Page last updated: 2024-11-01

nifedipine and Hypertension, Pregnancy-Induced

nifedipine has been researched along with Hypertension, Pregnancy-Induced in 54 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Hypertension, Pregnancy-Induced: A condition in pregnant women with elevated systolic (

Research Excerpts

ExcerptRelevanceReference
"We evaluated whether combined oral hydrochlorothiazide and lisinopril therapy produced superior short-term blood pressure control when compared with nifedipine among postpartum individuals with hypertension requiring pharmacologic treatment."9.69Oral combined hydrochlorothiazide and lisinopril vs nifedipine for postpartum hypertension: a comparative-effectiveness pilot randomized controlled trial. ( Amro, F; Blackwell, SC; Chauhan, SP; Fishel Bartal, M; Lawal, D; Pedroza, C; Samuel, J; Sibai, BM, 2023)
"The purpose is to investigate the influence of nifedipine, labetalol, and magnesium sulfate on blood pressure control, blood coagulation, and maternal and infant outcome in those suffering from pregnancy-induced hypertension (PIH)."9.51Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension. ( Gu, S; Shao, Y; Zhang, X, 2022)
"To compare oral nifedipine and intravenous labetalol in the treatment of acute severe hypertension in pregnancy (SHP)."9.41Oral nifedipine may be a preferential option for treating acute severe hypertension during pregnancy: a meta-analysis. ( Cui, S; Ou, M; Yu, Y; Zhang, F; Zhao, S, 2023)
"To compare the change in cerebral perfusion pressure before and after intravenous labetalol vs oral nifedipine in the setting of acute severe hypertension in pregnancy."9.34Intravenous labetalol versus oral nifedipine for acute hypertension in pregnancy: effects on cerebral perfusion pressure. ( Belfort, MA; Clark, SL; Fox, KA; Sangi-Haghpeykar, H; Tolcher, MC, 2020)
"To compare the efficacy of intravenous labetalol with oral nifedipine in the treatment of severe hypertension in pregnancy with blood pressure ≥160/110 mm Hg."9.30IV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy-A randomized controlled trial. ( Sowjanya, R; Tatapudi, R; Zulfeen, M, 2019)
"490 pregnant women with mild to moderate chronic hypertension were randomized into three groups; methyldopa group (n = 166), nifedipine group (n = 160) and control or no medication group (n = 164) who were followed from the beginning of pregnancy till the end of puerperium to record maternal and fetal outcome."9.30Methyldopa versus nifedipine or no medication for treatment of chronic hypertension during pregnancy: A multicenter randomized clinical trial. ( Abdallah, S; Gaber, W; Gamal, A; Hamza, H; Marawan, H; Rezk, M; Salama, M, 2019)
"Both intravenous hydralazine and oral nifedipine are equally effective in lowering of blood pressure in acute hypertensive emergency of pregnancy."9.24Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. ( Gupta, A; Sharma, C; Soni, A; Verma, A; Verma, S, 2017)
"These findings demonstrated the superiority of oral nifedipine 50,60,90 mg, especially oral nifedipine 50 mg tablets, in the treatment of severe hypertension during pregnancy than IV labetalol 300 mg, while oral nifedipine 60,90 mg also showed superiority in the successful treatment rate of severe hypertension during pregnancy than IV hydralazine 15,25 mg."9.22Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials. ( Cheng, Y; Jiang, YF; Li, JB; Wu, HZ; Yu, D; Zhu, ZN, 2022)
" Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy and are therefore recommended in international guidelines for treatment of hypertension."9.22Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. ( Allegaert, K; Flint, RB; Mian, P; Schoenmakers, S; van de Vusse, D; Versmissen, J; Visser, W, 2022)
"As administered in this trial, oral nifedipine lowered blood pressure more quickly than did intravenous labetalol during hypertensive emergency in pregnancy."9.17Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial. ( Sharma, C; Shekhar, S; Thakur, S; Verma, S, 2013)
"Oral nifedipine and intravenous labetalol regimens are similarly effective in the acute control of severe hypertension in pregnancy."9.16Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial. ( Omar, SZ; Raheem, IA; Saaid, R; Tan, PC, 2012)
