nifedipine has been researched along with Drug Withdrawal Symptoms in 47 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to determine whether calcium channel antagonists attenuated hypoxia/hypoglycemia- or glutamate-induced reduction in 2-deoxyglucose (2-DG) uptake of hippocampal slices obtained from ethanol withdrawal rats." | 7.69 | Calcium channel blockers improve hypoxia/hypoglycemia-induced impairment of rat hippocampal 2-deoxyglucose uptake in vitro after ethanol withdrawal. ( Shibata, S; Shindou, T; Tominaga, K; Watanabe, S, 1995) |
| "We investigated the effect of abrupt cessation of nifedipine after regular administration (20 mg, four times daily) for 5 weeks in seven patients with stable angina pectoris." | 7.68 | Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris. ( Koutishenko, N; Martsevich, SY; Metelitsa, VI, 1993) |
| "The contractures were not due to depolarization (membrane potential, Vm, did not change during Cd2+ removal) or to an influx of external Ca2+ (the transient tension increase was recorded when solutions either lacked Ca2+, or contained 2 mM Co2+)." | 5.31 | Cadmium withdrawal contractures in rat soleus muscle fibres. ( Dulhunty, AF; Mould, J, 2000) |
| "Pretreatment with nifedipine partially restores the analgesic action of morphine in morphine-tolerant rats." | 5.29 | Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1993) |
| "We compared the effects of abrupt cessation of nifedipine and isosorbide dinitrate therapy in patients with stable angina pectoris." | 5.08 | Withdrawal effects of antianginal therapy: comparison of isosorbide dinitrate and nifedipine. ( Koutishenko, N; Metelitsa, VI, 1998) |
| "Reports of acute ischemic events after withdrawal of calcium antagonist therapy in outpatients and during bypass surgery in patients with prior angina at rest prompted the examination of the effect of nifedipine withdrawal in 81 patients who had completed a prospective, double-blind randomized trial of nifedipine versus placebo for rest angina." | 5.05 | Acute nifedipine withdrawal: consequences of preoperative and late cessation of therapy in patients with prior unstable angina. ( Achuff, SC; Baughman, KL; Gerstenblith, G; Gottlieb, SO; Mellits, ED; Ouyang, P; Traill, TA; Weisfeldt, ML, 1984) |
| "The acute effects of nifedipine withdrawal were studied in 81 patients with angina at rest who had completed a prospective, double-blind, randomized trial of nifedipine versus placebo." | 5.05 | Safety of acute calcium antagonist withdrawal: studies in patients with unstable angina withdrawn from nifedipine. ( Gerstenblith, G; Gottlieb, SO, 1985) |
| " Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated." | 3.74 | L-type calcium channel blockade attenuates morphine withdrawal: in vivo interaction between L-type calcium channels and corticosterone. ( Ahmadiani, A; Esmaeili-Mahani, S; Fathi, Y; Hosseinpanah, F; Motamedi, F, 2008) |
| " In vivo studies have indicated the involvement of dihydropyridine-sensitive (L-type) voltage-gated channels in morphine abuse." | 3.72 | Effects of nifedipine on behavioral and biochemical parameters in rats after multiple morphine administration. ( Mitcheva, M; Vitcheva, V, 2004) |
