nifedipine has been researched along with Esophageal Achalasia in 44 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Esophageal Achalasia: A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying were compared in 11 patients with Chagasic achalasia." | 9.07 | Short report: comparison of the effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying in patients with Chagasic achalasia. ( Figueiredo, MC; Iazigi, N; Matsuda, NM; Oliveira, RB, 1992) |
| "A study was carried out in 30 patients affected by a mild or moderate degree of oesophageal achalasia to compare the clinical and manometric effects of sublingual nifedipine and pneumatic dilatation." | 9.07 | Prospective clinical and manometric study comparing pneumatic dilatation and sublingual nifedipine in the treatment of oesophageal achalasia. ( Bortolotti, M; Coccia, G; Dodero, M; Michetti, P, 1991) |
| "Utilizing the rationale that the calcium channel blocker nifedipine decreases lower esophageal sphincter pressure, we performed a double-blind, placebo-controlled, crossover trial of sublingual nifedipine in achalasia, a disorder whose treatment depends on reduction in lower esophageal sphincter pressure." | 9.06 | The role of nifedipine therapy in achalasia: results of a randomized, double-blind, placebo-controlled study. ( Dubovik, S; Lange, RC; McCallum, RW; Traube, M, 1989) |
| "The effect of a new calcium antagonist, nifedipine, which has a spasmolytic activity on smooth muscle cells, was studied on the esophageal function of 20 patients with achalasia of mild and moderate degree." | 9.05 | Clinical and manometric effects of nifedipine in patients with esophageal achalasia. ( Bortolotti, M; Labò, G, 1981) |
| "This study was carried out to demonstrate the possible return of esophageal peristalsis in patients affected by esophageal achalasia chronically treated with sublingual nifedipine and to investigate which parameters are correlated with the return of peristalsis." | 7.68 | Return of esophageal peristalsis after nifedipine therapy in patients with idiopathic esophageal achalasia. ( Bortolotti, M; Coccia, G; Dodero, M; Michetti, P, 1992) |
| "We studied the esophageal effects of nifedipine in 20 patients with achalasia (20 mg sublingually) and nine patients with high-amplitude peristaltic esophageal contractions (nutcracker esophagus) (20 mg orally)." | 7.67 | Effects of nifedipine in achalasia and in patients with high-amplitude peristaltic esophageal contractions. ( Hongo, M; Magyar, L; McCallum, RW; Traube, M, 1984) |
| "The effects of sublingual isosorbide dinitrate (5 mg) and nifedipine (20 mg) were compared in 15 patients with achalasia." | 7.66 | Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation. ( Gelfond, M; Gilat, T; Rozen, P, 1982) |
| "The effect of nifedipine, one of calcium antagonists, was studied on esophageal function of 10 patients with achalasia." | 7.66 | [Clinical effect of nifedipine in patients with achalasia]. ( Hongo, M, 1982) |
| "The effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying were compared in 11 patients with Chagasic achalasia." | 5.07 | Short report: comparison of the effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying in patients with Chagasic achalasia. ( Figueiredo, MC; Iazigi, N; Matsuda, NM; Oliveira, RB, 1992) |
| "Utilizing the rationale that the calcium channel blocker nifedipine decreases lower esophageal sphincter pressure, we performed a double-blind, placebo-controlled, crossover trial of sublingual nifedipine in achalasia, a disorder whose treatment depends on reduction in lower esophageal sphincter pressure." | 5.06 | The role of nifedipine therapy in achalasia: results of a randomized, double-blind, placebo-controlled study. ( Dubovik, S; Lange, RC; McCallum, RW; Traube, M, 1989) |
