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nifedipine and Elevated Cholesterol

nifedipine has been researched along with Elevated Cholesterol in 19 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Research Excerpts

ExcerptRelevanceReference
"Essential hypertension is associated with enhanced biological activity of endothelin-1 (ET-1) and impaired endothelium-dependent vasodilatation."9.12Chronic treatment with long-acting nifedipine reduces vasoconstriction to endothelin-1 in essential hypertension. ( Corti, R; Luscher, TF; Noll, G; Salvetti, A; Spieker, L; Sudano, I; Taddei, S; Virdis, A, 2007)
"55 g/day of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on BP and serum lipids were assessed in 18 males with hypertension (WHO stage I-II)."9.07Effects of fish oil, nifedipine and their combination on blood pressure and lipids in primary hypertension. ( Eritsland, J; Hjermann, I; Hysing, J; Landmark, K; Mundal, HH; Thaulow, E, 1993)
"To investigate a possible relation between hypercholesterolemia and detrusor smooth muscle function, we studied the contractile response to potassium challenge, carbachol (CCh), and the components of CCh-induced contractile mechanism in high-cholesterol diet-fed rats."7.78The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels. ( Balkanci, ZD; Bayrak, S; Erdem, A; Karabulut, I; Karaismailoğlu, S; Pehlivanoğlu, B, 2012)
"Essential hypertension is associated with enhanced biological activity of endothelin-1 (ET-1) and impaired endothelium-dependent vasodilatation."5.12Chronic treatment with long-acting nifedipine reduces vasoconstriction to endothelin-1 in essential hypertension. ( Corti, R; Luscher, TF; Noll, G; Salvetti, A; Spieker, L; Sudano, I; Taddei, S; Virdis, A, 2007)
" We studied 293 patients (below 65 years of age) under treatment with either lisinopril (n = 144) or nifedipine (n = 149) for mild to moderate hypertension for 10 weeks, and with serum cholesterol above 6."5.07Effect and tolerability of combining lovastatin with nifedipine or lisinopril. ( Bratland, B; Dahlöf, B; Gisholt, K; Os, I; Syvertsen, JO; Tretli, S, 1993)
"55 g/day of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on BP and serum lipids were assessed in 18 males with hypertension (WHO stage I-II)."5.07Effects of fish oil, nifedipine and their combination on blood pressure and lipids in primary hypertension. ( Eritsland, J; Hjermann, I; Hysing, J; Landmark, K; Mundal, HH; Thaulow, E, 1993)
"To investigate a possible relation between hypercholesterolemia and detrusor smooth muscle function, we studied the contractile response to potassium challenge, carbachol (CCh), and the components of CCh-induced contractile mechanism in high-cholesterol diet-fed rats."3.78The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels. ( Balkanci, ZD; Bayrak, S; Erdem, A; Karabulut, I; Karaismailoğlu, S; Pehlivanoğlu, B, 2012)
"We compared the effect of two different calcium channel blockers (CCB), Nifedipine (1,4-dihydropyridine calcium antagonist) and Diltiazem (a benzothiazepine agent) on plasma components and the development of atherosclerotic plaque in experimental hypercholesterolemia."3.69Differential effect of two calcium channel blockers--nifedipine and diltiazem--on atherogenesis in hypercholesterolemic hamster. ( Pojoga, L; Raicu, M; Simionescu, M; Simionescu, N, 1996)
"Hypertension and hypercholesterolemia are frequently associated, and their treatment is proven to reduce cardiovascular risk."2.42Combined antihypertensive and lipid-lowering treatment. ( Cesari, M; Pessina, AC, 2004)
"Nifedipine has been implicated as an inhibitor of dietary induced atherosclerosis in rabbits."1.27The beneficial influence of nifedipine on the regression of the cholesterol-induced atherosclerosis in rabbits. ( Niedmann, PD; Seidel, D; Thiery, J, 1987)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.79)18.7374
1990's9 (47.37)18.2507
2000's4 (21.05)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Martínez-Jiménez, C1
Cruz-Angeles, J1
Videa, M1
Martínez, LM1
Navarro-Dorado, J1
Garcia-Alonso, M1
van Breemen, C1
Tejerina, T1
Fameli, N1
Balkanci, ZD1
Pehlivanoğlu, B1
Bayrak, S1
Karabulut, I1
Karaismailoğlu, S1
Erdem, A1
Cesari, M1
Pessina, AC1
Miroshnichenko, AO1
Liashenko, VP1
Lukashov, SM1
Sudano, I1
Virdis, A1
Taddei, S1
Spieker, L1
Corti, R1
Noll, G1
Salvetti, A1
Luscher, TF1
Iskenderov, BG1
Burmistrova, LF1
Berenshteĭn, NV1
Lokhina, TV1
Ohata, I1
Sakamoto, N1
Nagano, K1
Maeno, H1
Pauletto, P1
Da Ros, S1
Zoleo, M1
Ragazzi, E1
Chinellato, A1
Pandolfo, L1
Froldi, G1
Caparrotta, L1
Fassina, G1
Os, I1
Bratland, B1
Dahlöf, B1
Gisholt, K1
Syvertsen, JO1
Tretli, S1
Landmark, K1
Thaulow, E1
Hysing, J1
Mundal, HH1
Eritsland, J1
Hjermann, I1
Raicu, M1
Pojoga, L1
Simionescu, N1
Simionescu, M1
Feuerstein, GZ1
Fisher, M1
Nunnart, J1
Ruffolo, RR1
Kato, H1
Okada, R1
Enoki, M1
Oogushi, K1
Emura, S1
Takashima, T1
Ohmori, K1
Nayler, WG1
Cohn, PF1
Lundholm, CE1
Sundbom, L1
Lundholm, L1
Thiery, J1
Niedmann, PD1
Seidel, D1

