nifedipine and Chronic Illness studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Research Excerpts

Excerpt	Relevance	Reference
"Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial."	9.22	Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial. ( Bor, JH; Lagro-Janssen, AL; Smits, P; Souwer, IH, 2016)
"Our study clearly demonstrates that the therapeutic use of topical nifedipine and lidocaine ointment should be extended to the conservative treatment of chronic anal fissure."	9.10	Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. ( Antropoli, C; Antropoli, M; Attena, F; Balzano, A; Bove, A; De Stefano, G; Molino, D; Perrotti, P, 2002)
"This double-blind study compared the efficacy and safety of once daily amlodipine (5-10 mg/day) vs twice daily nifedipine (40-80 mg/day) in 244 patients with chronic stable angina pectoris."	9.09	[Amlodipine versus nifedipine retard. A randomized double-blind comparative study on long-term efficacy and safety of amlodipine and nifedipine retard in the monotherapy of chronic stable angina pectoris]. ( Kupper, W; Sauerbrey-Wullkopf, N, 2001)
"We investigated the efficacy of nilvadipine, a calcium channel inhibitor, for psychiatric symptoms and tardive dyskinesia in 30 patients with chronic schizophrenia in a placebo-controlled double-blind crossover study."	9.08	Nilvadipine is effective for chronic schizophrenia in a double-blind placebo-controlled study. off. ( Asai, M; Ashikari, I; Kanba, S; Ohnishi, K; Yagi, G; Yamada, K, 1996)
"Because blood viscosity is significantly raised in patients with essential hypertension (EH), the hemorheological effects of a 4-month chronic treatment with the calcium antagonist nilvadipine (FK 235, 5-isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4- (m-nitrophenyl)-3,5-pyridinedicarboxylate, CAS 75530-68-6) on elevated blood viscosity was investigated prospectively in patients with EH, and compared with those in normotensive individuals of similar age."	9.08	Chronic hemorheological effects of the calcium antagonist nilvadipine in essential hypertension. ( Izumi, Y; Kitadai, M; Satoh, K; Takahashi, T; Tsuda, Y, 1997)
"Compared with placebo, adding betaxolol 20 mg every day to nifedipine (up to 60 mg/day in divided doses) or diltiazem (up to 360 mg/day in divided doses) for a 3-week treatment period in 135 patients with stable angina pectoris significantly (p < 0."	9.07	Safety and compatibility of betaxolol hydrochloride combined with diltiazem or nifedipine therapy in stable angina pectoris. ( Friedman, R; Glasser, SP; Smith, LK; Talibi, T; Weir, EK, 1994)
"In a double blind crossed ten-week study with a randomized beginning the authors compared in 25 patients with chronic stable angina pectoris (II-III according to NYHA classification) and with normal blood pressure the effect of placebo, nifedipine, diltiazem and in 16 of the patients (who completed treatment with the combined drugs) also a combination of nifedipine and diltiazem."	9.06	[Effectiveness of nifedipine, diltiazem and their combination in the treatment of chronic stable angina pectoris]. ( Koukalová, H; Lupínek, Z; Meluzín, J, 1990)
"We performed a prospective, randomized, double-blind, crossover study to compare the efficacy and safety of vasodilation with the calcium entry blocker nifedipine with that of isosorbide dinitrate (ISDN) and their combination as treatment for heart failure."	9.06	A prospective, randomized, double-blind, crossover study to compare the efficacy and safety of chronic nifedipine therapy with that of isosorbide dinitrate and their combination in the treatment of chronic congestive heart failure. ( Amin, J; Elkayam, U; Mehra, A; Rahimtoola, SH; Vasquez, J; Weber, L, 1990)
"The efficacy of nifedipine, a calcium channel antagonist, in the treatment of chronic idiopathic urticaria, was evaluated in a double-blinded, placebo-controlled, crossover trial."	9.06	Therapy of chronic idiopathic urticaria with nifedipine: demonstration of beneficial effect in a double-blinded, placebo-controlled, crossover trial. ( Bressler, RB; Huston, DP; Sowell, K, 1989)
"18 patients with II NYHA class chronic congestive heart failure (CCHF) had been given nifedipine (Cordipin) 54."	9.06	[Evaluation of the effect of nifedipine in patients with chronic congestive heart failure]. ( Bechler-Lisińska, J; Broks-Bratkowska, B; Cholewa, M; Dryjański, T; Gawor, Z; Górski, L; Markiewicz, K, 1989)
"This study evaluated the safety, antianginal and antiischemic effects of amlodipine, a dihydropyridine calcium antagonist, in patients with chronic stable angina pectoris."	9.06	Clinical safety and efficacy of once-a-day amlodipine for chronic stable angina pectoris. ( Glasser, SP; West, TW, 1988)
"The effect on bronchial smooth muscle of slow release theophylline plus placebo and theophylline plus slow release nifedipine administered for a prolonged period to 12 asthmatic and hypertensive patients has been studied."	9.06	Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma. ( Lombardi, C; Spedini, C, 1986)
"Calcium-channel blockers such as verapamil and nifedipine have been shown to inhibit exercise-induced asthma as well as acutely induced bronchoconstriction, but little is known of their chronic effects, if any, on bronchial asthma."	9.05	Nifedipine in chronic bronchial asthma: a randomized double-blind crossover trial against placebo. ( Boismare, F; Lemercier, JP; Leprevost, A; Moore, ND; Ozenne, G; Pasquis, P; Tardif, C, 1985)
"Nifedipine, as most calcium-antagonist drugs, is widely used for the treatment of angina pectoris and primary hypertension."	8.80	[Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report]. ( Luca, S; Romeo, S, 1999)
"5% nifedipine ointment, used as an agent in chemical sphincterotomy, appears to offer a significant healing rate for acute anal fissure and might prevent its evolution to chronicity."	7.73	Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity. ( Beltsis, A; Chatzimavroudis, G; Katsinelos, P; Katsinelos, T; Kountouras, J; Papaziogas, B; Paroutoglou, G; Zavos, C, 2006)
"The purpose of this study was to demonstrate the effect of oral nifedipine on maximal resting anal pressure (MRAP) in healthy volunteers and to evaluate its role in the treatment of chronic anal fissure (CAF)."	7.72	Oral nifedipine in the treatment of chronic anal fissure. ( Ağaoğlu, N; Arslan, MK; Cengiz, S; Türkyilmaz, S, 2003)
"Anal manometry was performed on eight healthy volunteers and 15 patients with chronic anal fissure before and after oral administration of nifedipine 20 mg."	7.70	Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. ( Cook, TA; Humphreys, MM; McC Mortensen, NJ, 1999)
"In order to clarify a possible pathophysiological role of medullasin, a neutrophil elastase-like proteinase, in nifedipine (NF)-induced gingival overgrowth, the distributions of medullasin-positive cells immunostained in specimens from patients with NF-induced gingival overgrowth and chronic marginal gingivitis were compared in three different biopsy areas."	7.69	Possible roles of medullasin in nifedipine-induced human gingival overgrowth. ( Aoki, Y; Kato, I; Kunimatsu, K; Ozaki, Y, 1996)
"To investigate the effect of 7 to 14 days of therapy with nifedipine (sustained-release preparation) on the 24-hour blood pressure patterns of pregnant women with pre-eclampsia or chronic hypertension, and to test the utility of blood pressure monitoring in modulating the timing and dosage of the drug."	7.69	24-hour blood pressure monitoring to evaluate the effects of nifedipine in pre-eclampsia and in chronic hypertension in pregnancy. ( Benedetto, C; Carandente, F; Chiarolini, L; Giarola, M; Maulà, V; Zonca, M, 1997)
"We have confirmed the usefulness of nifedipine in the treatment of pain present in lesions of multiple skin leiomyomata."	7.69	Pain in multiple leiomyomas alleviated by nifedipine. ( Chandi, SM; George, S; Jacob, M; Pulimood, S, 1997)
" This study evaluated the influence of aging, superimposed chronic hypertension on aging, and treatment with nifedipine on cardiac myosin isozyme proportions."	7.68	Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine. ( Blomquist, TM; Minser, R; Pathak, D; Raizada, V; Woodfin, B, 1993)
"The effect of nilvadipine, a newly developed calcium antagonist, on regional cerebral blood flow (rCBF) was investigated in 7 patients with chronic cerebral infarction."	7.68	Effect of single oral administration of nilvadipine on cerebral blood flow in chronic cerebral infarction. ( Bokura, K; Kobayashi, S; Murao, M; Okada, K; Suyama, N; Tsunematsu, T; Yamaguchi, S, 1992)
"The effect of 2-month treatment with isosorbide dinitrate (120 mg day-1), nifedipine (2 x 20 mg day-1) and their combination has been assessed in 16 patients with mild to moderate chronic cardiac failure."	7.68	Long-term effect of isosorbide dinitrate and nifedipine, singly and in association, in patients with chronic heart failure. ( Feuereisl, R; Jezek, V; Jezková, J; Michaljanic, A; Niederle, P, 1990)
"The acute hemodynamic response to a single oral dose of nitrendipine (10-20 mg) was evaluated in eight subjects with severe chronic congestive heart failure during right heart catheterization."	7.67	Acute hemodynamic effects of nitrendipine in chronic congestive heart failure. ( Cohn, JN; Levine, TB; Olivari, MT, 1984)
"The hemodynamic effects of 20 to 40 mg of oral nifedipine were compared with those of intravenous nitroprusside in 11 patients with severe chronic congestive heart failure (CHF)."	7.67	Comparison of hemodynamic responses to nifedipine and nitroprusside in severe chronic congestive heart failure. ( Elkayam, U; McKay, CR; Rahimtoola, SH; Torkan, B; Weber, L, 1984)
"After 20 mg sublingual nifedipine in 12 men with clinical stable chronic cor pulmonale the mean arterial pressure and systemic vascular resistance fell, cardiac index rose, and mean pulmonary arterial (Ppa) and wedge (Ppaw) pressures, right atrial pressure, and PaO2 remained unchanged."	7.67	Nifedipine in chronic cor pulmonale: acute and relatively long-term effects. ( Ashutosh, K; Dunsky, M; Hill, N; Mookherjee, S; Smulyan, H; Vardan, S; Warner, R, 1988)
"Nine patients with chronic, severe (New York Heart Association class III to IV) congestive heart failure were studied to determine the acute effects of 10 mg of sublingual nifedipine on left ventricular (LV) function."	7.67	Sublingual nifedipine: acute effects in severe chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy. ( Bass, TA; Conetta, DA; Miller, AB, 1985)
" The sublingual adminstration of nifedipine reversed both the acute and the delayed cerebral arterial spasm."	7.66	Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine. ( Allen, GS; Bahr, AL, 1979)
"Nifedipine was applied for the secondary prophylaxis of affective phasic disorders."	6.68	[A trial of the use of nifedipine for preventing relapses in affective and schizoaffective psychoses]. ( Snedkova, LV, 1996)
" To determine the mechanism of action of nifedipine and its dose-response relation, 14 patients with stable angina were treated with nifedipine 10, 20 and 30 mg 4 times daily as single-agent therapy in a double-blind, randomized, placebo-controlled crossover trial."	6.67	Effects of nifedipine on myocardial perfusion during exercise in chronic stable angina pectoris. ( Gervino, E; Jarisch, WR; Rice, KR; Stone, PH, 1990)
" However, 2 h after dosing there was a significant prolongation during stress testing in the time to onset of both 1 mm ST depression on the ECG (by 28%) and to angina (by 37%) compared with atenolol alone, but no benefit was apparent by 12 h after dosing."	6.66	Slow release nifedipine plus atenolol in chronic stable angina pectoris. ( Challenor, VF; George, CF; Renwick, AG; Waller, DG, 1989)
" Treatment was titrated to produce at least a 30% increase in treadmill exercise duration over placebo baseline and then maintained at that dosage for an additional 3 weeks."	6.66	Comparison of atenolol and nifedipine in chronic stable angina pectoris. ( Kostis, JB; Narahara, KA; Shapiro, W; Thandroyen, F; Zohman, LR, 1989)
"This was a nested cohort study of women with chronic hypertension and a singleton pregnancy recruited to the PANDA (Pregnancy And chronic hypertension: NifeDipine vs lAbetalol as antihypertensive treatment) study at one of three UK maternity units."	5.30	Longitudinal changes in vascular function parameters in pregnant women with chronic hypertension and association with adverse outcome: a cohort study. ( Chappell, LC; Cruickshank, JK; Khalil, A; Mills, C; Myers, JE; Nelson-Piercy, C; Seed, PT; Watt-Coote, I; Webster, LM, 2019)
