nifedipine has been researched along with Gingival Overgrowth in 87 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Gingival Overgrowth: Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Eighteen children were also receiving nifedipine (also known to cause gingival overgrowth) and were considered separately." | 9.10 | Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. ( Kelly, D; McKaig, SJ; Shaw, L, 2002) |
| "Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine." | 8.12 | Amlodipine Induced Gum Hypertrophy: A Rare Case Report. ( Bohra, GK; Chhabra, V; Kumar, D; Midha, N; Reddy, SC, 2022) |
| "The aim of this study was to establish an in vitro model of nifedipine-induced gingival overgrowth and characterize the anti-fibrotic effect of hepatocyte growth factor (HGF) using this model." | 8.12 | Hepatocyte growth factor exhibits anti-fibrotic effects in an in vitro model of nifedipine-induced gingival overgrowth. ( Igarashi-Takeuchi, H; Numabe, Y; Yamazaki, K, 2022) |
| "Nifedipine-induced gingival overgrowth (NGO) is a multifactorial pathogenesis with increased extracellular matrix including collagen and glycans, inflammatory cytokines, and phenotype changes of fibroblasts." | 7.96 | Transcriptional Analysis Reveals Key Genes in the Pathogenesis of Nifedipine-Induced Gingival Overgrowth. ( Huang, L; Ju, Y; Wang, S; Zhao, S, 2020) |
| "This investigation aimed to establish the basis of a pharmacotherapy for nifedipine-induced gingival overgrowth." | 7.83 | Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth. ( Akimoto, Y; Arikawa, K; Fujii, A; Hiratsuka, K; Komiya, M; Matsumoto, H; Ono, M; Takeuchi, R, 2016) |
| "Nifedipine-induced gingival overgrowth (NIGO) is characterized by cell proliferation and extracellular matrix (ECM) component accumulation in gingival connective tissues, with varying degrees of inflammation and fibrosis." | 7.81 | Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study. ( Chen, LJ; Li, WL; Tang, M; Wu, CH; Yang, J; Zhao, SL, 2015) |
| "In this case report, we describe the clinical course over a 14-year follow-up in a 47-year-old diabetes patient with severe chronic periodontitis and nifedipine-induced gingival overgrowth." | 7.78 | Clinical case report of long-term follow-up in type-2 diabetes patient with severe chronic periodontitis and nifedipine-induced gingival overgrowth. ( Fujinami, K; Shibukawa, Y; Yamashita, S, 2012) |
| "We have previously demonstrated that the mechanism of nifedipine (NIF)-induced gingival overgrowth is related to the observation that proliferation and cell cycle progression of gingival fibroblasts derived from NIF reactive patient (NIFr) are greater than those from NIF non-reactive patient (NIFn)." | 7.77 | Reduction in lipopolysaccharide-induced apoptosis of fibroblasts obtained from a patient with gingival overgrowth during nifedipine-treatment. ( Akimoto, Y; Fujii, A; Matsumoto, H; Takeuchi, R, 2011) |
| "Drug-induced gingival overgrowth (DIGO) is a significant problem for periodontologists and this side effect is frequently associated with three particular drugs: phenytoin, cyclosporin A and nifedipine." | 7.76 | Non-surgical treatment of gingival overgrowth induced by nifedipine: a case report on an elderly patient. ( Cabral, PA; Cimões, R; de Carvalho Farias, B; Gusmão, ES; Jamelli, SR, 2010) |
| "A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect." | 7.75 | Therapy for nifedipine-induced gingival overgrowth by Saireito in rats. ( Ara, T; Hattori, T; Kawakami, T; Nakano, K; Tamura, A; Wang, PL, 2009) |
| "The purpose of this study was to clarify the main contributory factor of nifedipine-induced gingival overgrowth either by Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) or interleukin-1beta (IL-1beta)." | 7.74 | Stimulation of cells derived from nifedipine-induced gingival overgrowth with Porphyromonas gingivalis, lipopolysaccharide, and interleukin-1beta. ( Chou, HP; Li, CL; Lu, HK; Wang, LF; Wang, MY, 2007) |
| "The present study showed that neither GCF nor plasma nifedipine levels appeared to be a risk factor for nifedipine-induced gingival overgrowth." | 7.74 | Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth. ( Bozkurt, A; Cağlayan, F; Dinçel, A; Güncü, GN; Karabulut, E; Ozmen, S, 2007) |
| "Nifedipine (NIF), a calcium channel blocker, is well known to induce gingival overgrowth (GO) as an adverse effect, and ketoconazole (KTZ), an azole antifungal agent, has been implicated in various drug interactions." | 7.73 | Enhancement of nifedipine-induced gingival overgrowth by concomitant ketoconazole in rats. ( Amano, A; Kamisaki, Y; Kato, T; Morisaki, I, 2005) |
| "Gingival overgrowth is a common side effect of cyclosporine A (CsA) therapy." | 7.72 | Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. ( Boratyńska, M; Klinger, M; Radwan-Oczko, M; Zietek, M, 2003) |
| "An immunohistochemical study was conducted to compare distributions of mast cell subpopulations in normal human gingiva and in gingival overgrowth induced by nifedipine and immunosuppressive medication." | 7.72 | Mast cell subpopulations in gingival overgrowth induced by immunosuppressive and nifedipine medication. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2004) |
| "Tissue samples were collected from patients with healthy periodontium (H group), adult periodontitis (P group), surgically extracted teeth (S group), and nifedipine-induced gingival overgrowth (NIGO group)." | 7.72 | Immunohistochemical analysis of Th1/Th2 cytokine profiles and androgen receptor expression in the pathogenesis of nifedipine-induced gingival overgrowth. ( Chou, HH; Huang, WT; Kuo, MY; Lu, HK, 2003) |
| "Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity." | 7.72 | Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. ( Almeida, OP; Benatti, C; Sampaio, JE; Spolidorio, DM; Spolidorio, LC, 2003) |
| "This investigation was performed to evaluate the effect of cyclosporine alone and in combination with nifedipine on gingival overgrowth." | 7.72 | The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. ( Ansari, G; Einollahi, B; Khoori, AH; Moozeh, MB, 2003) |
| "The immunomodulating effects of both immunosuppressive and nifedipine medication have been associated with drug-induced gingival overgrowth." | 7.71 | Macrophage subpopulations in gingival overgrowth induced by nifedipine and immunosuppressive medication. ( Knuuttila, ML; Laukkanen, P; Nurmenniemi, PK; Pernu, HE, 2002) |
| "Nifedipine and cyclosporin A (CsA) induce gingival overgrowth." | 7.71 | Macrophages and lymphocyte subpopulations in nifedipine- and cyclosporin A-associated human gingival overgrowth. ( Knuuttila, ML; Pernu, HE, 2001) |
