obstetric Labor, Premature	2015
[Use of calcium channel blockers (CCB) for tocolysis in France and abroad]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2015, Volume: 44, Issue:4 Topics: Adult; Calcium Channel Blockers; Female; France; Hospitals, Maternity; Humans; Nifedipine; Obstetric	2015
The safety of tocolytics used for the inhibition of preterm labour. Expert opinion on drug safety, 2016, Volume: 15, Issue:9 Topics: Animals; Female; Humans; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregnancy; Prematu	2016
Progesterone and nifedipine for maintenance tocolysis after arrested preterm labor: A systematic review and meta-analysis of randomized controlled trial. Taiwanese journal of obstetrics & gynecology, 2016, Volume: 55, Issue:3 Topics: Drug Therapy, Combination; Female; Humans; Maintenance Chemotherapy; Nifedipine; Obstetric Labor, Pr	2016
Prematurity prevention: the role of acute tocolysis. Current opinion in obstetrics & gynecology, 2009, Volume: 21, Issue:2 Topics: Acute Disease; Administration, Oral; Calcium Channel Blockers; Clinical Trials as Topic; Female; Hum	2009
[Tocolytic therapy in threatened preterm labor]. Ginekologia polska, 2010, Volume: 81, Issue:2 Topics: Calcium Channel Blockers; Cyclooxygenase Inhibitors; Female; Humans; Magnesium Sulfate; Nifedipine;	2010
Calcium channel blockers for the management of preterm birth: a review. American journal of perinatology, 2011, Volume: 28, Issue:1 Topics: Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Practice Patterns,	2011
Nifedipine in the management of preterm labor: a systematic review and metaanalysis. American journal of obstetrics and gynecology, 2011, Volume: 204, Issue:2 Topics: Adrenergic beta-2 Receptor Agonists; Female; Humans; Magnesium Sulfate; Nifedipine; Obstetric Labor,	2011
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
[Nifedipine first choice in management of threatening preterm labor]. Nederlands tijdschrift voor geneeskunde, 2002, Oct-19, Volume: 146, Issue:42 Topics: Administration, Oral; Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Infant Mor	2002
[Which tocolytic drugs in case of preterm labor?]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2002, Volume: 31, Issue:7 Suppl Topics: Clinical Trials as Topic; Female; France; Humans; Nifedipine; Obstetric Labor, Premature; Practice G	2002
[Special management for threatened preterm delivery in multiple pregnancies]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2002, Volume: 31, Issue:7 Suppl Topics: Adrenal Cortex Hormones; Drug Therapy, Combination; Female; France; Humans; Infant, Newborn; Nifedip	2002
Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials. BJOG : an international journal of obstetrics and gynaecology, 2003, Volume: 110, Issue:12 Topics: Adrenergic beta-Agonists; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Randomi	2003
Calcium channel blockers for inhibiting preterm labour; a systematic review of the evidence and a protocol for administration of nifedipine. The Australian & New Zealand journal of obstetrics & gynaecology, 2003, Volume: 43, Issue:3 Topics: Calcium Channel Blockers; Clinical Protocols; Contraindications; Female; Humans; Nifedipine; Obstetr	2003
Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. The Cochrane database of systematic reviews, 2004, Issue:3 Topics: Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Prematu	2004
Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipine. American journal of obstetrics and gynecology, 2004, Volume: 190, Issue:6 Topics: Adult; Calcium Gluconate; Female; Gestational Age; Humans; Hypocalcemia; Magnesium Sulfate; Maternal	2004
Use of calcium channel antagonists for preterm labor. Obstetrics and gynecology clinics of North America, 2005, Volume: 32, Issue:3 Topics: Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy	2005
The quality of nifedipine studies used to assess tocolytic efficacy: a systematic review. Journal of perinatal medicine, 2005, Volume: 33, Issue:4 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Publications; Randomized Controll	2005
Calcium channel blockers for tocolysis: a review of their role and safety following reports of serious adverse events. European journal of obstetrics, gynecology, and reproductive biology, 2006, Jun-01, Volume: 126, Issue:2 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Pre	2006
A quality assessment tool to evaluate tocolytic studies. BJOG : an international journal of obstetrics and gynaecology, 2006, Volume: 113 Suppl 3 Topics: Adrenergic beta-Agonists; Calcium Channel Blockers; Clinical Trials as Topic; Female; Humans; Meta-A	2006
Emerging tocolytics for maintenance therapy of preterm labour: oxytocin antagonists and calcium channel blockers. BJOG : an international journal of obstetrics and gynaecology, 2006, Volume: 113 Suppl 3 Topics: Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Oxytocin; Pregnanc	2006
Preterm labour. The present and future of tocolysis. Best practice & research. Clinical obstetrics & gynaecology, 2007, Volume: 21, Issue:5 Topics: Adrenergic beta-Agonists; Female; Humans; Indomethacin; Magnesium Sulfate; Nifedipine; Obstetric Lab	2007
The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban. Expert opinion on investigational drugs, 2007, Volume: 16, Issue:6 Topics: Adrenergic beta-Agonists; Antidiuretic Hormone Receptor Antagonists; Calcium Channel Blockers; Femal	2007
Developments in the pharmacotherapeutic management of spontaneous preterm labor. Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:7 Topics: Female; Fetus; Glucocorticoids; Health Care Costs; Humans; Magnesium Sulfate; Nifedipine; Obstetric	2008
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Article	Year
Tocolysis in the management of preterm prelabor rupture of membranes at 22-33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM). BMC pregnancy and childbirth, 2021, Sep-08, Volume: 21, Issue:1 Topics: Administration, Oral; Double-Blind Method; Female; Fetal Membranes, Premature Rupture; Gestational A	2021
Effectiveness of an oral versus sublingual loading dose of nifedipine for tocolysis. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2020, Volume: 148, Issue:3 Topics: Administration, Oral; Administration, Sublingual; Adult; Brazil; Female; Gestational Age; Humans; Ni	2020
Nifedipine for Acute Tocolysis of Preterm Labor: A Placebo-Controlled Randomized Trial. Obstetrics and gynecology, 2021, 07-01, Volume: 138, Issue:1 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolytic Agents; Young Ad	2021
Effect of maintenance tocolysis with nifedipine in established preterm labour on pregnancy prolongation and neonatal outcome. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2018, Volume: 38, Issue:2 Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Gestational Age; Humans; India; Infa	2018
Nifedipine alone or combined with sildenafil citrate for management of threatened preterm labour: a randomised trial. BJOG : an international journal of obstetrics and gynaecology, 2019, Volume: 126, Issue:6 Topics: Administration, Intravaginal; Administration, Oral; Adult; Drug Monitoring; Drug Synergism; Female;	2019
A comparative study on the efficacy of nifedipine and indomethacin for prevention of preterm birth as monotherapy and combination therapy: a randomized clinical trial. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, Volume: 33, Issue:19 Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregn	2020
A comparison of three tocolytics for preterm labor: a randomized clinical trial. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:8 Topics: Adolescent; Adult; Drug Administration Routes; Female; Gestational Age; Humans; Indomethacin; Magnes	2014
48-hours administration of nifedipine in spontaneous preterm labor - Doppler blood flow assessment of placental and fetal circulation. Neuro endocrinology letters, 2013, Volume: 34, Issue:7 Topics: Adult; Dose-Response Relationship, Drug; Female; Fetus; Hemodynamics; Humans; Middle Cerebral Artery	2013
Comparison of nifedipine and progesterone for maintenance tocolysis after arrested preterm labour. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2014, Volume: 34, Issue:4 Topics: Adult; Female; Humans; Maintenance Chemotherapy; Nifedipine; Obstetric Labor, Premature; Pregnancy;	2014