"Nilvadipine is a calcium channel inhibitor used commonly for the treatment of cerebrovascular insufficiency."	5.29	Effectiveness of nilvadipine in two cases of chronic schizophrenia. ( Asai, M; Ashikari, I; Kanba, S; Onishi, K; Yagi, G; Yamada, K, 1995)
"Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial."	5.22	Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial. ( Bor, JH; Lagro-Janssen, AL; Smits, P; Souwer, IH, 2016)
"Our study clearly demonstrates that the therapeutic use of topical nifedipine and lidocaine ointment should be extended to the conservative treatment of chronic anal fissure."	5.10	Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. ( Antropoli, C; Antropoli, M; Attena, F; Balzano, A; Bove, A; De Stefano, G; Molino, D; Perrotti, P, 2002)
"This double-blind study compared the efficacy and safety of once daily amlodipine (5-10 mg/day) vs twice daily nifedipine (40-80 mg/day) in 244 patients with chronic stable angina pectoris."	5.09	[Amlodipine versus nifedipine retard. A randomized double-blind comparative study on long-term efficacy and safety of amlodipine and nifedipine retard in the monotherapy of chronic stable angina pectoris]. ( Kupper, W; Sauerbrey-Wullkopf, N, 2001)
"We examined the antianginal and anti-ischemic effects of oral zatebradine, a direct sinus node inhibitor that has no blood pressure-lowering or negative inotropic effects in patients with chronic stable angina pectoris taking extended-release nifedipine."	5.08	Addition of zatebradine, a direct sinus node inhibitor, provides no greater exercise tolerance benefit in patients with angina taking extended-release nifedipine: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study ( Baiker, WM; Frishman, WH; Pepine, CJ; Weiss, RJ, 1995)
"We investigated the efficacy of nilvadipine, a calcium channel inhibitor, for psychiatric symptoms and tardive dyskinesia in 30 patients with chronic schizophrenia in a placebo-controlled double-blind crossover study."	5.08	Nilvadipine is effective for chronic schizophrenia in a double-blind placebo-controlled study. off. ( Asai, M; Ashikari, I; Kanba, S; Ohnishi, K; Yagi, G; Yamada, K, 1996)
"The safety and tolerability of mibefradil, a selective T-type calcium channel antagonist, were evaluated in 3,430 patients with essential hypertension and chronic stable angina pectoris treated in 15 double-blind placebo and active-controlled clinical trials and 2 open-label, long-term safety studies."	5.08	Safety of mibefradil, a new once-a-day, selective T-type calcium channel antagonist. ( Charlon, V; Kobrin, I; Lindberg, E; Pordy, R, 1997)
"Because blood viscosity is significantly raised in patients with essential hypertension (EH), the hemorheological effects of a 4-month chronic treatment with the calcium antagonist nilvadipine (FK 235, 5-isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4- (m-nitrophenyl)-3,5-pyridinedicarboxylate, CAS 75530-68-6) on elevated blood viscosity was investigated prospectively in patients with EH, and compared with those in normotensive individuals of similar age."	5.08	Chronic hemorheological effects of the calcium antagonist nilvadipine in essential hypertension. ( Izumi, Y; Kitadai, M; Satoh, K; Takahashi, T; Tsuda, Y, 1997)
"Compared with placebo, adding betaxolol 20 mg every day to nifedipine (up to 60 mg/day in divided doses) or diltiazem (up to 360 mg/day in divided doses) for a 3-week treatment period in 135 patients with stable angina pectoris significantly (p < 0."	5.07	Safety and compatibility of betaxolol hydrochloride combined with diltiazem or nifedipine therapy in stable angina pectoris. ( Friedman, R; Glasser, SP; Smith, LK; Talibi, T; Weir, EK, 1994)
"Altogether 12 patients with stable angina pectoris of effort were examined for the efficacy of nicardipine as compared to nifedipine and placebo by means of pharmacodynamic studies using treadmill."	5.06	[The comparative efficacy of nicardipine and nifedipine in stenocardia patients]. ( Martsevich, SIu; Metelitsa, VI; Simkhaev, LS; Slastnikova, ID, 1990)
"Since not all patients tolerate beta-blockers, the efficacy of nifedipine and isosorbide dinitrate was evaluated alone and in combination in patients with stable angina pectoris."	5.06	Nifedipine and isosorbide dinitrate alone and in combination for patients with chronic stable angina: a double-blind crossover study. ( Olson, LC; Vlay, SC, 1990)
"In a double blind crossed ten-week study with a randomized beginning the authors compared in 25 patients with chronic stable angina pectoris (II-III according to NYHA classification) and with normal blood pressure the effect of placebo, nifedipine, diltiazem and in 16 of the patients (who completed treatment with the combined drugs) also a combination of nifedipine and diltiazem."	5.06	[Effectiveness of nifedipine, diltiazem and their combination in the treatment of chronic stable angina pectoris]. ( Koukalová, H; Lupínek, Z; Meluzín, J, 1990)
"We performed a prospective, randomized, double-blind, crossover study to compare the efficacy and safety of vasodilation with the calcium entry blocker nifedipine with that of isosorbide dinitrate (ISDN) and their combination as treatment for heart failure."	5.06	A prospective, randomized, double-blind, crossover study to compare the efficacy and safety of chronic nifedipine therapy with that of isosorbide dinitrate and their combination in the treatment of chronic congestive heart failure. ( Amin, J; Elkayam, U; Mehra, A; Rahimtoola, SH; Vasquez, J; Weber, L, 1990)
"The efficacy of nifedipine, a calcium channel antagonist, in the treatment of chronic idiopathic urticaria, was evaluated in a double-blinded, placebo-controlled, crossover trial."	5.06	Therapy of chronic idiopathic urticaria with nifedipine: demonstration of beneficial effect in a double-blinded, placebo-controlled, crossover trial. ( Bressler, RB; Huston, DP; Sowell, K, 1989)
"18 patients with II NYHA class chronic congestive heart failure (CCHF) had been given nifedipine (Cordipin) 54."	5.06	[Evaluation of the effect of nifedipine in patients with chronic congestive heart failure]. ( Bechler-Lisińska, J; Broks-Bratkowska, B; Cholewa, M; Dryjański, T; Gawor, Z; Górski, L; Markiewicz, K, 1989)
"6 years (range 50 to 75), with stable angina pectoris were administered propranolol until beta blockade was evident."	5.06	Comparative study of the effect of nifedipine versus diltiazem on exercise performance, serum propranolol levels, and ST-segment abnormalities in patients with chronic stable angina taking propranolol. ( Krikler, DM; Krikler, S; Robinson, K, 1989)
"This study evaluated the safety, antianginal and antiischemic effects of amlodipine, a dihydropyridine calcium antagonist, in patients with chronic stable angina pectoris."	5.06	Clinical safety and efficacy of once-a-day amlodipine for chronic stable angina pectoris. ( Glasser, SP; West, TW, 1988)
"The effect on bronchial smooth muscle of slow release theophylline plus placebo and theophylline plus slow release nifedipine administered for a prolonged period to 12 asthmatic and hypertensive patients has been studied."	5.06	Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma. ( Lombardi, C; Spedini, C, 1986)
" The incidence of severe hypertension was significantly lower when nifedipine (odds ratio, 0."	5.05	Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. ( Bellos, I; Daskalakis, G; Loutradis, D; Papapanagiotou, A; Pergialiotis, V, 2020)
"Calcium-channel blockers such as verapamil and nifedipine have been shown to inhibit exercise-induced asthma as well as acutely induced bronchoconstriction, but little is known of their chronic effects, if any, on bronchial asthma."	5.05	Nifedipine in chronic bronchial asthma: a randomized double-blind crossover trial against placebo. ( Boismare, F; Lemercier, JP; Leprevost, A; Moore, ND; Ozenne, G; Pasquis, P; Tardif, C, 1985)
"Nifedipine, as most calcium-antagonist drugs, is widely used for the treatment of angina pectoris and primary hypertension."	4.80	[Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report]. ( Luca, S; Romeo, S, 1999)
" The American College of Obstetricians and Gynecologists recommends that acute-onset, severe hypertension be treated with first line-therapy (intravenous labetalol, intravenous hydralazine or oral nifedipine) within 60 minutes to reduce risk of maternal morbidity and death."	3.96	Identification of factors associated with delayed treatment of obstetric hypertensive emergencies. ( Akerman, MB; Elsayad, A; Halpern, TA; Heiselman, CJ; Heo, HJ; Kantorowska, A; Muscat, JC; Sicuranza, GB; Vintzileos, AM, 2020)
"Labetalol is commonly used for control of hypertension in pregnancy."	3.77	False-positive amphetamine toxicology screen results in three pregnant women using labetalol. ( Wu, D; Yee, LM, 2011)
"From August 1997 to August 2002, patients with chronic anal fissure attending our outpatient clinic were treated with a protocol that included: topical isosorbide dinitrate, 2."	3.73	Long-term results of "chemical sphincterotomy" for chronic anal fissure: a prospective study. ( Goldin, E; Israeli, E; Levy, S; Lysy, J; Rozentzweig, G; Strauss-Liviatan, N, 2006)
"5% nifedipine ointment, used as an agent in chemical sphincterotomy, appears to offer a significant healing rate for acute anal fissure and might prevent its evolution to chronicity."	3.73	Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity. ( Beltsis, A; Chatzimavroudis, G; Katsinelos, P; Katsinelos, T; Kountouras, J; Papaziogas, B; Paroutoglou, G; Zavos, C, 2006)
"The purpose of this study was to demonstrate the effect of oral nifedipine on maximal resting anal pressure (MRAP) in healthy volunteers and to evaluate its role in the treatment of chronic anal fissure (CAF)."	3.72	Oral nifedipine in the treatment of chronic anal fissure. ( Ağaoğlu, N; Arslan, MK; Cengiz, S; Türkyilmaz, S, 2003)
"Anal manometry was performed on eight healthy volunteers and 15 patients with chronic anal fissure before and after oral administration of nifedipine 20 mg."	3.70	Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. ( Cook, TA; Humphreys, MM; McC Mortensen, NJ, 1999)
"The short-term effects of nifedipine on glomerular hemodynamics, sieving function, and renal tubular function were assessed in 10 patients suffering from biopsy-verified chronic glomerulonephritis."	3.69	Contrasting short-term effects of nifedipine on glomerular and tubular functions in glomerulonephritic patients. ( Berg, KJ; Fauchald, P; Hartmann, A; Holdaas, H; Lund, K; Reisaeter, A, 1994)
"In order to clarify a possible pathophysiological role of medullasin, a neutrophil elastase-like proteinase, in nifedipine (NF)-induced gingival overgrowth, the distributions of medullasin-positive cells immunostained in specimens from patients with NF-induced gingival overgrowth and chronic marginal gingivitis were compared in three different biopsy areas."	3.69	Possible roles of medullasin in nifedipine-induced human gingival overgrowth. ( Aoki, Y; Kato, I; Kunimatsu, K; Ozaki, Y, 1996)
"To investigate the effect of 7 to 14 days of therapy with nifedipine (sustained-release preparation) on the 24-hour blood pressure patterns of pregnant women with pre-eclampsia or chronic hypertension, and to test the utility of blood pressure monitoring in modulating the timing and dosage of the drug."	3.69	24-hour blood pressure monitoring to evaluate the effects of nifedipine in pre-eclampsia and in chronic hypertension in pregnancy. ( Benedetto, C; Carandente, F; Chiarolini, L; Giarola, M; Maulà, V; Zonca, M, 1997)
"We have confirmed the usefulness of nifedipine in the treatment of pain present in lesions of multiple skin leiomyomata."	3.69	Pain in multiple leiomyomas alleviated by nifedipine. ( Chandi, SM; George, S; Jacob, M; Pulimood, S, 1997)
" This study evaluated the influence of aging, superimposed chronic hypertension on aging, and treatment with nifedipine on cardiac myosin isozyme proportions."	3.68	Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine. ( Blomquist, TM; Minser, R; Pathak, D; Raizada, V; Woodfin, B, 1993)
