Page last updated: 2024-11-01

nifedipine and Drug Overdose

nifedipine has been researched along with Drug Overdose in 19 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"Glucagon has been used to treat the hypotension associated with calcium channel antagonist poisoning in adult patients."7.69The use of glucagon in nifedipine poisoning complicated by clonidine ingestion. ( Fant, JS; Fiser, RT; James, LP; Kearns, GL, 1997)
"A 60-year-old man receiving nifedipine was admitted in a comatose condition 3 h after ingesting 5,000 mg of eperisone and 2."3.76A case of torsades de pointes induced by severe QT prolongation after an overdose of eperisone and triazolam in a patient receiving nifedipine. ( Amino, M; Inokuchi, S; Morita, S; Saito, T; Yamagiwa, T; Yamamoto, R, 2010)
"A 37-year-old woman presented with persistent hypotension and noncardiogenic pulmonary edema after massive nifedipine overdose."3.71Continuous calcium chloride infusion for massive nifedipine overdose. ( Lam, YM; Lau, CP; Tse, HF, 2001)
"In a patient with hepatic failure of middle grade diltiazem at standard therapeutic dosis for unstable angina caused collateral fuss on atrioventricular conduction."3.69[Overdosing on diltiazem in heptic insufficiency]. ( Falsini, G; Grazzini, M; Palmerini, L; Rossini, D, 1995)
"Glucagon has been used to treat the hypotension associated with calcium channel antagonist poisoning in adult patients."3.69The use of glucagon in nifedipine poisoning complicated by clonidine ingestion. ( Fant, JS; Fiser, RT; James, LP; Kearns, GL, 1997)
"Hypotension, sinus node suppression, and dysrhythmias often occur with calcium channel blocker overdoses, but atrioventricular nodal block occurs more often with verapamil (chi 2 test, P < ."3.68A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment. ( Borys, D; Ramoska, EA; Spiller, HA; Winter, M, 1993)
"Cardiogenic shock was induced by administering a nifedipine (NP) infusion of 0."1.36Addition of phenylephrine to high-dose insulin in dihydropyridine overdose does not improve outcome. ( Anderson, CP; Cole, JB; Engebretsen, KM; Holger, JS; Morgan, MW; Stellpflug, SJ, 2010)
"An incident is reported in which 2 intravenous drug abusers died as the result of uncontrolled experimentation with intravenous injection of the common anti-hypertensive and anti-anginal drug Nifedipine (Adalat t."1.28Two deaths from intravenous nifedipine abuse. ( Busuttil, A; Fernando, GC; Purdue, BN, 1991)
" At severely toxic levels when arterial blood pressure fell by 50%, all three drugs decreased cardiac output."1.28Effects of calcium channel blocker overdose-induced toxicity in the conscious dog. ( Gambone, LM; Schoffstall, JM; Shaw, RP; Sit, SP; Spivey, WH, 1991)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (63.16)18.2507
2000's4 (21.05)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eren Cevik, S1
Tasyurek, T1
Guneysel, O1
Yamagiwa, T1
Amino, M1
Morita, S1
Yamamoto, R1
Saito, T1
Inokuchi, S1
Engebretsen, KM1
Morgan, MW1
Stellpflug, SJ1
Cole, JB1
Anderson, CP1
Holger, JS1
Wells, CD1
Luckritz, TC1
Rady, MY1
Zornik, JM1
Leighton, JA1
Patel, BM1
Miller, MA1
Masneri, DA1
Herold, T1
Pfaender, M1
Casetti, PG1
Azzolini, M1
Baldi, ML1
Valli, A1
Lip, GY1
Ferner, RE2
Rossini, D1
Falsini, G1
Palmerini, L1
Grazzini, M1
Antón Aranda, E1
Martí Cabane, J1
Utrilla Mínguez, R1
Mehd, US1
Nanavati, PR1
Ravichandran, P1
Ramoska, EA1
Spiller, HA1
Winter, M1
Borys, D1
Backlin, SA1
Haddad, LM1
Fant, JS1
James, LP1
Fiser, RT1
Kearns, GL2
Lam, YM1
Tse, HF1
Lau, CP1
Purdue, BN1
Fernando, GC1
Busuttil, A1
Schoffstall, JM1
Spivey, WH1
Gambone, LM1
Shaw, RP1
Sit, SP1
Monkman, S1
Riley, J1
Cholerton, S1
Idle, JR1
Bateman, DN1
Wells, TG1
Graham, CJ1
Moss, MM1

Reviews

1 review available for nifedipine and Drug Overdose

ArticleYear
Poisoning with anti-hypertensive drugs: calcium antagonists.
    Journal of human hypertension, 1995, Volume: 9, Issue:3