"We included all RCTs that compared intravenous labetalol with oral nifedipine for treatment of severe hypertension during pregnancy, addressing relevant efficacy and safety outcomes."8.93Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis. ( Gupta, N; Kirubakaran, R; Pareek, P; Shekhar, S, 2016)
"To assess whether readmission for hypertension by 6 weeks postpartum differed between patients discharged on nifedipine or labetalol."8.12Postpartum Readmission for Hypertension After Discharge on Labetalol or Nifedipine. ( Do, SC; Druzin, ML; El-Sayed, YY; Girsen, AI; Herrero, T; Kan, P; Leonard, SA; Lyell, DJ; Panelli, DM, 2022)
"A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted."7.78Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy. ( Battistoni, GI; Bezzeccheri, V; Cecchi, L; Cecchi, S; Giannubilo, SR; Landi, B; Tranquilli, AL; Vitali, P, 2012)
"Investigation of methyldopa and nifedipine effects on maternal and fetal hemodynamics in women with mild gestational hypertension during the third pregnancy trimester."7.78Effects of methyldopa and nifedipine on uteroplacental and fetal hemodynamics in gestational hypertension. ( Folic, MD; Folic, MM; Jankovic, SM; Varjacic, MR, 2012)
"Alpha-methyldopa is a regularly used antihypertensive drug during pregnancy."7.76[Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver]. ( Monostory, K; Ozsvár, Z; Solymossi, Z, 2010)
"A meta-analysis of randomized controlled trials suggests that nifedipine appears to be a reasonable agent for treatment of acute severe hypertension in pregnancy."7.73Nifedipine for severe hypertension in pregnancy: emotion or evidence? ( Côté, AM; Magee, LA; von Dadelszen, P, 2005)
"Nifedipine was found to be more effective than other antihypertensive medications to reduce blood pressure, particularly in patients with severe hypertension."6.82Comparative efficacy and safety of oral nifedipine with other antihypertensive medications in the management of hypertensive disorders of pregnancy: a systematic review and meta-analysis of randomized controlled trials. ( Adela, R; George, R; Joy, CA; Thomas, C; Undela, K; Varghese, B, 2022)
"We evaluated whether combined oral hydrochlorothiazide and lisinopril therapy produced superior short-term blood pressure control when compared with nifedipine among postpartum individuals with hypertension requiring pharmacologic treatment."5.69Oral combined hydrochlorothiazide and lisinopril vs nifedipine for postpartum hypertension: a comparative-effectiveness pilot randomized controlled trial. ( Amro, F; Blackwell, SC; Chauhan, SP; Fishel Bartal, M; Lawal, D; Pedroza, C; Samuel, J; Sibai, BM, 2023)
"The purpose is to investigate the influence of nifedipine, labetalol, and magnesium sulfate on blood pressure control, blood coagulation, and maternal and infant outcome in those suffering from pregnancy-induced hypertension (PIH)."5.51Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension. ( Gu, S; Shao, Y; Zhang, X, 2022)
"To compare oral nifedipine and intravenous labetalol in the treatment of acute severe hypertension in pregnancy (SHP)."5.41Oral nifedipine may be a preferential option for treating acute severe hypertension during pregnancy: a meta-analysis. ( Cui, S; Ou, M; Yu, Y; Zhang, F; Zhao, S, 2023)
"To compare the change in cerebral perfusion pressure before and after intravenous labetalol vs oral nifedipine in the setting of acute severe hypertension in pregnancy."5.34Intravenous labetalol versus oral nifedipine for acute hypertension in pregnancy: effects on cerebral perfusion pressure. ( Belfort, MA; Clark, SL; Fox, KA; Sangi-Haghpeykar, H; Tolcher, MC, 2020)
"The use of labetalol and nifedipine were not related to any significant changes in maternal Doppler, which is reassuring about the safety of these drugs when treating acute severe hypertension in pregnancy."5.34To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension. ( Gainder, S; Prakash, M; Saha, SC; Thakur, M, 2020)