"The effect of nilvadipine, a newly developed calcium antagonist, on regional cerebral blood flow (rCBF) was investigated in 7 patients with chronic cerebral infarction."	3.68	Effect of single oral administration of nilvadipine on cerebral blood flow in chronic cerebral infarction. ( Bokura, K; Kobayashi, S; Murao, M; Okada, K; Suyama, N; Tsunematsu, T; Yamaguchi, S, 1992)
"Fourteen normotensive patients with liver disease (6 with cirrhosis and 8 with chronic hepatitis) and 7 healthy volunteers were given a single oral dose of nilvadipine 2 mg."	3.68	Elevated plasma nilvadipine concentration after single and chronic oral administration to patients with chronic liver disease. ( Fujishima, M; Ito, Y; Kikuchi, M; Kobayashi, K; Takata, Y; Tsukashima, A; Ueno, M; Yoshizumi, T, 1992)
"The effect of 2-month treatment with isosorbide dinitrate (120 mg day-1), nifedipine (2 x 20 mg day-1) and their combination has been assessed in 16 patients with mild to moderate chronic cardiac failure."	3.68	Long-term effect of isosorbide dinitrate and nifedipine, singly and in association, in patients with chronic heart failure. ( Feuereisl, R; Jezek, V; Jezková, J; Michaljanic, A; Niederle, P, 1990)
"The acute hemodynamic response to a single oral dose of nitrendipine (10-20 mg) was evaluated in eight subjects with severe chronic congestive heart failure during right heart catheterization."	3.67	Acute hemodynamic effects of nitrendipine in chronic congestive heart failure. ( Cohn, JN; Levine, TB; Olivari, MT, 1984)
"The hemodynamic effects of 20 to 40 mg of oral nifedipine were compared with those of intravenous nitroprusside in 11 patients with severe chronic congestive heart failure (CHF)."	3.67	Comparison of hemodynamic responses to nifedipine and nitroprusside in severe chronic congestive heart failure. ( Elkayam, U; McKay, CR; Rahimtoola, SH; Torkan, B; Weber, L, 1984)
"Catheterization of the pulmonary artery and radiocirculography were used in 30 patients with chronic bronchitis (CB) in order to study changes in hemodynamics induced by intravenous injections of 5 and 10 mg verapamil or by 4-5 weeks of the treatment with finoptin and corinfar."	3.67	[The effect of calcium antagonists on pulmonary hemodynamics in patients with chronic bronchitis with manifest and latent pulmonary hypertension]. ( Volkova, LI, 1989)
"After 20 mg sublingual nifedipine in 12 men with clinical stable chronic cor pulmonale the mean arterial pressure and systemic vascular resistance fell, cardiac index rose, and mean pulmonary arterial (Ppa) and wedge (Ppaw) pressures, right atrial pressure, and PaO2 remained unchanged."	3.67	Nifedipine in chronic cor pulmonale: acute and relatively long-term effects. ( Ashutosh, K; Dunsky, M; Hill, N; Mookherjee, S; Smulyan, H; Vardan, S; Warner, R, 1988)
"Nine patients with chronic, severe (New York Heart Association class III to IV) congestive heart failure were studied to determine the acute effects of 10 mg of sublingual nifedipine on left ventricular (LV) function."	3.67	Sublingual nifedipine: acute effects in severe chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy. ( Bass, TA; Conetta, DA; Miller, AB, 1985)
" The sublingual adminstration of nifedipine reversed both the acute and the delayed cerebral arterial spasm."	3.66	Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine. ( Allen, GS; Bahr, AL, 1979)
"Anal fissure is a tear in the lining of the anal canal distal to the dentate line, which most commonly occurs in the posterior midline."	2.78	Conservative versus surgical treatment for chronic anal idiopathic fissure: a prospective randomized trial. ( Cestaro, G; de Rosa, M; Gentile, M; Massa, S; Vitiello, C, 2013)
"The glycerol ointment was the only treatment statistically better than both 'no treatment' and vehicle."	2.72	Anti-irritants II: Efficacy against cumulative irritation. ( Andersen, F; Andersen, KE; Bindslev-Jensen, C; Fullerton, A; Hedegaard, K; Petersen, TK, 2006)
"Nifedipine gastrointestinal therapeutic system (GITS) is a once-daily formulation of nifedipine that provides stable plasma concentrations over the entire 24 h dosing interval."	2.69	Effectiveness of nifedipine GITS in combination with atenolol in chronic stable angina. ( Baird, MG; Bélanger, L; Erne, P; Klinke, P; Kostuk, WJ; Lotan, C; Marmor, A; Motro, M; Palant, A; Sclarowski, S; Stolero, D; Toal, CB; Turpie, A; Weiss, A; Zilberman, A, 1999)
"The treatment with nifedipine GITS 30-60 mg/day (monotherapy or combination) lasted for 6 months."	2.69	[Treatment of chronic stable angina: follow-up study with nifedipine gastrointestinal therapeutic system. SENIOR Study Group]. ( de Lombera Romero, F; Fuertes García, A; González Juanatey, JR; Luengo Fernández, E; Palencia Pérez, MA; Sagués Cabarro, F; Vargas García, R; Wilke Delgado, M, 2000)
"Nifedipine was applied for the secondary prophylaxis of affective phasic disorders."	2.68	[A trial of the use of nifedipine for preventing relapses in affective and schizoaffective psychoses]. ( Snedkova, LV, 1996)
" After a 4 week run-in period on atenolol, patients were randomly allocated to receive either atenolol alone or its combination with nifedipine and then crossed over to the alternative treatment for a further 4 weeks."	2.67	Comparison of the efficacy of atenolol and its combination with slow-release nifedipine in chronic stable angina. ( Adnams, C; Commerford, P; Meyer, TE, 1993)
"The efficacy of amlodipine, a long half-life dihydropyridine calcium antagonist, at the dosage of 5-10 mg/day in a single daily administration, has been compared with that of nifedipine R, a short half-life dihydropyridine, at the dosage of 20-40 mg b."	2.67	Amlodipine versus nifedipine retard in the treatment of chronic ischemic heart disease. ( Cardillo, R; Castelli, D; Circo, A; Mangiameli, S; Platania, F; Scaccianoce, G, 1992)
"Carvedilol 25 mg b."	2.67	Treatment of chronic stable angina with carvedilol in comparison with nifedipine s.r. ( Derr, I; Eberhardt, R; Ehmer, B; Rudorf, J; Uberbacher, HJ; van der Does, R, 1991)
" To determine the mechanism of action of nifedipine and its dose-response relation, 14 patients with stable angina were treated with nifedipine 10, 20 and 30 mg 4 times daily as single-agent therapy in a double-blind, randomized, placebo-controlled crossover trial."	2.67	Effects of nifedipine on myocardial perfusion during exercise in chronic stable angina pectoris. ( Gervino, E; Jarisch, WR; Rice, KR; Stone, PH, 1990)
" However, 2 h after dosing there was a significant prolongation during stress testing in the time to onset of both 1 mm ST depression on the ECG (by 28%) and to angina (by 37%) compared with atenolol alone, but no benefit was apparent by 12 h after dosing."	2.66	Slow release nifedipine plus atenolol in chronic stable angina pectoris. ( Challenor, VF; George, CF; Renwick, AG; Waller, DG, 1989)
" Treatment was titrated to produce at least a 30% increase in treadmill exercise duration over placebo baseline and then maintained at that dosage for an additional 3 weeks."	2.66	Comparison of atenolol and nifedipine in chronic stable angina pectoris. ( Kostis, JB; Narahara, KA; Shapiro, W; Thandroyen, F; Zohman, LR, 1989)
"A double-blind, placebo-controlled study was performed to assess whether a new calcium antagonist, nisoldipine, in doses of either 5 mg or 10 mg daily, in combination with beta-adrenergic-blocking drugs (combination therapy) was more effective than beta-adrenergic-blocking drugs alone (single therapy) in the treatment of chronic stable angina."	2.66	Efficacy of nisoldipine combined with beta-adrenergic-blocking drugs in the treatment of chronic stable angina. ( Banim, SO; Creamer, JE; O'Keefe, JC, 1987)
" Nifedipine pharmacokinetics after a single oral dose and sustained dosing (three times daily for five days) were not significantly different."	2.66	Haemodynamic effects of combined oral nifedipine and sublingual nitroglycerin in patients with chronic stable angina. ( Boje, KM; Fung, HL; Parker, JO; Yoshitomi, K, 1987)
"Nisoldipine is an effective antianginal agent which performs well in comparison to nifedipine."	2.66	Comparative antianginal effects of nisoldipine and nifedipine in patients with chronic stable angina. ( Chaitman, BR; Crean, PA; Lam, J; Waters, DD, 1987)
" The absence of reflex tachycardia found in previous chronic oral dosing studies with this drug appears to take some days to develop in humans."	2.66	PY 108-068--acute effects of a single oral dose in chronic stable angina. ( de Buitleir, M; Krikler, DM; Krikler, S, 1986)
" In this dosage nifedipine did not show any significant change in exercise duration and the variables obtained using computer assisted exercise testing when compared to placebo."	2.65	Evaluation of verapamil and high dose nifedipine in patients with chronic stable angina with objective methods. ( Bowles, MJ; Davies, AB; Khurmi, NS; Raftery, EB; Subramanian, VB, 1984)
"Pregnancy-induced hypertension is a major cause of maternal and fetal morbidity and mortality."	2.61	Hypertension and Pregnancy: Management and Future Risks. ( Jim, B; Reddy, S, 2019)
"Anal fissure is a common disorder that is effectively treated and prevented with conservative measures in its acute form, whereas chronic fissures may require medical or surgical therapy."	2.46	Anal fissure. ( Herzig, DO; Lu, KC, 2010)
"Anal fissure is a common disorder which may cause symptoms at any age."	2.43	Chemical sphincterotomy--first line of treatment for chronic anal fissure. ( Baten, MA; Chowdhury, RA; Haq, Z; Khatun, M; Rahman, M, 2005)
"Autonomic dysreflexia is a hypertensive clinical emergency for persons with spinal cord injury at T-6 level or above."	1.35	Recurrent autonomic dysreflexia due to chronic aortic dissection in an adult male with cervical spinal cord injury. ( Hughes, PL; Oo, T; Soni, BM; Vaidyanathan, S, 2008)
"Nifedipine-treated animals displayed hemodynamics, LV dilatation, hypertrophy, and loss of function similar to those of the untreated group."	1.35	Comparative study of vasodilators in an animal model of chronic volume overload caused by severe aortic regurgitation. ( Arsenault, M; Beaudoin, J; Champetier, S; Couet, J; Lachance, D; Plante, E; Roussel, E, 2009)
"Edema was assessed plethysmometrically by evaluating paw volume changes."	1.34	Adrenalectomy potentiates the anti-inflammatory activity of a calcium channel blocker. ( Banerjee, A; Nivsarkar, M; Vaghasiya, R, 2007)
" We report two cases that developed cerebrovascular and cardiovascular adverse events associated with aggressive treatment of increased blood pressure by the use of sublingual nifedipine capsule."	1.32	Adverse events associated with aggressive treatment of increased blood pressure. ( Akay, S; Ayrik, C; Cevik, AA; Yanturali, S, 2004)
"Postmortem examination confirmed congestive heart failure with chronic, fibrosing cardiomyopathy similar to that in other gorillas."	1.30	Chronic hypertension with subsequent congestive heart failure in a western lowland gorilla (Gorilla gorilla gorilla). ( Barnhart, JS; Bell, MD; Miller, CL; Schwartz, AM, 1999)
"The effect on myocardial function and structure of long-term administration of quinapril (10-20 mg daily), an angiotensin-converting-enzyme (ACE) inhibitor, was investigated in 24 patients (18 men, 6 women; mean age 48 [20-65] years) with chronic isolated asymptomatic aortic or mitral regurgitation."	1.29	[Long-term treatment with quinapril in chronic aortic and mitral insufficiency]. ( Schömig, A; Schön, HR, 1995)
"Nilvadipine is a calcium channel inhibitor used commonly for the treatment of cerebrovascular insufficiency."	1.29	Effectiveness of nilvadipine in two cases of chronic schizophrenia. ( Asai, M; Ashikari, I; Kanba, S; Onishi, K; Yagi, G; Yamada, K, 1995)
" The time to Cmax was not significantly different in the two groups."	1.27	Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency. ( Burkholder, DE; Krol, GJ; Lasseter, KC; Murdoch, AA; Shamblen, EC; Taylor, RJ; Vanov, SK, 1984)
"8 cases of vasogenic facial pain are presented with delineation of differentiating clinical features."	1.27	Vasogenic facial pain (cluster headache). ( Eversole, LR; Stone, CE, 1987)
" There was a fourfold increase in the elimination half-life (434 +/- 74 minutes in the cirrhotics compared with 102 +/- 11 minutes in the healthy subjects)."	1.27	Pharmacokinetics of nifedipine after oral administration in chronic liver disease. ( Ene, MD; Roberts, CJ, 1987)

