nifedipine has been researched along with Epilepsy in 27 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topiramate (TPM), a new generation antiepileptic drug was investigated for its anticonvulsant effects in various models of genetically determined and chemically induced epilepsy in rodents." | 7.72 | Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy. ( Citraro, R; Constanti, A; De Sarro, G; Ferreri, G; Russo, E, 2004) |
| "The authors report the use of nifedipine as a coadjuvant drug in the treatment of three patients with uncontrolled epilepsy." | 7.67 | [Nifedipine as a coadjuvant drug in the treatment of uncontrolled epilepsy: a preliminary report]. ( Lago, IS; Ohlweiler, L; Rotta, NT, 1989) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.89 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Hasan, M; Marson, AG; Pulman, J, 2013) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.81 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Baillie, N; Chaisewikul, R; Marson, AG, 2001) |
| "Levetiracetam (LEV) is a widely used antiepileptic agent for partial refractory epilepsy in humans." | 3.79 | Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER). ( Arita, K; Hanaya, R; Ishihara, K; Kurisu, K; Sasa, M; Seki, T; Serikawa, T; Yan, HD, 2013) |
| "Topiramate (TPM), a new generation antiepileptic drug was investigated for its anticonvulsant effects in various models of genetically determined and chemically induced epilepsy in rodents." | 3.72 | Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy. ( Citraro, R; Constanti, A; De Sarro, G; Ferreri, G; Russo, E, 2004) |
| "Carbamazepine (CBZ) is widely used in the treatment of epilepsy." | 3.70 | Metabolism of carbamazepine by CYP3A6: a model for in vitro drug interactions studies. ( Barra, Y; Bourgarel-Rey, V; Charvet, B; Desobry, A; Mesdjian, E; Mirrione, A; Sérée, E, 1999) |
| "The aim of the present investigation was to compare the antiepileptic efficacy of the specific L-type calcium channel blocker nifedipine in hippocampal and neocortical slice preparations in the Mg2+-free model of epilepsy." | 3.70 | Contribution of L-type calcium channels to epileptiform activity in hippocampal and neocortical slices of guinea-pigs. ( Frieler, A; Grigat, M; Köhling, R; Speckmann, EJ; Straub, H, 2000) |
| " The paper addresses this question by exploring the antiepileptic efficacy of the L-type calcium channel blockers verapamil and nifedipine in low-Mg(2+)-epilepsy in rat hippocampal slices of different postnatal (PN) ages." | 3.70 | Differential involvement of L-type calcium channels in epileptogenesis of rat hippocampal slices during ontogenesis. ( Köhling, R; Speckmann, EJ; Straub, H, 2000) |
| "The antiepileptic effect of the dihydropyridine calcium channel blocker nifedipine was tested in neocortical slice preparations (n=27) from patients ranging in age from four to 46 years (mean=25) who underwent surgery for the treatment of intractable epilepsy." | 3.70 | Effects of nifedipine on rhythmic synchronous activity of human neocortical slices. ( Ebner, A; Höhling, JM; Köhling, R; Lücke, A; Oppel, F; Pannek, H; Speckmann, EJ; Straub, H; Tuxhorn, I; Wolf, P, 2000) |
| "The authors report the use of nifedipine as a coadjuvant drug in the treatment of three patients with uncontrolled epilepsy." | 3.67 | [Nifedipine as a coadjuvant drug in the treatment of uncontrolled epilepsy: a preliminary report]. ( Lago, IS; Ohlweiler, L; Rotta, NT, 1989) |
| "Nifedipine is an L-type voltage-dependent calcium channel blocker." | 1.40 | Effect of nifedipine on hippocampal neuron number in penicillin-induced epileptic rats. ( Akdogan, I; Kaya, E; Yilmaz, I; Yonguc, GN, 2014) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Hasan, M | 1 |
| Pulman, J | 1 |
| Marson, AG | 2 |
| Yilmaz, I | 1 |
| Akdogan, I | 1 |
| Kaya, E | 1 |
| Yonguc, GN | 1 |
| Yan, HD | 1 |
| Ishihara, K | 2 |
| Seki, T | 1 |
| Hanaya, R | 1 |
| Kurisu, K | 1 |
| Arita, K | 1 |
| Serikawa, T | 2 |
| Sasa, M | 2 |
| Gorji, A | 2 |
| Moddel, G | 1 |
| Speckmann, EJ | 5 |
| El-Abhar, HS | 1 |
| El Gawad, HM | 1 |
| Russo, E | 1 |
| Constanti, A | 1 |
| Ferreri, G | 1 |
| Citraro, R | 1 |
| De Sarro, G | 1 |
| Rüschenschmidt, C | 1 |
| Straub, H | 4 |
| Köhling, R | 4 |
| Siep, E | 1 |
| Galanopoulou, AS | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Karpova, MN | 2 |
| Abrosimov, IIu | 1 |
| Pankov, OIu | 2 |
| Lakinina, MV | 1 |
| Ullal, GR | 2 |
| Satishchandra, P | 1 |
| Shankar, SK | 1 |
| DeLorenzo, RJ | 1 |
| Pal, S | 1 |
| Sombati, S | 1 |
| Mesdjian, E | 1 |
| Sérée, E | 1 |
| Charvet, B | 1 |
| Mirrione, A | 1 |
| Bourgarel-Rey, V | 1 |
| Desobry, A | 1 |
| Barra, Y | 1 |
| Frieler, A | 1 |
| Grigat, M | 1 |
| Höhling, JM | 1 |
| Lücke, A | 1 |
| Tuxhorn, I | 1 |
| Ebner, A | 1 |
| Wolf, P | 1 |
| Pannek, H | 1 |
| Oppel, F | 1 |
| Amano, H | 1 |
| Amano, T | 1 |
| Matsubayashi, H | 1 |
| Jacome, DE | 1 |
