nifedipine has been researched along with Edema in 50 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial." | 9.22 | Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial. ( Bor, JH; Lagro-Janssen, AL; Smits, P; Souwer, IH, 2016) |
| "Administration of nifedipine increased foot volume and natriuresis simultaneously, thereby supporting the hypothesis that development of ankle oedema with CEB is a local phenomenon at the site of vasodilation." | 9.08 | Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention? ( de Jong, DJ; Huysmans, FT; Kloke, HJ; Koene, RA; van Hamersvelt, HW, 1996) |
| "61 outpatients suffering from essential hypertension with diastolic blood pressure adjusted to < or = 95 mmHg by nifedipine, and simultaneous lower-leg edema." | 9.07 | [Effect of nilvadipine on nifedipine-induced edema of the lower leg. Results of a double-blind randomized comparative study]. ( Schmitt, W; Vollmuth, M, 1994) |
| "We studied the incidence of oedema 2 weeks following initiation of nifedipine therapy for hypertension in a group of 10 diabetic subjects, and also measured skin blood flow (SBF) with a laser Doppler flowmeter, before and after lowering the foot." | 9.06 | Dependent oedema and attenuation of postural vasoconstriction associated with nifedipine therapy for hypertension in diabetic patients. ( Rayman, G; Tooke, JE; Williams, SA, 1989) |
| "Nicardipine and nifedipine are structurally similar dihydropyridine calcium channel blockers with demonstrated efficacy in the treatment of stable angina pectoris." | 9.06 | Randomized double-blind comparison of side effects of nicardipine and nifedipine in angina pectoris. The Nicardipine Investigators Group. ( DeWood, MA; Wolbach, RA, 1990) |
| "Nifedipine has been used in hypertension, mainly as a third-line drug for rapid blood pressure reduction, for over 10 years." | 9.06 | Is nifedipine a suitable first-line treatment for essential hypertension in general practice? ( Adams-Strump, BJ; Gaw, N; Langan, JJ; Murray, TS; Sullivan, FM, 1987) |
| "Nifedipine, as most calcium-antagonist drugs, is widely used for the treatment of angina pectoris and primary hypertension." | 8.80 | [Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report]. ( Luca, S; Romeo, S, 1999) |
| "Among the L-type calcium channel blockers (CCBs), particularly dihydropyridines like nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester], a common adverse effect is vasodilatory edema." | 7.74 | The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay. ( Black, N; Dhamija, S; Kowala, MC; Liachenko, S; Madore, S; Major, TC; Morenko, B; Okerberg, C; Sobocinski, G; Tinholt, P, 2008) |
| "Our results confirm, in SHR, that lacidipine induces a very moderate edema formation." | 7.69 | [Edema-inducing properties of lacidipine, nitrendipine and nifedipine in the spontaneously hypertensive rat]. ( Courseau, C; Garay, R; Giraud, F; Hannaert, P; Pallotta, M; Rota, R, 1994) |
| "The authors examined the efficacy and safety of the combination of verapamil and nifedipine in the control of hypertension." | 7.69 | Verapamil and nifedipine in combination for the treatment of hypertension. ( Bottini, PB; Carr, AA; Kaesemeyer, WH; Prisant, LM, 1994) |
| " We have shown previously that exposing the rat or rabbit microcirculation to nifedipine increases the permeability of the post-capillary venule, the segment of microcirculation that is known to control inflammatory oedema." | 7.69 | Cardiac inotropes inhibit the oedema caused by nifedipine in rabbit skin. ( Taherzadeh, M; Warren, JB, 1997) |
| " The effects of the calcium channel blockers, verapamil and nifedipine on myocardial ischaemia and oedema evoked by endothelin-1 (ET-1) or IRL 1620, an ETB receptor-selective agonist were studied in anaesthetized and conscious rats." | 7.69 | Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat. ( Filep, JG; Földes-Filep, E; Fournier, A; Skrobik, Y, 1996) |