"490 pregnant women with mild to moderate chronic hypertension were randomized into three groups; methyldopa group (n = 166), nifedipine group (n = 160) and control or no medication group (n = 164) who were followed from the beginning of pregnancy till the end of puerperium to record maternal and fetal outcome."5.30Methyldopa versus nifedipine or no medication for treatment of chronic hypertension during pregnancy: A multicenter randomized clinical trial. ( Abdallah, S; Gaber, W; Gamal, A; Hamza, H; Marawan, H; Rezk, M; Salama, M, 2019)
"To compare the efficacy of intravenous labetalol with oral nifedipine in the treatment of severe hypertension in pregnancy with blood pressure ≥160/110 mm Hg."5.30IV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy-A randomized controlled trial. ( Sowjanya, R; Tatapudi, R; Zulfeen, M, 2019)
"Both intravenous hydralazine and oral nifedipine are equally effective in lowering of blood pressure in acute hypertensive emergency of pregnancy."5.24Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. ( Gupta, A; Sharma, C; Soni, A; Verma, A; Verma, S, 2017)
" Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy and are therefore recommended in international guidelines for treatment of hypertension."5.22Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. ( Allegaert, K; Flint, RB; Mian, P; Schoenmakers, S; van de Vusse, D; Versmissen, J; Visser, W, 2022)
"These findings demonstrated the superiority of oral nifedipine 50,60,90 mg, especially oral nifedipine 50 mg tablets, in the treatment of severe hypertension during pregnancy than IV labetalol 300 mg, while oral nifedipine 60,90 mg also showed superiority in the successful treatment rate of severe hypertension during pregnancy than IV hydralazine 15,25 mg."5.22Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials. ( Cheng, Y; Jiang, YF; Li, JB; Wu, HZ; Yu, D; Zhu, ZN, 2022)
"As administered in this trial, oral nifedipine lowered blood pressure more quickly than did intravenous labetalol during hypertensive emergency in pregnancy."5.17Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial. ( Sharma, C; Shekhar, S; Thakur, S; Verma, S, 2013)
"Oral nifedipine and intravenous labetalol regimens are similarly effective in the acute control of severe hypertension in pregnancy."5.16Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial. ( Omar, SZ; Raheem, IA; Saaid, R; Tan, PC, 2012)
"A series of small pharmacokinetic studies illustrate higher oral clearance of labetalol and nifedipine during pregnancy."5.12The Impact of Pregnancy on Antihypertensive Drug Metabolism and Pharmacokinetics: Current Status and Future Directions. ( Daubert, MA; Fashe, MM; Garcia, JE; Lee, CR; Loop, MS; Mulrenin, IR; Urrutia, RP, 2021)
"The aim of the present study was to determine whether the beneficial effect of oral supplementation with calcium and conjugated linoleic acid (CLA) in the reduction of the incidence of pregnancy-induced hypertension (PIH) is related with changes in plasma levels of prostanoids, renin, angiotensin II, calciotropic hormones, and plasma and intracellular ionized free calcium."5.12Calcium and conjugated linoleic acid reduces pregnancy-induced hypertension and decreases intracellular calcium in lymphocytes. ( Arévalo-Herrera, M; Ersheng, G; Garcia, RG; Herrera, JA; Herrera, S; López-Jaramillo, P; Shahabuddin, AK, 2006)
"Hydralazine, labetalol, and nifedipine are the recommended first-line treatments for severe hypertension in pregnancy."5.01First-line antihypertensive treatment for severe hypertension in pregnancy: A systematic review and network meta-analysis. ( Alavifard, S; Chase, R; Chaumont, A; Gaudet, L; Janoudi, G; Lanes, A; Walker, M, 2019)
"We included all RCTs that compared intravenous labetalol with oral nifedipine for treatment of severe hypertension during pregnancy, addressing relevant efficacy and safety outcomes."4.93Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis. ( Gupta, N; Kirubakaran, R; Pareek, P; Shekhar, S, 2016)
"Oral nifedipine, and possibly labetalol and methyldopa, are suitable options for treatment of severe hypertension in pregnancy/postpartum."4.90Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review. ( Firoz, T; Gordon, R; MacDonell, K; Magee, LA; Payne, BA; Vidler, M; von Dadelszen, P, 2014)