| "The aim of the present study was to determine whether calcium channel antagonists attenuated hypoxia/hypoglycemia- or glutamate-induced reduction in 2-deoxyglucose (2-DG) uptake of hippocampal slices obtained from ethanol withdrawal rats." | 3.69 | Calcium channel blockers improve hypoxia/hypoglycemia-induced impairment of rat hippocampal 2-deoxyglucose uptake in vitro after ethanol withdrawal. ( Shibata, S; Shindou, T; Tominaga, K; Watanabe, S, 1995) |
| "The effect of abrupt discontinuation of nifedipine (N) on exercise tolerance and myocardial ischemia was studied in 7 patients with stable angina pectoris of effort (AP)." | 3.69 | [The nifedipine withdrawal syndrome in patients with stable stenocardia of effort]. ( Kutishenko, NP; Martsevich, SIu; Metelitsa, VI, 1995) |
| "We investigated the effect of abrupt cessation of nifedipine after regular administration (20 mg, four times daily) for 5 weeks in seven patients with stable angina pectoris." | 3.68 | Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris. ( Koutishenko, N; Martsevich, SY; Metelitsa, VI, 1993) |
| "Nifedipine, in a slow release preparation, was given at a mean daily dosage of 47 +/- 4 mg to 12 patients with severe hypertension in whom arterial pressure was not satisfactorily controlled (mean arterial pressure 132 +/- 4 4 mm Hg) by the combination of a converting enzyme inhibitor and a diuretic." | 3.67 | Effect of chronic nifedipine in patients inadequately controlled by a converting enzyme inhibitor and a diuretic. ( Mimran, A; Ribstein, J, 1985) |
| "The contractures were not due to depolarization (membrane potential, Vm, did not change during Cd2+ removal) or to an influx of external Ca2+ (the transient tension increase was recorded when solutions either lacked Ca2+, or contained 2 mM Co2+)." | 1.31 | Cadmium withdrawal contractures in rat soleus muscle fibres. ( Dulhunty, AF; Mould, J, 2000) |
| "Pretreatment with nifedipine partially restores the analgesic action of morphine in morphine-tolerant rats." | 1.29 | Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1993) |
| "Nifedipine treatment abolished the signs of abstinence and normalized the hot-plate latencies in morphine-dependent, naloxone-treated rats." | 1.28 | Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1990) |
| "Although withdrawal symptoms have been reported following abrupt cessation of therapy with some cardiovascular drugs, there is no detailed report on similar complications of the cessation of therapy with calcium antagonists." | 1.27 | Rebound of vasospastic angina after cessation of long-term treatment with nifedipine. ( Gagnon, RM; Lemire, JG; Lette, J; Morissette, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (27.66) | 18.7374 |
| 1990's | 27 (57.45) | 18.2507 |
| 2000's | 7 (14.89) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| El Ganouni, S | 1 |
| Hanoun, N | 1 |
| Boni, C | 1 |
| Tazi, A | 1 |
| Hakkou, F | 1 |
| Hamon, M | 1 |
| Vitcheva, V | 1 |
| Mitcheva, M | 1 |
| Chiladakis, JA | 1 |
| Alexopoulos, D | 1 |
| Leventhal, L | 1 |
| Cosmi, S | 1 |
| Deecher, D | 1 |
| Katsura, M | 1 |
| Torigoe, F | 1 |
| Hayashida, S | 1 |
| Honda, T | 1 |
| Tsujimura, A | 1 |
| Ohkuma, S | 1 |
| Esmaeili-Mahani, S | 1 |
| Fathi, Y | 1 |
| Motamedi, F | 1 |
| Hosseinpanah, F | 1 |
| Ahmadiani, A | 1 |
| Gottlieb, SO | 2 |
| Ouyang, P | 1 |
| Achuff, SC | 1 |
| Baughman, KL | 1 |
| Traill, TA | 1 |
| Mellits, ED | 1 |
| Weisfeldt, ML | 1 |
