nifedipine has been researched along with Drug-Related Side Effects and Adverse Reactions in 15 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This trial investigated the antihypertensive efficacy and effects on the morning BP surge of awakening versus bedtime administration of nifedipine in essential hypertension." | 9.14 | Reduction of morning blood pressure surge after treatment with nifedipine GITS at bedtime, but not upon awakening, in essential hypertension. ( Alonso, I; Ayala, DE; Fernández, JR; Hermida, RC; Mojón, A, 2009) |
| "DISTINCT (reDefining Intervention with Studies Testing Innovative Nifedipine GITS - Candesartan Therapy) aimed to determine the dose-response and tolerability of nifedipine GITS and/or candesartan cilexetil therapy in participants with hypertension." | 5.19 | Nifedipine plus candesartan combination increases blood pressure control regardless of race and improves the side effect profile: DISTINCT randomized trial results. ( Cha, G; Gil-Extremera, B; Haller, H; Harvey, P; Heyvaert, F; Kjeldsen, SE; Lewin, AJ; Mancia, G; Sica, D; Villa, G, 2014) |
| " This trial investigated the antihypertensive efficacy and effects on the morning BP surge of awakening versus bedtime administration of nifedipine in essential hypertension." | 5.14 | Reduction of morning blood pressure surge after treatment with nifedipine GITS at bedtime, but not upon awakening, in essential hypertension. ( Alonso, I; Ayala, DE; Fernández, JR; Hermida, RC; Mojón, A, 2009) |
| "In the case of medication bezoars, these concretions occur within the digestive tract and are composed of medications and/or medication vehicles." | 2.40 | Medication bezoars: a literature review and report of a case. ( Castle, SS; Streetman, DS; Taylor, JR, 1998) |
| "Nifedipine may cause cardiorespiratory adverse effects warranting a close monitoring." | 1.42 | [Adverse effects and hemodynamic effects of nifedipine as a tocolytic]. ( Audibert, F; Bussières, JF; Carceller, AM; Ferreira, E; Lachance, C; Martin, B; Spiesser-Robelet, L; Touzin, K, 2015) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Kjeldsen, SE | 1 |
| Sica, D | 1 |
| Haller, H | 1 |
| Cha, G | 1 |
| Gil-Extremera, B | 1 |
| Harvey, P | 1 |
| Heyvaert, F | 1 |
| Lewin, AJ | 1 |
| Villa, G | 1 |
| Mancia, G | 1 |
| Spiesser-Robelet, L | 1 |
| Martin, B | 1 |
| Carceller, AM | 1 |
| Bussières, JF | 1 |
| Touzin, K | 1 |
| Audibert, F | 1 |
| Lachance, C | 1 |
| Ferreira, E | 1 |
| Hermida, RC | 1 |
| Ayala, DE | 1 |
| Mojón, A | 1 |
| Alonso, I | 1 |
| Fernández, JR | 1 |
| Bussek, A | 1 |
| Schmidt, M | 1 |
| Bauriedl, J | 1 |
| Ravens, U | 1 |
| Wettwer, E | 1 |
| Lohmann, H | 1 |
| Wu, CS | 1 |
| Sung, SF | 1 |
| Tong, SH | 1 |
| Ong, CT | 1 |
| Patil, K | 1 |
| Tabibian, JH | 1 |
| Lake, M | 1 |
| Sisson, S | 1 |
| Taylor, JR | 1 |
| Streetman, DS | 1 |
| Castle, SS | 1 |
| Elston, DM | 1 |
| Harding, JJ | 1 |
| van Heyningen, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Multifactorial, Randomized, Double-Blind, Placebo-Controlled Dose-Finding Study of Nifedipine GITS and Candesartan in Combination Compared to Monotherapy in Adult Patients With Essential Hypertension[NCT01303783] | Phase 2 | 1,381 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nifedipine and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Medication bezoars: a literature review and report of a case.
Topics: Aged; Bezoars; Drug-Related Side Effects and Adverse Reactions; Humans; Male; Nifedipine; Risk Facto | 1998 |
2 trials available for nifedipine and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Nifedipine plus candesartan combination increases blood pressure control regardless of race and improves the side effect profile: DISTINCT randomized trial results.
Topics: Administration, Oral; Aged; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Press | 2014 |
Reduction of morning blood pressure surge after treatment with nifedipine GITS at bedtime, but not upon awakening, in essential hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Drug-Related Side Ef | 2009 |
12 other studies available for nifedipine and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
[Adverse effects and hemodynamic effects of nifedipine as a tocolytic].
Topics: Blood Pressure; Drug-Related Side Effects and Adverse Reactions; Female; Heart Rate; Heart Rate, Fet | 2015 |
Cardiac tissue slices with prolonged survival for in vitro drug safety screening.
Topics: 4-Aminopyridine; Action Potentials; Animal Testing Alternatives; Animals; Animals, Laboratory; Anti- | 2012 |
Multiple cerebral infarctions related to famotidine-induced eosinophilia.
Topics: Acarbose; Adrenergic alpha-1 Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulc | 2012 |
Nifedipine XL-induced dysuria.
Topics: Adult; Calcium Channel Blockers; Delayed-Action Preparations; Diagnosis, Differential; Drug-Related | 2012 |
Photo quiz. Drug-induced pemphigus foliaceus.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Stero | 2000 |
Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide.
Topics: Aged; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Cataract; Cyclopenthiazide; Diureti | 1988 |