| "The purpose of the study was to compare mitotic activity in the basal cell layer of normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth." | 7.71 | Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2001) |
| "Nifedipine (NIF) may aggravate cyclosporin A (CsA)-induced gingival overgrowth because the potentiated gingival overgrowth has been observed in the patients treated with CsA and NIF." | 7.71 | Does nifedipine aggravate cyclosporin--induced gingival overgrowth? An experiment in rats. ( Chiang, CY; Chiu, HC; Fu, E; Liu, D, 2001) |
| "It has previously been shown that, while cyclosporin A (CsA) and nifedipine both cause gingival overgrowth in the rat, the combined use of these drugs increases the severity of overgrowth." | 7.71 | Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats. ( Almeida, OP; Gonzaga, HF; Neves, KA; Spoildorio, LC; Spolidorio, DM, 2002) |
| "Nifedipine is used as a long-acting vasodilator, and a primary side effect is the induction of gingival overgrowth, which is characterized by an accumulation of collagenous components within the gingival connective tissue." | 7.71 | Nifedipine induces gingival overgrowth in rats through a reduction in collagen phagocytosis by gingival fibroblasts. ( Asahara, Y; Azuma, H; Kataoka, M; Kido, J; Kunikiyo, K; Nagata, T; Sawa, T; Shimizu, Y, 2001) |
| "The purpose of this study was to examine the composition of subgingival plaque of 140 periodontal lesions in 35 patients with cardiovascular disorders who were administered nifedipine and manifested nifedipine-induced gingival overgrowth (GO)." | 7.70 | Subgingival microflora associated with nifedipine-induced gingival overgrowth. ( Andronikaki, A; Kamma, JJ; Mitsis, F; Nakou, M, 1998) |
| "Fifteen-day-old Fischer rats were treated orally with single or combined applications of CsA, nifedipine, and/or diltiazem for 40 days; and induced gingival overgrowth, rat growth, and blood drug levels were compared among the different experimental groups." | 7.70 | Effects of combined oral treatments with cyclosporine A and nifedipine or diltiazem on drug-induced gingival overgrowth in rats. ( Amano, A; Daikoku, H; Fujimori, Y; Fukui, N; Morisaki, I; Murakami, J, 2000) |
| "The purpose of this study was to compare the distribution of Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth by means of an immunohistochemical study." | 7.70 | Density of CD1a-labeled Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 1999) |
| "To clarify the possible pathophysiological role of medullasin, a neutrophil elastase-like proteinase, in nifedipine (NF)-induced gingival overgrowth, a rat model of gingival overgrowth was first established using a diet containing NF." | 7.70 | Role of medullasin in nifedipine-induced gingival overgrowth in rats. ( Aoki, Y; Hara, Y; Kato, I; Kato, Y; Kunimatsu, K; Ozaki, Y; Tajiri, K, 1998) |
| "The prevalence and severity of gingival overgrowth in organ-transplant patients medicated with cyclosporin are greater in patients concomitantly medicated with nifedipine; however, no relationship between the gingival overgrowth and any of the nifedipine pharmacological variables has been demonstrated." | 7.69 | Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients. ( Ellis, JS; Kelly, PJ; Seymour, RA; Thomason, JM, 1997) |
| "This study has been designed to investigate the immunogenetic susceptibility of Cyclosporine-A (CsA) immunosuppressed renal transplant patients to development of gingival overgrowth, and the amplifying effect of calcium channel blockers on the severity of this clinical entity." | 7.69 | Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A. ( Aydin, AE; Aygün, S; Carin, M; Cebeci, I; Firatli, E; Güç, U; Kantarci, A; Tanyeri, H; Tuncer, O, 1996) |
| "The factors associated with cyclosporin A (CsA)- and nifedipine (Nif)-induced gingival overgrowth were investigated in 113 renal transplant recipients receiving CsA alone (Group 1) [n = 61], CsA and Nif (Group 2) [n = 28], or azathioprine (Aza) (Control Group) [n = 24]." | 7.69 | Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens. ( Barbaro, A; Margiotta, V; Pizzo, G; Pizzo, I, 1996) |
| "In order to clarify a possible pathophysiological role of medullasin, a neutrophil elastase-like proteinase, in nifedipine (NF)-induced gingival overgrowth, the distributions of medullasin-positive cells immunostained in specimens from patients with NF-induced gingival overgrowth and chronic marginal gingivitis were compared in three different biopsy areas." | 7.69 | Possible roles of medullasin in nifedipine-induced human gingival overgrowth. ( Aoki, Y; Kato, I; Kunimatsu, K; Ozaki, Y, 1996) |
| "Drug-induced gingival overgrowth (DIGO) is one of the side effects produced by therapeutic agents, most commonly phenytoin, nifedipine and cyclosporin A." | 5.41 | Drug-Induced Gingival Overgrowth-Molecular Aspects of Drug Actions. ( Droździk, A; Droździk, M, 2023) |
| "Nifedipine alone was not sufficient to promote gingival enlargement or periodontal destruction in the absence of the ligature." | 5.36 | Effect of nifedipine on gingival enlargement and periodontal breakdown in ligature-induced periodontitis in rats. ( Fernandes, MI; Gaio, EJ; Oppermann, RV; Rados, PV; Rösing, CK; Susin, C, 2010) |
| "Drug-induced gingival overgrowth (DIGO) is a frequent adverse medication reaction that is generally caused by cyclosporine, phenytoin, and nifedipine, which belong to the category of immunosuppressants, anticonvulsants, and calcium channel blockers, respectively." | 5.22 | Bibliometric analysis of research trends and characteristics of drug-induced gingival overgrowth. ( Song, J; Wang, X; Wu, J; Zhang, R; Zhu, J, 2022) |
| " Eighteen children were also receiving nifedipine (also known to cause gingival overgrowth) and were considered separately." | 5.10 | Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. ( Kelly, D; McKaig, SJ; Shaw, L, 2002) |
| "Drug-induced gingival overgrowth is an iatrogenic disease caused by the use of phenytoin, cyclosporine, nifedipine, and other medications in the susceptible patient." | 4.79 | Prevention and treatment considerations in patients with drug-induced gingival enlargement. ( Hall, EE, 1997) |
| "Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine." | 4.12 | Amlodipine Induced Gum Hypertrophy: A Rare Case Report. ( Bohra, GK; Chhabra, V; Kumar, D; Midha, N; Reddy, SC, 2022) |