| "Manometric studies have been performed to determine the effect of nifedipine on lower oesophageal sphincter (LOS) pressure and distal oesophageal motility in healthy subjects, in patients with diffuse oesophageal spasm, and in a patient with achalasia." | 5.05 | Effect of nifedipine on oesophageal motility and gastric emptying. ( Blackwell, JN; Heading, RC; Holt, S, 1981) |
| "Verapamil and diltiazem have been shown in animals (opossum, baboon) to produce decreased contractions in esophageal smooth muscle, resulting in a decreased amplitude of peristalsis and decreased lower esophageal sphincter pressures." | 3.75 | Calcium-channel blocking agents for gastrointestinal disorders. ( Castell, DO, 1985) |
| "Twelve children were treated with nifedipine, (dysphagia n = 6, gastroesophageal reflux n = 5, swallowing disorder n = 1)." | 3.71 | [Primary esophageal motor disorders in childhood, genuine achalasia excluded]. ( Devouge, E; Gottrand, F; Guimber, D; Lamblin, MD; Michaud, L; Turck, D, 2002) |
| "We studied the esophageal effects of nifedipine in 20 patients with achalasia (20 mg sublingually) and nine patients with high-amplitude peristaltic esophageal contractions (nutcracker esophagus) (20 mg orally)." | 3.67 | Effects of nifedipine in achalasia and in patients with high-amplitude peristaltic esophageal contractions. ( Hongo, M; Magyar, L; McCallum, RW; Traube, M, 1984) |
| "Radionuclide oesophageal transit studies and manometry have been carried out in 15 patients with achalasia of the cardia, before treatment, after a course of nifedipine and after pneumatic bag dilatation." | 3.67 | Quantitative assessment of the response to therapy in achalasia of the cardia. ( Atkinson, M; Hardy, JG; Robertson, CS, 1989) |
| "The effects of sublingual isosorbide dinitrate (5 mg) and nifedipine (20 mg) were compared in 15 patients with achalasia." | 3.66 | Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation. ( Gelfond, M; Gilat, T; Rozen, P, 1982) |
| "The effect of nifedipine, one of calcium antagonists, was studied on esophageal function of 10 patients with achalasia." | 3.66 | [Clinical effect of nifedipine in patients with achalasia]. ( Hongo, M, 1982) |
| "Based on in vivo studies on isolated muscle strips of the LES and on manometric in vivo studies on 8 mongrel dogs, 6 healthy volunteers, 6 patients with achalasia and 3 subjects with diffuse esophageal spasm we could demonstrate that nifedipine causes a long-lasting relaxation of smooth muscle, the esophagus and LES." | 3.65 | [Clinical and experimental studies on the efficiency of nifedipine on smooth muscle strips of the esophagus (author's transl)]. ( Golenhofen, K; Lepsien, G; Schattenmann, G; Siewert, R; Weiser, HF, 1977) |
| "Chagas disease is a neglected tropical disease." | 2.58 | Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis. ( Borges Migliavaca, C; Colpani, V; Falavigna, M; Nascimento Cruz, L; Oliveira Dantas, R; René Pinto de Sousa Miguel, S; Stein, C, 2018) |
| "Achalasia is a common primary oesophageal motor disorder." | 2.40 | Review article: pharmacological options in achalasia. ( Annese, V; Bassotti, G, 1999) |
| "A cohort of 566 patients with achalasia (46% men, mean age at diagnosis: 48." | 1.62 | Risk of Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Patients With Achalasia: A Long-Term Prospective Cohort Study in Italy. ( Bazzoli, F; Ferretti, S; Fortunato, F; Lugaresi, M; Marasco, G; Mattioli, S; Tassi, V; Zagari, RM, 2021) |
| "Diffuse esophageal spasm (DES) causes chest pain and/or dysphagia in adults." | 1.39 | Diffuse esophageal spasm in children referred for manometry. ( Cocjin, J; Hyman, PE; Lavenbarg, T; Rosen, JM, 2013) |