| " Nilvadipine (FK 235, FR 34235) suppressed ischemia (20 min)-reflow (20 min)-induced paw edema of mice (ED30:0." | 7.68 | Inhibition by nilvadipine of ischemic and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase. ( Oyanagui, Y; Sato, S, 1991) |
| " We have investigated the mechanism of capsaicin-induced mouse ear oedema compared with that of arachidonic acid (AA)-induced ear oedema, and evaluated the possible involvement of neuropeptides in the development of capsaicin-induced oedema." | 7.68 | Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. ( Inoue, H; Koshihara, Y; Nagata, N, 1993) |
| "To assess the effect of potent vasodilator therapy in patients with severe or resistant hypertension, 10 patients underwent therapy with captopril and nifedipine alone and in combination." | 7.67 | Effects of combination therapy with captopril and nifedipine in severe or resistant hypertension. ( Lane, TJ; Podesla, S; Viadero, JJ; White, WB, 1986) |
| " Most adverse events were mild or moderate and the investigators' overall evaluation of tolerability was excellent or good for 91% of patients." | 6.67 | A study of the efficacy and safety of amlodipine for the treatment of hypertension in general practice. ( Varrone, J, 1991) |
| " Although the safety profile of nifedipine has been generally regarded as favorable, a few reports of clinically significant adverse effects in specific patient groups have appeared in the literature." | 5.26 | Nifedipine therapy in angina pectoris: evaluation of safety and side effects. ( Terry, RW, 1982) |
| "Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial." | 5.22 | Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial. ( Bor, JH; Lagro-Janssen, AL; Smits, P; Souwer, IH, 2016) |
| "The increased efficacy on ambulatory BP as well as the significantly reduced prevalence of edema after bedtime as compared to morning ingestion of nifedipine should be taken into account when prescribing this medication to patients with essential hypertension." | 5.13 | Chronotherapy with nifedipine GITS in hypertensive patients: improved efficacy and safety with bedtime dosing. ( Ayala, DE; Fernández, JR; Hermida, RC; Mojón, A, 2008) |
| "Amiloride and chlorthalidone pretreatment induced marked volume depletion, with a 2-3% reduction in body weight, a 5-10% increase in haematocrit and a 14-23% increase in plasma colloid osmotic pressure." | 5.11 | Foot volume increase on nifedipine is not prevented by pretreatment with diuretics. ( Huysmans, FT; van der Heijden, AG; van Hamersvelt, HW, 2004) |
| "002; multivariate analysis of variance), with 7 significant univariate treatment effects, all favoring COER-verapamil, being noted-pedal edema, polyuria, rapid heart beat or palpitations, hives, muscle cramps, abdominal cramps, and headaches." | 5.09 | Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life. ( Anderson, RB; Hollenberg, NK; Williams, GH, 1999) |
| "Administration of nifedipine increased foot volume and natriuresis simultaneously, thereby supporting the hypothesis that development of ankle oedema with CEB is a local phenomenon at the site of vasodilation." | 5.08 | Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention? ( de Jong, DJ; Huysmans, FT; Kloke, HJ; Koene, RA; van Hamersvelt, HW, 1996) |
| "These data suggest that (1) dobutamine stress can be used to induce cardiac ischemia in elderly patients with coronary artery disease, (2) nifedipine-GITS provides symptomatic angina relief in elderly patients, (3) peripheral edema is frequent in elderly patients on nifedipine-GITS, and (4) ultrafast computed cine-tomography testing can be used to assess ventricular performance, but current methodology may not detect perfusion or wall motion abnormalities during angina." | 5.07 | Early experience with dobutamine stress testing and cardiac cine-tomographic imaging in the elderly: antianginal effects of nifedipine-GITS. ( Abbott, J; Caputo, G; Schwartz, JB, 1993) |