| " This longitudinal study aims to assess the proliferative and antiapoptotic effects of cyclosporin, nifedipine and phenytoin on gingival connective tissue cells of nonhuman primate, as well as to analyze a possible role of myofibroblasts in gingival overgrowth." | 3.88 | Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys. ( Ervolino, E; Kanno, CM; Oliveira, JA; Soubhia, AMP, 2018) |
| "The aim of the current study was to assess the association between 3 different calcium channel blockers (CCBs) (nifedipine, amlodipine and felodipine) and gingival overgrowth in patients with a diagnosis of severe refractory hypertension." | 3.88 | Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients. ( de Souza, RC; Ferreira, DC; Fischer, RG; Gonçalves, LS; Vidal, F, 2018) |
| "This investigation aimed to establish the basis of a pharmacotherapy for nifedipine-induced gingival overgrowth." | 3.83 | Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth. ( Akimoto, Y; Arikawa, K; Fujii, A; Hiratsuka, K; Komiya, M; Matsumoto, H; Ono, M; Takeuchi, R, 2016) |
| "Nifedipine-induced gingival overgrowth (NIGO) is characterized by cell proliferation and extracellular matrix (ECM) component accumulation in gingival connective tissues, with varying degrees of inflammation and fibrosis." | 3.81 | Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study. ( Chen, LJ; Li, WL; Tang, M; Wu, CH; Yang, J; Zhao, SL, 2015) |
| "Fragments of gingival tissue collected from patients clinically diagnosed with gingival overgrowth after chronic administration of nifedipine and amlodipine were processed for paraffin embedding." | 3.80 | Role of transforming growth factor β-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth. ( Andrei, AM; Banită, IM; Berbecaru-Iovan, A; Munteanu, C; Pisoschi, CG; Popescu, F; Stănciulescu, CE, 2014) |
| "The aim of this study is to compare gingival changes induced by short- and long-term tacrolimus and nifedipine administration, alone or in combination, and evaluate the expression levels of tumor suppressor phosphatase and tensin homolog (PTEN) in drug-induced gingival overgrowth." | 3.79 | Effects of tacrolimus and nifedipine, alone or in combination, on gingival tissues. ( Arik, N; Cetinkaya, BO; Erisgin, Z; Gacar, A; Gulbahar, MY; Keles, GC; Pamuk, F, 2013) |
| " Confluent gingival fibroblasts derived from healthy individuals (n = 4) and those with dihydropyridine-induced gingival overgrowth (DIGO) (n = 6) were stimulated for 48 h with IL-1β (10 ng/mL), nifedipine (0." | 3.78 | Nitric oxide inhibits androgen receptor-mediated collagen production in human gingival fibroblasts. ( Chen, YC; Lee, HW; Li, CL; Lin, SJ; Lu, HK; Wang, LF, 2012) |
| "In this case report, we describe the clinical course over a 14-year follow-up in a 47-year-old diabetes patient with severe chronic periodontitis and nifedipine-induced gingival overgrowth." | 3.78 | Clinical case report of long-term follow-up in type-2 diabetes patient with severe chronic periodontitis and nifedipine-induced gingival overgrowth. ( Fujinami, K; Shibukawa, Y; Yamashita, S, 2012) |
| "We have previously demonstrated that the mechanism of nifedipine (NIF)-induced gingival overgrowth is related to the observation that proliferation and cell cycle progression of gingival fibroblasts derived from NIF reactive patient (NIFr) are greater than those from NIF non-reactive patient (NIFn)." | 3.77 | Reduction in lipopolysaccharide-induced apoptosis of fibroblasts obtained from a patient with gingival overgrowth during nifedipine-treatment. ( Akimoto, Y; Fujii, A; Matsumoto, H; Takeuchi, R, 2011) |
| "Drug-induced gingival overgrowth (DIGO) is a significant problem for periodontologists and this side effect is frequently associated with three particular drugs: phenytoin, cyclosporin A and nifedipine." | 3.76 | Non-surgical treatment of gingival overgrowth induced by nifedipine: a case report on an elderly patient. ( Cabral, PA; Cimões, R; de Carvalho Farias, B; Gusmão, ES; Jamelli, SR, 2010) |
| "To understand the role of the androgen receptor in gingival overgrowth, the effects of flutamide on interleukin-1 beta- and nifedipine-induced gene expression of connective tissue growth factor (CTGF/CCN2) and collagen production in gingival fibroblasts were examined." | 3.76 | Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts. ( Lee, YH; Li, CL; Lu, HK; Tseng, CC; Wang, LF, 2010) |
| "The chronic usage of nifedipine is associated with the appearance of gingival overgrowth (GO)." | 3.76 | Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. ( Batista, AC; Castro, LA; de Spíndula-Filho, JV; Elias, LS; Leles, CR; Mendonça, EF; Oton-Leite, AF, 2010) |
| "It has been stated that cyclosporin and nifedipine produce gingival overgrowth." | 3.74 | Nifedipine and cyclosporin affect fibroblast calcium and gingiva. ( Battino, M; Bullon, P; Gallardo, I; Goteri, G; Newman, HN; Ribas, J; Rubini, C, 2007) |
| "The present study showed that neither GCF nor plasma nifedipine levels appeared to be a risk factor for nifedipine-induced gingival overgrowth." | 3.74 | Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth. ( Bozkurt, A; Cağlayan, F; Dinçel, A; Güncü, GN; Karabulut, E; Ozmen, S, 2007) |
| "To investigate the prevalence and risk indicator of nifedipine-induced gingival overgrowth in a community population in Beijing." | 3.74 | [Analysis of risk indicator for nifedipine-induced gingival hyperplasia]. ( Li, P; Li, X; Luan, QX, 2007) |
| "Gingival overgrowth is a side-effect of nifedipine and cyclosporin medications." | 3.74 | Expression of fibronectin-binding integrins in gingival epithelium in drug-induced gingival overgrowth. ( Häkkinen, L; Knuuttila, M; Larjava, H; Pernu, H; Walsh, P, 2007) |
| "The hypothesis that nifedipine-induced gingival enlargement in periodontitis patients can be treated with the adjunctive use of tetracycline (TCN) fibers was tested in this study." | 3.73 | Tetracycline fibers as an adjunct in the treatment of nifedipine-induced gingival enlargement. ( Aristodemou, E; Goodson, M; Konstantinidis, AB; Sakellari, D; Socransky, S; Vouros, ID, 2005) |
| "The therapeutic combination of cyclosporine A and nifedipine could be a significant risk factor for gingival overgrowth in subjects susceptible to either agent." | 3.73 | Synergism between nifedipine and cyclosporine A on the incorporation of [35S]sulfate into human gingival fibroblast cultures in vitro. ( Flynn, JC; Henderson, JS; Johnson, RB, 2006) |