| "Esophageal achalasia is a rare disease and there have been very few reports about it, especially in children." | 1.35 | Diagnosis and management of esophageal achalasia in children: analysis of 13 cases. ( Cai, W; Xu, CD; Zaouche, A; Zhang, Y, 2009) |
| "The surgical treatment for stage III achalasia with markedly dilated and sigmoid-shaped esophagus is a matter of controversy." | 1.31 | Laparoscopic esophagogastrostomy: an alternative minimally invasive treatment for achalasia stage III. ( Ablassmaier, B; Jacobi, CA; Müller, JM; Opitz, I; Stoesslein, R, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (47.73) | 18.7374 |
| 1990's | 16 (36.36) | 18.2507 |
| 2000's | 3 (6.82) | 29.6817 |
| 2010's | 2 (4.55) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Jayant, SS | 1 |
| Gupta, R | 1 |
| Agrawal, K | 1 |
| Das, L | 1 |
| Dutta, P | 1 |
| Bhansali, A | 1 |
| Zagari, RM | 1 |
| Marasco, G | 1 |
| Tassi, V | 1 |
| Ferretti, S | 1 |
| Lugaresi, M | 1 |
| Fortunato, F | 1 |
| Bazzoli, F | 1 |
| Mattioli, S | 1 |
| Borges Migliavaca, C | 1 |
| Stein, C | 1 |
| Colpani, V | 1 |
| René Pinto de Sousa Miguel, S | 1 |
| Nascimento Cruz, L | 1 |
| Oliveira Dantas, R | 1 |
| Falavigna, M | 1 |
| Zhang, Y | 1 |
| Xu, CD | 1 |
| Zaouche, A | 1 |
| Cai, W | 1 |
| Rosen, JM | 1 |
| Lavenbarg, T | 1 |
| Cocjin, J | 1 |
| Hyman, PE | 1 |
| Devouge, E | 1 |
| Michaud, L | 1 |
| Lamblin, MD | 1 |
| Guimber, D | 1 |
| Turck, D | 1 |
| Gottrand, F | 1 |
| Gelfond, M | 1 |
| Rozen, P | 2 |
| Gilat, T | 2 |
| Thomas, E | 1 |
| Lebow, RA | 1 |
| Gubler, RJ | 1 |
| Bryant, LR | 1 |
| Traube, M | 4 |
| McCallum, RW | 4 |
| Hongo, M | 3 |
| Magyar, L | 1 |
| Blackwell, JN | 1 |
| Holt, S | 1 |
| Heading, RC | 1 |
| Berger, K | 1 |
| Bortolotti, M | 5 |
| Labò, G | 1 |
| Arber, N | 1 |
| Grossman, A | 1 |
| Tiomny, E | 1 |
| Rattan, J | 1 |
| Kadish, U | 1 |
| Novis, B | 1 |
| Neuman, G | 1 |
| Lilos, P | 1 |
| Allescher, HD | 1 |
| Emblem, R | 1 |
| Stringer, MD | 1 |
| Hall, CM | 1 |
| Spitz, L | 1 |
| Ganatra, JV | 1 |
| Bostwick, HE | 1 |
| Medow, MS | 1 |
| Beneck, D | 1 |
| Berezin, S | 1 |
| Spiess, AE | 1 |
| Kahrilas, PJ | 1 |
| Alonso, P | 1 |
| González-Conde, B | 1 |
| Macenlle, R | 1 |
| Pita, S | 1 |
| Vázquez-Iglesias, JL | 1 |
| Bassotti, G | 1 |
| Annese, V | 1 |
| Ablassmaier, B | 1 |
| Jacobi, CA | 1 |
| Stoesslein, R | 1 |
| Opitz, I | 1 |
| Müller, JM | 1 |
| Kobler, E | 1 |
| Nüesch, HJ | 1 |
| Deyhle, P | 1 |
| Weiser, HF | 1 |
| Lepsien, G | 1 |
| Golenhofen, K | 1 |
| Schattenmann, G | 1 |
| Siewert, R | 1 |
| Moussalli, J | 1 |
| Cadranel, JF | 1 |
| Danel, B | 1 |
| Plantier, F | 1 |
| Benhamou, Y | 1 |
| Opolon, P | 1 |
| Figueiredo, MC | 1 |
| Oliveira, RB | 1 |
| Iazigi, N | 1 |
| Matsuda, NM | 1 |
| Castell, DO | 2 |
| Coccia, G | 2 |
| Michetti, P | 2 |
| Dodero, M | 2 |
| Wallin, L | 1 |
| Boesby, S | 1 |
| Elta, GH | 1 |
| Kochman, ML | 1 |
| Triadafilopoulos, G | 1 |
| Aaronson, M | 1 |
| Sackel, S | 1 |
| Burakoff, R | 1 |
| Palombo, C | 1 |
| Mian, M | 1 |
| Bertelli, A | 1 |
| Dubovik, S | 1 |
| Lange, RC | 1 |
| Robertson, CS | 1 |
| Hardy, JG | 1 |
| Atkinson, M | 1 |
| Stepenko, AS | 1 |
| Nechaev, VM | 1 |
| Román García, FJ | 1 |
| Montes Santiago, J | 1 |
| Román García, F | 1 |
| González Quintela, A | 1 |
| Schroeder, JS | 1 |
| Román, FJ | 1 |
| Montes, J | 1 |
| Nasrallah, SM | 1 |
| Tommaso, CL | 1 |
| Singleton, RT | 1 |
| Backhaus, EA | 1 |
9 reviews available for nifedipine and Esophageal Achalasia
| Article | Year |
|---|---|
Triple A (Allgrove) syndrome due to AAAS gene mutation with a rare association of amyotrophy.
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Calcium Channel Blockers; Esophageal Achalasia; Huma | 2021 |
Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.