"To assess whether readmission for hypertension by 6 weeks postpartum differed between patients discharged on nifedipine or labetalol."4.12Postpartum Readmission for Hypertension After Discharge on Labetalol or Nifedipine. ( Do, SC; Druzin, ML; El-Sayed, YY; Girsen, AI; Herrero, T; Kan, P; Leonard, SA; Lyell, DJ; Panelli, DM, 2022)
" The American College of Obstetricians and Gynecologists recommends that acute-onset, severe hypertension be treated with first line-therapy (intravenous labetalol, intravenous hydralazine or oral nifedipine) within 60 minutes to reduce risk of maternal morbidity and death."3.96Identification of factors associated with delayed treatment of obstetric hypertensive emergencies. ( Akerman, MB; Elsayad, A; Halpern, TA; Heiselman, CJ; Heo, HJ; Kantorowska, A; Muscat, JC; Sicuranza, GB; Vintzileos, AM, 2020)
"Nine mothers were treated with labetalol and/or MgSO4 during pregnancy, three mothers with labetalol, MgSO4 and nifedipine, and 19 mothers with nifedipine only."3.79Maternal antihypertensive drugs may influence cerebral oxygen extraction in preterm infants during the first days after birth. ( Bos, AF; Kooi, EM; van den Berg, PP; Verhagen, EA, 2013)
"Investigation of methyldopa and nifedipine effects on maternal and fetal hemodynamics in women with mild gestational hypertension during the third pregnancy trimester."3.78Effects of methyldopa and nifedipine on uteroplacental and fetal hemodynamics in gestational hypertension. ( Folic, MD; Folic, MM; Jankovic, SM; Varjacic, MR, 2012)
"A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted."3.78Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy. ( Battistoni, GI; Bezzeccheri, V; Cecchi, L; Cecchi, S; Giannubilo, SR; Landi, B; Tranquilli, AL; Vitali, P, 2012)
"Labetalol is commonly used for control of hypertension in pregnancy."3.77False-positive amphetamine toxicology screen results in three pregnant women using labetalol. ( Wu, D; Yee, LM, 2011)
"Alpha-methyldopa is a regularly used antihypertensive drug during pregnancy."3.76[Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver]. ( Monostory, K; Ozsvár, Z; Solymossi, Z, 2010)
"A meta-analysis of randomized controlled trials suggests that nifedipine appears to be a reasonable agent for treatment of acute severe hypertension in pregnancy."3.73Nifedipine for severe hypertension in pregnancy: emotion or evidence? ( Côté, AM; Magee, LA; von Dadelszen, P, 2005)
"Hypertension during pregnancy is associated with a higher risk of cardiovascular disease and kidney failure."3.01Evaluation and Management of Hypertensive Disorders of Pregnancy. ( Bajpai, D; Dumanski, S; Popa, C; Shah, S; Verma, P, 2023)
"Nifedipine was found to be more effective than other antihypertensive medications to reduce blood pressure, particularly in patients with severe hypertension."2.82Comparative efficacy and safety of oral nifedipine with other antihypertensive medications in the management of hypertensive disorders of pregnancy: a systematic review and meta-analysis of randomized controlled trials. ( Adela, R; George, R; Joy, CA; Thomas, C; Undela, K; Varghese, B, 2022)
"Complications in early-onset mild gestational hypertension (GH) are better predicted by total peripheral vascular resistance (TPVR) > 1350 dyne than by blood pressure."2.77Medical treatment of early-onset mild gestational hypertension reduces total peripheral vascular resistance and influences maternal and fetal complications. ( Gagliardi, G; Giannini, L; Manfellotto, D; Novelli, GP; Pisani, I; Tiralongo, GM; Valensise, H; Vasapollo, B, 2012)
"Pregnancy-induced hypertension is a major cause of maternal and fetal morbidity and mortality."2.61Hypertension and Pregnancy: Management and Future Risks. ( Jim, B; Reddy, S, 2019)
"The HDP spectrum includes gestational hypertension (HTN), preeclampsia, eclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome, chronic HTN, and chronic HTN with superimposed preeclampsia."1.72Hypertensive Conditions: Hypertensive Disorders in Pregnancy. ( Daly, PL; Goodwin, ET; Kipnis, CM; Smith, DK, 2022)
"IgA nephropathy is one of the most common causes of renal hypertension."1.48Pregnancy-induced complications in IgA nephropathy: A case report. ( Chen, H; Fan, L; Li, X; Tian, G; Wu, Y, 2018)