| "The effect of nifedipine and interleukin-alpha (IL-1alpha) on the cell proliferation and DNA synthesis was studied in human gingival fibroblasts derived from 5 patients who developed gingival overgrowth (nifedipine responders) and 5 patients who did not develop gingival overgrowth (nifedipine non-responders) in response to nifedipine." | 3.73 | The effect of IL-1alpha and nifedipine on cell proliferation and DNA synthesis in cultured human gingival fibroblasts. ( Akimoto, Y; Fujii, A; Matsumoto, H; Sato, N, 2005) |
| "Gingival overgrowth is a common side effect of cyclosporine A (CsA) therapy." | 3.72 | Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A. ( Boratyńska, M; Klinger, M; Radwan-Oczko, M; Zietek, M, 2003) |
| "An immunohistochemical study was conducted to compare distributions of mast cell subpopulations in normal human gingiva and in gingival overgrowth induced by nifedipine and immunosuppressive medication." | 3.72 | Mast cell subpopulations in gingival overgrowth induced by immunosuppressive and nifedipine medication. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2004) |
| "Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity." | 3.72 | Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. ( Almeida, OP; Benatti, C; Sampaio, JE; Spolidorio, DM; Spolidorio, LC, 2003) |
| "Tissue samples were collected from patients with healthy periodontium (H group), adult periodontitis (P group), surgically extracted teeth (S group), and nifedipine-induced gingival overgrowth (NIGO group)." | 3.72 | Immunohistochemical analysis of Th1/Th2 cytokine profiles and androgen receptor expression in the pathogenesis of nifedipine-induced gingival overgrowth. ( Chou, HH; Huang, WT; Kuo, MY; Lu, HK, 2003) |
| "It has previously been shown that, while cyclosporin A (CsA) and nifedipine both cause gingival overgrowth in the rat, the combined use of these drugs increases the severity of overgrowth." | 3.71 | Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats. ( Almeida, OP; Gonzaga, HF; Neves, KA; Spoildorio, LC; Spolidorio, DM, 2002) |
| "Nifedipine and cyclosporin A (CsA) induce gingival overgrowth." | 3.71 | Macrophages and lymphocyte subpopulations in nifedipine- and cyclosporin A-associated human gingival overgrowth. ( Knuuttila, ML; Pernu, HE, 2001) |
| "The purpose of the study was to compare mitotic activity in the basal cell layer of normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth." | 3.71 | Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2001) |
| "Nifedipine (NIF) may aggravate cyclosporin A (CsA)-induced gingival overgrowth because the potentiated gingival overgrowth has been observed in the patients treated with CsA and NIF." | 3.71 | Does nifedipine aggravate cyclosporin--induced gingival overgrowth? An experiment in rats. ( Chiang, CY; Chiu, HC; Fu, E; Liu, D, 2001) |
| "Patients taking nifedipine are at high risk for gingival enlargement, and gingivitis acts as a predisposing factor." | 3.71 | Prevalence and risk of gingival enlargement in patients treated with nifedipine. ( Berini, L; Brunet, L; Farré, M; Mendieta, C; Miranda, J; Roset, P, 2001) |
| "Gingival overgrowth samples were obtained from patients undergoing therapy with phenytoin (n = 9), nifedipine (n = 4), cyclosporin A (n = 5), and control tissues from systemically healthy donors (n = 9)." | 3.71 | Connective tissue growth factor in drug-induced gingival overgrowth. ( Firatli, E; Hong, HH; Kantarci, A; Sheff, MC; Trackman, PC; Uygur, C; Uzel, MI, 2001) |
| "The purpose of this study was to examine the composition of subgingival plaque of 140 periodontal lesions in 35 patients with cardiovascular disorders who were administered nifedipine and manifested nifedipine-induced gingival overgrowth (GO)." | 3.70 | Subgingival microflora associated with nifedipine-induced gingival overgrowth. ( Andronikaki, A; Kamma, JJ; Mitsis, F; Nakou, M, 1998) |
| "The purpose of this study was to compare the distribution of Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth by means of an immunohistochemical study." | 3.70 | Density of CD1a-labeled Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 1999) |
| "Drug-induced gingival overgrowth (DGO) is one of the well-recognized side effects of cyclosporin A (CsA) or nifedipine (Ni)." | 3.70 | Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results. ( Atilla, G; Baylas, H; Ilgenli, T, 1999) |
| "A higher proportion (72%) of the amlodipine group were categorised as having gingival overgrowth compared with only 53% of the nifedipine group, chi square=4." | 3.70 | The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth. ( Boomer, S; Campbell, BA; Hull, PS; Irwin, CR; Jamal, S; James, JA; Johnson, RW; Linden, GJ; Marley, JJ; Maxwell, AP; Short, CD; Spratt, H, 2000) |
| "Fifteen-day-old Fischer rats were treated orally with single or combined applications of CsA, nifedipine, and/or diltiazem for 40 days; and induced gingival overgrowth, rat growth, and blood drug levels were compared among the different experimental groups." | 3.70 | Effects of combined oral treatments with cyclosporine A and nifedipine or diltiazem on drug-induced gingival overgrowth in rats. ( Amano, A; Daikoku, H; Fujimori, Y; Fukui, N; Morisaki, I; Murakami, J, 2000) |
| " Gingival overgrowth was present in 41% of liver recipients receiving cyclosporin with or without nifedipine, but not in the majority receiving tacrolimus at the final examination." | 3.70 | Oral health in children undergoing liver transplantation. ( Beighton, D; O'Brien, G; Roberts, GJ; Sheehy, EC, 2000) |
| "In order to clarify a possible pathophysiological role of medullasin, a neutrophil elastase-like proteinase, in nifedipine (NF)-induced gingival overgrowth, the distributions of medullasin-positive cells immunostained in specimens from patients with NF-induced gingival overgrowth and chronic marginal gingivitis were compared in three different biopsy areas." | 3.69 | Possible roles of medullasin in nifedipine-induced human gingival overgrowth. ( Aoki, Y; Kato, I; Kunimatsu, K; Ozaki, Y, 1996) |
| "The factors associated with cyclosporin A (CsA)- and nifedipine (Nif)-induced gingival overgrowth were investigated in 113 renal transplant recipients receiving CsA alone (Group 1) [n = 61], CsA and Nif (Group 2) [n = 28], or azathioprine (Aza) (Control Group) [n = 24]." | 3.69 | Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens. ( Barbaro, A; Margiotta, V; Pizzo, G; Pizzo, I, 1996) |