The NIFTY study: a multicentre randomised double-blind placebo-controlled trial of nifedipine maintenance tocolysis in fetal fibronectin-positive women in threatened preterm labour. The Australian & New Zealand journal of obstetrics & gynaecology, 2014, Volume: 54, Issue:3 Topics: Adult; Double-Blind Method; Female; Fibronectins; Gestational Age; Humans; Infant, Newborn; Kaplan-M	2014
Nifedipine versus atosiban in the treatment of threatened preterm labour (Assessment of Perinatal Outcome after Specific Tocolysis in Early Labour: APOSTEL III-Trial). BMC pregnancy and childbirth, 2014, Mar-03, Volume: 14 Topics: Administration, Oral; Adolescent; Adult; Dose-Response Relationship, Drug; Female; Follow-Up Studies	2014
Comparison between nitroglycerin dermal patch and nifedipine for treatment of preterm labor: a randomized clinical trial. Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:9 Topics: Apgar Score; Birth Weight; Cesarean Section; Female; Gestational Age; Humans; Infant, Newborn; Inten	2014
Nifedipine versus terbutaline, tocolytic effectiveness and maternal and neonatal adverse effects: a randomized, controlled pilot trial. Basic & clinical pharmacology & toxicology, 2015, Volume: 116, Issue:3 Topics: Adult; Female; Follow-Up Studies; Humans; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; P	2015
Pharmacokinetics of nifedipine slow-release during sustained tocolysis. International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:1 Topics: Adult; Bayes Theorem; Biological Availability; Body Weight; Chemistry, Pharmaceutical; Delayed-Actio	2015
Randomized comparison of nifedipine and placebo in fibronectin-negative women with symptoms of preterm labor and a short cervix (APOSTEL-I Trial). American journal of perinatology, 2015, Volume: 32, Issue:5 Topics: Adult; Cervical Length Measurement; Female; Fibronectins; Gestational Age; Humans; Netherlands; Nife	2015
Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands. European journal of obstetrics, gynecology, and reproductive biology, 2015, Volume: 186 Topics: Female; Gestational Age; Humans; Length of Stay; Netherlands; Nifedipine; Obstetric Labor, Premature	2015
Tocolysis in women with advanced preterm labor: a secondary analysis of a randomized clinical trial. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:5 Topics: Administration, Intravenous; Administration, Oral; Administration, Rectal; Adolescent; Adult; Female	2016
Fetal fibronectin status and cervical length in women with threatened preterm labor and the effectiveness of maintenance tocolysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:10 Topics: Adult; Cervical Length Measurement; Female; Fibronectins; Humans; Nifedipine; Obstetric Labor, Prema	2016
Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial. BJOG : an international journal of obstetrics and gynaecology, 2016, Volume: 123, Issue:7 Topics: Adult; Analysis of Variance; Double-Blind Method; Female; Fetal Membranes, Premature Rupture; Follow	2016
RETRACTED: Nicorandil vs nifedipine for the treatment of preterm labour: a randomized clinical trial. European journal of obstetrics, gynecology, and reproductive biology, 2015, Volume: 195 Topics: Adolescent; Adult; Double-Blind Method; Female; Fetal Diseases; Headache; Humans; Nicorandil; Nifedi	2015
Nifedipine versus placebo in the treatment of preterm prelabor rupture of membranes: a randomized controlled trial: Assessment of perinatal outcome by use of tocolysis in early labor-APOSTEL IV trial. European journal of obstetrics, gynecology, and reproductive biology, 2016, Volume: 205 Topics: Adult; Female; Fetal Membranes, Premature Rupture; Humans; Nifedipine; Obstetric Labor, Premature; P	2016
Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstetrics and gynecology, 2008, Volume: 112, Issue:6 Topics: Adult; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Nifedipine; Obstetric La	2008
Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstetrics and gynecology, 2008, Volume: 112, Issue:6 Topics: Adult; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Nifedipine; Obstetric La	2008
Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstetrics and gynecology, 2008, Volume: 112, Issue:6 Topics: Adult; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Nifedipine; Obstetric La	2008
Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstetrics and gynecology, 2008, Volume: 112, Issue:6 Topics: Adult; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Nifedipine; Obstetric La	2008
Two dose regimens of nifedipine for management of preterm labor: a randomized controlled trial. American journal of perinatology, 2009, Volume: 26, Issue:8 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolytic Agents; Uterine	2009
Healthcare evaluation of the use of atosiban and fibronectin for the management of pre-term labour. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2009, Volume: 29, Issue:6 Topics: Decision Trees; Female; Fibronectins; Health Services Research; Humans; Nifedipine; Obstetric Labor,	2009
Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial). BMC pregnancy and childbirth, 2009, Sep-01, Volume: 9 Topics: Cervical Length Measurement; Cohort Studies; Cost-Benefit Analysis; Female; Fibronectins; Humans; La	2009
Assessment of perinatal outcome after sustained tocolysis in early labour (APOSTEL-II trial). BMC pregnancy and childbirth, 2009, Sep-09, Volume: 9 Topics: Cervical Length Measurement; Clinical Protocols; Drug Administration Schedule; Female; Fibronectins;	2009
An examination of the clinical benefits and cost-effectiveness of tocolytic replacement following recurrent preterm labor. American journal of perinatology, 2010, Volume: 27, Issue:1 Topics: Adult; Cost-Benefit Analysis; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pre	2010
Comparison of success rate of nifedipine, progesterone, and bed rest for inhibiting uterine contraction in threatened preterm labor. The journal of obstetrics and gynaecology research, 2011, Volume: 37, Issue:7 Topics: 17 alpha-Hydroxyprogesterone Caproate; Adolescent; Adult; Bed Rest; Delayed-Action Preparations; Fem	2011
Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 113, Issue:3 Topics: Adult; Drug Administration Schedule; Female; Humans; Indomethacin; Nifedipine; Obstetric Labor, Prem	2011
A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012, Volume: 25, Issue:4 Topics: Adolescent; Adult; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Genotype; Half-	2012
Single dose 17 alpha-hydroxyprogesterone caproate in preterm labor: a randomized trial. Archives of gynecology and obstetrics, 2012, Volume: 285, Issue:3 Topics: 17 alpha-Hydroxyprogesterone Caproate; Adrenal Cortex Hormones; Adult; Double-Blind Method; Drug The	2012
The tocolytic role of nifedipine in preventing preterm labour pain. Mymensingh medical journal : MMJ, 2012, Volume: 21, Issue:1 Topics: Adult; Analgesia, Obstetrical; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; To	2012
Nifedipine versus fenoterol in the management of preterm labor: a randomized, multicenter clinical study. Gynecologic and obstetric investigation, 2012, Volume: 74, Issue:2 Topics: Adolescent; Adult; Costs and Cost Analysis; Female; Fenoterol; Humans; Nifedipine; Obstetric Labor,	2012
Effect of antenatal tocolysis on neonatal outcomes. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012, Volume: 25, Issue:12 Topics: Female; Gestational Age; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Magnesium	2012
Effect of cervical length to the efficacy of nifedipine and bed rest for inhibiting threatened preterm labor. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2012, Volume: 95, Issue:5 Topics: Bed Rest; Cervix Uteri; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolytic	2012
Nifedipine compared with atosiban for treating preterm labor: a randomized controlled trial. Obstetrics and gynecology, 2012, Volume: 120, Issue:6 Topics: Adult; Cross-Over Studies; Female; Gestational Age; Humans; Infant, Newborn; Middle Aged; Nifedipine	2012
Effect of maintenance tocolysis with nifedipine in threatened preterm labor on perinatal outcomes: a randomized controlled trial. JAMA, 2013, Jan-02, Volume: 309, Issue:1 Topics: Adult; Double-Blind Method; Drug Administration Schedule; Enterocolitis, Necrotizing; Female; Fetal	2013