Research

Studies (204)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Left Ventricular Ejection Fraction

Timeframe	Studies, this research(%)	All Research%
pre-1990	88 (43.14)	18.7374
1990's	73 (35.78)	18.2507
2000's	29 (14.22)	29.6817
2010's	11 (5.39)	24.3611
2020's	3 (1.47)	2.80

Authors	Studies
Sierra-Arango, F	1
de la Hoz-Valle, J	1
Espinosa, JP	1
Moreno-Montoya, J	1
Vásquez Roldan, M	1
Pérez-Riveros, ED	1
Kantorowska, A	1
Heiselman, CJ	1
Halpern, TA	1
Akerman, MB	1
Elsayad, A	1
Muscat, JC	1
Sicuranza, GB	1
Vintzileos, AM	1
Heo, HJ	1
Bellos, I	1
Pergialiotis, V	1
Papapanagiotou, A	1
Loutradis, D	1
Daskalakis, G	1
Webster, LM	1
Myers, JE	2
Nelson-Piercy, C	1
Mills, C	1
Watt-Coote, I	1
Khalil, A	1
Seed, PT	1
Cruickshank, JK	1
Chappell, LC	1
Shawkat, E	1
Mistry, H	1
Chmiel, C	1
Webster, L	1
Chappell, L	1
Johnstone, ED	1
Reddy, S	1
Jim, B	1
de Rosa, M	1
Cestaro, G	1
Vitiello, C	1
Massa, S	1
Gentile, M	1
Maimaitiyimin, D	1
Tao, Y	1
Shi, W	1
Upur, H	1
Aikemu, A	1
Olson-Chen, C	1
Seligman, NS	1
Sbaraglini, ML	1
Bellera, CL	1
Fraccaroli, L	1
Larocca, L	1
Carrillo, C	1
Talevi, A	1
Alba Soto, CD	1
Souwer, IH	1
Bor, JH	1
Smits, P	1
Lagro-Janssen, AL	1
Vaidyanathan, S	1
Hughes, PL	1
Oo, T	1
Soni, BM	1
Medhi, B	1
Rao, RS	1
Prakash, A	1
Prakash, O	1
Kaman, L	1
Pandhi, P	1
Plante, E	1
Lachance, D	1
Beaudoin, J	1
Champetier, S	1
Roussel, E	1
Arsenault, M	1
Couet, J	1
Herzig, DO	1
Lu, KC	1
Ishii, T	1
Kawamura, T	1
Tsuboi, N	1
Hosoya, T	1
Yee, LM	1
Wu, D	1
Maschio, G	1
Marcantoni, C	1
Bernich, P	1
Perrotti, P	1
Bove, A	1
Antropoli, C	1
Molino, D	1
Antropoli, M	1
Balzano, A	1
De Stefano, G	1
Attena, F	1
Merenstein, D	1
Rosenbaum, D	1
Morel, OE	1
Buvry, A	1
Le Corvoisier, P	1
Tual, L	1
Favret, F	1
León-Velarde, F	1
Crozatier, B	1
Richalet, JP	1
Ezri, T	1
Susmallian, S	1
Ağaoğlu, N	1
Cengiz, S	1
Arslan, MK	1
Türkyilmaz, S	1
Arakawa, TK	1
Mlynarczyk, M	1
Kaushal, KM	1
Zhang, L	1
Ducsay, CA	1
Yanturali, S	1
Akay, S	1
Ayrik, C	1
Cevik, AA	1
Haq, Z	1
Rahman, M	1
Chowdhury, RA	1
Baten, MA	1
Khatun, M	1
Ho, KS	1
Ho, YH	1
Scognamiglio, R	3
Negut, C	1
Palisi, M	1
Fasoli, G	3
Dalla-Volta, S	2
Katsinelos, P	2
Papaziogas, B	2
Koutelidakis, I	1
Paroutoglou, G	2
Dimiropoulos, S	1
Souparis, A	1
Atmatzidis, K	1
Tranqui, P	1
Trottier, DC	1
Victor, C	1
Freeman, JB	1
Lysy, J	1
Israeli, E	1
Levy, S	1
Rozentzweig, G	1
Strauss-Liviatan, N	1
Goldin, E	1
Andersen, F	1
Hedegaard, K	1
Petersen, TK	1
Bindslev-Jensen, C	1
Fullerton, A	1
Andersen, KE	1
Kountouras, J	1
Beltsis, A	1
Chatzimavroudis, G	1
Zavos, C	1
Katsinelos, T	1
Dart, AM	1
Otterstad, JE	1
Kirwan, BA	1
Parker, JD	1
de Brouwer, S	1
Poole-Wilson, PA	1
Lubsen, J	1
Buell, C	1
Tobinick, E	1
Lamp, K	1
Banerjee, A	1
Vaghasiya, R	1
Nivsarkar, M	1
Olivari, MT	1
Levine, TB	1
Cohn, JN	1
Lasseter, KC	1
Shamblen, EC	1
Murdoch, AA	1
Burkholder, DE	1
Krol, GJ	1
Taylor, RJ	1
Vanov, SK	1
Kuz'ko, NV	1
Katsenovich, RA	1
Kostko, SZ	1
Arifdzhanova, UA	1
Khashimov, KhA	1
Vakhidova, MA	1
Gaucher, LR	1
Payen, DM	1
Minsart, PJ	1
Peltier, PM	1
Ordronneau, JJ	1
Grolleau, JY	1
Subramanian, VB	2
Bowles, MJ	2
Khurmi, NS	3
Davies, AB	2
Raftery, EB	2
Elkayam, U	2
Weber, L	2
Torkan, B	1
McKay, CR	1
Rahimtoola, SH	5
Fox, KM	1
Deanfield, J	1
Selwyn, A	1
Krikler, S	3
Wright, C	1
Dawson, JR	1
Whitaker, NH	1
Sutton, GC	1
Zyvoloski, MG	1
Brooks, HL	1
Gross, GJ	1
Warltier, DC	1
Bala Subramanian, V	1
Gaul, G	1
Blazek, G	1
Deutsch, E	1
Heeger, H	1
Hartmann, A	1
Lund, K	1
Holdaas, H	1
Fauchald, P	1
Reisaeter, A	1
Berg, KJ	1
Tanne, D	1
Reicher-Reiss, H	1
Boyko, V	1
Behar, S	1
Frishman, WH	4
Pepine, CJ	1
Weiss, RJ	1
Baiker, WM	1
Schön, HR	2
Schömig, A	1
Volkova, LI	2
Shteĭngart, IuN	1
Meyer, TE	1
Adnams, C	1
Commerford, P	1
Nistri, S	1
Dalla Volta, S	1
Bonow, RO	2
Zebrowski, EJ	1
Pylypas, SP	1
Odlum, O	1
Johnson, RB	1
Röthlisberger, C	2
Sareli, P	2
Wisenbaugh, T	2
Neĭko, IeM	1
Serediuk, NM	1
Orynchak, MA	1
Oka, M	1
Morris, KG	1
McMurtry, IF	1
Raizada, V	1
Pathak, D	1
Blomquist, TM	1
Minser, R	1
Woodfin, B	1
Glasser, SP	3
Friedman, R	1
Talibi, T	1
Smith, LK	1
Weir, EK	1
Ikram, H	1
Low, CJ	1
Shirlaw, TM	1
Foy, SG	1
Crozier, IG	1
Richards, AM	1
Horsburgh, RJ	1
Manoshkina, EM	1
Metelitsa, VI	3
Aĭvazian, TA	1
Duda, SG	1
Filatova, NP	1
De Caprio, L	1
Acanfora, D	1
Odierna, L	1
Di Palma, A	1
Romaniello, C	1
Rengo, C	1
Giordano, A	1
Rengo, F	2
Okada, O	1
Naitou, T	1
Katou, K	1
Tanabe, N	1
Kouchi, F	1
Yamagishi, F	1
Sugita, T	1
Kuriyama, T	1
Watanabe, S	1
Ward, WA	1
Van Moore, A	1
Snedkova, LV	1
Kelbaek, H	1
Aldershvile, J	1
Skagen, K	1
Hildebrandt, P	1
Nielsen, SL	1
Cheng, DC	1
Jiang, MT	1
Asokumar, B	1
Boylen, P	1
Sandler, A	1
Di Somma, S	1
de Divitiis, M	1
Bertocchi, F	1
Carotenuto, A	1
Cudemo, G	1
Petitto, M	1
Napodano, M	1
de Divitiis, O	1
Kunimatsu, K	1
Ozaki, Y	1
Aoki, Y	1
Kato, I	1
Peers, C	2
Carpenter, E	2
Hatton, CJ	2
Wyatt, CN	2
Bee, D	2
Yamada, K	2
Kanba, S	2
Ashikari, I	2
Ohnishi, K	1
Yagi, G	2
Asai, M	2
Irish, AB	1
Thompson, CH	1
Kemp, GJ	1
Taylor, DJ	1
Radda, GK	1
Onishi, K	1
Benedetto, C	1
Zonca, M	1
Giarola, M	1
Maulà, V	1
Chiarolini, L	1
Carandente, F	1
Murayama, S	2
Yamakado, T	2
Nakano, T	2
Kobrin, I	1
Charlon, V	1
Lindberg, E	1
Pordy, R	1
Tsuda, Y	1
Satoh, K	1
Kitadai, M	1
Izumi, Y	1
Takahashi, T	1
George, S	1
Pulimood, S	1
Jacob, M	1
Chandi, SM	1
Zanolla, L	1
Franceschini, L	1
Rossi, L	1
Ochan, M	1
Amigoni, S	1
Zardini, P	1
Martsevich, SIu	2
Kutishenko, PP	1
Alimova, EV	1
Slastnikova, ID	2
Van Wagoner, DR	1
Pond, AL	1
Lamorgese, M	1
Rossie, SS	1
McCarthy, PM	1
Nerbonne, JM	1
Miller, CL	1
Schwartz, AM	1
Barnhart, JS	1
Bell, MD	1
Luca, S	1
Romeo, S	1
Toal, CB	1
Motro, M	1
Baird, MG	1
Klinke, P	1
Sclarowski, S	1
Zilberman, A	1
Marmor, A	1
Kostuk, WJ	2
Lotan, C	1
Weiss, A	1
Erne, P	1
Palant, A	1
Stolero, D	1
Bélanger, L	1
Turpie, A	1
Cook, TA	1
Humphreys, MM	1
McC Mortensen, NJ	1
Fuertes García, A	1
Sagués Cabarro, F	1
González Juanatey, JR	1
de Lombera Romero, F	1
Luengo Fernández, E	1
Palencia Pérez, MA	1
Vargas García, R	1
Wilke Delgado, M	1
Brisinda, G	1
Maria, G	1
Banning, AP	1
Prendergast, B	1
Tomita, G	1
Niwa, Y	1
Shinohara, H	1
Hayashi, N	1
Yamamoto, T	1
Kitazawa, Y	1
Grayburn, PA	1
Sauerbrey-Wullkopf, N	1
Kupper, W	2
Novaro, GM	1
Rodriguez, LL	1
Workman, AJ	1
Kane, KA	1
Rankin, AC	1
Storme, L	1
Parker, TA	1
Kinsella, JP	1
Rairigh, RL	1
Abman, SH	1
Figueira, RH	1
Guimarães, F	1
Wagner, M	1
Bozza, AE	1
Dohmann, HJ	1
Allen, GS	2
Bahr, AL	2
Bonaduce, D	1
Ferrara, N	1
Postiglione, M	1
Petretta, M	1
Covelli, A	1
Romano, E	1
Banghart, SB	1
Akhadov, ShV	1
Belousov, IuB	1
Borisova, EO	1
Volkov, MG	1
Glezer, GA	1
Moskalenko, NP	1
Gaponenko, VA	1
Stoliarov, AS	1
Saitova, RA	1
Simbirina, TE	1
Neĭman, DIu	1
Chilikina, ON	1
Akhmetova, MG	1
Babaev, AB	1
Circo, A	1
Scaccianoce, G	1
Platania, F	1
Castelli, D	1
Cardillo, R	1
Mangiameli, S	1
Tomashets, EA	1
Mazur, NA	1
Masenko, VP	1
Vesel'skiĭ, ISh	1
Sanik, AV	1
Kobayashi, S	1
Yamaguchi, S	1
Okada, K	1
Suyama, N	1
Bokura, K	1
Murao, M	1
Tsunematsu, T	1
Hiraoka, N	1
Oonishi, T	1
Kasai, A	1
Ueda, K	1
Hamada, M	1
DiBianco, R	1
Takata, Y	1
Yoshizumi, T	1
Ito, Y	1
Kikuchi, M	1
Ueno, M	1
Tsukashima, A	1
Kobayashi, K	1
Fujishima, M	1
Maslova, NP	1
Baranova, EI	1
Barabanova, NG	1
Duckeck, W	1
Schwarzkopf, HJ	1
Bleifeld, W	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure: a Randomized Clinical Trial[NCT04153032]	Phase 2	183 participants (Anticipated)	Interventional	2019-12-01	Recruiting
Effects of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure[NCT04320498]	Phase 4	41 participants (Actual)	Interventional	2019-01-01	Completed
Does Adjunctive Treatment With Vaginal Nifedipine Result in Symptomatic Improvement in Patients With Levator Myalgia and Pelvic Floor Pain Who Are Undergoing Pelvic Floor Physical Therapy?[NCT01586286]		0 participants (Actual)	Interventional	2012-07-31	Withdrawn (stopped due to No patients were recruited over a 12 month period)
A Comparative Efficacy and Safety Study of Lateral Subcutaneous Sphincterotomy and Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure[NCT03855046]	Phase 4	340 participants (Anticipated)	Interventional	2019-09-01	Recruiting
Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease)[NCT01052428]	Phase 2/Phase 3	38 participants (Actual)	Interventional	2004-08-31	Completed
The Study to Define the Unique Molecular Mechanisms of Mitral Regurgitation in Order to Find New Targeted Therapy to Attenuate the Remodeling and Delay the Need for Surgery and Improve Surgical Outcomes.[NCT01052532]		65 participants (Actual)	Observational	2005-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Left Ventricular Ejection Fraction Is a calculation of heart pump function determined from the volume after complete filling minus the volume after complete contraction divided by the volume after complete filling. A value of 55% or greater is normal. (NCT01052428)
Timeframe: 5 visits per Participant over 2 years (about every 6 months)

Left Ventricular End Diastolic Volume Indexed to Body Surface Area

Intervention	percent (Mean)
	Month 0 (n=19,19)	Month 3 (n=1,0)	Month 6 (n=17,19)	Month 9 (n=1,1)	Month 12 (n=14,15)	Month 15 (n=3,2)	Month 18 (n=14,18)	Month 21 (n=5,0)	Month 24 (n=16,18)
Placebo	62.62	63.90	63.80	41.90	61.70	44.70	60.95	53.79	59.95
Toprol XL	62.09	NA	61.29	54.81	62.77	68.47	62.05	NA	63.02

Left Ventricular End Diastolic Volume Indexed to Body Surface Area: As an indicator of heart size, the blood volume of the heart is related to the body size. The end diastolic volume is the blood volume of the heart at the end of filling, just before contraction. The relation of heart blood volume to body size is more accurate in determining pathology because larger people require a larger heart blood volume. The values that are too high or too low indicate a diseased myocardium. (NCT01052428)
Timeframe: 5 visits per Participant over 2 years (about every 6 months)

Left Ventricular End Systolic Volume Indexed to Body Surface Area

Intervention	ml/m^2 (Mean)
	Month 0 (n=19,19)	Month 3 (n=1,0)	Month 6 (n=17,19)	Month 9 (n=1,0)	Month 12 (n=14,15)	Month 15 (n=3,2)	Month 18 (n=14,18)	Month 21 (n=5,0)	Month 24 (n=16,18)
Placebo	91.66	90.93	90.84	70.56	88.99	82.73	90.16	85.75	87.31
Toprol XL	95.74	NA	95.24	NA	95.71	98.16	97.6	NA	95.16

Left Ventricular End Systolic Volume Indexed to Body Surface Area As an indicator of heart size, the blood volume of the heart is related to the body size. The end systolic volume is the blood volume of the heart at the end of contraction and is an index of the pump function of the heart. This relation to body size is more accurate in determining pathology because larger people require a larger heart blood volume. The values that are too high or too low indicate a diseased myocardium. (NCT01052428)
Timeframe: 5 visits per Participant over 2 years (about every 6 months)

Left Ventricular End-diastolic Mass Indexed to Left Ventricular End-diastolic Volume

Intervention	ml/m^2 (Mean)
	Month 0 (n=19,19)	Month 3 (n=1,0)	Month 6 (n=17,19)	Month 9 (n=1,0)	Month 12 (n=14,15)	Month 15 (n=3,2)	Month 18 (n=14,18)	Month 21 (n=5,0)	Month 24 (n=16,18)
Placebo	34.01	32.83	32.53	40.99	33.70	47.25	34.99	39.97	34.47
Toprol XL	35.98	NA	36.53	NA	35.89	30.97	36.72	NA	35.13

Left Ventricular End-diastolic Mass Indexed to Left Ventricular End-diastolic Volume As an indicator of heart muscle mass and heart blood volume, the mass indexed to end diastolic volume determines whether there is an adequate amount of heart muscle to pump the heart blood volume obtained from a three-dimensional analysis. The values that are too high or too low indicate a diseased myocardium. (NCT01052428)
Timeframe: 5 visits per Participant over 2 years (about every 6 months)

Left Ventricular End-Diastolic Radius to Wall Thickness

Intervention	g/ml (Mean)
	Month 0 (n=19,19)	Month 3 (n=1,0)	Month 6 (n=17,19)	Month 9 (n=1,1)	Month 12 (n=14,15)	Month 15 (n=3,2)	Month 18 (n=14,18)	Month 21 (n=5,0)	Month 24 (n=16,18)
Placebo	0.61	0.53	0.62	0.67	0.65	0.65	0.65	0.61	0.64
Toprol XL	0.61	NA	0.6	0.53	0.60	0.55	0.59	NA	0.62

Left Ventricular End-Diastolic Radius to Wall Thickness As an indicator of heart muscle mass and heart volume chamber diameter, the end-diastolic radius indexed to end diastolic wall thickness determines whether there is an adequate amount of heart muscle to pump the heart blood volume obtained from a two-dimensional analysis. The values that are too high or too low indicate a diseased myocardium. (NCT01052428)
Timeframe: 5 visits per Participant over 2 years (about every 6 months)

Peak Early Filling Rate: Rate of Change Over Time

Intervention	unitless (Mean)
	Month 0 (n=19,19)	Month 3 (n=1,0)	Month 6 (n=17,19)	Month 9 (n=1,1)	Month 12 (n=14,15)	Month 15 (n=3,2)	Month 18 (n=14,18)	Month 21 (n=5,0)	Month 24 (n=16,18)
Placebo	4.76	5.02	4.51	4.15	4.46	4.61	4.43	4.72	4.52
Toprol XL	4.69	NA	4.85	5.74	4.79	5.02	4.77	NA	4.59