| "61 outpatients suffering from essential hypertension with diastolic blood pressure adjusted to < or = 95 mmHg by nifedipine, and simultaneous lower-leg edema." | 5.07 | [Effect of nilvadipine on nifedipine-induced edema of the lower leg. Results of a double-blind randomized comparative study]. ( Schmitt, W; Vollmuth, M, 1994) |
| "In a multicentre crossover study of 97 patients with mild hypertension, the incidence and severity of adverse effects were observed during the first 14 days of treatment with amlodipine, nifedipine retard or placebo." | 5.07 | Early side-effects of antihypertensive therapy: comparison of amlodipine and nifedipine retard. ( Bremner, AD; Fell, PJ; Hosie, J; James, IG; Saul, PA; Taylor, SH, 1993) |
| "We studied the incidence of oedema 2 weeks following initiation of nifedipine therapy for hypertension in a group of 10 diabetic subjects, and also measured skin blood flow (SBF) with a laser Doppler flowmeter, before and after lowering the foot." | 5.06 | Dependent oedema and attenuation of postural vasoconstriction associated with nifedipine therapy for hypertension in diabetic patients. ( Rayman, G; Tooke, JE; Williams, SA, 1989) |
| "Nifedipine has been used in hypertension, mainly as a third-line drug for rapid blood pressure reduction, for over 10 years." | 5.06 | Is nifedipine a suitable first-line treatment for essential hypertension in general practice? ( Adams-Strump, BJ; Gaw, N; Langan, JJ; Murray, TS; Sullivan, FM, 1987) |
| "Nicardipine and nifedipine are structurally similar dihydropyridine calcium channel blockers with demonstrated efficacy in the treatment of stable angina pectoris." | 5.06 | Randomized double-blind comparison of side effects of nicardipine and nifedipine in angina pectoris. The Nicardipine Investigators Group. ( DeWood, MA; Wolbach, RA, 1990) |
| "Nifedipine, as most calcium-antagonist drugs, is widely used for the treatment of angina pectoris and primary hypertension." | 4.80 | [Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report]. ( Luca, S; Romeo, S, 1999) |
| "Among the L-type calcium channel blockers (CCBs), particularly dihydropyridines like nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester], a common adverse effect is vasodilatory edema." | 3.74 | The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay. ( Black, N; Dhamija, S; Kowala, MC; Liachenko, S; Madore, S; Major, TC; Morenko, B; Okerberg, C; Sobocinski, G; Tinholt, P, 2008) |
| "The authors examined the efficacy and safety of the combination of verapamil and nifedipine in the control of hypertension." | 3.69 | Verapamil and nifedipine in combination for the treatment of hypertension. ( Bottini, PB; Carr, AA; Kaesemeyer, WH; Prisant, LM, 1994) |
| "Our results confirm, in SHR, that lacidipine induces a very moderate edema formation." | 3.69 | [Edema-inducing properties of lacidipine, nitrendipine and nifedipine in the spontaneously hypertensive rat]. ( Courseau, C; Garay, R; Giraud, F; Hannaert, P; Pallotta, M; Rota, R, 1994) |
| " The effects of the calcium channel blockers, verapamil and nifedipine on myocardial ischaemia and oedema evoked by endothelin-1 (ET-1) or IRL 1620, an ETB receptor-selective agonist were studied in anaesthetized and conscious rats." | 3.69 | Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat. ( Filep, JG; Földes-Filep, E; Fournier, A; Skrobik, Y, 1996) |
| " We have shown previously that exposing the rat or rabbit microcirculation to nifedipine increases the permeability of the post-capillary venule, the segment of microcirculation that is known to control inflammatory oedema." | 3.69 | Cardiac inotropes inhibit the oedema caused by nifedipine in rabbit skin. ( Taherzadeh, M; Warren, JB, 1997) |
| " On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia." | 3.69 | Massive vulvar edema complicating tocolysis in a patient with twins. A case report. ( Bennert, H; Stubblefield, PG; Trice, L, 1996) |
