nifedipine has been researched along with Fissure in Ano in 29 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Fissure in Ano: A painful linear tear at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this prospective study was to assess the effectiveness in healing anal fissure (AF) of lacidipine, a calcium channel blocker with a better tolerability in comparison to other calcium antagonists." | 9.10 | Oral lacidipine in the treatment of anal fissure. ( Ansaloni, L; Bernabè, A; Gardini, G; Ghetti, R; Riccardi, R; Tranchino, RM, 2002) |
| "Our study clearly demonstrates that the therapeutic use of topical nifedipine and lidocaine ointment should be extended to the conservative treatment of chronic anal fissure." | 9.10 | Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. ( Antropoli, C; Antropoli, M; Attena, F; Balzano, A; Bove, A; De Stefano, G; Molino, D; Perrotti, P, 2002) |
| " The aim was to test the efficacy of local application of nifedipine gel" in healing acute anal fissure by relaxing the internal anal sphincter." | 9.09 | Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicenter study. ( Antropoli, C; Antropoli, M; De Stefano, G; Martino, A; Migliore, G; Perrotti, P; Piazza, P; Rubino, M, 1999) |
| "We aimed to evaluate efficacy and safety of the use of nifedipine gel with lidocaine in the treatment of acute anal fissures in children by reviewing the cases of 106 children with acute anal fissure treated conservatively by nifedipine gel with lidocaine between the years 2003-2012." | 7.83 | Anal fissure in children: a 10-year clinical experience with nifedipine gel with lidocaine. ( Abu-Kishk, I; Berkovitch, M; Efrati, Y; Klin, B, 2016) |
| "5% nifedipine ointment, used as an agent in chemical sphincterotomy, appears to offer a significant healing rate for acute anal fissure and might prevent its evolution to chronicity." | 7.73 | Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity. ( Beltsis, A; Chatzimavroudis, G; Katsinelos, P; Katsinelos, T; Kountouras, J; Papaziogas, B; Paroutoglou, G; Zavos, C, 2006) |
| "The purpose of this study was to demonstrate the effect of oral nifedipine on maximal resting anal pressure (MRAP) in healthy volunteers and to evaluate its role in the treatment of chronic anal fissure (CAF)." | 7.72 | Oral nifedipine in the treatment of chronic anal fissure. ( Ağaoğlu, N; Arslan, MK; Cengiz, S; Türkyilmaz, S, 2003) |
| "Anal manometry was performed on eight healthy volunteers and 15 patients with chronic anal fissure before and after oral administration of nifedipine 20 mg." | 7.70 | Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. ( Cook, TA; Humphreys, MM; McC Mortensen, NJ, 1999) |
| "We recommend the addition of either oral or topical nifedipine to conservative measures to significantly improve pain relief and healing rates in patients with fissure-in-ano." | 5.17 | Randomized controlled pilot trial of nifedipine as oral therapy vs. topical application in the treatment of fissure-in-ano. ( Agrawal, V; Gupta, R; Kaushal, G, 2013) |
| "The aim of this prospective study was to assess the effectiveness in healing anal fissure (AF) of lacidipine, a calcium channel blocker with a better tolerability in comparison to other calcium antagonists." | 5.10 | Oral lacidipine in the treatment of anal fissure. ( Ansaloni, L; Bernabè, A; Gardini, G; Ghetti, R; Riccardi, R; Tranchino, RM, 2002) |
| "Our study clearly demonstrates that the therapeutic use of topical nifedipine and lidocaine ointment should be extended to the conservative treatment of chronic anal fissure." | 5.10 | Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. ( Antropoli, C; Antropoli, M; Attena, F; Balzano, A; Bove, A; De Stefano, G; Molino, D; Perrotti, P, 2002) |
| " The aim was to test the efficacy of local application of nifedipine gel" in healing acute anal fissure by relaxing the internal anal sphincter." | 5.09 | Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicenter study. ( Antropoli, C; Antropoli, M; De Stefano, G; Martino, A; Migliore, G; Perrotti, P; Piazza, P; Rubino, M, 1999) |