Peak Early Filling Rate The peak early filling rate of change is calculated from the slope of the volume during the early filling of the heart with respect to time. The higher values indicate a very healthy heart muscle and lower values are indicative of a very stiff muscle. (NCT01052428)
Timeframe: 5 visits per Participant over 2 years (about every 6 months)

Systolic Longitudinal Strain

Intervention	EDV/sec (Mean)
	Month 0 (n=19,19)	Month 3 (n=1,0)	Month 6 (n=17,19)	Month 9 (n=1,0)	Month 12 (n=14,15)	Month 15 (n=3,2)	Month 18 (n=14,18)	Month 21 (n=5,0)	Month 24 (n=16,18)
Placebo	2.27	2.58	2.38	1.56	2.26	1.83	1.95	1.73	2.17
Toprol XL	2.12	NA	2.08	NA	2.24	2.28	2.26	NA	2.25

Systolic Longitudinal Strain. By identifying two points on the heart, the strain is the difference between the distance between these two points at the end of filling of the heart and the end of contraction divided by the length at the end of filling. Thus, the measure is like the ejection fraction, however the strain is more localized to a specified segment in the heart muscle. The higher values indicate a healthy heart. (NCT01052428)
Timeframe: 5 visits per Participant over 2 years (about every 6 months)

Intervention	percent/%Systolic interval (Mean)
	Month 0 (n=19,19)	Month 3 (n=1,0)	Month 6 (n=17,19)	Month 9 (n=1,0)	Month 12 (n=14,15)	Month 15 (n=3,2)	Month 18 (n=14,18)	Month 21 (n=5,0)	Month 24 (n=16,18)
Placebo	87.94	115.07	45.90	37.2	87.85	52.95	88.11	67.53	79.94
Toprol XL	82.55	NA	78.68	NA	80.04	88.34	79.29	NA	85.18

Article	Year
Clinical Outcomes of Medical Management Options for Chronic Anal Fissures in a Long-Term Follow-up: Systematic Review and Meta-Analysis. Digestive diseases (Basel, Switzerland), 2023, Volume: 41, Issue:5 Topics: Adult; Chronic Disease; Fissure in Ano; Glycerol; Humans; Nifedipine; Nitroglycerin; Treatment Outco	2023
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:4 Topics: Abruptio Placentae; Amlodipine; Antihypertensive Agents; Atenolol; Cesarean Section; Chronic Disease	2020
Hypertension and Pregnancy: Management and Future Risks. Advances in chronic kidney disease, 2019, Volume: 26, Issue:2 Topics: Antihypertensive Agents; Aspirin; Cardiovascular Diseases; Chronic Disease; Diuretics; Female; Human	2019
Hypertensive Emergencies in Pregnancy. Critical care clinics, 2016, Volume: 32, Issue:1 Topics: Antihypertensive Agents; Cesarean Section; Chronic Disease; Congenital Abnormalities; Emergencies; E	2016
Recent advances in the pharmacotherapy of chronic anal fissure: an update. Asian journal of surgery, 2008, Volume: 31, Issue:3 Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel	2008
Recent advances in the pharmacotherapy of chronic anal fissure: an update. Asian journal of surgery, 2008, Volume: 31, Issue:3 Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel	2008
Recent advances in the pharmacotherapy of chronic anal fissure: an update. Asian journal of surgery, 2008, Volume: 31, Issue:3 Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel	2008
Recent advances in the pharmacotherapy of chronic anal fissure: an update. Asian journal of surgery, 2008, Volume: 31, Issue:3 Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel	2008
Anal fissure. The Surgical clinics of North America, 2010, Volume: 90, Issue:1 Topics: Acute Disease; Anal Canal; Botulinum Toxins, Type A; Calcium Channel Blockers; Chronic Disease; Dilt	2010
Lessons from large interventional trials on antihypertensive therapy in chronic renal disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17 Suppl 11 Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Chronic Disease; Clini	2002
Chemical sphincterotomy--first line of treatment for chronic anal fissure. Mymensingh medical journal : MMJ, 2005, Volume: 14, Issue:1 Topics: Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Isos	2005
Medical treatment of chronic valvular regurgitation. The Journal of heart valve disease, 1995, Volume: 4 Suppl 2 Topics: Angiotensin-Converting Enzyme Inhibitors; Aortic Valve Insufficiency; Chronic Disease; Humans; Isoqu	1995
[Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report]. Minerva cardioangiologica, 1999, Volume: 47, Issue:6 Topics: Aged; Angina Pectoris; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Chronic Disease;	1999
Vasodilator therapy for chronic aortic and mitral regurgitation. The American journal of the medical sciences, 2000, Volume: 320, Issue:3 Topics: Aortic Valve Insufficiency; Chronic Disease; Digoxin; Heart Ventricles; Hemodynamics; Humans; Mitral	2000
Bepridil treatment of chronic stable angina: a review of comparative studies versus placebo, nifedipine, and diltiazem. The American journal of cardiology, 1992, Apr-09, Volume: 69, Issue:11 Topics: Adult; Aged; Angina Pectoris; Bepridil; Chronic Disease; Diltiazem; Female; Humans; Male; Meta-Analy	1992
Vasodilator therapy in chronic severe aortic regurgitation. Journal of the American College of Cardiology, 1990, Volume: 16, Issue:2 Topics: Aortic Valve Insufficiency; Chronic Disease; Digitalis Glycosides; Echocardiography; Hemodynamics; H	1990
Beta-adrenoceptor antagonists plus nifedipine in the treatment of chronic stable angina pectoris. Cardiovascular drugs and therapy, 1989, Volume: 3 Suppl 1 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Chronic Disease; Dihydropyridines; Drug Therapy, Combi	1989
Combination therapy with calcium-channel blockers and beta blockers for chronic stable angina pectoris. The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Calcium Channel Blockers; Chronic Disease; Cl	1985
Nifedipine in combination therapy for chronic hypertension. A review. The American journal of medicine, 1985, Oct-11, Volume: 79, Issue:4A Topics: Adrenergic beta-Antagonists; Chronic Disease; Drug Therapy, Combination; Humans; Hypertension; Nifed	1985
Calcium antagonists and chronic cardiac failure. Postgraduate medical journal, 1986, Volume: 62, Issue:730 Topics: Calcium Channel Blockers; Chronic Disease; Diltiazem; Heart Failure; Humans; Nifedipine; Verapamil	1986
Cerebral blood flow autoregulation and hypertension. The American journal of the medical sciences, 1985, Volume: 289, Issue:1 Topics: Aged; Animals; Antihypertensive Agents; Brain Diseases; Cerebrovascular Circulation; Chronic Disease	1985
Calcium-channel blockers and systemic hypertension. Journal of clinical hypertension, 1985, Volume: 1, Issue:2 Topics: Acute Disease; Angina Pectoris; Animals; Calcium Channel Blockers; Chronic Disease; Diltiazem; Drug	1985