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (9.26)29.6817
2010's30 (55.56)24.3611
2020's19 (35.19)2.80

Authors

AuthorsStudies
Mulrenin, IR1
Garcia, JE1
Fashe, MM1
Loop, MS1
Daubert, MA1
Urrutia, RP1
Lee, CR1
Ashworth, D1
Battersby, C1
Green, M1
Hardy, P1
McManus, RJ1
Cluver, C1
Chappell, LC1
Wu, HZ1
Cheng, Y1
Yu, D1
Li, JB1
Jiang, YF1
Zhu, ZN1
Dublin, S1
Idu, A1
Avalos, LA1
Cheetham, TC1
Easterling, TR1
Chen, L2
Holt, VL1
Nance, N1
Bider-Canfield, Z1
Neugebauer, RS1
Reynolds, K1
Badon, SE1
Shortreed, SM1
George, R1
Thomas, C1
Joy, CA1
Varghese, B1
Undela, K1
Adela, R1
Do, SC1
Leonard, SA1
Kan, P1
Panelli, DM1
Girsen, AI1
Lyell, DJ1
El-Sayed, YY1
Druzin, ML1
Herrero, T1
van de Vusse, D1
Mian, P1
Schoenmakers, S1
Flint, RB1
Visser, W1
Allegaert, K1
Versmissen, J1
Shao, Y1
Gu, S1
Zhang, X1
Kipnis, CM1
Daly, PL1
Goodwin, ET1
Smith, DK1
Fishel Bartal, M1
Blackwell, SC1
Pedroza, C1
Lawal, D1
Amro, F1
Samuel, J1
Chauhan, SP1
Sibai, BM1
Wasif, U1
Al-Shehab, U1
Lo, DF1
Ou, M1
Zhang, F1
Cui, S1
Zhao, S1
Yu, Y1
Bajpai, D1
Popa, C1
Verma, P1
Dumanski, S1
Shah, S1
Salama, M1
Rezk, M1
Gaber, W1
Hamza, H1
Marawan, H1
Gamal, A1
Abdallah, S1
Alavifard, S1
Chase, R1
Janoudi, G1
Chaumont, A1
Lanes, A1
Walker, M1
Gaudet, L1
Kantorowska, A1
Heiselman, CJ1
Halpern, TA1
Akerman, MB1
Elsayad, A1
Muscat, JC1
Sicuranza, GB1
Vintzileos, AM1
Heo, HJ1
Ekawati, FM1
Lau, P1
Tolcher, MC1
Fox, KA1
Sangi-Haghpeykar, H1
Clark, SL1
Belfort, MA1
Thakur, M1
Gainder, S1
Saha, SC1
Prakash, M1
Martin, C1
Pappas, J1
Johns, K1
Figueroa, H1
Balli, K1
Yao, R1
Mary, S1
Small, HY1
Siwy, J1
Mullen, W1
Giri, A1
Delles, C1
Sharma, KJ1
Kilpatrick, SJ2
Sharma, C2
Soni, A1
Gupta, A1
Verma, A1
Verma, S2
Wang, Y1
Shi, D1
Shawkat, E1
Mistry, H1
Chmiel, C1
Webster, L1
Chappell, L1
Johnstone, ED1
Myers, JE1
Chen, H1
Li, X1
Wu, Y1
Fan, L1
Tian, G1
Miller, MJ1
Butler, P1
Gilchriest, J1
Taylor, A1
Lutgendorf, MA1
Zulfeen, M1
Tatapudi, R1
Sowjanya, R1
Reddy, S1
Jim, B1
Zhang, Z1
Lu, J1
Qin, X1
Easterling, T1
Mundle, S1
Bracken, H1
Parvekar, S1
Mool, S1
Magee, LA4
von Dadelszen, P3
Shochet, T1
Winikoff, B1
Arulkumaran, N1
Lightstone, L1
Wang, L1
Liu, ZQ1
Huo, YQ1
Yao, LJ1
Wei, XG1
Wang, YF1
Shekhar, S2
Thakur, S1
Gizzo, S1
Noventa, M1
Saccardi, C1
Paccagnella, G1
Patrelli, TS1
Cosmi, E1
D'Antona, D1
Firoz, T1
MacDonell, K1
Payne, BA1
Gordon, R1
Vidler, M1
Vadhera, RB1
Simon, M1
Gupta, N2
Kirubakaran, R1
Pareek, P1
Clark, SM1
Dunn, HE1
Hankins, GD1
Olson-Chen, C1
Seligman, NS1
Abreo, A1
Greene, N1
Melsop, K1
Peterson, N1
Shields, LE1
Main, EK1
Liu, Z1
Wang, XY1
Yan, NN1
Ozsvár, Z1
Solymossi, Z1
Monostory, K1
Folic, MM1
Jankovic, SM1
Varjacic, MR1
Folic, MD1
Yee, LM1
Wu, D1
Raheem, IA1
Saaid, R1
Omar, SZ1
Tan, PC1
Vasapollo, B1
Novelli, GP1
Gagliardi, G1
Tiralongo, GM1
Pisani, I1
Manfellotto, D1
Giannini, L1
Valensise, H1
Giannubilo, SR1
Bezzeccheri, V1
Cecchi, S1
Landi, B1
Battistoni, GI1
Vitali, P1
Cecchi, L1
Tranquilli, AL1
Verhagen, EA1
Kooi, EM1
van den Berg, PP1
Bos, AF1
Côté, AM1
Heazell, AE1
Mahomoud, S1
Pirie, AM1
Herrera, JA1
Arévalo-Herrera, M1
Shahabuddin, AK1
Ersheng, G1
Herrera, S1
Garcia, RG1
López-Jaramillo, P1
Dalmia, S1
Deka, D1
Mittal, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy[NCT01912677]Phase 4894 participants (Actual)Interventional2015-04-30Completed
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial[NCT03262961]Phase 2/Phase 380 participants (Anticipated)Interventional2016-09-15Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