[Clinical observations on the prevention and treatment of premature labor with nifedipine]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 2002, Volume: 33, Issue:2 Topics: Adult; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy;	2002
Hemodynamic and metabolic effects after nifedipine and ritodrine tocolysis. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2003, Volume: 82, Issue:1 Topics: Adult; Cohort Studies; Female; Glucose; Hemodynamics; Humans; Metabolism; Nifedipine; Obstetric Labo	2003
Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor. Journal of perinatal medicine, 2004, Volume: 32, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Drug Administration Schedule; Female; Gestational Age; Huma	2004
Atosiban and nifedipin for the treatment of preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2005, Volume: 91, Issue:1 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Oxytocics; Pregnancy; Tocolytic Agents; Vaso	2005
Nifedipine versus ritodrine for suppression of preterm labor. Comparison of their efficacy and secondary effects. European journal of obstetrics, gynecology, and reproductive biology, 2006, Volume: 127, Issue:2 Topics: Administration, Oral; Adult; Female; Gestational Age; Humans; Infusions, Intravenous; Nifedipine; Ob	2006
Long-term follow up of children exposed in utero to nifedipine or ritodrine for the management of preterm labour. BJOG : an international journal of obstetrics and gynaecology, 2006, Volume: 113, Issue:3 Topics: Adult; Affective Symptoms; Child; Child Behavior Disorders; Female; Follow-Up Studies; Gestational A	2006
Tocolysis in women with preterm labor between 32 0/7 and 34 6/7 weeks of gestation: a randomized controlled pilot study. American journal of obstetrics and gynecology, 2006, Volume: 194, Issue:4 Topics: Adult; Female; Humans; Infant, Newborn; Infant, Premature; Length of Stay; Magnesium Sulfate; Nifedi	2006
Tocolytic efficacy of nifedipine versus ritodrine in preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2007, Volume: 97, Issue:2 Topics: Apgar Score; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; R	2007
Psychological factors in preterm labor and psychotherapeutic intervention. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2007, Volume: 97, Issue:3 Topics: Female; Gestational Age; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Prospective Stud	2007
Magnesium sulfate compared with nifedipine for acute tocolysis of preterm labor: a randomized controlled trial. Obstetrics and gynecology, 2007, Volume: 110, Issue:1 Topics: Administration, Oral; Adult; Female; Humans; Infusions, Intravenous; Magnesium Sulfate; Nifedipine;	2007
Terbutaline versus nifedipine for prolongation of pregnancy in patients with preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2008, Volume: 100, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Female; Humans; Injections, Subcutaneous; Nifedipine; Obste	2008
Magnesium sulfate compared with nifedipine for acute tocolysis of preterm labor: a randomized controlled trial. Obstetrics and gynecology, 2007, Volume: 110, Issue:5 Topics: Adult; Bias; Female; Humans; Magnesium Sulfate; Meta-Analysis as Topic; Nifedipine; Obstetric Labor,	2007
Safety and efficacy of oral nifedipine versus terbutaline injection in preterm labor. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:11 Topics: Administration, Oral; Adult; Blood Pressure; Female; Gestational Age; Humans; Injections, Intravenou	2007
Tocolytic effectiveness of nifedipine versus ritodrine and follow-up of newborns: a randomised controlled trial. Acta obstetricia et gynecologica Scandinavica, 2008, Volume: 87, Issue:3 Topics: Adrenergic beta-Agonists; Adult; Birth Weight; Calcium Channel Blockers; Child, Preschool; Female; F	2008
Nifedipine gastrointestinal therapeutic system (GITS) as an alternative to slow-release for tocolysis--tolerance and pharmacokinetic profile. European journal of obstetrics, gynecology, and reproductive biology, 2008, Volume: 140, Issue:1 Topics: Administration, Oral; Adult; Delayed-Action Preparations; Female; Humans; Nifedipine; Obstetric Labo	2008
Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study. American journal of obstetrics and gynecology, 1993, Volume: 169, Issue:4 Topics: Administration, Oral; Administration, Sublingual; Adult; Chi-Square Distribution; Female; Humans; In	1993
Nifedipine versus ritodrine for suppression of preterm labour. British journal of obstetrics and gynaecology, 1993, Volume: 100, Issue:12 Topics: Adult; Blood Pressure; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy	1993
Clinical comparison of oral nifedipine and subcutaneous terbutaline for initial tocolysis. American journal of perinatology, 1993, Volume: 10, Issue:4 Topics: Administration, Oral; Adult; Female; Humans; Infant, Newborn; Injections, Subcutaneous; Nifedipine;	1993
Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstetrics and gynecology, 1997, Volume: 90, Issue:2 Topics: Administration, Oral; Adult; Female; Fetal Membranes, Premature Rupture; Humans; Infusions, Intraven	1997
A randomized comparison of nifedipine and ritodrine for suppression of preterm labor. European journal of obstetrics, gynecology, and reproductive biology, 1998, Volume: 77, Issue:2 Topics: Adult; Blood Glucose; Blood Pressure; Female; Gestational Age; Humans; Nifedipine; Obstetric Labor,	1998
A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1998, Volume: 61, Issue:3 Topics: Abortion, Threatened; Adult; Apgar Score; Blood Glucose; Female; Fetus; Gestational Age; Hemodynamic	1998
Maintenance oral nifedipine for preterm labor: a randomized clinical trial. American journal of obstetrics and gynecology, 1999, Volume: 181, Issue:4 Topics: Adult; Female; Gestational Age; Humans; Magnesium Sulfate; Nifedipine; Obstetric Labor, Premature; P	1999
Prevention of preterm delivery: nifedipine or magnesium sulfate. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1999, Volume: 66, Issue:3 Topics: Administration, Oral; Female; Humans; Injections, Intravenous; Magnesium Sulfate; Nifedipine; Obstet	1999
Neonatal effects of nifedipine and ritodrine for preterm labor. Obstetrics and gynecology, 2000, Volume: 95, Issue:4 Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Nifedipine; Obstetric Labor	2000
Nifedipine versus terbutaline in management of preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2002, Volume: 76, Issue:3 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; Terbuta	2002
[Treatment with calcium antagonist nifedipine in pathology of the preliminary period]. Rossiiskii meditsinskii zhurnal : organ Ministerstva zdravookhraneniia RSFSR, 1992, Issue:3 Topics: Adult; Female; Humans; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregnancy; Time Fact	1992
Comparison of nifedipine and ritodrine for the treatment of preterm labor. American journal of perinatology, 1991, Volume: 8, Issue:6 Topics: Adult; Birth Weight; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Nifedipine;	1991
A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal, and neonatal outcome. American journal of obstetrics and gynecology, 1990, Volume: 163, Issue:1 Pt 1 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; Prospective St	1990
Nifedipine versus ritodrine for suppressing preterm labor. The Journal of reproductive medicine, 1990, Volume: 35, Issue:6 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Prospective Studies; Ritodrine	1990
[A randomized study of the treatment of threatened premature labor. Nifedipine versus ritodrine]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1990, Volume: 19, Issue:4 Topics: Adult; Apgar Score; Female; Heart Rate, Fetal; Humans; Infant, Newborn; Nifedipine; Obstetric Labor,	1990
Cardiovascular and metabolic effects associated with nifedipine and ritodrine tocolysis. American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:3 Topics: Blood Glucose; Blood Pressure; Chlorides; Drug Administration Schedule; Female; Hematocrit; Hemodyna	1989
The use of a calcium antagonist (nifedipine) to suppress preterm labour. British journal of obstetrics and gynaecology, 1986, Volume: 93, Issue:9 Topics: Administration, Oral; Adult; Clinical Trials as Topic; Female; Humans; Nifedipine; Obstetric Labor,	1986