| Gerstenblith, G | 2 |
| Mysliwiec, M | 1 |
| Rydzewski, A | 1 |
| Bulhak, W | 1 |
| Lette, J | 1 |
| Gagnon, RM | 1 |
| Lemire, JG | 1 |
| Morissette, M | 1 |
| Kay, R | 1 |
| Blake, J | 1 |
| Rubin, D | 1 |
| Shibata, S | 1 |
| Shindou, T | 1 |
| Tominaga, K | 1 |
| Watanabe, S | 1 |
| Li, QP | 1 |
| Rao, MR | 1 |
| Martsevich, SIu | 2 |
| Kutishenko, NP | 2 |
| Metelitsa, VI | 4 |
| Colombo, G | 1 |
| Agabio, R | 1 |
| Lobina, C | 1 |
| Reali, R | 1 |
| Melis, F | 1 |
| Fadda, F | 1 |
| Gessa, GL | 1 |
| Zharkovsky, A | 2 |
| Cebers, G | 1 |
| Antkiewicz-Michaluk, L | 4 |
| Michaluk, J | 4 |
| Romańska, I | 3 |
| Vetulani, J | 4 |
| Martsevich, SY | 1 |
| Koutishenko, N | 2 |
| Morrone, LA | 2 |
| Romanelli, L | 1 |
| Amico, MC | 1 |
| Valeri, P | 2 |
| Suzuki, T | 1 |
| Mizoguchi, H | 1 |
| Motegi, H | 1 |
| Awano, H | 1 |
| Misawa, M | 1 |
| Mehta, JL | 1 |
| Subramanian, VB | 1 |
| Karolewicz, B | 1 |
| Bouchenafa, O | 1 |
| Littleton, JM | 1 |
| Shulman, A | 1 |
| Jagoda, J | 1 |
| Laycock, G | 1 |
| Kelly, H | 1 |
| Garibova, TL | 1 |
| Val'dman, EA | 1 |
| Voronina, TA | 1 |
| Kraĭneva, VA | 1 |
| Piepponen, TP | 1 |
| Kivastik, T | 1 |
| Ahtee, L | 1 |
| Mould, J | 1 |
| Dulhunty, AF | 1 |
| Beeley, L | 1 |
| Talbot, J | 1 |
| Lederballe Pedersen, O | 1 |
| Mikkelsen, E | 1 |
| Ross, PJ | 1 |
| Lewis, MJ | 1 |
| Henderson, AH | 1 |
| Muller, JE | 1 |
| Gunther, SJ | 1 |
| Silverstone, PH | 2 |
| Done, C | 1 |
| Sharp, T | 1 |
| Schnur, P | 2 |
| Espinoza, M | 1 |
| Flores, R | 1 |
| Ortiz, S | 1 |
| Vallejos, S | 1 |
| Wainwright, M | 1 |
| Attenburrow, MJ | 1 |
| Robson, P | 1 |
| Oneglia, C | 1 |
| Sabatini, T | 1 |
| Ghizzoni, G | 1 |
| Rusconi, C | 1 |
| Martinelli, B | 1 |
| Severini, C | 1 |
| Katta, BB | 1 |
| Yamamoto, M | 1 |
| Gotoh, Y | 1 |
| Imaizumi, Y | 1 |
| Watanabe, M | 1 |
| Mimran, A | 1 |
| Ribstein, J | 1 |
| Bala Subramanian, V | 1 |
| Sosnowski, M | 1 |
| Markiewicz, A | 1 |
| Lough, FC | 1 |
1 review available for nifedipine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[A clinical case: coronary vasospasm induced by exercise after stopping nifedipine therapy].
Topics: Coronary Disease; Coronary Vasospasm; Delayed-Action Preparations; Electrocardiography; Exercise; Ex | 1992 |
6 trials available for nifedipine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Acute nifedipine withdrawal: consequences of preoperative and late cessation of therapy in patients with prior unstable angina.
Topics: Angina Pectoris; Angina, Unstable; Blood Pressure; Clinical Trials as Topic; Coronary Artery Bypass; | 1984 |
Calcium channel blocking drugs in the management of drug dependence, withdrawal and craving. A clinical pilot study with nifedipine and verapamil.
Topics: Adult; Calcium Channel Blockers; Female; Humans; Male; Middle Aged; Nifedipine; Pilot Projects; Subs | 1998 |
Withdrawal effects of antianginal therapy: comparison of isosorbide dinitrate and nifedipine.
Topics: Adult; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Exercise Test; Exercise Tolerance; | 1998 |
Beta-blocker withdrawal syndrome.
Topics: Heart Rate; Humans; Hyperthyroidism; Nifedipine; Nitrites; Posture; Propranolol; Substance Withdrawa | 1979 |
The calcium channel antagonist nifedipine causes confusion when used to treat opiate withdrawal in morphine-dependent patients.