Topics: Adolescent; Adult; Aged; Chagas Disease; Esophageal Achalasia; Female; Humans; Isosorbide; Male; Mid | 2018 |
Calcium-channel blockers and the gastrointestinal tract. American College of Gastroenterology's Committee on FDA related matters.
Topics: Animals; Calcium Channel Blockers; Digestive System; Diltiazem; Esophageal Achalasia; Esophageal Dis | 1984 |
[What is assured in the therapy of achalasia?].
Topics: Botulinum Toxins; Calcium Channel Blockers; Combined Modality Therapy; Diagnosis, Differential; Dila | 1993 |
Treating achalasia: from whalebone to laparoscope.
Topics: Botulinum Toxins; Cholinergic Agents; Clinical Trials as Topic; Dilatation; Esophageal Achalasia; Hu | 1998 |
Review article: pharmacological options in achalasia.
Topics: Botulinum Toxins; Calcium Channel Blockers; Esophageal Achalasia; Humans; Nifedipine; Nitrates | 1999 |
[Calcium antagonists: accounts on new perspectives of their use and an update on side effects].
Topics: Adult; Animals; Asthma; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Esophageal Ach | 1989 |
Calcium-channel blocking agents for gastrointestinal disorders.
Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Esophageal Achalasia; Esopha | 1985 |
Combination therapy with isosorbide dinitrate: current status and the future.
Topics: Angina Pectoris; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Esophageal Achalasia; Exe | 1985 |
8 trials available for nifedipine and Esophageal Achalasia
| Article | Year |
|---|---|
Effect of nifedipine on oesophageal motility and gastric emptying.
Topics: Adolescent; Adult; Clinical Trials as Topic; Depression, Chemical; Esophageal Achalasia; Esophagogas | 1981 |
Clinical and manometric effects of nifedipine in patients with esophageal achalasia.
Topics: Adult; Drug Evaluation; Esophageal Achalasia; Esophagogastric Junction; Female; Humans; Male; Manome | 1981 |
Short report: comparison of the effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying in patients with Chagasic achalasia.
Topics: Administration, Sublingual; Adult; Aged; Chagas Disease; Esophageal Achalasia; Esophagus; Female; Hu | 1992 |
Medical treatment of esophageal achalasia. Double-blind crossover study with oral nifedipine, verapamil, and placebo.
Topics: Administration, Oral; Double-Blind Method; Esophageal Achalasia; Esophagogastric Junction; Esophagus | 1991 |
Prospective clinical and manometric study comparing pneumatic dilatation and sublingual nifedipine in the treatment of oesophageal achalasia.
Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Dilatation; Esophageal Achal | 1991 |
The role of nifedipine therapy in achalasia: results of a randomized, double-blind, placebo-controlled study.
Topics: Administration, Sublingual; Adult; Aged; Double-Blind Method; Drug Administration Schedule; Esophage | 1989 |
Calcium-channel blocking agents for gastrointestinal disorders.
Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Esophageal Achalasia; Esopha | 1985 |
Primary esophageal motor disorders: clinical response to nifedipine.
Topics: Adult; Aged; Esophageal Achalasia; Esophageal Diseases; Esophagogastric Junction; Female; Humans; Ma | 1985 |
28 other studies available for nifedipine and Esophageal Achalasia
| Article | Year |
|---|---|
Risk of Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Patients With Achalasia: A Long-Term Prospective Cohort Study in Italy.
Topics: Adenocarcinoma; Adult; Aged; Calcium Channel Blockers; Cohort Studies; Dilatation; Esophageal Achala | 2021 |
Diagnosis and management of esophageal achalasia in children: analysis of 13 cases.
Topics: Adolescent; Barium; Calcium Channel Blockers; Catheterization; Child; Child, Preschool; Contrast Med | 2009 |
Diffuse esophageal spasm in children referred for manometry.
Topics: Adolescent; Age Factors; Calcium Channel Blockers; Chest Pain; Child; Child, Preschool; Cohort Studi | 2013 |
[Primary esophageal motor disorders in childhood, genuine achalasia excluded].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Data Interpretation, Statistical; Deglutition Diso | 2002 |
Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation.
Topics: Adolescent; Adult; Aged; Esophageal Achalasia; Esophagus; Female; Humans; Isosorbide Dinitrate; Male | 1982 |
Nifedipine for the poor-risk elderly patient with achalasia: objective response demonstrated by solid meal study.
Topics: Aged; Eating; Esophageal Achalasia; Female; Humans; Nifedipine; Pentetic Acid; Radionuclide Imaging; | 1984 |
Effects of nifedipine in achalasia and in patients with high-amplitude peristaltic esophageal contractions.