| "This study has been designed to investigate the immunogenetic susceptibility of Cyclosporine-A (CsA) immunosuppressed renal transplant patients to development of gingival overgrowth, and the amplifying effect of calcium channel blockers on the severity of this clinical entity." | 3.69 | Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A. ( Aydin, AE; Aygün, S; Carin, M; Cebeci, I; Firatli, E; Güç, U; Kantarci, A; Tanyeri, H; Tuncer, O, 1996) |
| "A case of severe gingival overgrowth associated with combined drug therapy of cyclosporin A and nifedipine is reported." | 3.69 | Combined treatment approach to gingival overgrowth due to drug therapy. ( Darbar, UR; Hopper, C; Newman, HN; Speight, PM, 1996) |
| " Gingival overgrowth associated with cyclosporin (immunosuppressant agent) and nifedipine (calcium channel blocker) is well documented." | 3.69 | Periodontal management of gingival overgrowth in the heart transplant patient: a case report. ( Khocht, A; Schneider, LC, 1997) |
| "The prevalence and severity of gingival overgrowth in organ-transplant patients medicated with cyclosporin are greater in patients concomitantly medicated with nifedipine; however, no relationship between the gingival overgrowth and any of the nifedipine pharmacological variables has been demonstrated." | 3.69 | Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients. ( Ellis, JS; Kelly, PJ; Seymour, RA; Thomason, JM, 1997) |
| "Nifedipine was resumed during periodontal treatment when the patient's hypertension worsened." | 1.62 | Treatment of calcium channel blocker-induced gingival overgrowth without modifying medication. ( Miyashita, Y; Morikawa, S; Nakagawa, T; Nasu, M, 2021) |
| "Nifedipine alone was not sufficient to promote gingival enlargement or periodontal destruction in the absence of the ligature." | 1.36 | Effect of nifedipine on gingival enlargement and periodontal breakdown in ligature-induced periodontitis in rats. ( Fernandes, MI; Gaio, EJ; Oppermann, RV; Rados, PV; Rösing, CK; Susin, C, 2010) |
| "Phenytoin was used as a positive control." | 1.31 | Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders. ( Akimoto, Y; Fujii, A; Matsumoto, H; Noji, I, 2001) |
| "Drug-induced gingival overgrowth is an iatrogenic clinical condition, which affects a proportion of patients medicated for conditions such as hypertension, epilepsy and the prevention of organ transplant rejection." | 1.31 | Drug-induced gingival overgrowth: a case with auto-correction of incisor drifting. ( Butterworth, C; Chapple, I, 2001) |
| "Nifedipine and phenytoin were also tested to further support findings with CsA." | 1.30 | Regulation of gingival fibroblast interleukin-6 secretion by cyclosporine A. ( Dongari-Bagtzoglou, AI; Morton, RS, 1999) |
| "Gingival overgrowth was noticed in 29% of the patients." | 1.30 | The clinical effects of nifedipine on periodontal status. ( Caglayan, F; Caglayan, G; Eratalay, K; Tavassoli, S; Yamalik, N, 1998) |
| " Duration of treatment, dosage of drugs per kg body weight and serum cyclosporin levels were recorded." | 1.30 | Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. ( Ashley, FP; Koffman, CG; Morel, A; Ogg, CS; Rigden, SP; Smith, D; Wilson, RF, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (22.99) | 18.2507 |
| 2000's | 41 (47.13) | 29.6817 |
| 2010's | 19 (21.84) | 24.3611 |
| 2020's | 7 (8.05) | 2.80 |
| Authors | Studies |
|---|---|
| Reddy, SC | 1 |
| Midha, N | 1 |
| Chhabra, V | 1 |
| Kumar, D | 1 |
| Bohra, GK | 1 |
| Yamazaki, K | 1 |
| Igarashi-Takeuchi, H | 1 |
| Numabe, Y | 1 |
| Zhang, R | 1 |
| Wu, J | 1 |
| Zhu, J | 1 |
| Wang, X | 1 |
| Song, J | 1 |
| Droździk, A | 1 |
| Droździk, M | 1 |
| Nakayama, Y | 1 |
| Inoue, E | 1 |
| Kato, A | 1 |
| Iwai, Y | 1 |
| Takai-Yamazaki, M | 1 |
| Tsuruya, Y | 1 |
| Yamaguchi, A | 1 |
| Noda, K | 1 |
| Nomoto, T | 1 |
| Ganss, B | 1 |
| Ogata, Y | 1 |
| Ju, Y | 1 |
| Huang, L | 1 |
| Wang, S | 1 |
| Zhao, S | 1 |
| Morikawa, S | 1 |
| Nasu, M | 1 |
| Miyashita, Y | 1 |
| Nakagawa, T | 1 |
| Vidal, F | 1 |
| de Souza, RC | 1 |
| Ferreira, DC | 1 |
| Fischer, RG | 1 |
| Gonçalves, LS | 1 |
| Kanno, CM | 2 |
| Oliveira, JA | 2 |
| Ervolino, E | 1 |
| Soubhia, AMP | 1 |
| Kim, SS | 1 |
| Jackson-Boeters, L | 1 |
| Darling, MR | 1 |
| Rieder, MJ | 1 |
| Hamilton, DW | 1 |
| Pisoschi, CG | 1 |
| Stănciulescu, CE | 1 |
| Andrei, AM | 1 |
| Berbecaru-Iovan, A | 1 |
| Munteanu, C | 1 |
| Popescu, F | 1 |
| Banită, IM | 1 |
| Li, WL | 1 |
| Wu, CH | 1 |
| Yang, J | 1 |
| Tang, M | 1 |
| Chen, LJ | 1 |
| Zhao, SL | 1 |
| Chang, JH | 1 |
| Wang, LF | 4 |
| Lu, SL | 1 |
| Huang, CF | 1 |
| Lu, HK | 5 |
| Kato, T | 2 |
| Takiuchi, H | 1 |
| Yamaguchi, M | 1 |
| Naito, T | 1 |
| Takeuchi, R | 3 |
| Hiratsuka, K | 1 |
| Arikawa, K | 1 |
| Ono, M | 1 |
| Komiya, M | 1 |
| Akimoto, Y | 4 |
| Fujii, A | 4 |
| Matsumoto, H | 4 |
| de Carvalho Farias, B | 1 |
| Cabral, PA | 1 |
| Gusmão, ES | 1 |
| Jamelli, SR | 1 |
| Cimões, R | 1 |
| Hattori, T | 1 |
| Nakano, K | 1 |
| Kawakami, T | 1 |
| Tamura, A | 1 |
| Ara, T | 1 |
| Wang, PL | 1 |
| Tseng, CC | 1 |
| Lee, YH | 1 |
| Li, CL | 3 |
| Castro, LA | 1 |
| Elias, LS | 1 |
| Oton-Leite, AF | 1 |
| de Spíndula-Filho, JV | 1 |
| Leles, CR | 1 |
| Batista, AC | 1 |
| Mendonça, EF | 1 |
| Fernandes, MI | 1 |
| Gaio, EJ | 1 |
| Susin, C | 1 |
| Rösing, CK | 1 |
| Oppermann, RV | 1 |
| Rados, PV | 1 |
| Shimizu, T | 1 |
| Kubota, T | 1 |
| Nakasone, N | 1 |
| Abe, D | 1 |
| Morozumi, T | 1 |
| Yoshie, H | 1 |
| Kantarci, A | 5 |
| Nseir, Z | 1 |
| Kim, YS | 1 |
| Sume, SS | 1 |
| Trackman, PC | 4 |
| Nakib, N | 1 |
| Ashrafi, SS | 1 |
| Lin, SJ | 1 |
| Lee, HW | 1 |
| Chen, YC | 1 |
| Shibukawa, Y | 1 |
| Fujinami, K | 1 |
| Yamashita, S | 1 |
| Pamuk, F | 1 |
| Cetinkaya, BO | 1 |
| Gulbahar, MY | 1 |
| Gacar, A | 1 |
| Keles, GC | 1 |
| Erisgin, Z | 1 |
| Arik, N | 1 |
| Spoildorio, LC | 1 |
| Spolidorio, DM | 2 |
| Neves, KA | 1 |
| Gonzaga, HF | 1 |
| Almeida, OP | 2 |
| McKaig, SJ | 1 |
| Kelly, D | 1 |
| Shaw, L | 1 |
| Nishimura, F | 1 |
| Naruishi, H | 1 |
| Naruishi, K | 1 |
| Yamada, T | 1 |
| Sasaki, J | 1 |
| Peters, C | 1 |
| Uchiyama, Y | 1 |
| Murayama, Y | 1 |
| Nurmenniemi, PK | 4 |
| Pernu, HE | 5 |
| Laukkanen, P | 1 |
| Knuuttila, ML | 5 |
| Martins, RC | 1 |
| Werneck, CC | 1 |
| Rocha, LA | 1 |
| Feres-Filho, EJ | 1 |
| Silva, LC | 1 |
| Khoori, AH | 1 |
| Einollahi, B | 1 |
| Ansari, G | 1 |
| Moozeh, MB | 1 |
| Spolidorio, LC | 1 |
| Benatti, C | 1 |
| Sampaio, JE | 1 |
| Huang, WT | 1 |
| Chou, HH | 1 |
| Kuo, MY | 1 |
| Bullon, P | 3 |
| Pugnaloni, A | 1 |
| Gallardo, I | 2 |
| Machuca, G | 2 |
| Hevia, A | 1 |
| Battino, M | 2 |
| Radwan-Oczko, M | 1 |
| Boratyńska, M | 1 |
| Klinger, M | 1 |
| Zietek, M | 1 |
| Amano, A | 2 |