| "Twenty one different comparisons of medical therapies to heal anal fissure have been reported in 31 trials, including 9 agents-glyceryl trinitrate, isosorbide dinitrate, botulinum toxin, diltiazem, nifedipine, hydrocortisone, lidocaine, bran, placebo-as well as anal dilators and surgical sphincterotomy." | 4.82 | A systematic review of medical therapy for anal fissure. ( Nelson, R, 2004) |
| "Current study focuses on the formulation and characterization of lipophilic and hydrophilic gel formulations of nifedipine to treat anal fissure via anodermal application." | 3.96 | Development and ( Altanlar, N; Bagci, N; Bayindir, ZS; Inal, O; Yuksel, N, 2020) |
| "We aimed to evaluate efficacy and safety of the use of nifedipine gel with lidocaine in the treatment of acute anal fissures in children by reviewing the cases of 106 children with acute anal fissure treated conservatively by nifedipine gel with lidocaine between the years 2003-2012." | 3.83 | Anal fissure in children: a 10-year clinical experience with nifedipine gel with lidocaine. ( Abu-Kishk, I; Berkovitch, M; Efrati, Y; Klin, B, 2016) |
| "From August 1997 to August 2002, patients with chronic anal fissure attending our outpatient clinic were treated with a protocol that included: topical isosorbide dinitrate, 2." | 3.73 | Long-term results of "chemical sphincterotomy" for chronic anal fissure: a prospective study. ( Goldin, E; Israeli, E; Levy, S; Lysy, J; Rozentzweig, G; Strauss-Liviatan, N, 2006) |
| "5% nifedipine ointment, used as an agent in chemical sphincterotomy, appears to offer a significant healing rate for acute anal fissure and might prevent its evolution to chronicity." | 3.73 | Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity. ( Beltsis, A; Chatzimavroudis, G; Katsinelos, P; Katsinelos, T; Kountouras, J; Papaziogas, B; Paroutoglou, G; Zavos, C, 2006) |
| "The purpose of this study was to demonstrate the effect of oral nifedipine on maximal resting anal pressure (MRAP) in healthy volunteers and to evaluate its role in the treatment of chronic anal fissure (CAF)." | 3.72 | Oral nifedipine in the treatment of chronic anal fissure. ( Ağaoğlu, N; Arslan, MK; Cengiz, S; Türkyilmaz, S, 2003) |
| "Anal manometry was performed on eight healthy volunteers and 15 patients with chronic anal fissure before and after oral administration of nifedipine 20 mg." | 3.70 | Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. ( Cook, TA; Humphreys, MM; McC Mortensen, NJ, 1999) |
| "Anal fissure is a tear in the lining of the anal canal distal to the dentate line, which most commonly occurs in the posterior midline." | 2.78 | Conservative versus surgical treatment for chronic anal idiopathic fissure: a prospective randomized trial. ( Cestaro, G; de Rosa, M; Gentile, M; Massa, S; Vitiello, C, 2013) |
| "Anal fissure is a common disorder that is effectively treated and prevented with conservative measures in its acute form, whereas chronic fissures may require medical or surgical therapy." | 2.46 | Anal fissure. ( Herzig, DO; Lu, KC, 2010) |
| "Anal fissure is a common disorder which may cause symptoms at any age." | 2.43 | Chemical sphincterotomy--first line of treatment for chronic anal fissure. ( Baten, MA; Chowdhury, RA; Haq, Z; Khatun, M; Rahman, M, 2005) |
| "Fissure in ano is a troubling and painful condition that affects a great majority of the population world over." | 2.42 | Treatment of fissure in ano- revisited. ( Gupta, PJ, 2004) |
| "Anal fissure is common and painful disease of anorectum." | 1.46 | Preparation and characterization of textile-based carrier systems for anal fissure treatment. ( Karavana, SY; Önder, T; Rençber, S; Sarıışık, AM; Türkoğlu, GC, 2017) |
| "Low back pain is one of the most common complaints for which patients seek medical attention." | 1.36 | Anorectal fissures: an under-recognized cause of low back pain? Case report. ( Andrews, MB; Kimmell, KT; Lees, J; Rabb, CH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.34) | 18.2507 |
