nifedipine has been researched along with Innate Inflammatory Response in 33 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized, double-blind, multicentre trial compared the blood pressure lowering effects of a 12-week treatment of nifedipine GITS 20 mg vs enalapril 20 mg in 264 patients with mild-to-moderate hypertension." | 9.11 | Effects of nifedipine GITS 20 mg or enalapril 20 mg on blood pressure and inflammatory markers in patients with mild-moderate hypertension. ( Agabiti Rosei, E; Morelli, P; Rizzoni, D, 2005) |
| "Nifedipine-induced gingival overgrowth (NIGO) is characterized by cell proliferation and extracellular matrix (ECM) component accumulation in gingival connective tissues, with varying degrees of inflammation and fibrosis." | 7.81 | Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study. ( Chen, LJ; Li, WL; Tang, M; Wu, CH; Yang, J; Zhao, SL, 2015) |
| "We have studied the prophylactic administration of nifedipine and its molecular mechanism involved in reducing the transvascular leakage and inflammation in rats under hypoxia." | 7.78 | Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB. ( M, C; Mathew, T; P, H; S K S, S; S, S, 2012) |
| " The aim of the present study was to examine whether the CCBs nilvadipine and diltiazem reduce ocular inflammation in endotoxin-induced uveitis (EIU)." | 7.76 | Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis. ( Ishida, S; Koto, T; Nagai, N; Oike, Y, 2010) |
| "To explore the effects and related mechanism of nifedipine on vascular inflammation induced by cuff placement." | 7.76 | [Nifedipine attenuates vascular inflammation via inhibin NF-κB activity]. ( Gao, XY; Liu, SK; Lu, FQ; Yu, Q; Zhang, ST; Zhou, SM, 2010) |
| "This study was performed to assess whether nifedipine could prevent the decrease in hepatic cytochrome P450 induced by acute moderate hypoxia or an inflammatory reaction." | 7.69 | Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. ( Barakat, M; du Souich, P, 1996) |
| "This randomized, double-blind, multicentre trial compared the blood pressure lowering effects of a 12-week treatment of nifedipine GITS 20 mg vs enalapril 20 mg in 264 patients with mild-to-moderate hypertension." | 5.11 | Effects of nifedipine GITS 20 mg or enalapril 20 mg on blood pressure and inflammatory markers in patients with mild-moderate hypertension. ( Agabiti Rosei, E; Morelli, P; Rizzoni, D, 2005) |
| "Nifedipine-induced gingival overgrowth (NIGO) is characterized by cell proliferation and extracellular matrix (ECM) component accumulation in gingival connective tissues, with varying degrees of inflammation and fibrosis." | 3.81 | Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study. ( Chen, LJ; Li, WL; Tang, M; Wu, CH; Yang, J; Zhao, SL, 2015) |
| "We have studied the prophylactic administration of nifedipine and its molecular mechanism involved in reducing the transvascular leakage and inflammation in rats under hypoxia." | 3.78 | Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB. ( M, C; Mathew, T; P, H; S K S, S; S, S, 2012) |
| " The aim of the present study was to examine whether the CCBs nilvadipine and diltiazem reduce ocular inflammation in endotoxin-induced uveitis (EIU)." | 3.76 | Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis. ( Ishida, S; Koto, T; Nagai, N; Oike, Y, 2010) |
