Page last updated: 2024-11-01

nifedipine and Eclampsia

nifedipine has been researched along with Eclampsia in 17 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Eclampsia: Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).

Research Excerpts

ExcerptRelevanceReference
"Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia."9.10A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. ( Allen, JC; Anthony, J; Belfort, MA; Saade, GR, 2003)
"The objective was to compare the fetal and maternal effects between parenteral hydralazine and sublingual nifedipine used like antihypertensive drugs in the management of severe preeclampsia."9.07[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. ( Flores Padilla, LM; Walss Rodriguez, RJ, 1993)
"The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia."8.86Magnesium sulphate versus phenytoin for eclampsia. ( Chou, D; Duley, L; Henderson-Smart, DJ, 2010)
"To examine the efficacy of magnesium sulfate (MgSO4) as an anticonvulsant in eclampsia and imminent eclampsia."7.69Magnesium sulfate as an anticonvulsant in eclampsia. ( Raman, NV; Rao, CA, 1995)
" The treatment regimen included use of nifedipine as an antihypertensive, magnesium sulfate as an anticonvulsant, rapid interruption of pregnancy, and admission to the ICU."5.16Management of eclampsia at Assiut University Hospital, Egypt. ( Abd El Aal, DE; Shahin, AY, 2012)
"Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia."5.10A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. ( Allen, JC; Anthony, J; Belfort, MA; Saade, GR, 2003)
"In a prospective controlled trial 91 consecutive women with eclampsia were randomly allocated either to a magnesium sulphate and nifedipine regime or to a lytic cocktail and nifedipine group."5.07A safer and more effective treatment regimen for eclampsia. ( Bhalla, AK; Dhall, GI; Dhall, K, 1994)
"The objective was to compare the fetal and maternal effects between parenteral hydralazine and sublingual nifedipine used like antihypertensive drugs in the management of severe preeclampsia."5.07[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. ( Flores Padilla, LM; Walss Rodriguez, RJ, 1993)
"The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia."4.86Magnesium sulphate versus phenytoin for eclampsia. ( Chou, D; Duley, L; Henderson-Smart, DJ, 2010)
"To examine the efficacy of magnesium sulfate (MgSO4) as an anticonvulsant in eclampsia and imminent eclampsia."3.69Magnesium sulfate as an anticonvulsant in eclampsia. ( Raman, NV; Rao, CA, 1995)
"A review of the pathophysiology and treatment of pre-eclampsia indicates that vasospasm and vascular hyperreactivity are important elements in the disease process and its control."2.36Possible treatment of pre-eclampsia with calcium channel blocking agents. ( Zaret, GM, 1983)
"She also had retinal hemorrhages in both eyes and a hemorrhagic infarct in the left occipital lobe that resulted in a permanent right homonymous hemianopia and a persistently depressed acuity of 20/100 OS."1.33Permanent visual deficits secondary to the HELLP syndrome. ( Ayazifar, M; Murphy, MA, 2005)
"Posterior reversible encephalopathy syndrome (PRES) is an acronym that identifies a new clinico-neuroradiologic entity occurring in association with different conditions."1.33PRES: posterior or potentially reversible encephalopathy syndrome? ( Abbate, M; Ferlazzo, E; Granata, F; Mazzù, I; Musolino, R; Narbone, MC, 2006)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19903 (17.65)18.7374
1990's4 (23.53)18.2507
2000's6 (35.29)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arulkumaran, N1
Lightstone, L1
Vadhera, RB1
Simon, M1
Karunatilake, H1
Vithiya, K1
Arasalingam, A1
Piyasiri, A1
Duley, L1
Henderson-Smart, DJ1
Chou, D1
Abd El Aal, DE1
Shahin, AY1
Greene, MF1
Belfort, MA1
Anthony, J1
Saade, GR1
Allen, JC1
Murphy, MA1
Ayazifar, M1
Sharma, S1
Bagga, R1
Modi, M1
Narbone, MC1
Musolino, R1
Granata, F1
Mazzù, I1
Abbate, M1
Ferlazzo, E1
Zaret, GM1
Ram, CV2
Korzets, Z1
Ben-Chitrit, S1
Bernheim, J1
Bhalla, AK1
Dhall, GI1
Dhall, K1
Walss Rodriguez, RJ1
Flores Padilla, LM1
Raman, NV1
Rao, CA1
Meese, RB1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial[NCT03262961]Phase 2/Phase 380 participants (Anticipated)Interventional2016-09-15Recruiting
Labetalol Versus MgSO4 for the Prevention of Eclampsia Trial (LAMPET)[NCT00293735]Phase 2/Phase 30 participants (Actual)Interventional2015-06-30Withdrawn (stopped due to Lack of funding)
A Novel Protocol for Postpartum Magnesium Sulfate in Severe Preeclampsia When the Woman Received Less That 8 Hours Before Delivery. Six Versus Twenty-four Hours Postpartum[NCT02317146]Phase 2/Phase 3280 participants (Actual)Interventional2013-11-30Completed
Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia Receiving Treatment for More Than 8 Hours Before Delivery. A Randomized Multicenter Clinical Trial .[NCT02307201]Phase 2/Phase 31,114 participants (Actual)Interventional2014-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for nifedipine and Eclampsia