| Kamisaki, Y | 1 |
| Morisaki, I | 2 |
| Sakellari, D | 1 |
| Vouros, ID | 1 |
| Aristodemou, E | 1 |
| Konstantinidis, AB | 1 |
| Socransky, S | 1 |
| Goodson, M | 1 |
| Sato, N | 1 |
| Giusto, TJ | 1 |
| Flynn, JC | 2 |
| Henderson, JS | 3 |
| Johnson, RB | 4 |
| Buduneli, N | 1 |
| Buduneli, E | 1 |
| Cinar, S | 1 |
| Lappin, D | 1 |
| Kinane, DF | 1 |
| Walsh, P | 1 |
| Häkkinen, L | 1 |
| Pernu, H | 1 |
| Knuuttila, M | 1 |
| Larjava, H | 1 |
| Goteri, G | 1 |
| Rubini, C | 1 |
| Ribas, J | 1 |
| Newman, HN | 2 |
| Augustin, P | 1 |
| Firatli, E | 3 |
| Sheff, MC | 2 |
| Hasturk, H | 1 |
| Graves, DT | 1 |
| Sukkar, TZ | 1 |
| Thomason, JM | 2 |
| Cawston, TE | 1 |
| Lakey, R | 1 |
| Jones, D | 1 |
| Catterall, J | 1 |
| Seymour, RA | 2 |
| Chou, HP | 1 |
| Wang, MY | 1 |
| Walker, MR | 1 |
| Lovel, SF | 1 |
| Melrose, CA | 1 |
| Garcia, JF | 1 |
| Castro, AL | 1 |
| Crivelini, MM | 1 |
| Güncü, GN | 1 |
| Cağlayan, F | 2 |
| Dinçel, A | 1 |
| Bozkurt, A | 1 |
| Ozmen, S | 1 |
| Karabulut, E | 1 |
| Li, X | 1 |
| Luan, QX | 1 |
| Li, P | 1 |
| Kunimatsu, K | 2 |
| Ozaki, Y | 2 |
| Aoki, Y | 2 |
| Kato, I | 2 |
| Martinez-Sahuquillo, A | 1 |
| Rios, JV | 1 |
| Velasco, E | 1 |
| Rojas, J | 1 |
| Lacalle, JR | 1 |
| Margiotta, V | 1 |
| Pizzo, I | 1 |
| Pizzo, G | 1 |
| Barbaro, A | 1 |
| Cebeci, I | 1 |
| Aygün, S | 1 |
| Tanyeri, H | 1 |
| Aydin, AE | 1 |
| Carin, M | 1 |
| Güç, U | 1 |
| Tuncer, O | 1 |
| Darbar, UR | 1 |
| Hopper, C | 1 |
| Speight, PM | 1 |
| Tucci, MA | 1 |
| Tsao, AK | 1 |
| Zebrowski, EJ | 2 |
| Odlum, O | 1 |
| Khocht, A | 1 |
| Schneider, LC | 1 |
| Tavassoli, S | 1 |
| Yamalik, N | 1 |
| Caglayan, G | 1 |
| Eratalay, K | 1 |
| Ellis, JS | 1 |
| Kelly, PJ | 1 |
| Guillot, JL | 1 |
| Krolls, SO | 1 |
| Parkel, CO | 1 |
| Slezák, R | 1 |
| Desai, P | 1 |
| Silver, JG | 1 |
| Hall, EE | 1 |
| Nakou, M | 1 |
| Kamma, JJ | 1 |
| Andronikaki, A | 1 |
| Mitsis, F | 1 |
| Wilson, RF | 1 |
| Morel, A | 1 |
| Smith, D | 1 |
| Koffman, CG | 1 |
| Ogg, CS | 1 |
| Rigden, SP | 1 |
| Ashley, FP | 1 |
| Tajiri, K | 1 |
| Hara, Y | 1 |
| Kato, Y | 1 |
| Ilgenli, T | 1 |
| Atilla, G | 1 |
| Baylas, H | 1 |
| Morton, RS | 1 |
| Dongari-Bagtzoglou, AI | 1 |
| Inglés, E | 1 |
| Rossmann, JA | 1 |
| Caffesse, RG | 1 |
| Dai, X | 1 |
| James, JA | 1 |
| Marley, JJ | 1 |
| Jamal, S | 1 |
| Campbell, BA | 1 |
| Short, CD | 1 |
| Johnson, RW | 1 |
| Hull, PS | 1 |
| Spratt, H | 1 |
| Irwin, CR | 1 |
| Boomer, S | 1 |
| Maxwell, AP | 1 |
| Linden, GJ | 1 |
| Fukui, N | 1 |
| Fujimori, Y | 1 |
| Murakami, J | 1 |
| Daikoku, H | 1 |
| Sheehy, EC | 1 |
| Roberts, GJ | 1 |
| Beighton, D | 1 |
| O'Brien, G | 1 |
| Chiu, HC | 1 |
| Fu, E | 1 |
| Chiang, CY | 1 |
| Liu, D | 1 |
| Miranda, J | 1 |
| Brunet, L | 1 |
| Roset, P | 1 |
| Berini, L | 1 |
| Farré, M | 1 |
| Mendieta, C | 1 |
| Uzel, MI | 1 |
| Hong, HH | 1 |
| Uygur, C | 1 |
| Kataoka, M | 1 |
| Shimizu, Y | 1 |
| Kunikiyo, K | 1 |
| Asahara, Y | 1 |
| Azuma, H | 1 |
| Sawa, T | 1 |
| Kido, J | 1 |
| Nagata, T | 1 |
| Butterworth, C | 1 |
| Chapple, I | 1 |
| Noji, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Effects of PRF, CGF and AFG Application on Wound Healing Following Gingivectomy and Gingivoplasty Operations: a Randomized Controlled Clinical Trial[NCT04805463] | 19 participants (Actual) | Interventional | 2020-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for nifedipine and Gingival Overgrowth
| Article | Year |
|---|---|
Bibliometric analysis of research trends and characteristics of drug-induced gingival overgrowth.
Topics: Amlodipine; Anticonvulsants; Bibliometrics; Calcium Channel Blockers; Cyclosporine; Gingival Overgro | 2022 |
Drug-Induced Gingival Overgrowth-Molecular Aspects of Drug Actions.
Topics: Calcium Channel Blockers; Cyclosporine; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Nifedipin | 2023 |
Drug-induced gingival overgrowth.
Topics: Adult; Anticonvulsants; Calcium Channel Blockers; Child; Cyclosporine; Gingiva; Gingival Overgrowth; | 2011 |
Connective tissue metabolism and gingival overgrowth.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Connective Tissue; Connective Tissue Growth Facto | 2004 |
Drug-induced gingival overgrowth after phenytoin and nifedipine therapy. A case report.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Therapy, Combination; Female; Gingival Overgrowth; H | 1997 |
Drug-induced gingival enlargements.
Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppress | 1998 |
Prevention and treatment considerations in patients with drug-induced gingival enlargement.
Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Dental Prophylaxis; Gingival Overgrowth; Gi | 1997 |
1 trial available for nifedipine and Gingival Overgrowth
| Article | Year |
|---|---|
Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation.
Topics: Adolescent; Analysis of Variance; Calcium Channel Blockers; Child; Child, Preschool; Cyclosporine; D | 2002 |
79 other studies available for nifedipine and Gingival Overgrowth
| Article | Year |
|---|---|
Amlodipine Induced Gum Hypertrophy: A Rare Case Report.
Topics: Aged; Amlodipine; Calcium Channel Blockers; Gingival Hyperplasia; Gingival Overgrowth; Humans; Hyper | 2022 |
Hepatocyte growth factor exhibits anti-fibrotic effects in an in vitro model of nifedipine-induced gingival overgrowth.
Topics: Cells, Cultured; Connective Tissue Growth Factor; Fibroblasts; Gingiva; Gingival Overgrowth; Hepatoc | 2022 |
Follicular dendritic cell-secreted protein gene expression is upregulated and spread in nifedipine-induced gingival overgrowth.
Topics: Dendritic Cells, Follicular; Epithelial Attachment; Gingiva; Gingival Overgrowth; Humans; Nifedipine | 2020 |
Transcriptional Analysis Reveals Key Genes in the Pathogenesis of Nifedipine-Induced Gingival Overgrowth.
Topics: Adult; Aged; Cell Movement; Cell Proliferation; Fibroblasts; Gene Expression Profiling; Gene Express | 2020 |
Treatment of calcium channel blocker-induced gingival overgrowth without modifying medication.
Topics: Aged; Amlodipine; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Gingival Overgrowth; Humans; | 2021 |
Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients.
Topics: Adult; Aged; Amlodipine; Brazil; Calcium Channel Blockers; Felodipine; Female; Gingival Overgrowth; | 2018 |
Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys.
Topics: Actins; Animals; Apoptosis; Biopsy; Cell Proliferation; Cell Transdifferentiation; Cyclosporine; Gen | 2018 |
Nifedipine induces periostin expression in gingival fibroblasts through TGF-beta.