    Topics: Age Factors; Antihypertensive Agents; Calcium; Diltiazem; Drug Overdose; Humans; Hypertension; Nifed

1995

Other Studies

18 other studies available for nifedipine and Drug Overdose

ArticleYear
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
    The American journal of emergency medicine, 2014, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Ov

2014
A case of torsades de pointes induced by severe QT prolongation after an overdose of eperisone and triazolam in a patient receiving nifedipine.
    Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:2

    Topics: Anti-Anxiety Agents; Calcium Channel Blockers; Coma; Drug Interactions; Drug Overdose; Electrocardio

2010
Addition of phenylephrine to high-dose insulin in dihydropyridine overdose does not improve outcome.
    Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:8

    Topics: Animals; Calcium Channel Blockers; Drug Overdose; Hemodynamics; Insulin; Nifedipine; Phenylephrine;

2010
Bezoar formation requiring endoscopic removal after intentional overdose of extended-release nifedipine.
    Pharmacotherapy, 2006, Volume: 26, Issue:12

    Topics: Anticholesteremic Agents; Antidepressive Agents; Atorvastatin; Bezoars; Calcium Channel Blockers; Cy

2006
Delayed clinical decompensation and death after pediatric nifedipine overdose.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:2

    Topics: Calcium Channel Blockers; Child, Preschool; Drug Overdose; Fatal Outcome; Heart Failure; Humans; Mal

2007
Successful treatment of a massive atenolol and nifedipine overdose with CVVHDF.
    Minerva anestesiologica, 2008, Volume: 74, Issue:3

    Topics: Atenolol; Drug Overdose; Female; Hemodiafiltration; Humans; Middle Aged; Nifedipine; Remission Induc

2008
[Overdosing on diltiazem in heptic insufficiency].
    La Clinica terapeutica, 1995, Volume: 146, Issue:4

    Topics: Angina, Unstable; Diltiazem; Dose-Response Relationship, Drug; Drug Overdose; Electrocardiography, A

1995
[Doppler ultrasound in the diagnosis of ergotism].
    Neurologia (Barcelona, Spain), 1994, Volume: 9, Issue:5

    Topics: Administration, Rectal; Adult; Cerebral Arteries; Drug Overdose; Ergotamine; Ergotism; Female; Heada

1994
Nifedipine overdose in a 70 year old man.
    The Journal of the Association of Physicians of India, 1993, Volume: 41, Issue:9

    Topics: Aged; Bradycardia; Drug Overdose; Humans; Hypertension; Hypotension; Male; Nifedipine; Pulmonary Ede

1993
A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment.
    Annals of emergency medicine, 1993, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atropine; Calcium; Calcium Channel Blockers; Child; C

1993
Decongestant-induced hypertensive crisis.
    Canadian family physician Medecin de famille canadien, 1993, Volume: 39

    Topics: Adult; Charcoal; Chlorpheniramine; Drug Overdose; Drug Therapy, Combination; Emergency Medicine; Fem

1993
Resuscitation after nifedipine overdose exclusively with intravenous calcium chloride.
    The American journal of emergency medicine, 1996, Volume: 14, Issue:6

    Topics: Adult; Antidotes; Calcium Channel Blockers; Calcium Chloride; Drug Overdose; Emergencies; Female; Hu

1996
The use of glucagon in nifedipine poisoning complicated by clonidine ingestion.
    Pediatric emergency care, 1997, Volume: 13, Issue:6

    Topics: Adolescent; Antidotes; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Drug Interactio

1997
Continuous calcium chloride infusion for massive nifedipine overdose.
    Chest, 2001, Volume: 119, Issue:4

    Topics: Adult; Calcium; Calcium Channel Blockers; Calcium Chloride; Drug Overdose; Female; Humans; Hypotensi

2001
Two deaths from intravenous nifedipine abuse.
    International journal of legal medicine, 1991, Volume: 104, Issue:5

    Topics: Adult; Autopsy; Cardiopulmonary Resuscitation; Chromatography, Gas; Drug Overdose; Forensic Medicine

1991
Effects of calcium channel blocker overdose-induced toxicity in the conscious dog.
    Annals of emergency medicine, 1991, Volume: 20, Issue:10

    Topics: Animals; Coronary Circulation; Diltiazem; Dogs; Drug Overdose; Female; Hemodynamics; Infusions, Intr

1991
Pharmacokinetics and toxic effects of nifedipine in massive overdose.
    Human & experimental toxicology, 1990, Volume: 9, Issue:5

    Topics: Drug Overdose; Half-Life; Humans; Male; Middle Aged; Nifedipine

1990
Nifedipine poisoning in a child.
    Pediatrics, 1990, Volume: 86, Issue:1

    Topics: Blindness; Combined Modality Therapy; Drug Overdose; Emergencies; Female; Heart Block; Hemodynamics;

1990