Page last updated: 2024-11-01

nifedipine and Glioma

nifedipine has been researched along with Glioma in 24 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"C6 rat glioma cells resemble rat astroglia in culture in that both cell types accumulate lead (Pb) intracellularly from the medium."7.70Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells. ( Bratton, GR; Harris, ED; Mikeska, G; Qian, Y; Tiffany-Castiglioni, E, 1999)
"Examination was made of the effects of nilvadipine on membrane potential in cultured neuroblastoma-glioma hybrid NG108-15 cells using the current clamp method."7.69[Effects of nilvadipine on membrane potential in cultured neuroblastoma-glioma hybrid NG108-15 cells]. ( Akiyama, Y; Enomoto, K; Kawahara, M; Maeno, T; Moritake, K; Nagao, S; Yamasaki, T, 1994)
"The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method."7.67Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987)
"To examine if toosendanin (TSN) affects intracellular free-Ca(2+) concentration ([Ca(2+)](i)) in neuroblastoma pluglioma hybrid cells (NG108-15 cells)."3.72Toosendanin increases free-Ca(2+) concentration in NG108-15 cells via L-type Ca(2+) channels. ( Ding, J; Shi, YL; Xu, TH, 2004)
"C6 rat glioma cells resemble rat astroglia in culture in that both cell types accumulate lead (Pb) intracellularly from the medium."3.70Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells. ( Bratton, GR; Harris, ED; Mikeska, G; Qian, Y; Tiffany-Castiglioni, E, 1999)
"To clarify the altered response of calcium antagonists on pathological vessels, we investigated the effect of intracarotid infusion of nifedipine on the blood-brain barrier (BBB) permeability using a rat glioma model."3.69Selective increase in blood-tumor barrier permeability by calcium antagonists in transplanted rat brain tumors. ( Fukui, M; Ikezaki, K; Matsukado, K; Nomura, T, 1994)
"Examination was made of the effects of nilvadipine on membrane potential in cultured neuroblastoma-glioma hybrid NG108-15 cells using the current clamp method."3.69[Effects of nilvadipine on membrane potential in cultured neuroblastoma-glioma hybrid NG108-15 cells]. ( Akiyama, Y; Enomoto, K; Kawahara, M; Maeno, T; Moritake, K; Nagao, S; Yamasaki, T, 1994)
"The dinoflagellate toxin maitotoxin (MTX) elicited a sustained increase of [Ca2+]i in C6 glioma cells."3.68Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. ( Daly, JW; Gusovsky, F; Soergel, DG; Yasumoto, T, 1992)
"The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method."3.67Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987)
" Intracarotid administration of cisplatin to rat did not cause acute vascular damage in either the brain or brain tumor at the dosage used."1.29Capillary permeability in experimental rat glioma and effects of intracarotid CDDP administration on tumor drug delivery. ( Aoyagi, M; Hirakawa, K; Ichimura, K; Ohno, K; Suzuki, R; Tamaki, M, 1993)
" This close temporal and dose-response relationship strongly suggests that delta-opioid receptor-mediated increases in intracellular [Ca2+] results from inositol 1,4,5-trisphosphate-induced Ca2+ release from intracellular stores, in undifferentiated NG108-15 cells."1.29delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells. ( Lambert, DG; Smart, D, 1996)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19908 (33.33)18.7374
1990's13 (54.17)18.2507
2000's3 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xu, TH1
Ding, J1
Shi, YL1
Zakir Hossain, SM1
Shinohara, H1
Kitano, H1
Freedman, SB2
Miller, RJ2
Nomura, K1
Watanabe, T1
Nakamura, O1
Shibui, S1
Matsukado, K2
Nomura, T2
Ikezaki, K2
Fukui, M2
Yamasaki, T1
Akiyama, Y1
Kawahara, M1
Nagao, S1
Moritake, K1
Enomoto, K1
Maeno, T1
Chueh, SH1
Kao, LS1
Ichimura, K1
Ohno, K1
Aoyagi, M1
Tamaki, M1
Suzuki, R1
Hirakawa, K1
Smart, D1
Lambert, DG1
Hu, Q1
Huang, F1
Shi, Y1
Morikawa, H1
Fukuda, K1
Mima, H1
Shoda, T1
Kato, S1
Mori, K1
Qian, Y1
Mikeska, G1
Harris, ED1
Bratton, GR1
Tiffany-Castiglioni, E1
Li, SN1
Bräter, M1
Andreas, K1
Easter, A1
Spruce, AE1
Soergel, DG1
Yasumoto, T1
Daly, JW1
Gusovsky, F1
Caulfield, MP1
Robbins, J1
Brown, DA1
Gleason, MM1
Griffin, EC1
Nambi, P1
Aiyar, N1
Creba, JA1
Karobath, M1
Bodewei, R1
Hering, S1
Schubert, B1
Wollenberger, A1
Kongsamut, S1
Simon, BE1
Miwa, N1
Sugino, H1
Ueno, R1
Hayaishi, O1
Yoshida, T1
Shimizu, K1
Ushio, Y1
Hayakawa, T1
Kato, A1
Mogami, H1
Sakamoto, Y1
Kaba, K1
Tani, E1
Morimura, T1
Matsumoto, T1

Other Studies

24 other studies available for nifedipine and Glioma

ArticleYear
Toosendanin increases free-Ca(2+) concentration in NG108-15 cells via L-type Ca(2+) channels.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:5