16 reviews available for nifedipine and Hypertension, Pregnancy-Induced

ArticleYear
The Impact of Pregnancy on Antihypertensive Drug Metabolism and Pharmacokinetics: Current Status and Future Directions.
    Expert opinion on drug metabolism & toxicology, 2021, Volume: 17, Issue:11

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Labetalol; Nifedipine; Pha

2021
Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials.
    Hypertension in pregnancy, 2022, Volume: 41, Issue:2

    Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Hypertension, Pr

2022
Comparative efficacy and safety of oral nifedipine with other antihypertensive medications in the management of hypertensive disorders of pregnancy: a systematic review and meta-analysis of randomized controlled trials.
    Journal of hypertension, 2022, 10-01, Volume: 40, Issue:10

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Nifedipine; Pregnancy; Pre

2022
Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review.
    European journal of clinical pharmacology, 2022, Volume: 78, Issue:11

    Topics: Antihypertensive Agents; Female; Humans; Hypertension; Hypertension, Pregnancy-Induced; Labetalol; M

2022
Oral nifedipine may be a preferential option for treating acute severe hypertension during pregnancy: a meta-analysis.
    Hypertension in pregnancy, 2023, Volume: 42, Issue:1

    Topics: Blood Pressure; Female; Humans; Hypertension, Pregnancy-Induced; Labetalol; Nifedipine; Pregnancy

2023
Evaluation and Management of Hypertensive Disorders of Pregnancy.
    Kidney360, 2023, 10-01, Volume: 4, Issue:10

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Infant, Newborn; Labetalol

2023
First-line antihypertensive treatment for severe hypertension in pregnancy: A systematic review and network meta-analysis.
    Pregnancy hypertension, 2019, Volume: 18

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Nifedipine; Pregnancy; Pre

2019
Postpartum Hypertension: Etiology, Diagnosis, and Management.
    Obstetrical & gynecological survey, 2017, Volume: 72, Issue:4

    Topics: Antihypertensive Agents; Blood Pressure; Disease Management; Female; Humans; Hydralazine; Hypertensi

2017
Hypertension and Pregnancy: Management and Future Risks.
    Advances in chronic kidney disease, 2019, Volume: 26, Issue:2

    Topics: Antihypertensive Agents; Aspirin; Cardiovascular Diseases; Chronic Disease; Diuretics; Female; Human

2019
Severe pre-eclampsia and hypertensive crises.
    Best practice & research. Clinical obstetrics & gynaecology, 2013, Volume: 27, Issue:6

    Topics: Administration, Intravenous; Administration, Oral; Antihypertensive Agents; Critical Care; Early Dia

2013
Twin pregnancy after kidney transplantation: what's on? A case report and review of literature.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:17

    Topics: Adult; Anemia; Female; Humans; Hypertension, Pregnancy-Induced; Iron; Kidney Transplantation; Methyl

2014
Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review.
    BJOG : an international journal of obstetrics and gynaecology, 2014, Volume: 121, Issue:10

    Topics: Administration, Oral; Antihypertensive Agents; Female; Humans; Hydralazine; Hypertension, Pregnancy-

2014
Hypertensive emergencies in pregnancy.
    Clinical obstetrics and gynecology, 2014, Volume: 57, Issue:4

    Topics: Antihypertensive Agents; Eclampsia; Emergencies; Female; Humans; Hydralazine; Hypertension; Hyperten

2014
Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis.
    BJOG : an international journal of obstetrics and gynaecology, 2016, Volume: 123, Issue:1

    Topics: Administration, Intravenous; Administration, Oral; Adult; Antihypertensive Agents; Cost-Benefit Anal

2016
A review of oral labetalol and nifedipine in mild to moderate hypertension in pregnancy.
    Seminars in perinatology, 2015, Volume: 39, Issue:7

    Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension,

2015
Hypertensive Emergencies in Pregnancy.
    Critical care clinics, 2016, Volume: 32, Issue:1

    Topics: Antihypertensive Agents; Cesarean Section; Chronic Disease; Congenital Abnormalities; Emergencies; E

2016

Trials

15 trials available for nifedipine and Hypertension, Pregnancy-Induced

ArticleYear
Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Antihypertensive Agents; Blood Coagulation; Blood Pressure; Female; Humans; Hypertension; Hypertensi

2022
Oral combined hydrochlorothiazide and lisinopril vs nifedipine for postpartum hypertension: a comparative-effectiveness pilot randomized controlled trial.
    American journal of obstetrics and gynecology, 2023, Volume: 228, Issue:5