Article	Year
Fetal echocardiographic evaluation before and after nifedipine treatment in preterm labor. Echocardiography (Mount Kisco, N.Y.), 2022, Volume: 39, Issue:9 Topics: Diastole; Echocardiography; Female; Fetal Heart; Humans; Infant, Newborn; Nifedipine; Obstetric Labo	2022
Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth. Scientific reports, 2023, 04-06, Volume: 13, Issue:1 Topics: Animals; Female; Humans; Infant, Newborn; Mice; Myometrium; Nifedipine; Obstetric Labor, Premature;	2023
Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy. Pharmacological research, 2023, Volume: 195 Topics: Animals; Biological Products; Female; Humans; Infant, Newborn; Mice; Mifepristone; Nifedipine; Obste	2023
Effects of nifedipine on fetal cardiac function in preterm labor. Journal of perinatal medicine, 2020, Sep-25, Volume: 48, Issue:7 Topics: Adult; Cardiotocography; Female; Fetal Heart; Fetus; Humans; Infant, Newborn; Nifedipine; Obstetric	2020
Effects of nifedipine on endothelial function, assessed by flow-mediated vasodilatation in pregnant patients. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25 Topics: Adult; Female; Humans; Infant; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregnancy; P	2022
Sildenafil citrate in obstetrics - caution is advised. BJOG : an international journal of obstetrics and gynaecology, 2019, Volume: 126, Issue:6 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Obstetrics; Pregnancy; Sildenafil Citrate	2019
Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development. Autism research : official journal of the International Society for Autism Research, 2019, Volume: 12, Issue:7 Topics: Adult; Autism Spectrum Disorder; Child; Child, Preschool; Communication Disorders; Drug Therapy, Com	2019
Acute pulmonary failure due to pulmonary edema during tocolytic therapy with nifedipine. Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:4 Topics: Acute Disease; Adult; Female; Fetal Membranes, Premature Rupture; Humans; Nifedipine; Obstetric Labo	2013
Pregnancy outcomes and successful rate of nifedipine therapeutic protocol implementation in a hospital of San Juan. Boletin de la Asociacion Medica de Puerto Rico, 2013, Volume: 105, Issue:3 Topics: Adolescent; Adult; Dexamethasone; Drug Administration Schedule; Drug Evaluation; Female; Fetal Membr	2013
Preterm labor: current tocolytic options for the treatment of preterm labor. Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:5 Topics: Adrenergic beta-Agonists; Female; Glucocorticoids; Humans; Infant, Newborn; Nifedipine; Obstetric La	2014
Effect of magnesium sulfate and nifedipine on the risk of developing pulmonary edema in preterm births. Journal of perinatal medicine, 2014, Volume: 42, Issue:5 Topics: Adult; Azithromycin; Case-Control Studies; Drug Synergism; Erythromycin; Female; Humans; Infant, New	2014
What is the risk of preterm delivery after arrested preterm labor? American journal of perinatology, 2015, Volume: 32, Issue:1 Topics: Adult; Case-Control Studies; Cervical Length Measurement; Cervix Uteri; Cohort Studies; Female; Fibr	2015
[Tocolysis with nifedipin; its use in current practice]. Akusherstvo i ginekologiia, 2014, Volume: 53 Suppl 1 Topics: Calcium Channel Blockers; Female; Gestational Age; Humans; Longitudinal Studies; Nifedipine; Obstetr	2014
The influence of ritodrine alone or in combination with nifedipine on maternal cardiovascular side effects and pregnancy outcomes. Clinical and experimental obstetrics & gynecology, 2014, Volume: 41, Issue:5 Topics: Adult; Birth Weight; Calcium Channel Blockers; Cardiovascular Diseases; Cardiovascular System; Dose-	2014
[Treatment of preterm delivery with calcium channel blockers--Nifedipine]. Akusherstvo i ginekologiia, 2007, Volume: 46, Issue:9 Topics: Calcium Channel Blockers; Female; Gestational Age; Humans; Nifedipine; Obstetric Labor, Premature; P	2007
Side-effect and vital sign profile of nifedipine as a tocolytic for preterm labour. Hong Kong medical journal = Xianggang yi xue za zhi, 2008, Volume: 14, Issue:4 Topics: Administration, Sublingual; Adult; Analysis of Variance; Blood Pressure; Chi-Square Distribution; Do	2008
Management of recurrent preterm labor in twin gestations with nifedipine tocolysis. American journal of perinatology, 2008, Volume: 25, Issue:9 Topics: Administration, Oral; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gestat	2008
Tocolytics and preterm labour. BMJ (Clinical research ed.), 2009, Mar-05, Volume: 338 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications; Tocolyti	2009
Doppler velocimetry of the uterine, umbilical and fetal middle cerebral arteries in pregnant women undergoing tocolysis with oral nifedipine. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2009, Volume: 34, Issue:3 Topics: Adolescent; Adult; Blood Flow Velocity; Female; Gestational Age; Humans; Maternal-Fetal Exchange; Mi	2009
[Management of pre-term labor: use of nifedipine in Conakry, Guinea]. Medecine tropicale : revue du Corps de sante colonial, 2010, Volume: 70, Issue:2 Topics: Apgar Score; Delivery, Obstetric; Dizziness; Female; Headache; Humans; Infant, Newborn; Nifedipine;	2010
Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug. Archives of gynecology and obstetrics, 2011, Volume: 284, Issue:3 Topics: Adolescent; Adult; Female; Humans; Hypotension; Middle Aged; Nifedipine; Obstetric Labor, Premature;	2011
Nifedipine for the treatment of preterm labor in twin and singleton pregnancies. Archives of gynecology and obstetrics, 2011, Volume: 284, Issue:4 Topics: Adult; Databases, Factual; Female; Gestational Age; Hospitals, University; Humans; Indomethacin; Inf	2011
['Steroid psychosis' during treatment for premature labour]. Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:18 Topics: Adult; Antipsychotic Agents; Betamethasone; Female; Glucocorticoids; Haloperidol; Humans; Nifedipine	2011
Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies. American journal of obstetrics and gynecology, 2012, Volume: 206, Issue:3 Topics: Adult; Female; Humans; Indomethacin; Magnesium Sulfate; Myometrium; Nifedipine; Obstetric Labor, Pre	2012