Topics: Benzamides; Calcium Channel Blockers; Cell Adhesion Molecules; Cell Culture Techniques; Cell Nucleus | 2013 |
Role of transforming growth factor β-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth.
Topics: Adult; Amlodipine; Calcium Channel Blockers; Calcium Channels, L-Type; Connective Tissue Growth Fact | 2014 |
Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Gingival | 2015 |
NF-κB Enhances Androgen Receptor Expression through 5'-UTR Binding in Gingival Cells.
Topics: 5' Untranslated Regions; Aged; Blotting, Western; Case-Control Studies; Electrophoretic Mobility Shi | 2015 |
Ca-channel blocker-induced gingival overgrowth that improved with non-surgical therapy during visiting care: a case report.
Topics: Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Debridement; Essential Hyperte | 2015 |
Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth.
Topics: Aged; Apoptosis; Calcium Channel Blockers; Cell Count; Cell Cycle; Cell Proliferation; Cells, Cultur | 2016 |
Non-surgical treatment of gingival overgrowth induced by nifedipine: a case report on an elderly patient.
Topics: Aged; Dental Prophylaxis; Dental Scaling; Follow-Up Studies; Gingival Hemorrhage; Gingival Overgrowt | 2010 |
Therapy for nifedipine-induced gingival overgrowth by Saireito in rats.
Topics: Animals; Calcium Channel Blockers; Drugs, Chinese Herbal; Gingival Overgrowth; Male; Nifedipine; Rat | 2009 |
Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts.
Topics: Androgen Antagonists; Calcium Channel Blockers; Case-Control Studies; Cell Culture Techniques; Cells | 2010 |
Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study.
Topics: Adult; Aged; Apoptosis; bcl-2-Associated X Protein; Calcium Channel Blockers; Case-Control Studies; | 2010 |
Effect of nifedipine on gingival enlargement and periodontal breakdown in ligature-induced periodontitis in rats.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Calcium Channel Blockers; Connective Tissue; Cotton F | 2010 |
Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients.
Topics: Aged; Amlodipine; Calcium Channel Blockers; Case-Control Studies; Cathepsin L; Cluster Analysis; Fem | 2011 |
Reduction in lipopolysaccharide-induced apoptosis of fibroblasts obtained from a patient with gingival overgrowth during nifedipine-treatment.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Caspase 2; Caspa | 2011 |
Loss of basement membrane integrity in human gingival overgrowth.
Topics: Adult; Analysis of Variance; Basement Membrane; Case-Control Studies; Cell Adhesion Molecules; Colla | 2011 |
Nitric oxide inhibits androgen receptor-mediated collagen production in human gingival fibroblasts.
Topics: Aged; Case-Control Studies; Cells, Cultured; Collagen Type I; Dihydropyridines; Fibroblasts; Gingiva | 2012 |
Clinical case report of long-term follow-up in type-2 diabetes patient with severe chronic periodontitis and nifedipine-induced gingival overgrowth.
Topics: Calcium Channel Blockers; Chronic Periodontitis; Diabetes Mellitus, Type 2; Gingival Overgrowth; Gly | 2012 |
Effects of tacrolimus and nifedipine, alone or in combination, on gingival tissues.
Topics: Animals; Blood Vessels; Calcium Channel Blockers; Cell Count; Collagen; Connective Tissue; Drug Comb | 2013 |
Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats.
Topics: Analysis of Variance; Animals; Blood Vessels; Calcium Channel Blockers; Cyclosporine; Drug Synergism | 2002 |
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
Topics: Animals; Calcium; Calcium Channel Blockers; Cathepsin B; Cathepsin L; Cathepsins; Cells, Cultured; C | 2002 |
Macrophage subpopulations in gingival overgrowth induced by nifedipine and immunosuppressive medication.
Topics: Adult; Aged; Analysis of Variance; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Calcium | 2002 |
Molecular size distribution analysis of human gingival glycosaminoglycans in cyclosporin- and nifedipine-induced overgrowths.
Topics: Adolescent; Adult; Calcium Channel Blockers; Chondroitin Sulfates; Chromatography, Gel; Cyclosporine | 2003 |
The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients.
Topics: Adult; Age Factors; Calcium Channel Blockers; Cyclosporine; Dental Care for Chronically Ill; Dental | 2003 |
Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent.
Topics: Age Factors; Analysis of Variance; Animals; Calcium Channel Blockers; Connective Tissue; Cyclosporin | 2003 |
Immunohistochemical analysis of Th1/Th2 cytokine profiles and androgen receptor expression in the pathogenesis of nifedipine-induced gingival overgrowth.
Topics: Adult; Calcium Channel Blockers; Cell Nucleus; Connective Tissue; Female; Fibroblasts; Gingival Over | 2003 |
Ultrastructure of the gingiva in cardiac patients treated with or without calcium channel blockers.
Topics: Calcium Channel Blockers; Case-Control Studies; Diltiazem; Fibroblasts; Gingiva; Gingival Overgrowth | 2003 |
The effect of basic fibroblast growth factor on cell cycle in human gingival fibroblasts from nifedipine responder and non-responder.
Topics: CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cells, Cultured; Cyclin A; Cycli | 2004 |
Risk factors of gingival overgrowth in kidney transplant recipients treated with cyclosporine A.
Topics: Adult; Alleles; Amlodipine; Calcium Channel Blockers; Cyclosporine; Female; Gingival Overgrowth; HLA | 2003 |
Mast cell subpopulations in gingival overgrowth induced by immunosuppressive and nifedipine medication.
Topics: Adult; Aged; Case-Control Studies; Cell Count; Cyclosporine; Female; Gingiva; Gingival Overgrowth; H | 2004 |
Enhancement of nifedipine-induced gingival overgrowth by concomitant ketoconazole in rats.
Topics: Animals; Antifungal Agents; Calcium Channel Blockers; Drug Synergism; Gingival Overgrowth; Ketoconaz | 2005 |
Tetracycline fibers as an adjunct in the treatment of nifedipine-induced gingival enlargement.
Topics: Aged; Analysis of Variance; Anti-Bacterial Agents; Calcium Channel Blockers; Gingival Overgrowth; Hu | 2005 |
The effect of IL-1alpha and nifedipine on cell proliferation and DNA synthesis in cultured human gingival fibroblasts.
Topics: Aged; Calcium Channel Blockers; Case-Control Studies; Cell Proliferation; Cells, Cultured; DNA; DNA | 2005 |
Periodontal management of gingival overgrowth in a renal transplant patient: a case report.
Topics: Adult; Calcium Channel Blockers; Cyclosporine; Female; Gingival Overgrowth; Gingivectomy; Humans; Im | 2005 |
Synergism between nifedipine and cyclosporine A on the incorporation of [35S]sulfate into human gingival fibroblast cultures in vitro.
Topics: Analysis of Variance; Calcium Channel Blockers; Cells, Cultured; Cyclosporine; Drug Synergism; Fibro | 2006 |
Immunohistochemical evaluation of Ki-67 expression and apoptosis in cyclosporin A-induced gingival overgrowth.
Topics: Adult; Analysis of Variance; Apoptosis; Calcium Channel Blockers; Case-Control Studies; Cell Prolife | 2007 |
Expression of fibronectin-binding integrins in gingival epithelium in drug-induced gingival overgrowth.
Topics: Adult; Analysis of Variance; Antigens, Neoplasm; Calcium Channel Blockers; Cyclosporine; Drug Combin | 2007 |
Nifedipine and cyclosporin affect fibroblast calcium and gingiva.