    Topics: Antihypertensive Agents; Bayes Theorem; Blood Pressure; Double-Blind Method; Female; Humans; Hydroch

2023
Methyldopa versus nifedipine or no medication for treatment of chronic hypertension during pregnancy: A multicenter randomized clinical trial.
    Pregnancy hypertension, 2019, Volume: 17

    Topics: Administration, Oral; Adult; Antihypertensive Agents; Egypt; Female; Humans; Hypertension; Hypertens

2019
Intravenous labetalol versus oral nifedipine for acute hypertension in pregnancy: effects on cerebral perfusion pressure.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:3

    Topics: Administration, Oral; Adult; Antihypertensive Agents; Cerebrovascular Circulation; Cohort Studies; F

2020
To study the changes in maternal hemodynamics with intravenous labetalol or nifedipine in acute severe hypertension.
    Pregnancy hypertension, 2020, Volume: 21

    Topics: Administration, Intravenous; Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; F

2020
Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial.
    American journal of obstetrics and gynecology, 2017, Volume: 217, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Apgar Score; Double-Blind Method; Emergencies; Female; Humans; Hyd

2017
Lipid profile and cytokines in hypertension of pregnancy: A comparison of preeclampsia therapies.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:2

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Cytokines; Double-Blind Method; Drug Administration

2018
Implementation of a standardized nurse initiated protocol to manage severe hypertension in pregnancy.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, Volume: 33, Issue:6

    Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure Determination; Clinical Protocols; Dru

2020
IV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy-A randomized controlled trial.
    European journal of obstetrics, gynecology, and reproductive biology, 2019, Volume: 236

    Topics: Administration, Intravenous; Administration, Oral; Antihypertensive Agents; Double-Blind Method; Fem

2019
Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial.
    Lancet (London, England), 2019, Sep-21, Volume: 394, Issue:10203

    Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension,

2019
Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial.
    Obstetrics and gynecology, 2013, Volume: 122, Issue:5

    Topics: Administration, Intravenous; Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; D

2013
[Treatment of albuminuria in gestational hypertension puerpera in the severe preeclampeia stage by TCM therapy for stasis-removing and diuresis].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2009, Volume: 29, Issue:3

    Topics: Adult; Albuminuria; Diagnosis, Differential; Drug Therapy, Combination; Drugs, Chinese Herbal; Femal

2009
Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial.
    BJOG : an international journal of obstetrics and gynaecology, 2012, Volume: 119, Issue:1

    Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Emergenci

2012
Medical treatment of early-onset mild gestational hypertension reduces total peripheral vascular resistance and influences maternal and fetal complications.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2012, Volume: 40, Issue:3

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Echocardiography; Female; Humans; Hypertension, Preg

2012
Calcium and conjugated linoleic acid reduces pregnancy-induced hypertension and decreases intracellular calcium in lymphocytes.
    American journal of hypertension, 2006, Volume: 19, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Angiotensin II; Blood Pressure; Calcium; Calcium Channel Bl

2006

Other Studies

23 other studies available for nifedipine and Hypertension, Pregnancy-Induced

ArticleYear
Which antihypertensive treatment is better for mild to moderate hypertension in pregnancy?
    BMJ (Clinical research ed.), 2022, 01-18, Volume: 376

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Labetalol; Methyldopa; Nif

2022
Maternal and neonatal outcomes of antihypertensive treatment in pregnancy: A retrospective cohort study.
    PloS one, 2022, Volume: 17, Issue:5

    Topics: Antihypertensive Agents; Birth Weight; Female; Humans; Hypertension, Pregnancy-Induced; Infant; Infa

2022
Postpartum Readmission for Hypertension After Discharge on Labetalol or Nifedipine.
    Obstetrics and gynecology, 2022, 10-01, Volume: 140, Issue:4

    Topics: Antihypertensive Agents; Cohort Studies; Female; Humans; Hypertension; Hypertension, Pregnancy-Induc

2022
Hypertensive Conditions: Hypertensive Disorders in Pregnancy.
    FP essentials, 2022, Volume: 522

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Labetalol; Nifedipine; Pre

2022
Critical commentary on labetalol and nifedipine use in postpartum hypertension management.
    Journal of hypertension, 2023, 07-01, Volume: 41, Issue:7

    Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Hypertension, Pregnancy-Induc

2023
Identification of factors associated with delayed treatment of obstetric hypertensive emergencies.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:2