Reviews

2 reviews available for nifedipine and Elevated Cholesterol

ArticleYear
Combined antihypertensive and lipid-lowering treatment.
    Current hypertension reports, 2004, Volume: 6, Issue:4

    Topics: Anticholesteremic Agents; Antihypertensive Agents; Arteriosclerosis; Cardiovascular Diseases; Comorb

2004
Impact of nifedipine on vascular smooth muscle cell differentiation. Implications for atherogenesis.
    Drugs, 1994, Volume: 48 Suppl 1

    Topics: Animals; Aorta; Arteriosclerosis; Cell Differentiation; Humans; Hypercholesterolemia; Immunohistoche

1994

Trials

4 trials available for nifedipine and Elevated Cholesterol

ArticleYear
Chronic treatment with long-acting nifedipine reduces vasoconstriction to endothelin-1 in essential hypertension.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:2

    Topics: Acetylcholine; Adult; Brachial Artery; Calcium Channel Blockers; Delayed-Action Preparations; Dose-R

2007
[Hypotensive efficacy and tolerability of combination of dihydropyridine and non-dihydropyridine calcium antagonists in the treatment of patients with arterial hypertension].
    Kardiologiia, 2007, Volume: 47, Issue:11

    Topics: Adult; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Dose-Response Relation

2007
Effect and tolerability of combining lovastatin with nifedipine or lisinopril.
    American journal of hypertension, 1993, Volume: 6, Issue:8

    Topics: Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypercholesterole

1993
Effects of fish oil, nifedipine and their combination on blood pressure and lipids in primary hypertension.
    Journal of human hypertension, 1993, Volume: 7, Issue:1

    Topics: Adult; Blood Pressure; Cholesterol; Docosahexaenoic Acids; Double-Blind Method; Drug Therapy, Combin

1993

Other Studies

13 other studies available for nifedipine and Elevated Cholesterol

ArticleYear
Co-Amorphous Simvastatin-Nifedipine with Enhanced Solubility for Possible Use in Combination Therapy of Hypertension and Hypercholesterolemia.
    Molecules (Basel, Switzerland), 2018, Aug-28, Volume: 23, Issue:9

    Topics: Anticholesteremic Agents; Antihypertensive Agents; Calorimetry, Differential Scanning; Drug Combinat

2018
Calcium oscillations in human mesenteric vascular smooth muscle.
    Biochemical and biophysical research communications, 2014, Feb-28, Volume: 445, Issue:1

    Topics: Adolescent; Adult; Aged; Aniline Compounds; Boron Compounds; Calcium Signaling; Cell Membrane; Femal

2014
The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:11

    Topics: Amides; Animals; Calcium Channels, L-Type; Carbachol; Cholinergic Agonists; Disease Models, Animal;

2012
[Dynamics of calcium intake in the brain tissue in hypercholesterolemia].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2004, Volume: 50, Issue:5

    Topics: Animals; Brain; Calcium; Cholesterol; Disease Models, Animal; Hypercholesterolemia; Nifedipine; Rats

2004
Low density lipoprotein-lowering and high density lipoprotein-elevating effects of nicardipine in rats.
    Biochemical pharmacology, 1984, Jul-15, Volume: 33, Issue:14

    Topics: Acetates; Animals; Cholesterol; Clofibrate; Hypercholesterolemia; Hypolipidemic Agents; Lipoproteins

1984
Effect of calcium antagonists on isolated aorta from hypercholesterolemic Yoshida rats of different ages.
    General pharmacology, 1994, Volume: 25, Issue:7

    Topics: Aging; Animals; Aorta, Thoracic; Dinoprostone; Hypercholesterolemia; In Vitro Techniques; Male; Musc

1994
Differential effect of two calcium channel blockers--nifedipine and diltiazem--on atherogenesis in hypercholesterolemic hamster.
    Journal of submicroscopic cytology and pathology, 1996, Volume: 28, Issue:2

    Topics: Animals; Aorta, Thoracic; Aortic Valve; Arteriosclerosis; Calcium Channel Blockers; Coronary Vessels

1996
Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat.
    Pharmacology, 1997, Volume: 54, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Arteriosclerosis; Calcium Channel Blockers; C

1997
The antiatherogenic effect of nifedipine on intramural small coronary arterial lesions in cholesterol-fed rabbits.
    Angiology, 1998, Volume: 49, Issue:1

    Topics: Administration, Oral; Animals; Calcium Channel Blockers; Cholesterol; Cholesterol, Dietary; Coronary

1998
Calcium, calcium antagonism, atherosclerosis, and ischemia.
    Journal of cardiovascular pharmacology, 1992, Volume: 19 Suppl 2

    Topics: Animals; Arteriosclerosis; Calcium; Coronary Disease; Cytosol; Humans; Hypercholesterolemia; Hyperte

1992
Silent myocardial ischemia--classification and management.
    Hospital practice (Office ed.), 1990, Feb-28, Volume: 25, Issue:2A

    Topics: Angina Pectoris; Atenolol; Drug Therapy, Combination; Heart Function Tests; Hemodynamics; Humans; Hy

1990
Relationship between coronary atherosclerosis and "sudden cardiac death". Effects of age and calcium blockers in hypercholesterolemic mini-pigs.
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1989, Volume: 135, Issue:6

    Topics: Animals; Cholesterol; Coronary Artery Disease; Coronary Vessels; Death, Sudden; Female; Hypercholest

1989
The beneficial influence of nifedipine on the regression of the cholesterol-induced atherosclerosis in rabbits.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1987, Volume: 187, Issue:5

    Topics: Animals; Aorta; Apolipoproteins B; Arteriosclerosis; Cholesterol; Female; Hypercholesterolemia; Nife

1987