| Chaisewikul, R | 1 |
| Baillie, N | 1 |
| Lukyanetz, EA | 1 |
| Shkryl, VM | 1 |
| Kostyuk, PG | 1 |
| Gavranovic, M | 1 |
| Müller, T | 1 |
| Sofic, E | 1 |
| Bilalbegovic, Z | 1 |
| Glebov, RN | 1 |
| Germane, SK | 1 |
| Klusha, VE | 1 |
| Dubur, GIa | 1 |
| Rotta, NT | 1 |
| Ohlweiler, L | 1 |
| Lago, IS | 1 |
| Larkin, JG | 1 |
| Butler, E | 1 |
| Brodie, MJ | 1 |
| Wen, P | 1 |
| Frank, C | 1 |
| Sagratella, S | 1 |
| Benedetti, M | 1 |
| Scotti de Carolis, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
4 reviews available for nifedipine and Epilepsy
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Drug Therapy, Combination; Epilepsy; Flu | 2013 |
GABA receptors as broadcasters of sexually differentiating signals in the brain.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Epilepsy; Female; Gene Expression Regulation, D | 2005 |
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Epilepsy; Flunarizine; Humans; Nifedipin | 2001 |
1 trial available for nifedipine and Epilepsy
| Article | Year |
|---|---|
Anticonvulsants combined with nifedipine for epilepsy in adults.
Topics: Adolescent; Adult; Ambulatory Care; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; | 1991 |
22 other studies available for nifedipine and Epilepsy
| Article | Year |
|---|---|
Effect of nifedipine on hippocampal neuron number in penicillin-induced epileptic rats.
Topics: Animals; Calcium Channel Blockers; Cell Survival; Cerebral Cortex; Disease Models, Animal; Epilepsy; | 2014 |
Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER).
Topics: Animals; Anticonvulsants; Biophysics; Calcium; Calcium Channel Blockers; Dose-Response Relationship, | 2013 |
Background potassium concentrations and epileptiform discharges. II. Involvement of calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Epilepsy; Extracellular Space; Female; | 2003 |
Modulation of cortical nitric oxide synthase, glutamate, and redox state by nifedipine and taurine in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Antioxidants; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dose-Res | 2003 |
Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2004 |
Reduction of human neocortical and guinea pig CA1-neuron A-type currents by organic calcium channel blockers.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Animals; Calcium Channel Blockers; Child; Epilepsy; Fem | 2004 |
[Anticonvulsant activity of sodium valproate and various calcium antagonists during their combined use in mice].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combi | 1993 |
Dihydropyridine group of calcium channel antagonist in epilepsy.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrodes, Implanted; Electroencephalography; | 1994 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzoates; Calcium; Cells, Cultured; Dizocil | 1998 |
Metabolism of carbamazepine by CYP3A6: a model for in vitro drug interactions studies.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Biotrans | 1999 |
Contribution of L-type calcium channels to epileptiform activity in hippocampal and neocortical slices of guinea-pigs.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Epile | 2000 |
Differential involvement of L-type calcium channels in epileptogenesis of rat hippocampal slices during ontogenesis.
Topics: Age Factors; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Epilepsy | 2000 |
Effects of nifedipine on rhythmic synchronous activity of human neocortical slices.
Topics: Adolescent; Bicuculline; Calcium Channel Blockers; Child; Child, Preschool; Convulsants; Dose-Respon | 2000 |
Enhanced calcium influx in hippocampal CA3 neurons of spontaneously epileptic rats.
Topics: Animals; Calcium; Calcium Channels; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationshi | 2001 |
Exploding head syndrome and idiopathic stabbing headache relieved by nifedipine.
Topics: Aged; Anxiety Disorders; Calcium Channel Blockers; Calcium Channels; Diagnosis, Differential; Electr | 2001 |
Selective blockade of N-type calcium channels by levetiracetam.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Calcium Channels, N-Type; Dose-Response Relation | 2002 |
[Effect of a Ca-channel blocker, ryodipine, on focal and generalized epileptic activity].
Topics: Animals; Calcium Channel Blockers; Epilepsies, Partial; Epilepsy; Male; Nifedipine; Pentylenetetrazo | 1989 |
[Nifedipine as a coadjuvant drug in the treatment of uncontrolled epilepsy: a preliminary report].
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Nifedipine | 1989 |
Nifedipine for epilepsy? A pilot study.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Nife | 1988 |
Nifedipine for epilepsy?
Topics: Epilepsy; Humans; Nifedipine | 1988 |
Comparative influence of calcium blocker and purinergic drugs on epileptiform bursting in rat hippocampal slices.
Topics: Adenosine; Animals; Caffeine; Calcium; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; | 1988 |