Expression of selected genes in preterm premature rupture of fetal membranes. Acta obstetricia et gynecologica Scandinavica, 2012, Volume: 91, Issue:8 Topics: Adult; Calcium Channel Blockers; Calcium Channels, L-Type; Celecoxib; Cyclooxygenase 2 Inhibitors; D	2012
[Comparison of the rate of maternal complications of nifedipine and nicardipine in cases of preterm labor: historical study on two consecutive periods]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2012, Volume: 41, Issue:7 Topics: Adult; Calcium Channel Blockers; Female; France; Humans; Nicardipine; Nifedipine; Obstetric Labor, P	2012
Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic. American journal of perinatology, 2013, Volume: 30, Issue:4 Topics: Adolescent; Adult; Alleles; Cohort Studies; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug	2013
Maternal atrial fibrillation after sequential use of nifedipine and atosiban for treatment of preterm labor: case report. European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 166, Issue:2 Topics: Adult; Atrial Fibrillation; Drug Therapy, Combination; Female; Humans; Nifedipine; Obstetric Labor,	2013
Atosiban and nifedipine in the suppression of pre-term labour: a comparative study. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2013, Volume: 33, Issue:1 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Retrospective Studies; Toc	2013
Maternal admission characteristics as risk factors for preterm birth. European journal of obstetrics, gynecology, and reproductive biology, 2004, Jan-15, Volume: 112, Issue:1 Topics: Adult; Confidence Intervals; Female; Follow-Up Studies; Gestational Age; Hospitals, University; Huma	2004
Pregnancy and economic outcomes in patients treated for recurrent preterm labor. Journal of perinatology : official journal of the California Perinatal Association, 2004, Volume: 24, Issue:4 Topics: Administration, Oral; Adult; Case-Control Studies; Cost-Benefit Analysis; Costs and Cost Analysis; F	2004
Maternal hypoxia associated with nifedipine for threatened preterm labour. BJOG : an international journal of obstetrics and gynaecology, 2004, Volume: 111, Issue:4 Topics: Adult; Dyspnea; Female; Heart Septal Defects, Ventricular; Humans; Hypoxia; Nifedipine; Obstetric La	2004
Reply to article by King et al. The Australian & New Zealand journal of obstetrics & gynaecology, 2004, Volume: 44, Issue:3 Topics: Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnan	2004
Emerging issues over the choice of nifedipine, beta-agonists and atosiban for tocolysis in spontaneous preterm labour--a proposed systematic review by the International Preterm Labour Council. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2004, Volume: 24, Issue:3 Topics: Adrenergic beta-Agonists; Europe; Evidence-Based Medicine; Female; Humans; International Cooperation	2004
Response to "The drugs we deserve". BJOG : an international journal of obstetrics and gynaecology, 2004, Volume: 111, Issue:9 Topics: Calcium Channel Blockers; Double-Blind Method; Female; Humans; Nifedipine; Obstetric Labor, Prematur	2004
The short-term effect of nifedipine tocolysis on placental, fetal cerebral and atrioventricular Doppler waveforms. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2004, Volume: 24, Issue:7 Topics: Adult; Cerebral Arteries; Echocardiography, Doppler; Female; Humans; Nifedipine; Obstetric Labor, Pr	2004
Choosing calcium channel blockers for pregnant women with paroxysmal supraventriclar tachycardia and preterm labor: a case report. The Kaohsiung journal of medical sciences, 2004, Volume: 20, Issue:9 Topics: Adult; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy;	2004
Severe hypotension and fetal death due to tocolysis with nifedipine. BJOG : an international journal of obstetrics and gynaecology, 2005, Volume: 112, Issue:4 Topics: Adult; Female; Fetal Death; Humans; Hypotension; Nifedipine; Obstetric Labor, Premature; Pregnancy;	2005
Comment on the article "Acute pulmonary oedema during nicardipine therapy for premature labour. Report of five cases" by Vaast P., et al. [Eur J Obstet Gynecol Reprod Biol 2004;113:98-9]. European journal of obstetrics, gynecology, and reproductive biology, 2005, May-01, Volume: 120, Issue:1 Topics: Calcium Channel Blockers; Female; Humans; Nicardipine; Nifedipine; Obstetric Labor, Premature; Pregn	2005
Severe hyperinsulinaemic hypoglycaemia in a baby born to a mother taking oral ritodrine therapy for preterm labour. Hormone research, 2005, Volume: 64, Issue:2 Topics: Adult; Calcium Channel Blockers; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Ins	2005
Severe hypotension and fetal death due to tocolysis with nifedipine. BJOG : an international journal of obstetrics and gynaecology, 2005, Volume: 112, Issue:11 Topics: Female; Humans; Hypotension; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolysis; Tocolytic	2005
Severe hypotension and fetal death due to tocolysis with nifedipine. BJOG : an international journal of obstetrics and gynaecology, 2005, Volume: 112, Issue:11 Topics: Female; Fetal Death; Health Care Surveys; Humans; Hypotension; Nifedipine; Obstetric Labor, Prematur	2005
[Tocolysis with nifedipine: its use in current practice]. Gynecologie, obstetrique & fertilite, 2005, Volume: 33, Issue:12 Topics: Adult; Evidence-Based Medicine; Female; Humans; Nifedipine; Obstetric Labor, Premature; Patient Sele	2005
[Tocolysis with nifedipine: its use in current practice]. Gynecologie, obstetrique & fertilite, 2005, Volume: 33, Issue:12 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolysis; Tocolytic Agent	2005
[Tocolysis with nifedipine: its use in current practice. Gynecol Obstet Fertil 2005;33:483-7]. Gynecologie, obstetrique & fertilite, 2006, Volume: 34, Issue:1 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; Tocolysis; Toc	2006