Topics: Adult; Clonidine; Confusion; Double-Blind Method; Humans; Male; Methadone; Morphine Dependence; Nife | 1992 |
Safety of acute calcium antagonist withdrawal: studies in patients with unstable angina withdrawn from nifedipine.
Topics: Angina Pectoris; Angina, Unstable; Coronary Artery Bypass; Coronary Disease; Double-Blind Method; El | 1985 |
40 other studies available for nifedipine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Prevention of diazepam withdrawal syndrome by nifedipine-behavioural and neurochemical studies.
Topics: Animals; Anti-Anxiety Agents; Base Sequence; Behavior, Animal; Calcium Channel Blockers; Diazepam; D | 2004 |
Effects of nifedipine on behavioral and biochemical parameters in rats after multiple morphine administration.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Calcium Channel Blockers; Cytochrome P-450 Enz | 2004 |
Autonomic antecedents to variant angina exacerbation after beta-blockade withdrawal.
Topics: Adrenergic beta-Antagonists; Angina Pectoris, Variant; Autonomic Nervous System; Coronary Vasospasm; | 2005 |
Effect of calcium channel modulators on temperature regulation in ovariectomized rats.
Topics: Amines; Animals; Body Temperature Regulation; Calcium Channel Blockers; Calcium Channels; Cyclohexan | 2005 |
Ethanol physical dependence is accompanied by up-regulated expression of L-type high voltage-gated calcium channel alpha1 subunits in mouse brain.
Topics: Administration, Inhalation; Alcoholism; Animals; Brain; Calcium Channel Blockers; Calcium Channels, | 2005 |
L-type calcium channel blockade attenuates morphine withdrawal: in vivo interaction between L-type calcium channels and corticosterone.
Topics: Adrenalectomy; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Corticosterone; Drug Int | 2008 |
Calcium antagonist withdrawal syndrome.
Topics: Adult; Angina Pectoris; Humans; Male; Nifedipine; Pyridines; Substance Withdrawal Syndrome; Thrombos | 1983 |
Rebound of vasospastic angina after cessation of long-term treatment with nifedipine.
Topics: Adult; Angina Pectoris, Variant; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine | 1984 |
Possible coronary spasm rebound to abrupt nifedipine withdrawal.
Topics: Aged; Coronary Vasospasm; Humans; Male; Nifedipine; Pyridines; Recurrence; Substance Withdrawal Synd | 1982 |
Calcium channel blockers improve hypoxia/hypoglycemia-induced impairment of rat hippocampal 2-deoxyglucose uptake in vitro after ethanol withdrawal.
Topics: Animals; Calcium Channel Blockers; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Dr | 1995 |
[Effects of calcium antagonists on withdrawal of beta-receptor blockers in rats during left ventricular hypertrophy].
Topics: Animals; Hemodynamics; Hypertrophy, Left Ventricular; Isomerism; Male; Metoprolol; Myocardium; Nifed | 1995 |
[The nifedipine withdrawal syndrome in patients with stable stenocardia of effort].
Topics: Angina Pectoris; Electrocardiography; Exercise Test; Exercise Tolerance; Humans; Myocardial Ischemia | 1995 |
Effects of the calcium channel antagonist darodipine on ethanol withdrawal in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Ethanol; Male | 1995 |
Effect of Ro 15-4513 and nifedipine on the behaviour and potassium-evoked calcium uptake following withdrawal from chronic ethanol administration in rats.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Calcium; Calcium Channels; Cerebral Cortex; Etha | 1993 |
Differential involvement of voltage-dependent calcium channels in apomorphine-induced hypermotility and stereotypy.
Topics: Animals; Apomorphine; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Electroshock; M | 1994 |
Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine.
Topics: Analgesics; Animals; Cerebral Cortex; Drug Interactions; Drug Tolerance; Male; Morphine; Morphine De | 1993 |
Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris.