| "To explore the effects and related mechanism of nifedipine on vascular inflammation induced by cuff placement." | 3.76 | [Nifedipine attenuates vascular inflammation via inhibin NF-κB activity]. ( Gao, XY; Liu, SK; Lu, FQ; Yu, Q; Zhang, ST; Zhou, SM, 2010) |
| "This study was performed to assess whether nifedipine could prevent the decrease in hepatic cytochrome P450 induced by acute moderate hypoxia or an inflammatory reaction." | 3.69 | Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. ( Barakat, M; du Souich, P, 1996) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| "Edema was assessed plethysmometrically by evaluating paw volume changes." | 1.34 | Adrenalectomy potentiates the anti-inflammatory activity of a calcium channel blocker. ( Banerjee, A; Nivsarkar, M; Vaghasiya, R, 2007) |
| "Does nifedipine treatment reduce the development and progression of diabetic vascular complications? If the answer is yes, is this beneficial effect of nifedipine superior than that of other DHPs with equihypotensive properties? Does nifedipine treatment decrease the incidence of melanoma and/or prolong the survival of patients with this devastating disorder? These prospective studies will provide further valuable information whether blockade by nifedipine of the AGE-RAGE signaling could be clinically relevant." | 1.33 | Potential therapeutic implication of nifedipine, a dihydropyridine-based calcium antagonist, in advanced glycation end product (AGE)-related disorders. ( Nakamura, K; Takeuchi, M; Yamagishi, S, 2005) |
| "Acute inflammation was associated with enlarged colonic perimeter." | 1.29 | Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase. ( Guarner, F; Malagelada, JR; Mourelle, M; Salas, A; Vilaseca, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.15) | 18.7374 |
| 1990's | 9 (27.27) | 18.2507 |
| 2000's | 7 (21.21) | 29.6817 |
| 2010's | 10 (30.30) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 1 |
| Bhusari, KP | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Szychowski, KA | 1 |
| Skóra, B | 1 |
| Tabęcka-Łonczyńska, A | 1 |
| Morin, A | 1 |
| Mouzon, B | 1 |
| Ferguson, S | 1 |
| Paris, D | 1 |
| Browning, M | 1 |
| Stewart, W | 1 |
| Mullan, M | 1 |
| Crawford, F | 1 |
| Ding, S | 1 |
| Zhang, J | 1 |
| Yin, S | 1 |
| Lu, J | 1 |
| Hu, M | 1 |
| Du, J | 1 |
| Huang, J | 1 |
| Shen, B | 1 |
| Li, WL | 1 |
| Wu, CH | 1 |
| Yang, J | 1 |
| Tang, M | 1 |
| Chen, LJ | 1 |
| Zhao, SL | 1 |
| Sciullo, EM | 1 |
| Dong, B | 1 |
| Vogel, CF | 1 |
| Matsumura, F | 1 |
| Matsui, T | 1 |
| Takeuchi, M | 2 |
| Yamagishi, S | 2 |
| Ishida, S | 1 |
| Koto, T | 1 |
| Nagai, N | 1 |
| Oike, Y | 1 |
| Gao, XY | 1 |
| Yu, Q | 1 |
| Liu, SK | 1 |
| Lu, FQ | 1 |
| Zhou, SM | 1 |
| Zhang, ST | 1 |
| Vriens, J | 1 |
| Owsianik, G | 1 |
| Hofmann, T | 1 |
| Philipp, SE | 1 |
| Stab, J | 1 |
| Chen, X | 1 |
| Benoit, M | 1 |
| Xue, F | 1 |
| Janssens, A | 1 |
| Kerselaers, S | 1 |
| Oberwinkler, J | 1 |
| Vennekens, R | 1 |
| Gudermann, T | 1 |
| Nilius, B | 1 |
| Voets, T | 1 |
| S K S, S | 1 |
| P, H | 1 |
| Mathew, T | 1 |
| S, S | 1 |
| M, C | 1 |
| Lee, KM | 1 |
| Kang, HA | 1 |
| Ko, CB | 1 |
| Oh, EH | 1 |