[Tocolysis with nifedipine: its use in current practice. Gynecol Obstet Fertil 2005;33:483-7]. Gynecologie, obstetrique & fertilite, 2006, Volume: 34, Issue:1 Topics: Female; Humans; Nicardipine; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; P	2006
Nifedipine therapy for preterm labor: effects on placental, fetal cerebral and atrioventricular Doppler parameters in the first 48 hours. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2006, Volume: 27, Issue:4 Topics: Adult; Analysis of Variance; Arteries; Blood Pressure; Diastole; Female; Heart Rate; Heart Valves; H	2006
Nifedipine tocolysis associated atrial fibrillation responds to DC cardioversion. BJOG : an international journal of obstetrics and gynaecology, 2006, Volume: 113, Issue:7 Topics: Adult; Atrial Fibrillation; Electric Countershock; Female; Humans; Nifedipine; Obstetric Labor, Prem	2006
[Indications for respiratory complications during the use of oral nifedipine as a tocolytic agent, especially in patients with multiple pregnancies]. Nederlands tijdschrift voor geneeskunde, 2007, Jan-20, Volume: 151, Issue:3 Topics: Adult; Dyspnea; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome	2007
Magnesium sulfate tocolysis: time to quit. Obstetrics and gynecology, 2007, Volume: 109, Issue:3 Topics: Female; Humans; Magnesium Sulfate; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outc	2007
Magnesium sulfate tocolysis: time to quit. Obstetrics and gynecology, 2007, Volume: 109, Issue:3 Topics: Female; Humans; Magnesium Sulfate; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Outc	2007
Nifedipine-associated pulmonary complications in pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2007, Volume: 97, Issue:2 Topics: Adrenal Cortex Hormones; Female; Fetal Membranes, Premature Rupture; Fluid Therapy; Humans; Nifedipi	2007
Nifedipine serum levels in pregnant women undergoing tocolysis with nifedipine. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2007, Volume: 27, Issue:3 Topics: Administration, Oral; Chemistry, Pharmaceutical; Cross-Sectional Studies; Female; Gestational Age; H	2007
Feasibility of a randomized controlled trial testing nifedipine vs. placebo for the treatment of preterm labor. Journal of perinatal medicine, 2007, Volume: 35, Issue:4 Topics: Cohort Studies; Female; Humans; Infant, Newborn; Multicenter Studies as Topic; Nifedipine; Obstetric	2007
[Indications for respiratory complications during the use of oral nifedipine as a tocolytic agent, especially in patients with multiple pregnancies]. Nederlands tijdschrift voor geneeskunde, 2007, May-12, Volume: 151, Issue:19 Topics: Adrenal Cortex Hormones; Dyspnea; Female; Humans; Lung; Nifedipine; Obstetric Labor, Premature; Preg	2007
Nifedipine (sublingually) in obstetrics: caution for optimal results. Journal de gynecologie, obstetrique et biologie de la reproduction, 2007, Volume: 36, Issue:8 Topics: Administration, Sublingual; Female; Humans; Nifedipine; Obstetric Labor, Premature; Obstetrics; Preg	2007
Calcium-channel blockers: an increasing cause of pulmonary edema during tocolytic therapy. International journal of cardiology, 2008, Nov-28, Volume: 130, Issue:3 Topics: Administration, Sublingual; Adult; Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric L	2008
A cost decision analysis of 4 tocolytic drugs. American journal of obstetrics and gynecology, 2007, Volume: 197, Issue:4 Topics: Decision Trees; Drug Costs; Female; Humans; Indomethacin; Magnesium Sulfate; Nifedipine; Obstetric L	2007
The relaxant effect of nifedipine in human uterine smooth muscle and the BK(Ca) channel. American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:2 Topics: Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Humans; Nifedipine; Obstetric La	2008
Nifedipine concentration in maternal and umbilical cord blood after nifedipine gastrointestinal therapeutic system for tocolysis. BJOG : an international journal of obstetrics and gynaecology, 2008, Volume: 115, Issue:4 Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Female; Fetal Blood; Half-Life; H	2008
The management of preterm labour with intact membranes. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980, Oct-25, Volume: 58, Issue:17 Topics: Adrenergic beta-Agonists; Calcium; Ethanol; Extraembryonic Membranes; Female; Fenoterol; Hexoprenali	1980
Treatment of normotensive and hypertensive patients with preterm labor using oral nifedipine, a calcium antagonist. Archives of gynecology, 1984, Volume: 236, Issue:2 Topics: Adult; Female; Humans; Hypertension; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregna	1984
Deactivation of the uterus during normal and premature labor by the calcium antagonist nicardipine. American journal of obstetrics and gynecology, 1982, Mar-01, Volume: 142, Issue:5 Topics: Animals; Calcium Channel Blockers; Female; Labor, Obstetric; Nicardipine; Nifedipine; Obstetric Labo	1982
Treatment of premature labor with the calcium antagonist nifedipine. Archives of gynecology, 1980, Volume: 229, Issue:1 Topics: Adult; Female; Glucocorticoids; Humans; Infant, Newborn; Lung; Nifedipine; Obstetric Labor, Prematur	1980
Ritodrine tocolysis and neonatal intraventricular-periventricular hemorrhage. Gynecologic and obstetric investigation, 1995, Volume: 39, Issue:1 Topics: Cerebral Hemorrhage; Cerebral Ventricles; Female; Humans; Infant, Newborn; Infant, Premature, Diseas	1995
The influence of tocolytic therapy on serum digoxin-like immunoreactive substance concentration. Gynecologic and obstetric investigation, 1994, Volume: 37, Issue:1 Topics: Adult; Blood Proteins; Cardenolides; Digoxin; Female; Humans; Nifedipine; Obstetric Labor, Premature	1994
The combination of magnesium sulphate and nifedipine: a cause of neuromuscular blockade. British journal of obstetrics and gynaecology, 1994, Volume: 101, Issue:3 Topics: Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension; Magnesium Sulfate	1994
Myocardial infarction in the third trimester of pregnancy secondary to an aortic valve thrombus. Obstetrics and gynecology, 1993, Volume: 81, Issue:5 ( Pt 2) Topics: Adult; Aortic Valve; Female; Heart Valve Prosthesis; Heparin; Humans; Myocardial Infarction; Nifedip	1993