| " Nilvadipine (FK 235, FR 34235) suppressed ischemia (20 min)-reflow (20 min)-induced paw edema of mice (ED30:0." | 3.68 | Inhibition by nilvadipine of ischemic and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase. ( Oyanagui, Y; Sato, S, 1991) |
| " We have investigated the mechanism of capsaicin-induced mouse ear oedema compared with that of arachidonic acid (AA)-induced ear oedema, and evaluated the possible involvement of neuropeptides in the development of capsaicin-induced oedema." | 3.68 | Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. ( Inoue, H; Koshihara, Y; Nagata, N, 1993) |
| "To assess the effect of potent vasodilator therapy in patients with severe or resistant hypertension, 10 patients underwent therapy with captopril and nifedipine alone and in combination." | 3.67 | Effects of combination therapy with captopril and nifedipine in severe or resistant hypertension. ( Lane, TJ; Podesla, S; Viadero, JJ; White, WB, 1986) |
| "Exchangeable sodium, blood volume, plasma norepinephrine (NE), epinephrine, renin and aldosterone levels, and pressor responses to infused NE or angiotensin II (AII) were assessed in ten patients with essential hypertension on placebo, following 6 to 8 weeks of calcium-antagonist nifedipine (NIF), 3 X 10 to 20 mg/day, and after 6 to 8 weeks on NIF combined with the diuretic chlorthalidone (CHLOR), 25 to 50 mg/day." | 3.67 | Body sodium-blood volume state, aldosterone, and cardiovascular responsiveness after calcium entry blockade with nifedipine. ( Beretta-Piccoli, C; Bianchetti, MG; Bomio, F; Luisoli, S; Marone, C; Weidmann, P, 1985) |
| "Long-acting nifedipine tablets were given to 47 severely and moderately hypertensive patients with renal insufficiency, cardiovascular, cerebrovascular, and peripheral vascular disease, diabetes mellitus, asthma, and systemic lupus erythematosus." | 3.67 | Long-acting nifedipine in moderate and severe hypertensive patients with serious concomitant diseases. ( Bursztyn, M; Grossman, E; Rosenthal, T, 1985) |
| " Compared with placebo, barnidipine lowered blood pressure, with a trend toward a dose-response relationship over the dose range 10-30 mg." | 2.68 | Barnidipine, a novel calcium antagonist for once-daily treatment of hypertension: a multicenter, double-blind, placebo-controlled, dose-ranging study. Dutch Barnidipine Multicenter Study Group. ( Hart, W; Holwerda, NJ, 1997) |
| " Most adverse events were mild or moderate and the investigators' overall evaluation of tolerability was excellent or good for 91% of patients." | 2.67 | A study of the efficacy and safety of amlodipine for the treatment of hypertension in general practice. ( Varrone, J, 1991) |
| "Amlodipine treatment was associated with a slightly higher incidence of side effects compared with placebo, but most of this difference was the result of edema, which was usually well tolerated." | 2.66 | The safety of amlodipine. ( Osterloh, I, 1989) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| "Edema was assessed plethysmometrically by evaluating paw volume changes." | 1.34 | Adrenalectomy potentiates the anti-inflammatory activity of a calcium channel blocker. ( Banerjee, A; Nivsarkar, M; Vaghasiya, R, 2007) |
| " Although the safety profile of nifedipine has been generally regarded as favorable, a few reports of clinically significant adverse effects in specific patient groups have appeared in the literature." | 1.26 | Nifedipine therapy in angina pectoris: evaluation of safety and side effects. ( Terry, RW, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (34.00) | 18.7374 |
| 1990's | 22 (44.00) | 18.2507 |
| 2000's | 7 (14.00) | 29.6817 |
| 2010's | 2 (4.00) | 24.3611 |
| 2020's | 2 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 1 |
| Bhusari, KP | 1 |
| Liang, L | 1 |
| Kung, JY | 1 |
| Mitchelmore, B | 1 |
| Cave, A | 1 |
| Banh, HL | 1 |
| Rauser, MS | 1 |
| McGrane, IR | 1 |
| Fischer, R | 1 |