Topics: Esophageal Achalasia; Esophagogastric Junction; Esophagus; Humans; Nifedipine; Peristalsis; Pressure | 1984 |
Drugs can help oesophageal motility disorders.
Topics: Esophageal Achalasia; Esophageal Diseases; Humans; Hydralazine; Nifedipine; Nitrates | 1984 |
Nifedipine in the treatment of achalasia.
Topics: Esophageal Achalasia; Esophagus; Humans; Male; Middle Aged; Muscle, Smooth; Nifedipine; Pyridines | 1982 |
[Clinical effect of nifedipine in patients with achalasia].
Topics: Adult; Esophageal Achalasia; Esophagogastric Junction; Female; Humans; Male; Manometry; Middle Aged; | 1982 |
[Effects of calcium-antagonists on lower esophageal sphincter pressure. The possibility of application of nifedipine to achalasia].
Topics: Adult; Animals; Calcium Channel Blockers; Dogs; Esophageal Achalasia; Esophagogastric Junction; Fema | 1982 |
Achalasia in central Israel, 1973-83: clinical aspects.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Deglutition Disorders; Dilatation; Esophageal Acha | 1994 |
Current results of surgery for achalasia of the cardia.
Topics: Adolescent; Catheterization; Child; Child, Preschool; Esophageal Achalasia; Esophagus; Female; Hospi | 1993 |
Candida esophagitis in a child with achalasia.
Topics: Antifungal Agents; Candidiasis; Child; Esophageal Achalasia; Esophagitis; Esophagus; Fluconazole; Hu | 1996 |
Achalasia: the usefulness of manometry for evaluation of treatment.
Topics: Catheterization; Esophageal Achalasia; Esophagogastric Junction; Female; Humans; Male; Manometry; Mi | 1999 |
Laparoscopic esophagogastrostomy: an alternative minimally invasive treatment for achalasia stage III.
Topics: Aged; Calcium Channel Blockers; Esophageal Achalasia; Esophagostomy; Female; Follow-Up Studies; Fund | 2002 |
[Endoscopic placement of a cardial dilator--an alternative before surgery].
Topics: Adult; Aged; Dilatation; Endoscopy; Esophageal Achalasia; Humans; Middle Aged; Nifedipine; Psychothe | 1979 |
[Clinical and experimental studies on the efficiency of nifedipine on smooth muscle strips of the esophagus (author's transl)].
Topics: Adult; Animals; Dogs; Dose-Response Relationship, Drug; Esophageal Achalasia; Esophagus; Female; Hum | 1977 |
[Partially reversible secondary achalasia after thoracic radiation. Value of nifedipine].
Topics: Aged; Bone Neoplasms; Breast Neoplasms; Esophageal Achalasia; Female; Humans; Nifedipine; Radiation | 1992 |
Idiopathic achalasia: are there different types?
Topics: Esophageal Achalasia; Esophagogastric Junction; Humans; Nifedipine | 1992 |
Return of esophageal peristalsis after nifedipine therapy in patients with idiopathic esophageal achalasia.
Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Deglutition; Esophageal Acha | 1992 |
Prospective clinical and manometric study comparing pneumatic dilatation and sublingual nifedipine in the treatment of oesophageal achalasia.
Topics: Catheterization; Esophageal Achalasia; Humans; Manometry; Nifedipine | 1992 |
Achalasia treatment--is nifedipine a viable alternative?
Topics: Esophageal Achalasia; Humans; Nifedipine | 1992 |
On drugs and dilators for achalasia.
Topics: Catheterization; Esophageal Achalasia; Humans; Nifedipine | 1991 |
Quantitative assessment of the response to therapy in achalasia of the cardia.
Topics: Administration, Sublingual; Adult; Dilatation; Esophageal Achalasia; Esophagus; Female; Humans; Male | 1989 |
[Effect of calcium antagonists on esophageal motor activity in cardial achalasia].
Topics: Adult; Calcium Channel Blockers; Drug Evaluation; Esophageal Achalasia; Esophagus; Female; Fendiline | 1988 |
[Electromanometric evaluation of the effects of nifedipine in achalasic patients].
Topics: Adult; Aged; Esophageal Achalasia; Esophagogastric Junction; Female; Humans; Male; Manometry; Middle | 1987 |
Effects of nifedipine in achalasia and patients with high-amplitude peristaltic esophageal contractions.
Topics: Esophageal Achalasia; Esophagus; Humans; Nifedipine; Peristalsis | 1985 |