| Park, M | 1 |
| Lee, HY | 1 |
| Choi, HR | 1 |
| Yun, CH | 1 |
| Jung, WW | 1 |
| Oh, JW | 1 |
| Kang, HS | 1 |
| Nakamura, K | 1 |
| Agabiti Rosei, E | 1 |
| Morelli, P | 1 |
| Rizzoni, D | 1 |
| Naito, Y | 1 |
| Shimozawa, M | 1 |
| Manabe, H | 1 |
| Nakabe, N | 1 |
| Katada, K | 1 |
| Kokura, S | 1 |
| Yoshida, N | 1 |
| Ichikawa, H | 1 |
| Kon, T | 1 |
| Yoshikawa, T | 1 |
| Gao, X | 1 |
| Iwai, M | 1 |
| Inaba, S | 1 |
| Tomono, Y | 1 |
| Kanno, H | 1 |
| Mogi, M | 1 |
| Horiuchi, M | 1 |
| Banerjee, A | 1 |
| Vaghasiya, R | 1 |
| Nivsarkar, M | 1 |
| Rakusan, K | 1 |
| De Vries, GW | 1 |
| McLaughlin, A | 1 |
| Wenzel, MB | 1 |
| Perez, J | 1 |
| Harcourt, D | 1 |
| Lee, G | 1 |
| Garst, M | 1 |
| Wheeler, LA | 1 |
| Mourelle, M | 1 |
| Vilaseca, J | 1 |
| Guarner, F | 1 |
| Salas, A | 1 |
| Malagelada, JR | 1 |
| Barakat, M | 1 |
| du Souich, P | 1 |
| Neumann, C | 1 |
| Willershausen-Zönnchen, B | 1 |
| Klug, C | 1 |
| Darius, H | 1 |
| Sánchez, S | 1 |
| Bartrons, R | 1 |
| Rodríguez, L | 1 |
| González, P | 1 |
| Planas, ME | 1 |
| Andersson, SE | 1 |
| Le Greves, P | 1 |
| Vedder, H | 1 |
| Otten, U | 1 |
| Chen, WR | 1 |
| Yang, YX | 1 |
| Zheng, HQ | 1 |
| A, SY | 1 |
| Liu, F | 1 |
| Pinquier, JL | 1 |
| Urien, S | 1 |
| Chaumet-Riffaud, P | 1 |
| Tillement, JP | 1 |
| Belch, JJ | 1 |
| Nomoto, A | 1 |
| Mutoh, S | 1 |
| Hagihara, H | 1 |
| Yamaguchi, I | 1 |
| Chang, J | 1 |
| Blazek, E | 1 |
| Carlson, RP | 1 |
| Srivastava, VK | 1 |
| Saxena, KK | 1 |
| Gupta, B | 1 |
3 reviews available for nifedipine and Innate Inflammatory Response
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Coronary angiogenesis. From morphometry to molecular biology and back.
Topics: Aging; Animals; Capillaries; Coronary Vessels; Growth Substances; Heart; Humans; Inflammation; Model | 1995 |
Raynaud's phenomenon.
Topics: Antibody Formation; Blood Vessels; Endothelium, Vascular; Fatty Acids, Essential; Humans; Inflammati | 1989 |
1 trial available for nifedipine and Innate Inflammatory Response
| Article | Year |
|---|---|
Effects of nifedipine GITS 20 mg or enalapril 20 mg on blood pressure and inflammatory markers in patients with mild-moderate hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Blood Pressure Determination; | 2005 |
29 other studies available for nifedipine and Innate Inflammatory Response
| Article | Year |
|---|---|
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Calcium channel antagonists interfere with the mechanism of action of elastin-derived peptide VGVAPG in mouse cortical astrocytes in vitro.
Topics: Animals; Astrocytes; Calcium Channel Blockers; Dizocilpine Maleate; Elastin; Humans; Inflammation; M | 2022 |
Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain Concussion; Calcium Channel | 2020 |
Inflammatory cytokines tumour necrosis factor-α and interleukin-8 enhance airway smooth muscle contraction by increasing L-type Ca
Topics: Animals; Calcium; Calcium Channels, L-Type; Extracellular Space; Gene Expression Regulation; Inflamm | 2019 |
Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Gingival | 2015 |
Characterization of the pattern of the nongenomic signaling pathway through which TCDD-induces early inflammatory responses in U937 human macrophages.