Topics: Angina Pectoris; Exercise Test; Exercise Tolerance; Humans; Male; Middle Aged; Myocardial Ischemia; | 1993 |
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1993 |
Effects of nifedipine on physical dependence on barbital or diazepam in rats.
Topics: Analysis of Variance; Animals; Barbital; Body Weight; Calcium Channel Blockers; Calcium Channels; Di | 1995 |
Calcium blockers and risk of myocardial infarction and coronary heart disease mortality.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Hemod | 1996 |
Differences between haloperidol- and pimozide-induced withdrawal syndrome: a role for Ca2+ channels.
Topics: Animals; Antipsychotic Agents; Apomorphine; Calcium Channels; Haloperidol; Male; Motor Activity; Nif | 1995 |
[The possibility of the development of isosorbide dinitrate and nifedipine withdrawal syndromes in patients with stable stenocardia of effort].
Topics: Adult; Aged; Angina Pectoris; Exercise Tolerance; Humans; Isosorbide Dinitrate; Male; Middle Aged; N | 1997 |
Expression of c-Fos protein immunoreactivity in rat brain during ethanol withdrawal is prevented by nifedipine.
Topics: Animals; Brain; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Ethanol; Hippocampus; Im | 1998 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium | 1998 |
Effects of morphine in rats withdrawn from repeated nifedipine administration.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Calcium Channel Blockers; Catalepsy; Dihydropyri | 1999 |
Cadmium withdrawal contractures in rat soleus muscle fibres.
Topics: Animals; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cobalt; Contracture; | 2000 |
Beta-blocker withdrawal syndrome?
Topics: Angina Pectoris; Humans; Metoprolol; Nifedipine; Propanolamines; Substance Withdrawal Syndrome | 1979 |
Beta-blocker withdrawal syndrome.
Topics: Humans; Metoprolol; Nifedipine; Propanolamines; Propranolol; Pyridines; Substance Withdrawal Syndrom | 1979 |
Nifedipine therapy for Prinzmetal's angina.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Coronary Disease; Humans; Male; Myocardial Infarct | 1978 |
Clonidine but not nifedipine prevents the release of noradrenaline during naloxone-precipitated opiate withdrawal: an in vivo microdialysis study in the rat.
Topics: Animals; Behavior, Animal; Clonidine; Male; Microdialysis; Morphine Dependence; Naloxone; Nifedipine | 1992 |
Blocking naloxone-precipitated withdrawal in rats and hamsters.
Topics: Animals; Behavior, Animal; Clonidine; Cricetinae; Drug Implants; Mesocricetus; Morphine Dependence; | 1992 |
Morphine withdrawal in the hamster.
Topics: Animals; Clonidine; Cricetinae; Morphine; Naloxone; Nifedipine; Stereotyped Behavior; Substance With | 1992 |
Reproducible withdrawal contractions of isolated guinea-pig ileum after brief morphine exposure: effects of clonidine and nifedipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Nifedapine for protracted withdrawal syndrome.
Topics: Adult; Alcoholism; Combined Modality Therapy; Ethanol; Follow-Up Studies; Humans; Male; Nifedipine; | 1991 |
Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Cerebral Cor | 1990 |
Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Evoked Poten | 1990 |
Effect of chronic nifedipine in patients inadequately controlled by a converting enzyme inhibitor and a diuretic.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; Creatinine; Dipeptides; | 1985 |
Clinical and research applications of ambulatory Holter ST-segment and heart rate monitoring.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angina Pectoris, Variant; Blood Pressure; Corona | 1986 |
[Withdrawal syndrome after discontinuation of calcium channel blockers].
Topics: Coronary Disease; Coronary Vasospasm; Humans; Nifedipine; Substance Withdrawal Syndrome; Verapamil | 1988 |
Intraoperative coronary artery spasm.
Topics: Coronary Artery Bypass; Coronary Vasospasm; Humans; Intraoperative Complications; Male; Middle Aged; | 1985 |