Use of calcium antagonist (nifedipine) in premature labour. Journal of the Indian Medical Association, 1993, Volume: 91, Issue:1 Topics: Adult; Female; Humans; Isoxsuprine; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolysis; Ut	1993
Ritodrine and nifedipine as tocolytic agents: a preliminary comparison. Journal of perinatal medicine, 1995, Volume: 23, Issue:5 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Retrospective Studies; Ritodrine;	1995
Massive vulvar edema complicating tocolysis in a patient with twins. A case report. The Journal of reproductive medicine, 1996, Volume: 41, Issue:2 Topics: Adult; Betamethasone; Drug Therapy, Combination; Edema; Female; Glucocorticoids; Humans; Infant, New	1996
Variations between family physicians and obstetricians in the evaluation and treatment of preterm labor. The Journal of family practice, 1997, Volume: 45, Issue:4 Topics: Adrenergic beta-Agonists; Adult; Family Practice; Female; Humans; Male; Middle Aged; Nifedipine; Obs	1997
Calcium-channel blockers in the management of preterm labour. Lancet (London, England), 1997, Nov-08, Volume: 350, Issue:9088 Topics: Calcium Channel Blockers; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Ritodri	1997
Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstetrics and gynecology, 1997, Volume: 90, Issue:6 Topics: Bias; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Research Design; Ritodrine;	1997
Myocardial infarction during nifedipine therapy for preterm labor. The New England journal of medicine, 1999, Jan-14, Volume: 340, Issue:2 Topics: Adult; Calcium Channel Blockers; Female; Humans; Myocardial Infarction; Nifedipine; Obstetric Labor,	1999
Management of preterm labour. Nifedipine in management of preterm labour is safe. BMJ (Clinical research ed.), 1999, Jul-24, Volume: 319, Issue:7204 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolytic Agents	1999
Nifedipine versus ritodrine for suppression of preterm labor; a meta-analysis. Acta obstetricia et gynecologica Scandinavica, 2000, Volume: 79, Issue:7 Topics: Female; Humans; Meta-Analysis as Topic; Nifedipine; Obstetric Labor, Premature; Pregnancy; Reproduci	2000
Nifedipine as a safe and effective tocolytic agent in the treatment of preterm labor. American journal of obstetrics and gynecology, 2000, Volume: 183, Issue:2 Topics: Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolytic Agents	2000
Search for best tocolytic for preterm labour. Lancet (London, England), 2000, Aug-26, Volume: 356, Issue:9231 Topics: Female; Humans; Indomethacin; Nifedipine; Obstetric Labor, Premature; Pregnancy; Randomized Controll	2000
Tocolysis with nifedipine or beta-adrenergic agonists: a meta-analysis. Obstetrics and gynecology, 2002, Volume: 99, Issue:3 Topics: Adrenergic beta-Agonists; Female; Humans; Meta-Analysis as Topic; Nifedipine; Obstetric Labor, Prema	2002
Nifedipine for treatment of preterm labor: a historic prospective study. American journal of obstetrics and gynecology, 1992, Volume: 167, Issue:1 Topics: Embryonic and Fetal Development; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy;	1992
Hepatotoxicity with the administration of nifedipine for treatment of preterm labor. American journal of obstetrics and gynecology, 1992, Volume: 167, Issue:2 Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Female; Humans; Infusion Pumps; Liver; Mag	1992
Long term treatment with nifedipine retard to suppress preterm labour. Clinical and experimental obstetrics & gynecology, 1991, Volume: 18, Issue:1 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolysis	1991
Nifedipine pharmacokinetics during preterm labor tocolysis. American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:6 Pt 1 Topics: Adult; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolysis; Tocolytic Agent	1989
Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor. American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:6 Pt 1 Topics: Adolescent; Adult; Blood Circulation; Blood Flow Velocity; Female; Fetal Monitoring; Fetus; Humans;	1989
Neonatal bilirubin production after preterm labor tocolysis with nifedipine. Developmental pharmacology and therapeutics, 1989, Volume: 12, Issue:3 Topics: Bilirubin; Blood Glucose; Carboxyhemoglobin; Female; Gestational Age; Humans; Infant, Newborn; Nifed	1989
[The tocolytic action of nifedipine, a calcium antagonist]. Ginecologia y obstetricia de Mexico, 1987, Volume: 55 Topics: Drug Evaluation; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy; Pregnancy Trimes	1987
The use of a calcium agonist (nifedipine) to suppress preterm labor. British journal of obstetrics and gynaecology, 1987, Volume: 94, Issue:3 Topics: Ethics, Medical; Female; Humans; Nifedipine; Obstetric Labor, Premature; Pregnancy	1987
The effects of aminophylline and nifedipine on contractility of isolated pregnant human myometrium. American journal of obstetrics and gynecology, 1987, Volume: 157, Issue:1 Topics: Aminophylline; Cesarean Section; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniqu	1987
Comparison of nifedipine and diltiazem with salbutamol for prevention of preterm delivery in the ovariectomized, oestrogen-treated late pregnant rat. Journal of reproduction and fertility, 1986, Volume: 77, Issue:2 Topics: Albuterol; Animals; Benzazepines; Diltiazem; Female; Fetal Death; Nifedipine; Obstetric Labor, Prema	1986
Tocolytic and hemodynamic effects of nifedipine in the ewe. American journal of obstetrics and gynecology, 1985, Apr-15, Volume: 151, Issue:8 Topics: Animals; Blood Pressure; Female; Fetal Heart; Heart Rate; Hemodynamics; Infusions, Parenteral; Labor	1985
The management of preterm labor with the calcium channel-blocking agent nifedipine combined with the beta-mimetic terbutaline. Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:5 Topics: Adult; Calcium; Drug Therapy, Combination; Female; Fenoterol; Humans; Myometrium; Nifedipine; Obstet	1985