Topics: Animals; Calcium; Calcium Channel Blockers; Collagen; Cyclosporine; Fibroblasts; Gingiva; Gingival O | 2007 |
Apoptosis in gingival overgrowth tissues.
Topics: Anticonvulsants; Apoptosis; Calcium Channel Blockers; Case-Control Studies; Caspase 3; Cell Prolifer | 2007 |
Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory c
Topics: Calcium Channel Blockers; Case-Control Studies; Cells, Cultured; Cyclosporine; Down-Regulation; Fibr | 2007 |
Stimulation of cells derived from nifedipine-induced gingival overgrowth with Porphyromonas gingivalis, lipopolysaccharide, and interleukin-1beta.
Topics: Aged; Calcium Channel Blockers; Case-Control Studies; Collagen Type I; Connective Tissue Growth Fact | 2007 |
Orthodontic treatment of a patient with a renal transplant and drug-induced gingival overgrowth: a case report.
Topics: Adolescent; Antihypertensive Agents; Cyclosporine; Dental Care for Chronically Ill; Dental Enamel Hy | 2007 |
Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): histochemical and MMP-1 and -2 and collagen I gene expression analyses.
Topics: Animals; Anticonvulsants; Azo Compounds; Biopsy; Calcium Channel Blockers; Cebus; Collagen; Collagen | 2008 |
Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth.
Topics: Adult; Aged; Dental Plaque; Epidemiologic Methods; Female; Gingival Crevicular Fluid; Gingival Overg | 2007 |
[Analysis of risk indicator for nifedipine-induced gingival hyperplasia].
Topics: Adult; Aged; Aged, 80 and over; Calcium Channel Blockers; China; Cross-Sectional Studies; Female; Gi | 2007 |
Possible roles of medullasin in nifedipine-induced human gingival overgrowth.
Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Chronic Disease; Coloring Agents; Connecti | 1996 |
Evaluation of gingival and periodontal conditions following causal periodontal treatment in patients treated with nifedipine and diltiazem.
Topics: Analysis of Variance; Calcium Channel Blockers; Chi-Square Distribution; Dental Care for Chronically | 1996 |
Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens.
Topics: Adolescent; Adult; Azathioprine; Calcium Channel Blockers; Child; Cyclosporine; Dental Calculus; Den | 1996 |
Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A.
Topics: Adult; Antigenic Variation; Calcium Channel Blockers; Chi-Square Distribution; Cyclosporine; Diltiaz | 1996 |
Combined treatment approach to gingival overgrowth due to drug therapy.
Topics: Blood Loss, Surgical; Calcium Channel Blockers; Carbon Dioxide; Cyclosporine; Gingival Hemorrhage; G | 1996 |
Site-specific variations in metabolism by human fibroblasts exposed to nifedipine in vitro.
Topics: Analysis of Variance; Calcium Channel Blockers; Cells, Cultured; Collagen; Connective Tissue; Connec | 1997 |
Periodontal management of gingival overgrowth in the heart transplant patient: a case report.
Topics: Calcium Channel Blockers; Candidiasis, Oral; Connective Tissue; Cyclosporine; Epithelium; Fibrosis; | 1997 |
The clinical effects of nifedipine on periodontal status.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Angina Pectoris; Calcium Channel Blockers; Dental Pl | 1998 |
Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients.
Topics: Adult; Calcium Channel Blockers; Chi-Square Distribution; Cyclosporine; Dental Plaque Index; Dose-Re | 1997 |
Case presentation. Initiation of gingival overgrowth by an increased daily dosage of nifedipine.
Topics: Calcium Channel Blockers; Dose-Response Relationship, Drug; Gingival Overgrowth; Humans; Male; Nifed | 1994 |
Subgingival microflora associated with nifedipine-induced gingival overgrowth.
Topics: Adult; Age Factors; Aged; Bacteroidaceae; Bacteroides; Calcium Channel Blockers; Campylobacter; Capn | 1998 |
Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Azathioprine; Body We | 1998 |
Role of medullasin in nifedipine-induced gingival overgrowth in rats.
Topics: Animals; Gingival Overgrowth; Immunoenzyme Techniques; Inflammation Mediators; Macrophages; Male; Ne | 1998 |
Density of CD1a-labeled Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth.
Topics: Adult; Anti-Inflammatory Agents; Antigens, CD1; Azathioprine; Calcium Channel Blockers; Cell Count; | 1999 |
Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results.
Topics: Adult; Age Factors; Calcium Channel Blockers; Cyclosporine; Dental Plaque Index; Dental Prophylaxis; | 1999 |
Regulation of gingival fibroblast interleukin-6 secretion by cyclosporine A.
Topics: Anticonvulsants; Bacteria; Calcium Channel Blockers; Cell Division; Cells, Cultured; Cyclosporine; D | 1999 |
New clinical index for drug-induced gingival overgrowth.
Topics: Adult; Calcium Channel Blockers; Cyclosporine; Female; Gingival Overgrowth; Humans; Immunosuppressiv | 1999 |
Synergistic enhancement of collagenous protein synthesis by human gingival fibroblasts exposed to nifedipine and interleukin-1-beta in vitro.
Topics: Analysis of Variance; Cells, Cultured; Collagen; Culture Media; Dose-Response Relationship, Drug; Dr | 2000 |
The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth.
Topics: Adult; Amlodipine; Calcium Channel Blockers; Cyclosporine; Drug Therapy, Combination; Female; Gingiv | 2000 |
Effects of combined oral treatments with cyclosporine A and nifedipine or diltiazem on drug-induced gingival overgrowth in rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Calcium Channel Blockers; Cyclospo | 2000 |
Macrophages and lymphocyte subpopulations in nifedipine- and cyclosporin A-associated human gingival overgrowth.
Topics: Adult; Antibodies, Monoclonal; Antigens, CD; Antigens, CD20; Antigens, Differentiation, Myelomonocyt | 2001 |
Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth.
Topics: Adult; Aged; Azathioprine; Calcium Channel Blockers; Cell Count; Cyclosporine; Epithelial Cells; Epi | 2001 |
Oral health in children undergoing liver transplantation.
Topics: Adolescent; Case-Control Studies; Chi-Square Distribution; Child; Child, Preschool; Cyclosporine; De | 2000 |
Does nifedipine aggravate cyclosporin--induced gingival overgrowth? An experiment in rats.
Topics: Animals; Calcium Channel Blockers; Cyclosporine; Dental Enamel; Dentin; Disease Models, Animal; Dose | 2001 |
Prevalence and risk of gingival enlargement in patients treated with nifedipine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Calcium Channel Blockers; Cross-Se | 2001 |
Connective tissue growth factor in drug-induced gingival overgrowth.
Topics: Adult; Antibodies; Anticonvulsants; Calcium Channel Blockers; Carrier Proteins; Coloring Agents; Con | 2001 |
Nifedipine induces gingival overgrowth in rats through a reduction in collagen phagocytosis by gingival fibroblasts.
Topics: Animals; Cells, Cultured; Collagen; Fibroblasts; Flow Cytometry; Gingiva; Gingival Overgrowth; Immun | 2001 |
Drug-induced gingival overgrowth: a case with auto-correction of incisor drifting.
Topics: Calcium Channel Blockers; Gingival Overgrowth; Humans; Incisor; Kidney Transplantation; Male; Middle | 2001 |
Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders.
Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Calcium Channel Blockers; Cell Culture Technique | 2001 |