| 2000's | 16 (55.17) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Sierra-Arango, F | 1 |
| de la Hoz-Valle, J | 1 |
| Espinosa, JP | 1 |
| Moreno-Montoya, J | 1 |
| Vásquez Roldan, M | 1 |
| Pérez-Riveros, ED | 1 |
| Bagci, N | 1 |
| Bayindir, ZS | 1 |
| Inal, O | 1 |
| Altanlar, N | 1 |
| Yuksel, N | 1 |
| Sarıışık, AM | 1 |
| Karavana, SY | 1 |
| Türkoğlu, GC | 1 |
| Rençber, S | 1 |
| Önder, T | 1 |
| Forkel, S | 1 |
| Baltzer, AB | 1 |
| Geier, J | 1 |
| Buhl, T | 1 |
| Salem, AE | 1 |
| Mohamed, EA | 1 |
| Elghadban, HM | 1 |
| Abdelghani, GM | 1 |
| de Rosa, M | 1 |
| Cestaro, G | 1 |
| Vitiello, C | 1 |
| Massa, S | 1 |
| Gentile, M | 1 |
| Agrawal, V | 1 |
| Kaushal, G | 1 |
| Gupta, R | 1 |
| Klin, B | 1 |
| Efrati, Y | 1 |
| Berkovitch, M | 1 |
| Abu-Kishk, I | 1 |
| Medhi, B | 1 |
| Rao, RS | 1 |
| Prakash, A | 1 |
| Prakash, O | 1 |
| Kaman, L | 1 |
| Pandhi, P | 1 |
| Herzig, DO | 1 |
| Lu, KC | 1 |
| Kimmell, KT | 1 |
| Lees, J | 1 |
| Andrews, MB | 1 |
| Rabb, CH | 1 |
| Ansaloni, L | 1 |
| Bernabè, A | 1 |
| Ghetti, R | 1 |
| Riccardi, R | 1 |
| Tranchino, RM | 1 |
| Gardini, G | 1 |
| Perrotti, P | 2 |
| Bove, A | 1 |
| Antropoli, C | 2 |
| Molino, D | 1 |
| Antropoli, M | 2 |
| Balzano, A | 1 |
| De Stefano, G | 2 |
| Attena, F | 1 |
| Merenstein, D | 1 |
| Rosenbaum, D | 1 |
| Ağaoğlu, N | 1 |
| Cengiz, S | 1 |
| Arslan, MK | 1 |
| Türkyilmaz, S | 1 |
| Nelson, R | 1 |
| Gupta, PJ | 1 |
| Slim, K | 1 |
| Siproudhis, L | 1 |
| Haq, Z | 1 |
| Rahman, M | 1 |
| Chowdhury, RA | 1 |
| Baten, MA | 1 |
| Khatun, M | 1 |
| Ho, KS | 1 |
| Ho, YH | 1 |
| Katsinelos, P | 2 |
| Papaziogas, B | 2 |
| Koutelidakis, I | 1 |
| Paroutoglou, G | 2 |
| Dimiropoulos, S | 1 |
| Souparis, A | 1 |
| Atmatzidis, K | 1 |
| Tranqui, P | 1 |
| Trottier, DC | 1 |
| Victor, C | 1 |
| Freeman, JB | 1 |
| Lysy, J | 1 |
| Israeli, E | 1 |
| Levy, S | 1 |
| Rozentzweig, G | 1 |
| Strauss-Liviatan, N | 1 |
| Goldin, E | 1 |
| Kountouras, J | 1 |
| Beltsis, A | 1 |
| Chatzimavroudis, G | 1 |
| Zavos, C | 1 |
| Katsinelos, T | 1 |
| Chrysos, E | 1 |
| Xynos, E | 1 |
| Tzovaras, G | 1 |
| Zoras, OJ | 1 |
| Tsiaoussis, J | 1 |
| Vassilakis, SJ | 1 |
| Rubino, M | 1 |
| Martino, A | 1 |
| Migliore, G | 1 |
| Piazza, P | 1 |
| Cook, TA | 2 |
| Humphreys, MM | 1 |
| McC Mortensen, NJ | 1 |
| Mortensen, NJ | 1 |
| Brisinda, G | 1 |
| Maria, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure: a Randomized Clinical Trial[NCT04153032] | Phase 2 | 183 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting | ||
| Effects of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure[NCT04320498] | Phase 4 | 41 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| Does Adjunctive Treatment With Vaginal Nifedipine Result in Symptomatic Improvement in Patients With Levator Myalgia and Pelvic Floor Pain Who Are Undergoing Pelvic Floor Physical Therapy?[NCT01586286] | 0 participants (Actual) | Interventional | 2012-07-31 | Withdrawn (stopped due to No patients were recruited over a 12 month period) | |||
| A Comparative Efficacy and Safety Study of Lateral Subcutaneous Sphincterotomy and Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure[NCT03855046] | Phase 4 | 340 participants (Anticipated) | Interventional | 2019-09-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for nifedipine and Fissure in Ano
| Article | Year |
|---|---|
Clinical Outcomes of Medical Management Options for Chronic Anal Fissures in a Long-Term Follow-up: Systematic Review and Meta-Analysis.
Topics: Adult; Chronic Disease; Fissure in Ano; Glycerol; Humans; Nifedipine; Nitroglycerin; Treatment Outco | 2023 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Anal fissure.
Topics: Acute Disease; Anal Canal; Botulinum Toxins, Type A; Calcium Channel Blockers; Chronic Disease; Dilt | 2010 |
A systematic review of medical therapy for anal fissure.