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Longitudinal changes in vascular function parameters in pregnant women with chronic hypertension and association with adverse outcome: a cohort study. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2019, Volume: 53, Issue:5 Topics: Adult; Antihypertensive Agents; Birth Weight; Black People; Blood Pressure; Chronic Disease; Cohort	2019
Conservative versus surgical treatment for chronic anal idiopathic fissure: a prospective randomized trial. Updates in surgery, 2013, Volume: 65, Issue:3 Topics: Administration, Topical; Anal Canal; Chronic Disease; Defecation; Digestive System Surgical Procedur	2013
Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial. Annals of family medicine, 2016, Volume: 14, Issue:5 Topics: Administration, Oral; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Chilblains; Chronic Dis	2016
Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. Diseases of the colon and rectum, 2002, Volume: 45, Issue:11 Topics: Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Double-Blind Method; Drug Combina	2002
Topical nifedipine vs. topical glyceryl trinitrate for treatment of chronic anal fissure. Diseases of the colon and rectum, 2003, Volume: 46, Issue:6 Topics: Calcium Channel Blockers; Chronic Disease; Double-Blind Method; Female; Humans; Male; Nifedipine; Ni	2003
Randomized clinical trial comparing oral nifedipine with lateral anal sphincterotomy and tailored sphincterotomy in the treatment of chronic anal fissure. The British journal of surgery, 2005, Volume: 92, Issue:4 Topics: Administration, Oral; Adult; Anal Canal; Calcium Channel Blockers; Chronic Disease; Double-Blind Met	2005
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up. International journal of colorectal disease, 2006, Volume: 21, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg	2006
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up. International journal of colorectal disease, 2006, Volume: 21, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg	2006
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up. International journal of colorectal disease, 2006, Volume: 21, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg	2006
Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up. International journal of colorectal disease, 2006, Volume: 21, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surg	2006
Anti-irritants II: Efficacy against cumulative irritation. Contact dermatitis, 2006, Volume: 55, Issue:3 Topics: Adult; Chemistry, Pharmaceutical; Chronic Disease; Dermatitis, Irritant; Dose-Response Relationship,	2006
Predictive value of local and core laboratory echocardiographic assessment of cardiac function in patients with chronic stable angina: The ACTION study. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2007, Volume: 8, Issue:4 Topics: Angina Pectoris; Biomarkers; Calcium Channel Blockers; Chronic Disease; Coronary Artery Disease; Cor	2007
[Changes in the physical load tolerance of stenocardia patients taking obzidan, korinfar and izoptin separately and together]. Kardiologiia, 1984, Volume: 24, Issue:6 Topics: Adult; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Drug Th	1984
Evaluation of verapamil and high dose nifedipine in patients with chronic stable angina with objective methods. Acta medica Scandinavica. Supplementum, 1984, Volume: 681 Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Double-Blind Method; Drug Administration Schedule; El	1984
Factors influencing the treatment of chronic stable angina pectoris with nifedipine. Postgraduate medical journal, 1983, Volume: 59 Suppl 2 Topics: Angina Pectoris; Chronic Disease; Exercise Test; Female; Humans; Male; Nifedipine; Pyridines; Smokin	1983
Calcium antagonist drugs in chronic stable angina. Comparison of verapamil and nifedipine. British heart journal, 1981, Volume: 46, Issue:5 Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Double-Blin	1981
Randomized double-blind comparison of verapamil and nifedipine in chronic stable angina. The American journal of cardiology, 1982, Volume: 50, Issue:4 Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Double-Blind Method; Electrocardiography; Exercise Te	1982
Stroke risk after anterior wall acute myocardial infarction. SPRINT Study Group. Secondary Prevention Reinfarction Israeli Nifedipine Trial. The American journal of cardiology, 1995, Oct-15, Volume: 76, Issue:11 Topics: Aged; Atrial Fibrillation; Cerebrovascular Disorders; Chronic Disease; Female; Follow-Up Studies; Hu	1995
Addition of zatebradine, a direct sinus node inhibitor, provides no greater exercise tolerance benefit in patients with angina taking extended-release nifedipine: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study Journal of the American College of Cardiology, 1995, Volume: 26, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Benzazepines; Blood Pressure; Cardiovascular Agents	1995
Comparison of the efficacy of atenolol and its combination with slow-release nifedipine in chronic stable angina. Cardiovascular drugs and therapy, 1993, Volume: 7, Issue:6 Topics: Angina Pectoris; Atenolol; Blood Pressure; Chronic Disease; Delayed-Action Preparations; Double-Blin	1993
Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. The New England journal of medicine, 1994, Sep-15, Volume: 331, Issue:11 Topics: Adult; Aortic Valve Insufficiency; Chronic Disease; Digoxin; Female; Follow-Up Studies; Heart Valve	1994
Comparison of single dose nifedipine and captopril for chronic severe mitral regurgitation. The American journal of cardiology, 1994, May-15, Volume: 73, Issue:13 Topics: Adult; Captopril; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Hemodynamics;	1994
Comparison of single dose nifedipine and captopril for chronic severe mitral regurgitation. The American journal of cardiology, 1994, May-15, Volume: 73, Issue:13 Topics: Adult; Captopril; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Hemodynamics;	1994
Comparison of single dose nifedipine and captopril for chronic severe mitral regurgitation. The American journal of cardiology, 1994, May-15, Volume: 73, Issue:13 Topics: Adult; Captopril; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Hemodynamics;	1994
Comparison of single dose nifedipine and captopril for chronic severe mitral regurgitation. The American journal of cardiology, 1994, May-15, Volume: 73, Issue:13 Topics: Adult; Captopril; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Hemodynamics;	1994
Comparison of single-dose nifedipine and captopril for chronic severe aortic regurgitation. The American journal of cardiology, 1993, Oct-01, Volume: 72, Issue:11 Topics: Aortic Valve Insufficiency; Captopril; Chronic Disease; Double-Blind Method; Hemodynamics; Humans; N	1993
Safety and compatibility of betaxolol hydrochloride combined with diltiazem or nifedipine therapy in stable angina pectoris. The American journal of cardiology, 1994, Feb-01, Volume: 73, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Betaxolol; Chronic Disease; Diltiazem; Double-Blind	1994
Angiotensin converting enzyme inhibition in chronic stable angina: effects on myocardial ischaemia and comparison with nifedipine. British heart journal, 1994, Volume: 71, Issue:1 Topics: Adult; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Chronic Diseas	1994
[Effect of long-term monotherapy with propranolol and nifedipine on the quality of life and psychological status of patients with hypertension]. Terapevticheskii arkhiv, 1993, Volume: 65, Issue:9 Topics: Adult; Blood Pressure; Chronic Disease; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedip	1993
Acute effects of nifedipine, diltiazem and their combination in patients with chronic stable angina: a double-blind, randomized, cross-over, placebo-controlled study. European heart journal, 1993, Volume: 14, Issue:3 Topics: Aged; Angina Pectoris; Blood Pressure; Chronic Disease; Diltiazem; Double-Blind Method; Drug Therapy	1993
Management of finger ulcers in scleroderma. The Journal of hand surgery, 1995, Volume: 20, Issue:5 Topics: Adult; Algorithms; Anti-Infective Agents, Local; Chronic Disease; Combined Modality Therapy; Fingers	1995
[A trial of the use of nifedipine for preventing relapses in affective and schizoaffective psychoses]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1996, Volume: 96, Issue:1 Topics: Adult; Affective Disorders, Psychotic; Aged; Chronic Disease; Female; Humans; Male; Middle Aged; Nif	1996
Pre- and afterload reduction in chronic mitral regurgitation: a double-blind randomized placebo-controlled trial of the acute and 2 weeks' effect of nifedipine or isosorbide dinitrate treatment on left ventricular function and the severity of mitral regur British journal of clinical pharmacology, 1996, Volume: 41, Issue:6 Topics: Administration, Oral; Administration, Sublingual; Adult; Aged; Blood Pressure; Chronic Disease; Doub	1996
Treatment of hypertension associated with stable angina pectoris: favourable interaction between new metoprolol formulation (OROS) and nifedipine. Cardiologia (Rome, Italy), 1996, Volume: 41, Issue:7 Topics: Angina Pectoris; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blo	1996
Nilvadipine is effective for chronic schizophrenia in a double-blind placebo-controlled study. off. Journal of clinical psychopharmacology, 1996, Volume: 16, Issue:6 Topics: Adult; Aged; Calcium Channel Blockers; Chronic Disease; Cross-Over Studies; Double-Blind Method; Dys	1996
Effects of nicorandil, an antianginal potassium channel opener, on left ventricular systolic and diastolic function in patients with chronic coronary artery disease. The American journal of cardiology, 1997, Jun-15, Volume: 79, Issue:12 Topics: Adult; Aged; Chronic Disease; Coronary Disease; Diastole; Female; Humans; Male; Middle Aged; Niacina	1997
Safety of mibefradil, a new once-a-day, selective T-type calcium channel antagonist. The American journal of cardiology, 1997, Aug-21, Volume: 80, Issue:4B Topics: Aged; Amlodipine; Angina Pectoris; Benzimidazoles; Calcium Channel Blockers; Chronic Disease; Drug A	1997
Chronic hemorheological effects of the calcium antagonist nilvadipine in essential hypertension. Arzneimittel-Forschung, 1997, Volume: 47, Issue:8 Topics: Blood Pressure; Blood Viscosity; Calcium Channel Blockers; Chronic Disease; Female; Hematocrit; Huma	1997
Nifedipine GITS versus diltiazem in chronic stable angina: a randomised multicentre study. British journal of clinical practice. Supplement, 1997, Volume: 88 Topics: Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Diltiazem; Double-Blind Method; Exercise	1997
[The calcium antagonists diltiazem and nifedipine: a comparison of their efficacy in single and long-term use in patients with stable stenocardia of effort]. Terapevticheskii arkhiv, 1998, Volume: 70, Issue:8 Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Diltiazem; Double-Blind Method; Dr	1998
Effectiveness of nifedipine GITS in combination with atenolol in chronic stable angina. The Canadian journal of cardiology, 1999, Volume: 15, Issue:10 Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Atenolol; Chronic Disease; Double-Blind Method;	1999
[Treatment of chronic stable angina: follow-up study with nifedipine gastrointestinal therapeutic system. SENIOR Study Group]. Revista espanola de cardiologia, 2000, Volume: 53, Issue:1 Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Female; Humans; Male; Middle Aged;	2000
Intravenous L-arginine reduces VE/VCO2 slope acutely in patients with severe chronic heart failure. European journal of heart failure, 1999, Volume: 1, Issue:2 Topics: Arginine; Blood Pressure; Breath Tests; Carbon Dioxide; Chronic Disease; Cross-Over Studies; Exercis	1999
Changes in optic nerve head blood flow and retrobular hemodynamics following calcium-channel blocker treatment of normal-tension glaucoma. International ophthalmology, 1999, Volume: 23, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Calcium Channel Blockers; Chronic Disease; Cili	1999
[Amlodipine versus nifedipine retard. A randomized double-blind comparative study on long-term efficacy and safety of amlodipine and nifedipine retard in the monotherapy of chronic stable angina pectoris]. Herz, 2001, Volume: 26, Issue:2 Topics: Adult; Aged; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Data Interpreta	2001
[Initial experience. Comparative study of verapamil and nifedipine in the treatment of coronary insufficiency. Evaluation by a cycloergometric test]. Arquivos brasileiros de cardiologia, 1978, Volume: 31 Suppl 1 Topics: Adult; Aged; Chronic Disease; Cineangiography; Clinical Trials as Topic; Coronary Disease; Double-Bl	1978
[Comparative hypotensive effectiveness of various calcium antagonists in patients with persistent essential hypertension (randomized study)]. Kardiologiia, 1992, Volume: 32, Issue:11-12 Topics: Blood Pressure; Calcium Channel Blockers; Chronic Disease; Dihydropyridines; Diltiazem; Dose-Respons	1992
Amlodipine versus nifedipine retard in the treatment of chronic ischemic heart disease. La Clinica terapeutica, 1992, Volume: 140, Issue:1 Topics: Adult; Aged; Amlodipine; Calcium Channel Blockers; Chronic Disease; Coronary Disease; Delayed-Action	1992
Treatment of chronic stable angina with carvedilol in comparison with nifedipine s.r. European heart journal, 1991, Volume: 12, Issue:1 Topics: Adult; Aged; Angina Pectoris; Carbazoles; Carvedilol; Chronic Disease; Delayed-Action Preparations;	1991
[The comparative efficacy of nicardipine and nifedipine in stenocardia patients]. Terapevticheskii arkhiv, 1990, Volume: 62, Issue:10 Topics: Angina Pectoris; Chronic Disease; Coronary Disease; Electrocardiography; Exercise Test; Humans; Male	1990
[Differential use of peripheral vasodilators in the treatment of chronic circulatory failure in patients with mitral valve insufficiency]. Kardiologiia, 1990, Volume: 30, Issue:3 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Hydralazine;	1990
Effects of nifedipine on myocardial perfusion during exercise in chronic stable angina pectoris. The American journal of cardiology, 1990, May-01, Volume: 65, Issue:16 Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method	1990
Long-term nifedipine unloading therapy in asymptomatic patients with chronic severe aortic regurgitation. Journal of the American College of Cardiology, 1990, Volume: 16, Issue:2 Topics: Adult; Aortic Valve Insufficiency; Chronic Disease; Double-Blind Method; Echocardiography; Female; F	1990
Nifedipine and isosorbide dinitrate alone and in combination for patients with chronic stable angina: a double-blind crossover study. American heart journal, 1990, Volume: 120, Issue:2 Topics: Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Combinations;	1990
[Effectiveness of nifedipine, diltiazem and their combination in the treatment of chronic stable angina pectoris]. Casopis lekaru ceskych, 1990, Aug-03, Volume: 129, Issue:31 Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Diltiazem; Double-Blind Method; Drug Therapy, Combina	1990
[Effectiveness of depin-E in patients with chronic bronchitis]. Klinicheskaia meditsina, 1990, Volume: 68, Issue:6 Topics: Adult; Bronchi; Bronchitis; Bronchodilator Agents; Calcium Channel Blockers; Chronic Disease; Female	1990
[The effect of korinfar on the systemic hemodynamics and myocardial contractile function in hypertension patients]. Vrachebnoe delo, 1990, Issue:7 Topics: Adult; Chronic Disease; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Myocardial Co	1990
A prospective, randomized, double-blind, crossover study to compare the efficacy and safety of chronic nifedipine therapy with that of isosorbide dinitrate and their combination in the treatment of chronic congestive heart failure. Circulation, 1990, Volume: 82, Issue:6 Topics: Adolescent; Adult; Aged; Blood Pressure; Chronic Disease; Diuretics; Double-Blind Method; Drug Combi	1990
Slow release nifedipine plus atenolol in chronic stable angina pectoris. British journal of clinical pharmacology, 1989, Volume: 28, Issue:5 Topics: Adult; Aged; Angina Pectoris; Atenolol; Chronic Disease; Delayed-Action Preparations; Double-Blind M	1989
Clinical safety and efficacy of once-daily amlodipine for chronic stable angina pectoris. American heart journal, 1989, Volume: 118, Issue:5 Pt 2 Topics: Amlodipine; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Drug Administration Schedule	1989
Double-blind crossover comparison of amlodipine at three dose levels and placebo in chronic stable angina. American heart journal, 1989, Volume: 118, Issue:5 Pt 2 Topics: Aged; Amlodipine; Angina Pectoris; Chronic Disease; Double-Blind Method; Exercise Test; Female; Huma	1989
Therapy of chronic idiopathic urticaria with nifedipine: demonstration of beneficial effect in a double-blinded, placebo-controlled, crossover trial. The Journal of allergy and clinical immunology, 1989, Volume: 83, Issue:4 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle	1989
Comparison of atenolol and nifedipine in chronic stable angina pectoris. The American journal of cardiology, 1989, Jul-15, Volume: 64, Issue:3 Topics: Aged; Angina Pectoris; Atenolol; Chronic Disease; Double-Blind Method; Electrocardiography; Exercise	1989
[Evaluation of the effect of nifedipine in patients with chronic congestive heart failure]. Kardiologia polska, 1989, Volume: 32 Suppl 2 Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Digoxin; Diuresis; Female; Furosemide; Heart	1989
Comparative study of the effect of nifedipine versus diltiazem on exercise performance, serum propranolol levels, and ST-segment abnormalities in patients with chronic stable angina taking propranolol. The American journal of cardiology, 1989, Sep-19, Volume: 64, Issue:11 Topics: Aged; Angina Pectoris; Chronic Disease; Diltiazem; Double-Blind Method; Drug Therapy, Combination; E	1989
Combination therapy with calcium-channel blockers and beta blockers for chronic stable angina pectoris. The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Calcium Channel Blockers; Chronic Disease; Cl	1985
Comparative effects of calcium entry-blocking drugs, beta-blocking drugs, and their combination in patients with chronic stable angina. Circulation, 1987, Volume: 75, Issue:6 Pt 2 Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease	1987
Efficacy of nisoldipine combined with beta-adrenergic-blocking drugs in the treatment of chronic stable angina. Clinical cardiology, 1987, Volume: 10, Issue:6 Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Chronic Disease; Coronary Angiography; Double-Bl	1987
[Therapeutic value of a combination of trimetazidine with a calcium inhibitor in the treatment of chronic coronary insufficiency]. Presse medicale (Paris, France : 1983), 1986, Oct-16, Volume: 15, Issue:35 Topics: Chronic Disease; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Drug Therapy, Comb	1986
Clinical safety and efficacy of once-a-day amlodipine for chronic stable angina pectoris. The American journal of cardiology, 1988, Sep-15, Volume: 62, Issue:9 Topics: Aged; Amlodipine; Angina Pectoris; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Double	1988
[Comparative study of the effect of 3 calcium antagonists in chronic stable angina]. Revista medica de Chile, 1988, Volume: 116, Issue:7 Topics: Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Chronic Disease; Clinical Trials as	1988
Effect of pharmacologic therapy on angina frequency, ST segment depression during ambulatory ECG monitoring, and treadmill performance in patients with chronic stable mild angina. American heart journal, 1988, Volume: 115, Issue:1 Pt 1 Topics: Adult; Ambulatory Care; Angina Pectoris; Chronic Disease; Electrocardiography; Exercise Test; Female	1988
Haemodynamic effects of combined oral nifedipine and sublingual nitroglycerin in patients with chronic stable angina. European journal of clinical pharmacology, 1987, Volume: 33, Issue:4 Topics: Administration, Oral; Administration, Sublingual; Aged; Angina Pectoris; Chronic Disease; Delayed-Ac	1987
[Comparative effects of diltiazem and nifedipine combined with propranolol, in patients with chronic stable angina pectoris]. Revista medica de Chile, 1987, Volume: 115, Issue:6 Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Diltiazem;	1987
Calcium-channel blockers for combined angina pectoris and systemic hypertension. The American journal of cardiology, 1986, Feb-26, Volume: 57, Issue:7 Topics: Adult; Aged; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chr	1986
Comparative antianginal effects of nisoldipine and nifedipine in patients with chronic stable angina. American heart journal, 1987, Volume: 113, Issue:2 Pt 1 Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Double-B	1987
Calcium-channel blockers for combined systemic hypertension and myocardial ischemia. Circulation, 1987, Volume: 75, Issue:6 Pt 2 Topics: Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Coronary Disea	1987
PY 108-068--acute effects of a single oral dose in chronic stable angina. European journal of clinical pharmacology, 1986, Volume: 30, Issue:2 Topics: Administration, Oral; Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Chronic Disea	1986
Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma. European journal of clinical pharmacology, 1986, Volume: 31, Issue:1 Topics: Aged; Asthma; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifedip	1986
[Parallel double-blind clinical trial of nifedipine versus a placebo in patients with chronic cerebrovascular insufficiency]. Medicina clinica, 1985, Mar-02, Volume: 84, Issue:8 Topics: Cerebrovascular Disorders; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; N	1985
Nifedipine in chronic bronchial asthma: a randomized double-blind crossover trial against placebo. European journal of respiratory diseases, 1985, Volume: 67, Issue:4 Topics: Adolescent; Adult; Albuterol; Asthma; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Dou	1985
A comparison of two nifedipine dosages in the treatment of chronic angina. The Practitioner, 1986, Volume: 230, Issue:1411 Topics: Aged; Angina Pectoris; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Nife	1986