    Topics: Administration, Intravenous; Administration, Oral; Adult; After-Hours Care; Antihypertensive Agents;

2020
What if there is no reliable and appropriate medication for pregnancy hypertension available in Indonesian primary care?
    Pregnancy hypertension, 2020, Volume: 21

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Indonesia; Maternal Health

2020
Semiautonomous Treatment Algorithm for the Management of Severe Hypertension in Pregnancy.
    Obstetrics and gynecology, 2021, 02-01, Volume: 137, Issue:2

    Topics: Adult; Algorithms; Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Labetal

2021
Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.
    Hypertension (Dallas, Tex. : 1979), 2017, Volume: 69, Issue:5

    Topics: Animals; Antihypertensive Agents; Female; Hypertension, Pregnancy-Induced; Kidney; Nifedipine; Polym

2017
The effect of labetalol and nifedipine MR on blood pressure in women with chronic hypertension in pregnancy.
    Pregnancy hypertension, 2018, Volume: 11

    Topics: Adrenergic Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chronic D

2018
Pregnancy-induced complications in IgA nephropathy: A case report.
    Medicine, 2018, Volume: 97, Issue:15

    Topics: Adult; Antihypertensive Agents; Benzimidazoles; Benzoates; Biopsy; Blood Pressure; Cyclophosphamide;

2018
Case Report: Optical Coherence Tomography Can Find Typical Features in Pregnancy-induced Hypertension with Retinopathy.
    Optometry and vision science : official publication of the American Academy of Optometry, 2019, Volume: 96, Issue:5

    Topics: Adult; Blood Pressure; Drug Therapy, Combination; Female; Fluorescein Angiography; Humans; Hypertens

2019
Change of hs-CRP, sVCAM-1, NT-proBNP levels in patients with pregnancy-induced hypertension after therapy with magnesium sulfate and nifedipine.
    Asian Pacific journal of tropical medicine, 2013, Volume: 6, Issue:11

    Topics: Adult; Antihypertensive Agents; Biomarkers; C-Reactive Protein; Calcium Channel Blockers; Endotheliu

2013
Oral nifedipine or intravenous labetalol for severe hypertension?
    BJOG : an international journal of obstetrics and gynaecology, 2016, Volume: 123, Issue:1

    Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Labetalol; Nifedipine; Pra

2016
Severe maternal morbidity in a large cohort of women with acute severe intrapartum hypertension.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:1

    Topics: Adult; Antihypertensive Agents; California; Female; Humans; Hydralazine; Hypertension, Pregnancy-Ind

2016
[Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver].
    Orvosi hetilap, 2010, Mar-14, Volume: 151, Issue:11

    Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Blood Pres

2010
Effects of methyldopa and nifedipine on uteroplacental and fetal hemodynamics in gestational hypertension.
    Hypertension in pregnancy, 2012, Volume: 31, Issue:1

    Topics: Adult; Antihypertensive Agents; Female; Hemodynamics; Humans; Hypertension, Pregnancy-Induced; Methy

2012
False-positive amphetamine toxicology screen results in three pregnant women using labetalol.
    Obstetrics and gynecology, 2011, Volume: 117, Issue:2 Pt 2

    Topics: Adult; Amphetamine; Antihypertensive Agents; Cesarean Section; Chronic Disease; Cocaine; Cross React

2011
Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy.
    Archives of gynecology and obstetrics, 2012, Volume: 286, Issue:3

    Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Female; Humans; Hypertension, Pregnancy-Induc

2012
Maternal antihypertensive drugs may influence cerebral oxygen extraction in preterm infants during the first days after birth.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:9

    Topics: Antihypertensive Agents; Case-Control Studies; Cerebral Cortex; Cerebrovascular Circulation; Female;

2013
Nifedipine for severe hypertension in pregnancy: emotion or evidence?
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2005, Volume: 27, Issue:3

    Topics: Acute Disease; Canada; Capsules; Female; Humans; Hypertension, Pregnancy-Induced; Nifedipine; Pregna

2005
The treatment of severe hypertension in pregnancy: a review of current practice and knowledge in West-Midlands maternity units.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2004, Volume: 24, Issue:8

    Topics: Antihypertensive Agents; Female; Hospital Units; Humans; Hydralazine; Hypertension, Pregnancy-Induce

2004
Successful maternal and fetal outcome in a pregnancy with type V Takayasu's aortoarteritis.
    Archives of gynecology and obstetrics, 2008, Volume: 277, Issue:2

    Topics: Adult; Antihypertensive Agents; Arterial Occlusive Diseases; Calcium Channel Blockers; Diuretics; Fe

2008