nifedipine has been researched along with Down Syndrome in 1 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nifedipine effect was age related." | 1.28 | Long-term hemodynamic effects of nifedipine on congenital heart disease with Eisenmenger's mechanism in children. ( Schlemmer, M; Wimmer, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wimmer, M | 1 |
| Schlemmer, M | 1 |
1 other study available for nifedipine and Down Syndrome
| Article | Year |
|---|---|
Long-term hemodynamic effects of nifedipine on congenital heart disease with Eisenmenger's mechanism in children.
Topics: Child; Child, Preschool; Down Syndrome; Eisenmenger Complex; Heart Septal Defects; Hemodynamics; Hum | 1992 |