nifedipine and Labor, Premature

Research Excerpts

Research

Studies (205)

Authors

Clinical Trials (12)

Trial Overview

Trial Outcomes

Number of Participants With Preterm Birth

Number of Participants With Preterm Birth

Number of Participants With Preterm Birth

Number of Participants With Preterm Birth

Composite Neonatal Outcome

Delivery Within 2 Weeks of Randomization

Infant Birth Weight

Neonatal Intensive Care Unit Admission

Number of Participants Who Delivered Before 34 Weeks'

Number of Participants Who Delivered Before 37 Weeks'

Number of Participants With Chorioamnionitis

Number of Weeks Pregnancy Prolongation

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

Fetal Outcome 4 - Incidence of Fetal Loss

Fetal Outcome 5 - Incidence of Spontaneous Abortion

Fetal Outcome 6 - Incidence of All Stillbirth

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

Incidence of Hypertensive Disorders of Pregnancy

Incidence of Perinatal Mortality

Incidence of Preterm Birth

Incidence of Small for Gestational Age (SGA)

Maternal Outcome 1 - Incidence of Vaginal Bleeding

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

Maternal Outcome 4 - Incidence of Maternal Mortality

Maternal Outcome 5 - Incidence of Late Abortion

Maternal Outcome 6 - Change in Maternal Hemoglobin

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Composite Neonatal Morbidity

Gestational Age at Delivery

Neonatal Birth Weight

Number of Participants With Prevention of Preterm Delivery for 48 Hours With Attainment of Uterine Quiescence

Serious Maternal Adverse Effect

Time to Uterine Quiescence

Reviews

Trials

Other Studies