Article	Year
Identification of factors associated with delayed treatment of obstetric hypertensive emergencies. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:2 Topics: Administration, Intravenous; Administration, Oral; Adult; After-Hours Care; Antihypertensive Agents;	2020
The effect of labetalol and nifedipine MR on blood pressure in women with chronic hypertension in pregnancy. Pregnancy hypertension, 2018, Volume: 11 Topics: Adrenergic Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chronic D	2018
Investigation of the Hepato-Protective Effects of Imdur in a Rat Model of Chronic Mountain Sickness. Clinical laboratory, 2015, Volume: 61, Issue:9 Topics: Altitude Sickness; Animals; Biomarkers; Blood Pressure; C-Reactive Protein; Chronic Disease; Glutath	2015
Novel cruzipain inhibitors for the chemotherapy of chronic Chagas disease. International journal of antimicrobial agents, 2016, Volume: 48, Issue:1 Topics: Adult; Animals; Antiprotozoal Agents; Chagas Disease; Chronic Disease; Clofazimine; Cysteine Endopep	2016
Recurrent autonomic dysreflexia due to chronic aortic dissection in an adult male with cervical spinal cord injury. TheScientificWorldJournal, 2008, Jun-13, Volume: 8 Topics: Adrenergic alpha-Antagonists; Aortic Rupture; Autonomic Dysreflexia; Calcium Channel Blockers; Cervi	2008
Comparative study of vasodilators in an animal model of chronic volume overload caused by severe aortic regurgitation. Circulation. Heart failure, 2009, Volume: 2, Issue:1 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic V	2009
[CCB uptitration is superior to ARB uptitration in CKD patients who do not reach target blood pressure with ARB/CCB combined therapy]. Nihon Jinzo Gakkai shi, 2010, Volume: 52, Issue:7 Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Chro	2010
False-positive amphetamine toxicology screen results in three pregnant women using labetalol. Obstetrics and gynecology, 2011, Volume: 117, Issue:2 Pt 2 Topics: Adult; Amphetamine; Antihypertensive Agents; Cesarean Section; Chronic Disease; Cocaine; Cross React	2011
Is topical nifedipine effective for chronic anal fissures? The Journal of family practice, 2003, Volume: 52, Issue:3 Topics: Administration, Topical; Anesthetics, Local; Chronic Disease; Double-Blind Method; Evidence-Based Me	2003
Effects of nifedipine-induced pulmonary vasodilatation on cardiac receptors and protein kinase C isoforms in the chronically hypoxic rat. Pflugers Archiv : European journal of physiology, 2003, Volume: 446, Issue:3 Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Chronic Disease; Hematocrit; Hemodynamics;	2003
Oral nifedipine in the treatment of chronic anal fissure. Digestive surgery, 2003, Volume: 20, Issue:5 Topics: Administration, Oral; Adult; Calcium Channel Blockers; Chronic Disease; Female; Fissure in Ano; Huma	2003
Long-term hypoxia alters calcium regulation in near-term ovine myometrium. Biology of reproduction, 2004, Volume: 71, Issue:1 Topics: Animals; Calcium; Calcium Channel Blockers; Chronic Disease; Female; Gestational Age; Hypoxia; Myome	2004
Adverse events associated with aggressive treatment of increased blood pressure. International journal of clinical practice, 2004, Volume: 58, Issue:5 Topics: Administration, Oral; Aged; Aged, 80 and over; Brain Ischemia; Capsules; Chronic Disease; Female; He	2004
Long-term survival and functional results after aortic valve replacement in asymptomatic patients with chronic severe aortic regurgitation and left ventricular dysfunction. Journal of the American College of Cardiology, 2005, Apr-05, Volume: 45, Issue:7 Topics: Adult; Aortic Valve Insufficiency; Chronic Disease; Combined Modality Therapy; Drug Administration S	2005
Nonsurgical treatment of chronic anal fissure: nitroglycerin and dilatation versus nifedipine and botulinum toxin. Canadian journal of surgery. Journal canadien de chirurgie, 2006, Volume: 49, Issue:1 Topics: Administration, Topical; Adult; Anti-Dyskinesia Agents; Botulinum Toxins; Catheterization; Chronic D	2006
Long-term results of "chemical sphincterotomy" for chronic anal fissure: a prospective study. Diseases of the colon and rectum, 2006, Volume: 49, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Botulinum Toxins, Type A; Chronic Disease; Drug Administ	2006
Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity. World journal of gastroenterology, 2006, Oct-14, Volume: 12, Issue:38 Topics: Adult; Aged; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged; Nifedipine; Ointmen	2006
Resolution of chronic pain and fingertip ulceration due to hand-arm vibration syndrome following combination pharmacotherapy. Archives of dermatology, 2007, Volume: 143, Issue:10 Topics: Chronic Disease; Drug Therapy, Combination; Hand-Arm Vibration Syndrome; Humans; Male; Middle Aged;	2007
Adrenalectomy potentiates the anti-inflammatory activity of a calcium channel blocker. Journal of basic and clinical physiology and pharmacology, 2007, Volume: 18, Issue:4 Topics: Acute Disease; Adrenalectomy; Animals; Anti-Inflammatory Agents; Calcium Channel Blockers; Carrageen	2007
Acute hemodynamic effects of nitrendipine in chronic congestive heart failure. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 7 Topics: Adult; Aged; Calcium Channel Blockers; Cardiac Output; Chronic Disease; Female; Forearm; Heart Failu	1984
Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 7 Topics: Adult; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chronic Disea	1984
[Use of nifedipine derivatives in treating ischemic heart disease patients]. Vrachebnoe delo, 1984, Issue:9 Topics: Angina Pectoris; Cardiac Complexes, Premature; Chronic Disease; Coronary Disease; Dose-Response Rela	1984
Effects of nifedipine on pulmonary arterial hypertension in patients with respiratory insufficiency without acute failure. Respiration; international review of thoracic diseases, 1984, Volume: 45, Issue:4 Topics: Aged; Blood Pressure; Carbon Dioxide; Chronic Disease; Forced Expiratory Flow Rates; Heart Rate; Hum	1984
Comparison of hemodynamic responses to nifedipine and nitroprusside in severe chronic congestive heart failure. The American journal of cardiology, 1984, May-01, Volume: 53, Issue:9 Topics: Administration, Oral; Aged; Chronic Disease; Female; Ferricyanides; Heart; Heart Failure; Hemodynami	1984
Myocardial perfusion distal to an acute or chronic coronary artery occlusion: effects of diltiazem and nifedipine. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:2 Topics: Acute Disease; Animals; Calcium Channel Blockers; Chronic Disease; Coronary Circulation; Coronary Di	1982
Calcium channel blockers in chronic stable angina. A review. Herz, 1982, Volume: 7, Issue:4 Topics: Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Diltiazem; Electrocardiography; Humans;	1982
[A case of chronic pulmonary hypertension after fenfluramine intake]. Wiener klinische Wochenschrift, 1982, Nov-26, Volume: 94, Issue:22 Topics: Chronic Disease; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Middle Aged; Nifedipine; Obe	1982
Contrasting short-term effects of nifedipine on glomerular and tubular functions in glomerulonephritic patients. Journal of the American Society of Nephrology : JASN, 1994, Volume: 5, Issue:6 Topics: Adult; Aged; Albuminuria; Blood Pressure; Chronic Disease; Dextrans; Female; Glomerular Filtration R	1994
[Long-term treatment with quinapril in chronic aortic and mitral insufficiency]. Deutsche medizinische Wochenschrift (1946), 1995, Mar-31, Volume: 120, Issue:13 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Aortic Valve Insufficiency; Chronic Disease;	1995
[Individual approach to vasodilator treatment of pulmonary hypertension in chronic bronchitis]. Klinicheskaia meditsina, 1994, Volume: 72, Issue:6 Topics: Adult; Aminophylline; Bronchitis; Chronic Disease; Humans; Hydralazine; Hypertension, Pulmonary; Mid	1994
Management of chronic aortic regurgitation. The New England journal of medicine, 1994, Sep-15, Volume: 331, Issue:11 Topics: Aortic Valve Insufficiency; Chronic Disease; Digoxin; Heart Valve Prosthesis; Humans; Nifedipine; St	1994
Comparative metabolism of 3H-glucosamine by fibroblast populations exposed to cyclosporine. Journal of periodontology, 1994, Volume: 65, Issue:6 Topics: Adult; Cell Count; Cells, Cultured; Chronic Disease; Cyclosporine; Extracellular Matrix; Fibroblasts	1994
[The clofelin and nifedipine treatment of hypertensive crises in elderly patients]. Likars'ka sprava, 1993, Issue:4 Topics: Aged; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertens	1993
NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:3 Topics: Altitude; Animals; Chronic Disease; Glyburide; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male;	1993
Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine. Cardiovascular research, 1993, Volume: 27, Issue:10 Topics: Aging; Animals; Chronic Disease; Electrophoresis, Polyacrylamide Gel; Hypertension; Hypertrophy, Lef	1993
[Pulmonary hemodynamic effects of cold pressor test in patients with chronic lung disease]. Nihon Kyobu Shikkan Gakkai zasshi, 1993, Volume: 31, Issue:2 Topics: Chronic Disease; Cold Temperature; Female; Hemodynamics; Humans; Lung Diseases; Male; Middle Aged; N	1993
Comparison of nifedipine and metoprolol on collateral coronary blood flow in a swine model of chronic coronary obstruction and acute ischaemia during isoflurane anaesthesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:2 Topics: Adrenergic beta-Antagonists; Anesthetics, Inhalation; Animals; Calcium Channel Blockers; Chronic Dis	1996
Possible roles of medullasin in nifedipine-induced human gingival overgrowth. Archives of oral biology, 1996, Volume: 41, Issue:1 Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Chronic Disease; Coloring Agents; Connecti	1996
Ca2+ channel currents in type I carotid body cells of normoxic and chronically hypoxic neonatal rats. Brain research, 1996, Nov-11, Volume: 739, Issue:1-2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e	1996
Ca2+ channel currents in type I carotid body cells from normoxic and chronically hypoxic rats. Advances in experimental medicine and biology, 1996, Volume: 410 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e	1996
Intracellular free magnesium concentrations in skeletal muscle in chronic uraemia. Nephron, 1997, Volume: 76, Issue:1 Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Chron	1997
Effectiveness of nilvadipine in two cases of chronic schizophrenia. Psychiatry and clinical neurosciences, 1995, Volume: 49, Issue:4 Topics: Calcium Channel Blockers; Chronic Disease; Dyskinesia, Drug-Induced; Humans; Male; Middle Aged; Nife	1995
24-hour blood pressure monitoring to evaluate the effects of nifedipine in pre-eclampsia and in chronic hypertension in pregnancy. British journal of obstetrics and gynaecology, 1997, Volume: 104, Issue:6 Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Chronic Dise	1997
Pain in multiple leiomyomas alleviated by nifedipine. Pain, 1997, Volume: 73, Issue:1 Topics: Adult; Calcium Channel Blockers; Chronic Disease; Female; Humans; Leiomyoma; Nifedipine; Pain; Skin;	1997
Atrial L-type Ca2+ currents and human atrial fibrillation. Circulation research, 1999, Sep-03, Volume: 85, Issue:5 Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Ca	1999
Chronic hypertension with subsequent congestive heart failure in a western lowland gorilla (Gorilla gorilla gorilla). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 1999, Volume: 30, Issue:2 Topics: Animals; Animals, Zoo; Antihypertensive Agents; Ape Diseases; Blood Pressure Determination; Chronic	1999
Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. The British journal of surgery, 1999, Volume: 86, Issue:10 Topics: Administration, Oral; Adult; Calcium Channel Blockers; Chronic Disease; Female; Fissure in Ano; Huma	1999
Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. The British journal of surgery, 2000, Volume: 87, Issue:2 Topics: Administration, Oral; Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nifedipine; Pressur	2000
Left ventricular outflow tract obstruction unmasked by nifedipine: a therapeutic pitfall in the management of chronic aortic regurgitation. The Journal of heart valve disease, 2001, Volume: 10, Issue:5 Topics: Aortic Valve Insufficiency; Chronic Disease; Echocardiography; Humans; Male; Middle Aged; Nifedipine	2001
The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovascular research, 2001, Volume: 52, Issue:2 Topics: 4-Aminopyridine; Action Potentials; Aged; Atrial Fibrillation; Atrial Function; Calcium Channel Bloc	2001
Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung. American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:1 Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chronic Disease; Ductus Arteriosus; Enzyme Inhi	2002
Cerebral arterial spasm: part 10. Reversal of acute and chronic spasm in dogs with orally administered nifedipine. Neurosurgery, 1979, Volume: 4, Issue:1 Topics: Acute Disease; Administration, Oral; Animals; Cerebral Arterial Diseases; Chronic Disease; Dogs; Dru	1979
[Effects of the administration of Ca++ antagonist on bronchial resistance in subjects with chronic obstructive bronchopneumopathy]. Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:9 Topics: Adult; Airway Resistance; Calcium; Chronic Disease; Female; Humans; Lung Diseases, Obstructive; Male	1978
Drug treatment of chronic stable angina pectoris. British medical journal, 1978, Feb-25, Volume: 1, Issue:6111 Topics: Angina Pectoris; Chronic Disease; Humans; Nifedipine; Nitrites; Perhexiline; Verapamil	1978
Effects of nifedipine on artificially induced femoral and basilar artery contraction in vitro and reversal of acute and chronic vertebral basilar spasm by orally administered nifedipine in dogs. Neuroradiology, 1978, Volume: 16 Topics: Acute Disease; Animals; Basilar Artery; Chronic Disease; Dogs; Femoral Artery; Ischemic Attack, Tran	1978
[ Combined therapy with isosorbide dinitrate, propranolol and nifedipine in patients with chronic ischemic heart disease]. Kardiologiia, 1992, Volume: 32, Issue:11-12 Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Drug Therapy, Combination; Heart Rate; Hemodynamics;	1992
[The dynamics of the concentration of atrial natriuretic factor depending on changes in the arterial pressure level in patients with arterial hypertension]. Terapevticheskii arkhiv, 1992, Volume: 64, Issue:4 Topics: Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Captopril; Chronic Disease; Humans; Hydrochl	1992