| Souwer, IH | 1 |
| Bor, JH | 1 |
| Smits, P | 1 |
| Lagro-Janssen, AL | 1 |
| Hermida, RC | 1 |
| Ayala, DE | 1 |
| Mojón, A | 1 |
| Fernández, JR | 1 |
| van der Heijden, AG | 1 |
| Huysmans, FT | 2 |
| van Hamersvelt, HW | 2 |
| Belcaro, G | 1 |
| Cesarone, MR | 1 |
| Ricci, A | 1 |
| Cornelli, U | 1 |
| Rodhewald, P | 1 |
| Ledda, A | 1 |
| Di Renzo, A | 1 |
| Stuard, S | 1 |
| Cacchio, M | 1 |
| Vinciguerra, G | 1 |
| Gizzi, G | 1 |
| Pellegrini, L | 1 |
| Dugall, M | 1 |
| Fano, F | 1 |
| Major, TC | 1 |
| Dhamija, S | 1 |
| Black, N | 1 |
| Liachenko, S | 1 |
| Morenko, B | 1 |
| Sobocinski, G | 1 |
| Okerberg, C | 1 |
| Tinholt, P | 1 |
| Madore, S | 1 |
| Kowala, MC | 1 |
| Banerjee, A | 1 |
| Vaghasiya, R | 1 |
| Nivsarkar, M | 1 |
| Terry, RW | 1 |
| Gutiérrez Palau, L | 1 |
| Bolaños Miñambres, IF | 1 |
| Grunwald, Z | 1 |
| Guazzi, MD | 1 |
| Fiorentini, C | 1 |
| Olivari, MT | 1 |
| Bartorelli, A | 1 |
| Necchi, G | 1 |
| Polese, A | 1 |
| Inoue, H | 1 |
| Nagata, N | 1 |
| Koshihara, Y | 1 |
| Rota, R | 1 |
| Pallotta, M | 1 |
| Garay, R | 1 |
| Giraud, F | 1 |
| Courseau, C | 1 |
| Hannaert, P | 1 |
| Vollmuth, M | 1 |
| Schmitt, W | 1 |
| Kaesemeyer, WH | 1 |
| Carr, AA | 1 |
| Bottini, PB | 1 |
| Prisant, LM | 1 |
| Schwartz, JB | 1 |
| Caputo, G | 1 |
| Abbott, J | 1 |
| Bremner, AD | 1 |
| Fell, PJ | 1 |
| Hosie, J | 1 |
| James, IG | 1 |
| Saul, PA | 1 |
| Taylor, SH | 1 |
| Tailor, SA | 1 |
| Gupta, AK | 1 |
| Walker, SE | 1 |
| Shear, NH | 1 |
| Trice, L | 1 |
| Bennert, H | 1 |
| Stubblefield, PG | 1 |
| Filep, JG | 1 |
| Skrobik, Y | 1 |
| Fournier, A | 1 |
| Földes-Filep, E | 1 |
| Kloke, HJ | 1 |
| de Jong, DJ | 1 |
| Koene, RA | 1 |
| Ogawa, M | 1 |
| Ueda, S | 1 |
| Hamano, Y | 1 |
| Ito, K | 1 |
| Saisho, H | 1 |
| Akikusa, B | 1 |
| Massie, BM | 1 |
| Lacourcière, Y | 1 |
| Viskoper, R | 1 |
| Woittiez, A | 1 |
| Kobrin, I | 1 |
| Neumann, C | 1 |
| Willershausen-Zönnchen, B | 1 |
| Klug, C | 1 |
| Darius, H | 1 |
| Taherzadeh, M | 1 |
| Warren, JB | 1 |
| Hart, W | 1 |
| Holwerda, NJ | 1 |
| Lacolley, P | 1 |
| Poitevin, P | 1 |
| Koen, R | 1 |
| Levy, BI | 1 |
| Anderson, RB | 1 |
| Hollenberg, NK | 1 |
| Williams, GH | 1 |
| Luca, S | 1 |
| Romeo, S | 1 |
| Sirker, A | 1 |
| Missouris, CG | 1 |
| MacGregor, GA | 1 |
| Bridgman, JF | 1 |
| Oyanagui, Y | 1 |
| Sato, S | 1 |
| Varrone, J | 1 |
| DeWood, MA | 1 |
| Wolbach, RA | 1 |
| Chahine, RA | 1 |
| Feldman, RL | 1 |
| Giles, TD | 1 |
| Raizner, AE | 1 |
| Weiss, RJ | 1 |
| Nicod, P | 1 |
| Osterloh, I | 1 |
| Williams, SA | 1 |
| Rayman, G | 1 |
| Tooke, JE | 1 |
| Sullivan, FM | 1 |
| Murray, TS | 1 |
| Gaw, N | 1 |
| Langan, JJ | 1 |
| Adams-Strump, BJ | 1 |
| Srivastava, VK | 1 |
| Saxena, KK | 1 |
| Gupta, B | 1 |
| White, WB | 1 |
| Viadero, JJ | 1 |
| Lane, TJ | 1 |
| Podesla, S | 1 |
| Schnapp, P | 1 |
| Hermann, H | 1 |
| Cernak, P | 1 |
| Kahay, J | 1 |
| Marone, C | 1 |
| Luisoli, S | 1 |
| Bomio, F | 1 |
| Beretta-Piccoli, C | 1 |
| Bianchetti, MG | 1 |
| Weidmann, P | 1 |
| Tordjman, K | 1 |
| Rosenthal, T | 2 |
| Bursztyn, M | 2 |
| Grossman, E | 1 |
| Kaltenbach, M | 1 |
| Hopf, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Post Kidney Transplant Nocturnal Hypertension Prevalence and Management Study[NCT01120613] | 0 participants (Actual) | Interventional | 2010-04-30 | Withdrawn (stopped due to primary investigator left institution; not enough patients) | |||
| Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761] | Phase 4 | 471 participants (Actual) | Interventional | 2018-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nifedipine and Edema
| Article | Year |
|---|---|
Comparative peripheral edema for dihydropyridines calcium channel blockers treatment: A systematic review and network meta-analysis.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Edema; Humans; Hypertension; Ne | 2022 |
[Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report].