Topics: Adult; Botulinum Toxins, Type A; Child; Fissure in Ano; Humans; Neuromuscular Agents; Nifedipine; Ni | 2004 |
Treatment of fissure in ano- revisited.
Topics: Administration, Topical; Analgesics; Botulinum Toxins, Type A; Calcium Channel Blockers; Diet; Fissu | 2004 |
[Anal fissure. Which first line treatment?].
Topics: Botulinum Toxins, Type A; Dilatation; Diltiazem; Evidence-Based Medicine; Fecal Incontinence; Fissur | 2004 |
Chemical sphincterotomy--first line of treatment for chronic anal fissure.
Topics: Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Isos | 2005 |
10 trials available for nifedipine and Fissure in Ano
| Article | Year |
|---|---|
Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; B | 2018 |
Conservative versus surgical treatment for chronic anal idiopathic fissure: a prospective randomized trial.
Topics: Administration, Topical; Anal Canal; Chronic Disease; Defecation; Digestive System Surgical Procedur | 2013 |
Randomized controlled pilot trial of nifedipine as oral therapy vs. topical application in the treatment of fissure-in-ano.
Topics: Administration, Oral; Administration, Topical; Adult; Calcium Channel Blockers; Female; Fissure in A | 2013 |
Oral lacidipine in the treatment of anal fissure.
Topics: Administration, Oral; Adult; Aged; Calcium Channel Blockers; Dihydropyridines; Female; Fissure in An | 2002 |
Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Double-Blind Method; Drug Combina | 2002 |
Randomized clinical trial comparing oral nifedipine with lateral anal sphincterotomy and tailored sphincterotomy in the treatment of chronic anal fissure.
Topics: Administration, Oral; Adult; Anal Canal; Calcium Channel Blockers; Chronic Disease; Double-Blind Met | 2005 |
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg | 2006 |
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg | 2006 |
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg | 2006 |
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg | 2006 |
Effect of nifedipine on rectoanal motility.
Topics: Administration, Sublingual; Adult; Anal Canal; Calcium Channel Blockers; Case-Control Studies; Femal | 1996 |
Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicenter study.
Topics: Administration, Topical; Adult; Double-Blind Method; Female; Fissure in Ano; Humans; Male; Middle Ag | 1999 |
Nifedipine for treatment of anal fissures.
Topics: Administration, Topical; Calcium Channel Blockers; Fissure in Ano; Humans; Manometry; Nifedipine | 2000 |
12 other studies available for nifedipine and Fissure in Ano
| Article | Year |
|---|---|
Development and
Topics: Adhesiveness; Administration, Rectal; Drug Compounding; Drug Liberation; Fissure in Ano; Gels; Hydro | 2020 |
Preparation and characterization of textile-based carrier systems for anal fissure treatment.
Topics: Alginates; Anesthetics, Local; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fissure in Ano | 2017 |
Contact dermatitis caused by diltiazem cream and cross-reactivity with other calcium channel blockers.
Topics: Calcium Channel Blockers; Cross Reactions; Dermatitis, Allergic Contact; Diltiazem; Fissure in Ano; | 2018 |
Anal fissure in children: a 10-year clinical experience with nifedipine gel with lidocaine.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Drug Combinations; | 2016 |
Anorectal fissures: an under-recognized cause of low back pain? Case report.
Topics: Administration, Oral; Cathartics; Colonoscopy; Diagnosis, Differential; Drug Therapy, Combination; F | 2010 |
Is topical nifedipine effective for chronic anal fissures?
Topics: Administration, Topical; Anesthetics, Local; Chronic Disease; Double-Blind Method; Evidence-Based Me | 2003 |
Oral nifedipine in the treatment of chronic anal fissure.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Chronic Disease; Female; Fissure in Ano; Huma | 2003 |
Nonsurgical treatment of chronic anal fissure: nitroglycerin and dilatation versus nifedipine and botulinum toxin.
Topics: Administration, Topical; Adult; Anti-Dyskinesia Agents; Botulinum Toxins; Catheterization; Chronic D | 2006 |
Long-term results of "chemical sphincterotomy" for chronic anal fissure: a prospective study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Botulinum Toxins, Type A; Chronic Disease; Drug Administ | 2006 |
Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity.
Topics: Adult; Aged; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged; Nifedipine; Ointmen | 2006 |
Oral nifedipine reduces resting anal pressure and heals chronic anal fissure.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Chronic Disease; Female; Fissure in Ano; Huma | 1999 |
Oral nifedipine reduces resting anal pressure and heals chronic anal fissure.
Topics: Administration, Oral; Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nifedipine; Pressur | 2000 |