[The korinfar and actovegin treatment of patients with a chronic ischemic disorder of the cerebral circulation]. Likars'ka sprava, 1992, Issue:6 Topics: Adult; Aged; Brain Ischemia; Cerebrovascular Circulation; Chronic Disease; Drug Evaluation; Female;	1992
Effect of single oral administration of nilvadipine on cerebral blood flow in chronic cerebral infarction. Angiology, 1992, Volume: 43, Issue:10 Topics: Administration, Oral; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Cerebral In	1992
Effects of sublingually administered nifedipine on left ventricular isovolumic relaxation, diastolic filling, and distensibility in patients with chronic coronary artery disease. American heart journal, 1992, Volume: 124, Issue:3 Topics: Administration, Sublingual; Aged; Blood Pressure; Chronic Disease; Coronary Disease; Diastole; Femal	1992
Elevated plasma nilvadipine concentration after single and chronic oral administration to patients with chronic liver disease. European journal of clinical pharmacology, 1992, Volume: 42, Issue:5 Topics: Administration, Oral; Calcium Channel Blockers; Chronic Disease; Hemodynamics; Hepatitis; Humans; Li	1992
[The comparative efficacy and prognosis of the long-term treatment with korinfar of men and women suffering from hypertension]. Terapevticheskii arkhiv, 1991, Volume: 63, Issue:8 Topics: Adult; Calcium Channel Blockers; Chronic Disease; Dose-Response Relationship, Drug; Drug Evaluation;	1991
[Loading-induced ST-interval elevations in the case of normal coronary arteries. The angiographic demonstration of loading-induced coronary artery spasm]. Deutsche medizinische Wochenschrift (1946), 1991, Jan-11, Volume: 116, Issue:2 Topics: Angina Pectoris; Chronic Disease; Coronary Angiography; Coronary Vasospasm; Drug Therapy, Combinatio	1991
[The side effects of korinfar in hypertension patients]. Vrachebnoe delo, 1991, Issue:4 Topics: Adult; Blood Pressure; Cerebrovascular Circulation; Chronic Disease; Drug Evaluation; Female; Humans	1991
[The effect of calcium antagonists on the rate of gastric emptying in patients with duodenal peptic ulcer and the dumping syndrome]. Klinicheskaia meditsina, 1990, Volume: 68, Issue:10 Topics: Adult; Calcium Channel Blockers; Chronic Disease; Dumping Syndrome; Duodenal Ulcer; Female; Gastric	1990
[Spectral analysis and color-coded Doppler study of the changes in aortic regurgitation induced by vasodilators in asymptomatic patients with severe aortic insufficiency]. Giornale italiano di cardiologia, 1990, Volume: 20, Issue:9 Topics: Aortic Valve Insufficiency; Blood Pressure; Chronic Disease; Echocardiography, Doppler; Female; Hear	1990
[Nifangin in the combined treatment of chronic cor pulmonale]. Vrachebnoe delo, 1990, Issue:11 Topics: Adult; Calcium Channel Blockers; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Hemody	1990
[Fenigidin in the treatment of patients with chronic cholecystitis in combination with chronic ischemic heart disease]. Vrachebnoe delo, 1990, Issue:5 Topics: Administration, Sublingual; Biliary Tract; Cholecystitis; Chronic Disease; Coronary Disease; Drug Ev	1990
Long-term effect of isosorbide dinitrate and nifedipine, singly and in association, in patients with chronic heart failure. European heart journal, 1990, Volume: 11, Issue:12 Topics: Blood Pressure; Cardiac Output; Chronic Disease; Drug Therapy, Combination; Heart Failure; Hemodynam	1990
Nifedipine and impaired oxygenation in patients with chronic bronchitis and cor pulmonale. Lancet (London, England), 1989, May-20, Volume: 1, Issue:8647 Topics: Administration, Sublingual; Aged; Bronchitis; Chronic Disease; Female; Humans; Male; Middle Aged; Ni	1989
[The effect of calcium antagonists on pulmonary hemodynamics in patients with chronic bronchitis with manifest and latent pulmonary hypertension]. Terapevticheskii arkhiv, 1989, Volume: 61, Issue:8 Topics: Adult; Bronchitis; Calcium Channel Blockers; Chronic Disease; Drug Evaluation; Female; Hemodynamics;	1989
Oxygen therapy and vasodilator therapy in patients with chronic lung disease: the effects of episodic pulmonary hypertension during sleep and exercise performance. Japanese circulation journal, 1989, Volume: 53, Issue:10 Topics: Blood Pressure; Chronic Disease; Exercise Test; Hemodynamics; Humans; Hypertension, Pulmonary; Isoso	1989
Cold intolerance in patients with angina pectoris: effect of nifedipine and propranolol. British heart journal, 1989, Volume: 61, Issue:6 Topics: Adult; Angina Pectoris; Chronic Disease; Cold Temperature; Exercise Test; Female; Humans; Male; Midd	1989
Chronic fatigue syndrome: possible effective treatment with nifedipine. The American journal of medicine, 1988, Volume: 85, Issue:6 Topics: Adult; Chronic Disease; Fatigue; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Male; Nifed	1988
Vasogenic facial pain (cluster headache). International journal of oral and maxillofacial surgery, 1987, Volume: 16, Issue:1 Topics: Adult; Aged; Chronic Disease; Cluster Headache; Facial Pain; Female; Humans; Male; Middle Aged; Nife	1987
Nifedipine in chronic cor pulmonale: acute and relatively long-term effects. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Administration, Sublingual; Aged; Analysis of Variance; Carbon Dioxide; Chronic Disease; Drug Evalua	1988
Left ventricular diastolic filling characteristics and nifedipine effects on chronic aortic regurgitation. Chinese medical journal, 1988, Volume: 101, Issue:1 Topics: Adult; Aortic Valve Insufficiency; Chronic Disease; Diastole; Female; Heart Function Tests; Heart Ve	1988
[Use of calcium antagonists under outpatient polyclinic conditions in patients with chronic obstructive bronchitis complicated by cor pulmonale]. Problemy tuberkuleza, 1988, Issue:8 Topics: Adult; Ambulatory Care; Bronchitis; Carbon Dioxide; Chronic Disease; Drug Evaluation; Hemodynamics;	1988
[Treatment of pulmonary heart failure with calcium antagonists]. Sovetskaia meditsina, 1988, Issue:8 Topics: Adult; Bronchitis; Chronic Disease; Drug Evaluation; Humans; Male; Middle Aged; Nifedipine; Pulmonar	1988
[Effects of nifedipine on pulmonary hypertension in patients with chronic respiratory failure--a comparison with oxygen administration at rest and during exercise]. Nihon Kyobu Shikkan Gakkai zasshi, 1988, Volume: 26, Issue:8 Topics: Adolescent; Adult; Aged; Chronic Disease; Exercise; Humans; Hypertension, Pulmonary; Male; Middle Ag	1988
[Relation between hemodynamic reactions to corinfar and the status of peripheral circulation in middle-aged and elderly patients with ischemic heart disease and chronic heart failure]. Kardiologiia, 1988, Volume: 28, Issue:7 Topics: Age Factors; Aged; Chronic Disease; Coronary Disease; Female; Heart Failure; Hemodynamics; Humans; L	1988
[Effect of low flow oxygen and nifedipine on ventilation and hemodynamics in chronic lung diseases]. Nihon Kyobu Shikkan Gakkai zasshi, 1988, Volume: 26, Issue:5 Topics: Chronic Disease; Female; Hemodynamics; Humans; Lung Diseases; Male; Nifedipine; Oxygen Consumption;	1988
Kinetics of a single dose combination of nifedipine/acebutolol in patients with chronic liver disease. International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:10 Topics: Acebutolol; Adult; Aged; Chronic Disease; Drug Combinations; Female; Humans; Liver Diseases; Male; M	1988
[Effect of nifedipine (corinfar) on pulmonary ventilation at the peak of the action of propranolol in patients with ischemic heart disease associated with chronic obstructive bronchitis]. Kardiologiia, 1988, Volume: 28, Issue:9 Topics: Adult; Aged; Bronchi; Bronchitis; Chronic Disease; Coronary Disease; Female; Humans; Male; Middle Ag	1988
[Use of nifedipine in the broncho-obstructive syndrome]. Vrachebnoe delo, 1988, Issue:11 Topics: Administration, Sublingual; Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Drug Evaluat	1988
[Heart-filling pressure in patients with hypertension treated by nifedipine]. Vrachebnoe delo, 1988, Issue:12 Topics: Adult; Blood Pressure; Chronic Disease; Diastole; Drug Evaluation; Heart; Humans; Hypertension; Male	1988
[New developments in the treatment of chronic circulatory insufficiency]. Vestnik Akademii meditsinskikh nauk SSSR, 1987, Issue:9 Topics: Captopril; Chronic Disease; Heart Failure; Humans; Nifedipine	1987
Prognostic importance of the immediate hemodynamic response to nifedipine in patients with severe left ventricular dysfunction. Journal of the American College of Cardiology, 1987, Volume: 10, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Cardiac Output; Chronic Disease; Female; Follow-Up S	1987
[Effectiveness of calcium antagonists in the treatment of patients with chronic nonspecific lung diseases]. Klinicheskaia meditsina, 1988, Volume: 66, Issue:3 Topics: Adult; Aged; Aminophylline; Calcium Channel Blockers; Chronic Disease; Cinnarizine; Drug Evaluation;	1988
Pharmacokinetics of nifedipine after oral administration in chronic liver disease. Journal of clinical pharmacology, 1987, Volume: 27, Issue:12 Topics: Administration, Oral; Adult; Aged; Chronic Disease; Half-Life; Humans; Liver Diseases; Male; Middle	1987
[Characteristics of left ventricular diastolic filling and effects of nifedipine in patients with chronic aortic regurgitation]. Zhonghua xin xue guan bing za zhi, 1987, Volume: 15, Issue:5 Topics: Adult; Aortic Valve Insufficiency; Chronic Disease; Diastole; Female; Heart Ventricles; Humans; Male	1987
[Nifedipine in the emergency and chronic treatment of arterial hypertension]. Kardiologia polska, 1987, Volume: 30 Suppl Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Chronic Disease; Drug Therapy, Combination; Em	1987
[Essential and iatrogenic gingival hyperplasia. Its morphology and significance]. Revue de stomatologie et de chirurgie maxillo-faciale, 1986, Volume: 87, Issue:5 Topics: Adolescent; Adult; Chronic Disease; Cyclosporins; Female; Gingiva; Gingival Hyperplasia; Gingivectom	1986
[Possibilities of correcting early hemodynamic changes in patients with chronic nonspecific lung diseases using the calcium antagonist corinfar]. Terapevticheskii arkhiv, 1987, Volume: 59, Issue:1 Topics: Adolescent; Adult; Aged; Bronchitis; Chronic Disease; Hemodynamics; Humans; Middle Aged; Nifedipine	1987
[Effect of corinfar on serum digoxin levels in patients with chronic cardiac insufficiency]. Kardiologiia, 1987, Volume: 27, Issue:7 Topics: Aged; Calcium Channel Blockers; Chronic Disease; Digoxin; Drug Therapy, Combination; Heart Failure;	1987
[Effects of nifedipine on pulmonary circulation in patients with chronic cor pulmonale]. Kokyu to junkan. Respiration & circulation, 1987, Volume: 35, Issue:7 Topics: Adolescent; Adult; Aged; Cardiac Output; Chronic Disease; Female; Humans; Hypertension, Pulmonary; M	1987
Effects of nicardipine and nifedipine in chronic heart failure: a non invasive study. Cardiologia (Rome, Italy), 1987, Volume: 32, Issue:7 Topics: Aged; Chronic Disease; Exercise Test; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged	1987
Changes in myocardial metabolism during therapy in patients with chronic stable angina: a comparison of long-term dosing with propranolol and nicardipine. Circulation, 1986, Volume: 73, Issue:6 Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Cardiac Pacing, Artificial; Chronic Disease; Exercise	1986
[Hemodynamic effect of verapamil and nifedipine in chronic heart failure]. Klinicheskaia meditsina, 1986, Volume: 64, Issue:4 Topics: Calcium; Chronic Disease; Drug Evaluation; Female; Heart Failure; Hemodynamics; Humans; Male; Nifedi	1986
[Effect of nifedipine in chronic left ventricular insufficiency in patients with post-infarction heart aneurysm]. Terapevticheskii arkhiv, 1986, Volume: 58, Issue:5 Topics: Adult; Blood Pressure; Cardiac Output; Cardiomyopathy, Dilated; Chronic Disease; Heart Aneurysm; Hem	1986
[Effect of nifedipine on the clinical manifestations of ischemic heart disease occurring with stable stenocardia and the hemodynamic indices]. Kardiologiia, 1986, Volume: 26, Issue:8 Topics: Adult; Angina Pectoris; Chronic Disease; Coronary Disease; Drug Evaluation; Hemodynamics; Humans; Mi	1986
[Treatment of hypertension with the calcium antagonist korinfar and its combination with obzidan]. Terapevticheskii arkhiv, 1986, Volume: 58, Issue:6 Topics: Adult; Calcium Channel Blockers; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Hemody	1986
[Effects of oxygen and nifedipine on hemodynamics in secondary pulmonary hypertension--chronic pulmonary emphysema and chronic lung tuberculosis]. Nihon Kyobu Shikkan Gakkai zasshi, 1986, Volume: 24, Issue:9 Topics: Chronic Disease; Hemodynamics; Humans; Hypertension, Pulmonary; Nifedipine; Oxygen; Oxygen Consumpti	1986
[Treatment of chronic bronchial asthma]. Der Internist, 1985, Volume: 26, Issue:4 Topics: Asthma; Chronic Disease; Cromolyn Sodium; Glucocorticoids; Humans; Ketotifen; Male; Nifedipine; Para	1985
Chronic cerebral vasospasm: effect of calcium antagonists. Neurosurgery, 1986, Volume: 18, Issue:2 Topics: Animals; Cerebral Angiography; Chronic Disease; Disease Models, Animal; Dogs; Injections; Ischemic A	1986
[Effect of nifedipine (adalate) in neurology patients with arterial hypertension]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1985, Volume: 85, Issue:1 Topics: Adult; Aged; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Female; Humans	1985
Sublingual nifedipine: acute effects in severe chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy. The American journal of cardiology, 1985, May-01, Volume: 55, Issue:11 Topics: Administration, Oral; Adult; Aged; Cardiac Output; Cardiomyopathy, Dilated; Chronic Disease; Dose-Re	1985
Effect of vasodilators at rest and during exercise in young adults with cystic fibrosis and chronic cor pulmonale. The American review of respiratory disease, 1985, Volume: 131, Issue:4 Topics: Adult; Chronic Disease; Cystic Fibrosis; Exercise Test; Female; Hemodynamics; Humans; Hydralazine; M	1985
[The use of nifedipine in the treatment of hypertensive crises in patients with chronic uremia undergoing periodic hemodialysis]. La Clinica terapeutica, 1985, Jan-15, Volume: 112, Issue:1 Topics: Chronic Disease; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Renal Dialysis; Uremia	1985
Antihypertensive action of calcium blockade in hypertensive patients with chronic renal disease. Nephron, 1985, Volume: 41, Issue:4 Topics: Adult; Aged; Blood Pressure; Chronic Disease; Drug Therapy, Combination; Female; Humans; Hypertensio	1985

nifedipine and Chronic Illness