Topics: Aged; Angina Pectoris; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Chronic Disease; | 1999 |
20 trials available for nifedipine and Edema
| Article | Year |
|---|---|
Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Chilblains; Chronic Dis | 2016 |
Chronotherapy with nifedipine GITS in hypertensive patients: improved efficacy and safety with bedtime dosing.
Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rh | 2008 |
Foot volume increase on nifedipine is not prevented by pretreatment with diuretics.
Topics: Adult; Amiloride; Ankle; Body Weight; Calcium Channel Blockers; Chlorthalidone; Diuretics; Edema; Fe | 2004 |
Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Capilla | 2006 |
Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.
Topics: Drug Therapy, Combination; Edema; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Methyldopa; | 1980 |
[Nilvadipin for nifedipine induced calf edema. Results of a double blind randomized comparative study].
Topics: Aged; Blood Pressure; Body Weight; Calcium Channel Blockers; Double-Blind Method; Edema; Female; Hea | 1994 |
[Effect of nilvadipine on nifedipine-induced edema of the lower leg. Results of a double-blind randomized comparative study].
Topics: Aged; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Humans | 1994 |
Early experience with dobutamine stress testing and cardiac cine-tomographic imaging in the elderly: antianginal effects of nifedipine-GITS.
Topics: Age Factors; Angina Pectoris; Cineradiography; Coronary Angiography; Coronary Disease; Dobutamine; D | 1993 |
Early side-effects of antihypertensive therapy: comparison of amlodipine and nifedipine retard.
Topics: Adult; Aged; Amlodipine; Delayed-Action Preparations; Dizziness; Double-Blind Method; Edema; Female; | 1993 |
Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention?
Topics: Adult; Cross-Over Studies; Diazoxide; Edema; Female; Humans; Male; Nifedipine; Reproducibility of Re | 1996 |
Mibefradil in the treatment of systemic hypertension: comparative studies with other calcium antagonists.
Topics: Adult; Aged; Amlodipine; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Double-Blind Method; E | 1997 |
Barnidipine, a novel calcium antagonist for once-daily treatment of hypertension: a multicenter, double-blind, placebo-controlled, dose-ranging study. Dutch Barnidipine Multicenter Study Group.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Edema; Female; Flushing; He | 1997 |
Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Constipation; Dou | 1999 |
A study of the efficacy and safety of amlodipine for the treatment of hypertension in general practice.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Calcium Channel Blockers; Edema; Female; Headache; Human | 1991 |
Randomized double-blind comparison of side effects of nicardipine and nifedipine in angina pectoris. The Nicardipine Investigators Group.
Topics: Adult; Angina Pectoris; Dizziness; Double-Blind Method; Edema; Flushing; Foot Diseases; Headache; Hu | 1990 |
Efficacy and safety of amlodipine in vasospastic angina: an interim report of a multicenter, placebo-controlled trial. The Investigators of Study 160.
Topics: Amlodipine; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Vasospasm; | 1989 |
The safety of amlodipine.
Topics: Adrenergic beta-Antagonists; Aged; Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; D | 1989 |
Dependent oedema and attenuation of postural vasoconstriction associated with nifedipine therapy for hypertension in diabetic patients.
Topics: Adult; Aged; Clinical Trials as Topic; Diabetes Complications; Edema; Female; Humans; Hypertension; | 1989 |
Is nifedipine a suitable first-line treatment for essential hypertension in general practice?
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; | 1987 |
Nifedipine monotherapy in the hypertensive elderly: a placebo-controlled clinical trial.
Topics: Aged; Aged, 80 and over; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Edem | 1987 |
28 other studies available for nifedipine and Edema
| Article | Year |
|---|---|
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
A CYP3A4 Drug-Drug Interaction Between Nirmatrelvir/Ritonavir and Nifedipine Leading to Edema, Oliguria, and Acute Kidney Injury: A Case Report.
Topics: Acute Kidney Injury; Antiviral Agents; Cytochrome P-450 CYP3A; Edema; Humans; Nifedipine; Oliguria; | 2023 |
[Acute mountain sickness : How can it be treated and how can it be avoided?].
Topics: Acetazolamide; Acute Disease; Altitude Sickness; Anti-Inflammatory Agents; Dexamethasone; Diuretics; | 2014 |
The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channe | 2008 |
Adrenalectomy potentiates the anti-inflammatory activity of a calcium channel blocker.