ArticleYear
Severe pre-eclampsia and hypertensive crises.
    Best practice & research. Clinical obstetrics & gynaecology, 2013, Volume: 27, Issue:6

    Topics: Administration, Intravenous; Administration, Oral; Antihypertensive Agents; Critical Care; Early Dia

2013
Hypertensive emergencies in pregnancy.
    Clinical obstetrics and gynecology, 2014, Volume: 57, Issue:4

    Topics: Antihypertensive Agents; Eclampsia; Emergencies; Female; Humans; Hydralazine; Hypertension; Hyperten

2014
Magnesium sulphate versus phenytoin for eclampsia.
    The Cochrane database of systematic reviews, 2010, Oct-06, Issue:10

    Topics: Anticonvulsants; Clonazepam; Diazepam; Drug Combinations; Eclampsia; Female; Humans; Magnesium Sulfa

2010
Possible treatment of pre-eclampsia with calcium channel blocking agents.
    Medical hypotheses, 1983, Volume: 12, Issue:4

    Topics: Calcium Channel Blockers; Eclampsia; Female; Fetus; Humans; Hypertension; Nifedipine; Placenta; Pre-

1983
Hypertensive crisis.
    Cardiology clinics, 1984, Volume: 2, Issue:2

    Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia

1984
Hypertensive cardiovascular emergencies.
    Comprehensive therapy, 1985, Volume: 11, Issue:10

    Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia

1985

Trials

4 trials available for nifedipine and Eclampsia

ArticleYear
Management of eclampsia at Assiut University Hospital, Egypt.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2012, Volume: 116, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Antihypertensive Agents; Clinical Protocols; Combined Modality T

2012
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Calcium Channel Blockers; Eclampsia; Female; Humans; Logistic Models; Magnesium Sul

2003
A safer and more effective treatment regimen for eclampsia.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1994, Volume: 34, Issue:2

    Topics: Adult; Drug Synergism; Drug Therapy, Combination; Eclampsia; Female; Humans; Magnesium Sulfate; Nife

1994
[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents].
    Ginecologia y obstetricia de Mexico, 1993, Volume: 61

    Topics: Administration, Sublingual; Antihypertensive Agents; Apgar Score; Drug Evaluation; Eclampsia; Female

1993

Other Studies

7 other studies available for nifedipine and Eclampsia

ArticleYear
Hypertension and generalised tonic-clonic seizures occurring 41 days after elective caesarian section.
    The Ceylon medical journal, 2008, Volume: 53, Issue:1

    Topics: Adult; Cesarean Section; Eclampsia; Elective Surgical Procedures; Epilepsy, Generalized; Epilepsy, T

2008
Magnesium sulfate for preeclampsia.
    The New England journal of medicine, 2003, Jan-23, Volume: 348, Issue:4

    Topics: Anticonvulsants; Eclampsia; Female; History, 17th Century; History, 18th Century; History, 20th Cent

2003
Permanent visual deficits secondary to the HELLP syndrome.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2005, Volume: 25, Issue:2

    Topics: Adult; Blood Pressure; Brain Infarction; Drug Therapy, Combination; Eclampsia; Female; Furosemide; H

2005
Paraparesis with complete recovery in antepartum eclampsia.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2006, Volume: 93, Issue:3

    Topics: Adult; Antihypertensive Agents; Brain Diseases; Delivery, Obstetric; Eclampsia; Female; Follow-Up St

2006
PRES: posterior or potentially reversible encephalopathy syndrome?
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2006, Volume: 27, Issue:3

    Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Antihypertensive Agents; Brain; Brain Diseases; Cl

2006
Bradycardia as a presenting feature of late postpartum eclampsia.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9, Issue:8

    Topics: Adult; Bradycardia; Drug Therapy, Combination; Eclampsia; Female; Humans; Magnesium Sulfate; Nifedip

1994
Magnesium sulfate as an anticonvulsant in eclampsia.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1995, Volume: 49, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Birth Weight; Delivery, Obstetric; Eclampsia; Female; Humans; Ma

1995