nifedipine has been researched along with Colorectal Neoplasms in 6 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We show that nifedipine (NIFE), a calcium channel blocker, inhibits calcium influx to impair nuclear factor of activated T cell 2 (NFAT2) dephosphorylation, activation, and nuclear translocation, thus preventing transcriptional activation of downstream signaling molecules to suppress colorectal cancer (CRC) proliferation and metastasis." | 7.96 | Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation. ( Chen, Z; Ding, Y; Li, K; Lian, W; Liao, Q; Lin, C; Lin, W; Tang, L; Wang, H; Wu, L; Xu, L; Zhao, L; Zhou, R, 2020) |
| " Dosing 3 mg/kg/d cediranib for 4 days induced a marked hypertension of 35 to 50 mmHg." | 5.35 | Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy. ( Curwen, JO; Kendrew, J; Musgrove, HL; Ogilvie, DJ; Richmond, GH; Wedge, SR, 2008) |
| " We show that nifedipine (NIFE), a calcium channel blocker, inhibits calcium influx to impair nuclear factor of activated T cell 2 (NFAT2) dephosphorylation, activation, and nuclear translocation, thus preventing transcriptional activation of downstream signaling molecules to suppress colorectal cancer (CRC) proliferation and metastasis." | 3.96 | Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation. ( Chen, Z; Ding, Y; Li, K; Lian, W; Liao, Q; Lin, C; Lin, W; Tang, L; Wang, H; Wu, L; Xu, L; Zhao, L; Zhou, R, 2020) |
| "One of the most common signs of breast tumors is the presence of small deposits of calcium, known as microcalcifications." | 1.56 | Calcium signaling affects migration and proliferation differently in individual cancer cells due to nifedipine treatment. ( Babula, P; Chovancova, B; Durinikova, E; Hudecova, S; Krizanova, O; Liskova, V; Matuskova, M; Miklikova, S; Novakova, M; Penesova, A; Sevcikova, A, 2020) |
| " Dosing 3 mg/kg/d cediranib for 4 days induced a marked hypertension of 35 to 50 mmHg." | 1.35 | Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy. ( Curwen, JO; Kendrew, J; Musgrove, HL; Ogilvie, DJ; Richmond, GH; Wedge, SR, 2008) |
| "Celecoxib was the most effective anti-proliferative agent, and increased the G0/G1 phase proportion in the cell cycle after treatment more significantly than the other agents in all cell lines." | 1.32 | Comparison of the anti-proliferation and apoptosis-induction activities of sulindac, celecoxib, curcumin, and nifedipine in mismatch repair-deficient cell lines. ( Lin, YS; Tsao, PN; Wei, SC; Wong, JM; Wu, CH; Wu-Tsai, JJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chovancova, B | 1 |
| Liskova, V | 1 |
| Miklikova, S | 1 |
| Hudecova, S | 1 |
| Babula, P | 1 |
| Penesova, A | 1 |
| Sevcikova, A | 1 |
| Durinikova, E | 1 |
| Novakova, M | 1 |
| Matuskova, M | 1 |
| Krizanova, O | 1 |
| Wu, L | 1 |
| Lin, W | 1 |
| Liao, Q | 1 |
| Wang, H | 1 |
| Lin, C | 1 |
| Tang, L | 1 |
| Lian, W | 1 |
| Chen, Z | 1 |
| Li, K | 1 |
| Xu, L | 1 |
| Zhou, R | 1 |
| Ding, Y | 1 |
| Zhao, L | 1 |
| Martínez, C | 1 |
| García-Martín, E | 1 |
| Pizarro, RM | 1 |
| García-Gamito, FJ | 1 |
| Agúndez, JA | 1 |
| Wei, SC | 1 |
| Lin, YS | 1 |
| Tsao, PN | 1 |
| Wu-Tsai, JJ | 1 |
| Wu, CH | 1 |
| Wong, JM | 1 |
| Curwen, JO | 1 |
| Musgrove, HL | 1 |
| Kendrew, J | 1 |
| Richmond, GH | 1 |
| Ogilvie, DJ | 1 |
| Wedge, SR | 1 |
| Liepkalns, V | 1 |
| Durand, H | 1 |
| Bougeret, C | 1 |
6 other studies available for nifedipine and Colorectal Neoplasms
| Article | Year |
|---|---|
Calcium signaling affects migration and proliferation differently in individual cancer cells due to nifedipine treatment.
Topics: Antineoplastic Agents, Immunological; Apoptosis; Breast Neoplasms; Calcium Channel Blockers; Calcium | 2020 |
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Topics: Calcium Channel Blockers; Colorectal Neoplasms; Disease Progression; Humans; NFATC Transcription Fac | 2020 |
Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy.
Topics: Aged; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Colon; Colorectal Neoplasms; | 2002 |
Comparison of the anti-proliferation and apoptosis-induction activities of sulindac, celecoxib, curcumin, and nifedipine in mismatch repair-deficient cell lines.
Topics: Antineoplastic Agents; Apoptosis; Celecoxib; Cell Cycle; Cell Line, Tumor; Chemoprevention; Colorect | 2004 |
Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy.
Topics: Angiogenesis Inhibitors; Animals; Antihypertensive Agents; Antineoplastic Agents; Blood Pressure; Ca | 2008 |
Cell signalling associated with fibrinolytic ligand binding to human colorectal carcinoma cells.
Topics: Cell Communication; Colorectal Neoplasms; Egtazic Acid; Fibrinolysin; Fibrinolysis; Humans; Inositol | 1991 |