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell

2004
Drug assessment based on detection of L-glutamate released from C6 glioma cells using an enzyme-luminescence method.
    Analytical chemistry, 2008, May-15, Volume: 80, Issue:10

    Topics: 4-Aminopyridine; Animals; Brain Neoplasms; Carbamazepine; Cell Line, Tumor; Enzymes; Flunarizine; Gl

2008
Calcium channel activation: a different type of drug action.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:17

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1984
[Flow cytometric study of enhanced effect of anti-cancer drugs induced by nicardipine hydrochloride].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:10

    Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; DNA, Neoplasm; Doxorubicin; Flow Cytometry

1984
Selective increase in blood-tumor barrier permeability by calcium antagonists in transplanted rat brain tumors.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Calcium Channel Blockers; Cell Line; Cerebral Cortex;

1994
[Effects of nilvadipine on membrane potential in cultured neuroblastoma-glioma hybrid NG108-15 cells].
    No shinkei geka. Neurological surgery, 1994, Volume: 22, Issue:4

    Topics: Animals; Calcium Channel Blockers; Electrophysiology; Glioma; Membrane Potentials; Mice; Neuroblasto

1994
Extracellular ATP stimulates calcium influx in neuroblastoma x glioma hybrid NG108-15 cells.
    Journal of neurochemistry, 1993, Volume: 61, Issue:5

    Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Bradykinin; Calcium; Calcium Channel Blo

1993
Capillary permeability in experimental rat glioma and effects of intracarotid CDDP administration on tumor drug delivery.
    Journal of neuro-oncology, 1993, Volume: 16, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Capillaries; Capillary Permeability; Carotid Artery,

1993
delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells.
    Journal of neurochemistry, 1996, Volume: 66, Issue:4

    Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enkephalin

1996
Effect of calcium antagonists on regional cerebral blood flow in transplanted rat brain tumors.
    Journal of neuro-oncology, 1996, Volume: 27, Issue:1

    Topics: Analysis of Variance; Animals; Brain; Brain Neoplasms; Calcium Channel Blockers; Cerebrovascular Cir

1996
Inhibition of Toosendanin on the delayed rectifier potassium current in neuroblastoma x glioma NG108-15 cells.
    Brain research, 1997, Mar-14, Volume: 751, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1997
Tyrosine kinase inhibitors suppress N-type and T-type Ca2+ channel currents in NG108-15 cells.
    Pflugers Archiv : European journal of physiology, 1998, Volume: 436, Issue:1

    Topics: Animals; Benzoquinones; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Enzyme In

1998
Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells.
    Toxicology and applied pharmacology, 1999, Jul-01, Volume: 158, Issue:1

    Topics: Animals; Body Burden; Brain Neoplasms; Calcium Channel Blockers; Cell Membrane; Chromatography, Agar

1999
Nicardipine inhibits N-type calcium channels in dbcAMP-differentiated neuroblastoma x glioma hybrid cells (NG 108-15 cells).
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:2

    Topics: Bucladesine; Calcium Channel Blockers; Calcium Channels; Cell Transformation, Neoplastic; Glioma; Hu

1999
Modulation of calcium current by recombinant GABA(B) receptors.
    Neuroreport, 2000, Nov-09, Volume: 11, Issue:16

    Topics: Animals; Baclofen; Calcium Channel Blockers; Calcium Channels; GABA Agonists; Glioma; Hybrid Cells;

2000
Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry.
    Molecular pharmacology, 1992, Volume: 41, Issue:3

    Topics: Calcium; Calcium Channel Blockers; Carbachol; Endothelins; Glioma; Imidazoles; Insulin; Marine Toxin

1992
Neurotransmitters inhibit the omega-conotoxin-sensitive component of Ca current in neuroblastoma x glioma hybrid (NG 108-15) cells, not the nifedipine-sensitive component.
    Pflugers Archiv : European journal of physiology, 1992, Volume: 420, Issue:5-6

    Topics: Acetylcholine; Calcium; Calcium Channel Blockers; Glioma; Neuroblastoma; Nifedipine; Norepinephrine;

1992
Endothelin stimulates 86Rb efflux in rat glioma C6-Bu-1 cells.
    Neuropeptides, 1991, Volume: 20, Issue:1

    Topics: Alkaloids; Analysis of Variance; Animals; Calcium; Diltiazem; Endothelins; Glioma; Glyburide; Nifedi

1991
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
    Biochemical and biophysical research communications, 1986, Feb-13, Volume: 134, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1986
Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine.
    Biomedica biochimica acta, 1987, Volume: 46, Issue:8-9

    Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Glioma; Ion Channels; Neuroblasto

1987
Interaction of steroidal alkaloid toxins with calcium channels in neuronal cell lines.
    Life sciences, 1985, Apr-15, Volume: 36, Issue:15

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1985
Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture.
    Journal of neurochemistry, 1988, Volume: 50, Issue:5

    Topics: Aminoquinolines; Animals; Calcium; Cyclic GMP; Diltiazem; Dinoprost; Dinoprostone; Fluorescent Dyes;

1988
[Mechanism and overcoming of resistance in ACNU-resistant sublines of rat brain tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:9

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Membrane Permeability; Drug Resistance; Glioma

1986
Potentiation of vincristine effect in human and murine gliomas by calcium channel blockers or calmodulin inhibitors.
    Journal of neurosurgery, 1985, Volume: 63, Issue:6

    Topics: Animals; Brain Neoplasms; Calcium Channel Blockers; Calmodulin; Drug Synergism; Glioma; Humans; In V

1985