Topics: Acute Disease; Adrenalectomy; Animals; Anti-Inflammatory Agents; Calcium Channel Blockers; Carrageen | 2007 |
Nifedipine therapy in angina pectoris: evaluation of safety and side effects.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel | 1982 |
[Echocardiographic and arterial pressure changes after acute and prolonged (3 months) administration of nifedipine].
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Echocardiography; Edema; Heart; Humans; Hypertension; Leg | 1984 |
Painful edema, erythematous rash, and burning sensation due to nifedipine.
Topics: Edema; Erythema; Female; Humans; Middle Aged; Nifedipine; Pyridines | 1982 |
Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema.
Topics: Administration, Cutaneous; Animals; Arachidonic Acid; Calcitonin Gene-Related Peptide; Calcium; Caps | 1993 |
[Edema-inducing properties of lacidipine, nitrendipine and nifedipine in the spontaneously hypertensive rat].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Edema; Nifedipine; Nitrendipine | 1994 |
Verapamil and nifedipine in combination for the treatment of hypertension.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Drug Therapy, Combination; Edema; Female | 1994 |
Peripheral edema due to nifedipine-itraconazole interaction: a case report.
Topics: Aged; Antifungal Agents; Calcium Channel Blockers; Drug Interactions; Edema; Female; Humans; Itracon | 1996 |
Massive vulvar edema complicating tocolysis in a patient with twins. A case report.
Topics: Adult; Betamethasone; Drug Therapy, Combination; Edema; Female; Glucocorticoids; Humans; Infant, New | 1996 |
Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat.
Topics: Albumins; Animals; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Edema | 1996 |
Membranous nephropathy associated with oxaprozin treatment.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Capillaries; Complement C3; Edema; Epithe | 1996 |
Clinical assessment of periodontal conditions in patients treated with nifedipine.
Topics: Bicuspid; Calcium Channel Blockers; Cuspid; Edema; Female; Fibrosis; Gingiva; Gingival Diseases; Hum | 1996 |
Cardiac inotropes inhibit the oedema caused by nifedipine in rabbit skin.
Topics: Animals; Bradykinin; Calcium Channel Blockers; Cardiotonic Agents; Dinoprostone; Dobutamine; Dopamin | 1997 |
Different effects of calcium antagonists on fluid filtration of large arteries and albumin permeability in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Capillary Permeabilit | 1998 |
Dihydropyridine calcium channel blockers and peripheral side effects.
Topics: Calcium Channel Blockers; Dihydropyridines; Edema; Erythema; Exanthema; Humans; Hyperpigmentation; H | 2001 |
[Individual therapy of coronary disease].
Topics: Coronary Disease; Edema; Humans; Hypertension; Leg; Myocardial Infarction; Nifedipine; Pyridines | 1979 |
Erythematous oedema of the legs due to nifedipine.
Topics: Edema; Erythema; Female; Humans; Leg; Middle Aged; Nifedipine; Pyridines | 1978 |
Inhibition by nilvadipine of ischemic and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase.
Topics: Animals; Calcimycin; Carrageenan; Edema; Free Radicals; Ischemia; L-Lactate Dehydrogenase; Male; Mic | 1991 |
Calcium channel blockers in acute inflammation.
Topics: Animals; Carrageenan; Edema; Female; Foot; Histamine; Hyaluronoglucosaminidase; Inflammation; Male; | 1988 |
Effects of combination therapy with captopril and nifedipine in severe or resistant hypertension.
Topics: Adult; Aged; Blood Pressure; Captopril; Drug Evaluation; Drug Therapy, Combination; Edema; Female; H | 1986 |
Body sodium-blood volume state, aldosterone, and cardiovascular responsiveness after calcium entry blockade with nifedipine.
Topics: Aged; Aldosterone; Angiotensin II; Blood Volume; Calcium; Chlorthalidone; Drug Therapy, Combination; | 1985 |
Nifedipine-induced periorbital edema.
Topics: Angina Pectoris; Edema; Female; Humans; Hypertension; Middle Aged; Nifedipine; Orbital Diseases | 1985 |
Long-acting nifedipine in moderate and severe hypertensive patients with serious concomitant diseases.
Topics: Adult; Aged; Angina Pectoris; Asthma; Cerebrovascular Disorders; Diabetes Complications; Edema; Fema | 1985 |
Treatment of hypertrophic cardiomyopathy: relation to pathological mechanisms.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cardiac Catheterization; Cardio | 1985 |