Topics: Arachidonic Acid; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Line; Cyclooxygenase 2; Enzym | 2009 |
Nifedipine, a calcium channel blocker, inhibits inflammatory and fibrogenic gene expressions in advanced glycation end product (AGE)-exposed fibroblasts via mineralocorticoid receptor antagonistic activity.
Topics: Aldosterone; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Cell Line; Fibroblas | 2010 |
Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis.
Topics: Animals; Blood-Aqueous Barrier; Calcium Channel Blockers; Cell Adhesion; Chemokine CCL2; Diltiazem; | 2010 |
[Nifedipine attenuates vascular inflammation via inhibin NF-κB activity].
Topics: Animals; Blood Vessels; Chemokine CCL2; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Ni | 2010 |
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calc | 2011 |
Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.
Topics: Altitude Sickness; Animals; Calcium Channel Blockers; Capillary Permeability; Disease Models, Animal | 2012 |
Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Enalapril; Heart; Hydrogen Peroxide; Hypert | 2013 |
Potential therapeutic implication of nifedipine, a dihydropyridine-based calcium antagonist, in advanced glycation end product (AGE)-related disorders.
Topics: Calcium; Calcium Channel Blockers; Dihydropyridines; Disease Progression; Glycation End Products, Ad | 2005 |
Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species.
Topics: Aorta; Azetidinecarboxylic Acid; Biphenyl Compounds; Calcium Channel Blockers; Cell Adhesion; Cell M | 2006 |
Attenuation of monocyte chemoattractant protein-1 expression via inhibition of nuclear factor-kappaB activity in inflammatory vascular injury.
Topics: Animals; Blood Pressure; Blood Vessels; Calcium Channel Blockers; Cell Nucleus; Cell Proliferation; | 2007 |
Adrenalectomy potentiates the anti-inflammatory activity of a calcium channel blocker.
Topics: Acute Disease; Adrenalectomy; Animals; Anti-Inflammatory Agents; Calcium Channel Blockers; Carrageen | 2007 |
The antiinflammatory activity of topically applied novel calcium-channel antagonists.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calci | 1995 |
Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase.
Topics: Animals; Arginine; Colitis; Colon; Dexamethasone; Dilatation; Disease Models, Animal; Enzyme Inducti | 1996 |
Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction.
Topics: Animals; Area Under Curve; Bronchodilator Agents; Calcium Channel Blockers; Cytochrome P-450 Enzyme | 1996 |
Clinical assessment of periodontal conditions in patients treated with nifedipine.
Topics: Bicuspid; Calcium Channel Blockers; Cuspid; Edema; Female; Fibrosis; Gingiva; Gingival Diseases; Hum | 1996 |
Protective effect of nifedipine against carrageenan-induced inflammation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
Ruthenium red and capsaicin induce a neurogenic inflammatory response in the rabbit eye: effects of omega-conotoxin GVIA and tetrodotoxin.
Topics: Animals; Aqueous Humor; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Capsaicin; Eye; F | 1991 |
Biosynthesis and release of tachykinins from rat sensory neurons in culture.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Chromatography, High Pressure Liquid; Ganglia, Spinal; | 1991 |
[Anti-inflammatory effects of verapamil, nifedipine and nicardipine].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Dinoprostone; Female; Infl | 1990 |
Differences in the serum binding determinants of isradipine and darodipine--consequences for serum protein binding in various diseases.
Topics: Adult; Blood Proteins; Calcium Channel Blockers; Fatty Acids, Nonesterified; Female; Humans; Hydroge | 1989 |
Smooth muscle cell migration induced by inflammatory cell products and its inhibition by a potent calcium antagonist, nilvadipine.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cells, Cultured; Chemotaxis; Exudates a | 1988 |
Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Carbon Radioisotopes; Dose-R | 1987 |
Calcium channel blockers in acute inflammation.
Topics: Animals; Carrageenan; Edema; Female; Foot; Histamine; Hyaluronoglucosaminidase; Inflammation; Male; | 1988 |